Comparative study of Atridox vs. scaling in periodontitis treatment.

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Journal name: Journal of Indian Society of Periodontology
Original article title: A comparative evaluation of atrigel delivery system (10% doxycycline hyclate) Atridox with scaling and root planing and combination therapy in treatment of periodontitis: A clinical study
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:

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Author:

Mukhatar Ahmed Javali, K. L. Vandana


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: A comparative evaluation of atrigel delivery system (10% doxycycline hyclate) Atridox with scaling and root planing and combination therapy in treatment of periodontitis: A clinical study

Year: 2012 | Doi: 10.4103/0972-124X.94603

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

The treatment of periodontitis, which includes the bacterial infection of the gums and supporting structures of the teeth, presents a significant clinical challenge. Recent advancements have introduced local delivery of antimicrobial agents as a promising therapeutic approach. This study evaluates the efficacy of 10% doxycycline hyclate, administered subgingivally in conjunction with scaling and root planing (SRP), for the treatment of both aggressive and chronic periodontitis. The study involves a randomized crossover split mouth design with four patients, assessing various clinical parameters over a 90-day period to determine the effectiveness of different treatment modalities.

Local Delivery of Doxycycline: A Key Concept

The use of doxycycline hyclate in a gel formulation offers a localized, controlled release of the antibiotic into periodontal pockets, which contrasts with systemic antibiotics that can have wider, undesired effects. Doxycycline’s biodegradable polymer matrix allows for sustained antimicrobial levels, effectively targeting the bacterial pathogens responsible for periodontitis. Results from the study indicate that the combination of SRP with doxycycline delivery provides superior clinical outcomes compared to either treatment alone. Significant reductions in plaque index, bleeding index, and clinical attachment levels were observed, particularly in the SRP and doxycycline group, underscoring the efficacy of local antimicrobial delivery in enhancing periodontal treatment.

Conclusion

The findings of this study demonstrate that the adjunctive use of 10% doxycycline hyclate gel with SRP is more effective than SRP or doxycycline alone in reducing the clinical signs of periodontitis over a 90-day observation period. The enhanced results support the hypothesis that local antimicrobial delivery can significantly improve periodontal treatment outcomes, particularly in patients suffering from aggressive and chronic forms of the disease. This study emphasizes the potential for doxycycline as a viable option in periodontal therapy, encouraging further research into its application and effectiveness across diverse patient populations.

FAQ section (important questions/answers):

What was the main objective of the study conducted?

The study aimed to evaluate and compare the efficacy of local delivery of 10% doxycycline hyclate as an adjunct to scaling and root planing in treating periodontitis.

How were the participants divided for the study?

Participants were divided into three groups: scaling and root planing alone, scaling and root planing with doxycycline, and doxycycline alone, using a crossover split mouth design.

What clinical parameters were measured during the study?

Clinical parameters measured included plaque index, modified gingival index, bleeding index, clinical attachment level, and subgingival temperature, evaluated at specific intervals.

What were the significant findings after 90 days?

After 90 days, the SRP and doxycycline group showed better results in reducing clinical signs of periodontitis compared to the other groups.

What instructions were given to patients after doxycycline application?

Patients were instructed to avoid brushing, flossing, hard foods, and touching the treated area for seven days post-application.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Comparative study of Atridox vs. scaling in periodontitis treatment.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Study (Studying):
The keyword 'Study' refers to the systematic investigation conducted to evaluate the efficacy of local delivery of doxycycline hyclate adjunct to scaling and root planing in treating periodontitis. It emphasizes the methodical approach taken to gather data, analyze clinical outcomes, and draw conclusions for better periodontal care.

2) Bleeding:
In the context of the study, 'Bleeding' relates to one of the clinical parameters evaluated to assess the severity of periodontitis. It involves measuring the bleeding on probing, which indicates inflammation and disease progression in the periodontal tissues, influencing treatment decisions and outcomes.

3) Visit:
The term 'Visit' denotes the scheduled appointments for participants in the study. Each visit involved clinical evaluations and treatment procedures. Regular follow-up visits allowed for monitoring changes in clinical parameters, reinforcing the structured observation necessary for the study's validity and reliability.

4) Measurement:
The keyword 'Measurement' pertains to the clinical parameters quantified in the study, including plaque index, bleeding index, and clinical attachment level. Accurate measurements are essential for assessing the effectiveness of treatments, establishing a baseline, and determining the success of periodontal therapies over time.

5) Dressing:
In the study, 'Dressing' refers to the periodontal dressing applied post-treatment to retain the doxycycline gel in the periodontal pocket. This temporary covering protects the treated area, aids in the healing process, and ensures the localized delivery of the antimicrobial agent remains effective.

6) Disease:
The keyword 'Disease' relates to periodontitis, a condition characterized by inflammation and infection of the periodontal tissues. Understanding the disease's etiology and progression is critical for developing effective treatment strategies, as highlighted in the study, which aims to mitigate its clinical signs through local antimicrobial delivery.

7) Sign:
The term 'Sign' refers to clinical indicators of periodontitis, such as bleeding on probing and clinical attachment loss. These signs are pivotal for diagnosis and monitoring treatment efficacy, as they reflect the health status of periodontal tissues and the infection's response to therapeutic interventions.

8) Biodegradable:
In this study, 'Biodegradable' describes the nature of the doxycycline gel, which breaks down over time within the periodontal pocket. This property allows for sustained release of the antimicrobial agent, providing prolonged therapeutic effects while minimizing the need for removal of the substance after application.

9) Karnataka (Karṇāṭaka):
The keyword 'Karnataka' identifies the geographical location of the institution conducting the research. As a state in India, Karnataka's regulatory framework, patient demographics, and oral health challenges contribute specific context to the study, influencing participant selection and potential findings related to periodontitis treatment.

10) Science (Scientific):
The term 'Science' underscores the methodological and empirical approach employed in the study. It reflects the use of systematic investigations, data collection, and statistical analysis to validate findings, affirming the importance of scientific rigor in developing effective periodontal treatment modalities.

11) India:
In this context, 'India' denotes the country where the study was conducted. The diverse population and unique oral health issues in India provide crucial insights into the prevalence of periodontitis and the effectiveness of localized treatments like doxycycline gel for diverse patient groups.

12) Knowledge:
The keyword 'Knowledge' emphasizes the understanding and information gained from the study regarding the treatment of periodontitis. It illustrates the bridging of gaps in current literature, particularly concerning aggressive periodontitis, and adds to the overall body of evidence for better dental practices.

13) Suffering:
In the study, 'Suffering' relates to the pain and discomfort experienced by patients afflicted with periodontitis. Addressing suffering through effective treatments is essential, as it impacts patients’ quality of life and emphasizes the need for reliable therapeutic options to manage periodontal diseases.

14) Swelling:
The term 'Swelling' relates to one of the potential symptoms of periodontal disease. It indicates inflammation and tissue response to infection. Monitoring swelling in conjunction with other clinical parameters helps in evaluating the treatment's impact and determining the inflammatory status of periodontal tissues.

15) Relative:
The keyword 'Relative' refers to comparison and contrast between various treatment groups in the study. It emphasizes the need for assessing the effectiveness of doxycycline versus scaling and root planing alone, illustrating the importance of comparative analysis in clinical research.

16) Hygiene (Hygienic):
In the context of the study, 'Hygiene' pertains to oral hygiene practices that participants are instructed to follow post-treatment. Maintaining good oral hygiene is vital for preventing the recurrence of periodontal problems and ensuring the effectiveness of antimicrobial treatments.

17) Allergy:
The term 'Allergy' highlights the importance of screening patients for hypersensitivity to doxycycline, which could impact their candidacy for local antimicrobial delivery. Awareness of allergies is crucial to ensure patient safety and optimal treatment outcomes in periodontal therapy.

18) Animal:
In the study, 'Animal' references previous research conducted in animal models, particularly beagle dogs, to explore the efficacy of doxycycline. Animal studies provide foundational knowledge and insights, aiding in the development of human clinical trials by establishing initial product safety and effectiveness.

19) Male (Mālē):
The term 'Male' represents one of the demographic categories for study participants. Accurate representation of gender is essential in clinical research to understand potential differences in treatment responses, contributing to personalized oral healthcare based on gender-specific factors.

20) Food:
In this study, 'Food' relates to dietary instructions given to patients post-treatment to avoid specific types of foods that may disrupt healing or interfere with the retention of doxycycline gel in the periodontal pocket, underscoring the importance of patient compliance.

21) Pain (Paiṇ):
The keyword 'Pain' signifies a common symptom associated with periodontitis, affecting patients’ quality of life. Assessing pain levels during treatment and post-treatment is vital for gauging the success of periodontal therapies and modifying them based on individual patient experiences.

22) Hand:
In the study, 'Hand' refers to the manual instruments used for scaling and root planing procedures. The term emphasizes the significance of skilled hand movement by the clinician in effectively removing plaque and calculus, which is critical to the successful outcomes of periodontal therapy.

23) Drug:
The term 'Drug' pertains to the active pharmaceutical agent used in the study—doxycycline hyclate. Understanding the pharmacological properties, delivery mechanisms, and efficacy of this drug illustrates its role in managing periodontal infections as part of the broader treatment strategy.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Comparative study of Atridox vs. scaling in periodontitis treatment.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Chronic periodontitis, Scaling and root planing, Clinical attachment level, Animal Study, Doxycycline hyclate, Clinical parameter, Controlled Release Delivery System, Aggressive periodontitis, Periodontal dressing.

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