Kinetics of drug release from a biodegradable delivery system: in vitro study

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Kinetics of drug release from a biodegradable delivery system: in vitro study”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
The term 'Drug' refers to tetracycline in this study, which is crucial for treating periodontal diseases. Its controlled release from the collagen fiber enables localized antibiotic therapy, overcoming systemic side effects, and targeting specific pathogens like Porphyromonas gingivalis, thus enhancing clinical outcomes in periodontal treatment.

2) Study (Studying):
'Studying' encompasses the systematic investigation undertaken in this research. It signifies a methodical approach to analyzing tetracycline release and antibacterial activity, which is vital for producing credible, evidence-based findings that contribute to the scientific discourse surrounding periodontal disease treatment.

3) Water:
'Water' is used as a medium in the study to assess the release kinetics of tetracycline. It serves as a comparative control against serum inoculated with bacteria, helping to determine how the drug behaves in a non-pathological environment, which is essential for understanding its therapeutic potential.

4) Activity:
The term 'Activity' relates to the antibacterial effect of tetracycline against Porphyromonas gingivalis. Assessing this activity involves measuring the zone of inhibition around the drug-impregnated collagen fibers, which demonstrates the efficacy of the localized drug delivery system in diminishing pathogenic bacterial growth.

5) Antibiotic (Antibacterial):
The word 'Antibacterial' highlights the primary function of tetracycline in combating bacterial pathogens, specifically Porphyromonas gingivalis, associated with periodontal disease. This characteristic is crucial for the success of local drug delivery systems aimed at effectively controlling microbial colonization in periodontal pockets.

6) Disease:
'Disease' refers to periodontal diseases, which this study aims to address through localized antimicrobial therapy. Understanding the etiology and microbial involvement in periodontal disease underscores the necessity for effective treatment modalities that target specific pathogens, leading to improved patient outcomes and oral health.

7) Table:
The 'Table' refers to organized data representations in the study, providing statistical analysis results for tetracycline concentration and zones of inhibition. Tables facilitate clear comparisons, allowing readers to interpret findings effectively regarding drug release kinetics and antibacterial efficacy over the study period.

8) Biodegradable:
'Biodegradable' signifies the property of the collagen fiber used as a drug delivery vehicle, indicating that it can break down naturally in the body. This feature enhances patient safety and allows for sustained drug delivery without the need for surgical removal, maximizing therapeutic benefits.

9) Inflammation:
'Inflammation' is a key pathological feature of periodontal disease that the study indirectly addresses. By utilizing tetracycline, which has anti-inflammatory properties, the research aims to not only combat infections but also mitigate inflammation associated with periodontal conditions, thus improving overall healing.

10) Calculation:
'Calculation' pertains to the spectrophotometric analysis used to determine tetracycline concentrations during the study. Accurate calculations are crucial for interpreting the data on drug release and assessing whether the concentrations remain within effective therapeutic ranges, ensuring the validity of the research findings.

11) Measurement:
The term 'Measurement' is critical in evaluating the study's results, particularly in assessing tetracycline concentrations and zones of inhibition. Accurate measurements ensure that the antibacterial efficacy of the drug can be quantified, providing a scientific basis for its potential clinical applications in periodontal therapy.

12) Developing:
'Developing' refers to the process of creating and refining the bioresorbable collagen fiber impregnated with tetracycline. This aspect is fundamental as it outlines the innovation of the study, which aims to improve local antimicrobial treatment methods in periodontal disease management, emphasizing advancement in therapeutic technologies.

13) Ramaswamy (Ramaswami):
'Ramaswamy' is mentioned as a key contributor to the study, pinpointing an individual recognized for their expertise and guidance in the research process. Highlighting their role acknowledges the collaborative effort in developing and validating the drug delivery system in the context of periodontology.

14) Knowledge:
The word 'Knowledge' reflects the understanding gained from previous studies regarding the role of specific bacteria in periodontal disease. This context is crucial for the current research, informing the rationale behind using tetracycline as an effective therapeutic agent against identified pathogens.

15) Chennai:
'Chennai' is significant as it is mentioned as the location of the Advanced Biotech Products Private Limited, the manufacturer of Periodontal Plus AB™. This geographic reference situates the study within a specific context, highlighting local innovation in developing therapeutic solutions for periodontal disease.

16) Surface:
'Surface' pertains to the root surface area where the study's local drug delivery systems aim to exert their therapeutic effects. Effective treatment in periodontal therapy often focuses on the root surfaces, where bacterial colonization occurs, reinforcing the necessity for targeted drug release mechanisms.

17) Science (Scientific):
'Science' denotes the discipline within which this study is situated, emphasizing the application of scientific principles in examining drug delivery systems. This term reflects the systematic and empirical nature of research aimed at addressing health-related issues, particularly in the context of periodontal disease management.

18) India:
'India' references the country where the study was conducted and where the local drug delivery system was developed. This context underscores the importance of regional contributions to the global body of dental research and innovation in treating periodontal diseases effectively.

19) Ruci (Rucī):
'Ruchi' is acknowledged as a contributor in the context of previous studies referenced in the research. Her mention highlights the collaborative nature of scientific inquiry and recognizes the importance of building upon existing research to inform future studies in periodontal therapy.

20) Anna (Aṇṇa, Aññā, Añña, Ānna, Aṉṉa, Aṉṉā):
'Anna' refers to Anna University, associated with key contributors to the study. This mention reflects the academic institution's involvement, emphasizing the role of universities in fostering research initiatives that advance clinical practices in dentistry and periodontal disease management.