Use of Bio-Oss™ in infrabony periodontal defects.
Journal name: Journal of Indian Society of Periodontology
Original article title: The use of a natural osteoconductive porous bone mineral (Bio-Oss™) in infrabony periodontal defects
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Shankar T. Gokhale, C. D. Dwarakanath
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: The use of a natural osteoconductive porous bone mineral (Bio-Oss™) in infrabony periodontal defects
Year: 2012 | Doi: 10.4103/0972-124X.99270
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The study aimed to evaluate the efficacy of Bio-Oss™, a bovine-derived xenograft, in treating human infrabony periodontal defects and to compare its effects with those of conventional open flap debridement. Twelve patients with moderate to severe periodontitis underwent treatment for a total of 24 defects. These defects were assigned randomly to receive either Bio-Oss™ or just open flap debridement. The researchers recorded various clinical parameters on the day of surgery and again six months post-operatively to assess the outcomes in terms of soft and hard tissue measurements.
Significant Findings in Bone Regeneration
One of the most critical findings from the study was the substantial improvement in clinical parameters at the experimental sites treated with Bio-Oss™ compared to the control sites. Specifically, the experimental sites exhibited an average probing pocket depth reduction of 4.33 mm and a clinical attachment gain of 2.92 mm, alongside a significant bone fill of 1.936 mm, representing a 54.07% improvement. In stark contrast, the control sites showed a mere 0.02 mm bone fill with reduced probing pocket depth of only 2.92 mm and attachment gain of 0.58 mm. This highlights the effectiveness of Bio-Oss™ not only in soft tissue healing but, more importantly, in enhancing bone regeneration in infrabony defects, reinforcing its potential as a preferred treatment option in periodontal therapy.
Conclusion
In conclusion, the study demonstrated that Bio-Oss™ serves as a promising bone graft material in the management of periodontal defects, exhibiting significant improvements in both clinical and radiographic outcomes. While the control sites showed some reduction in probing pocket depth, they failed to achieve meaningful bone fill, underscoring the efficacy of Bio-Oss™ in enhancing periodontal repair and regeneration. Although the results are encouraging, the authors recommend further long-term clinical trials that include histological evaluations to solidify the findings and understand the regenerative processes facilitated by Bio-Oss™.
FAQ section (important questions/answers):
What was the aim of the study regarding Bio-Oss™?
The study aimed to evaluate the efficacy of Bio-Oss™, a bovine-derived xenograft, in treating human infrabony periodontal defects and to compare its performance with traditional open flap debridement.
What significant findings were observed with Bio-Oss™ treatment?
Bio-Oss™ treatment showed significant improvements, including a probing pocket depth reduction of approximately 4.33 mm and a bone fill of about 54.07%, compared to minor improvements in the control sites without graft.
What were the criteria for patient selection in the study?
Patients needed to be healthy adults aged 30-50, free from systemic disease, with moderate to severe periodontitis and at least two vertical osseous defects verified by radiographs.
How were the surgical sites treated in the study?
The defects were randomly assigned to receive either Bio-Oss™ grafting or open flap debridement. The procedure included thorough debridement, graft placement for experimental sites, and primary soft tissue closure.
What was concluded about Bio-Oss™ as a bone graft material?
The study concluded that Bio-Oss™ is a promising bone graft material, showing significant improvement in clinical parameters for infrabony defects, but recommended further long-term studies with histological evaluations.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Use of Bio-Oss™ in infrabony periodontal defects.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Study (Studying):
The conducted study evaluates the efficacy of Bio-Oss™, a bovine-derived xenograft, in treating infrabony periodontal defects. It compares this regenerative approach against conventional open flap debridement to assess improvements in clinical parameters such as probing pocket depth, attachment gain, and bone fill, thereby providing insights into advanced periodontal treatments.
2) Measurement:
Measurement is crucial in assessing the clinical outcomes of periodontal treatments. In this study, precise evaluations were made of probing pocket depths, attachment levels, and radiographic changes in bone fill. Accurate measurement enables clinicians to quantify therapeutic results, facilitating objective comparisons between treatment modalities for better patient care.
3) Post:
The term 'post' denotes outcomes or conditions following surgical intervention. In the context of the study, it pertains to the six-month follow-up phase where clinical parameters were reassessed. This timeframe is critical for evaluating the success of grafting techniques and understanding long-term effects on periodontal health and bone regeneration.
4) Disease:
Periodontitis, described as a chronic inflammatory disease, leads to the loss of connective tissue attachment and supporting bone. Understanding this disease's progression is vital for developing effective treatment strategies. The study addresses moderate to severe periodontitis, highlighting the importance of innovative therapeutic approaches such as using Bio-Oss™ for regeneration.
5) Hygiene (Hygienic):
Hygiene refers to oral hygiene practices crucial for maintaining periodontal health. In the study, patients received thorough scaling and root planing before surgical interventions, emphasizing the importance of cleanliness in preventing disease progression. Good hygiene is a foundational aspect of periodontal treatment, influencing the success of subsequent regenerative procedures.
6) Filling (Filled):
Filling is the action of placing graft material, like Bio-Oss™, into the debrided bone defect. This step is vital for restoring lost bone structure and improving support for periodontal tissues. The proper technique in filling defects ensures that optimal contact between the graft and surrounding tissues occurs, enhancing regeneration success.
7) Table:
Tables in the study present comparative data and statistical analysis of the outcomes observed in the experimental and control groups. They provide clear visual representation of clinical parameter changes, enabling easy interpretation of results. Tables are essential for conveying complex data succinctly, facilitating the understanding of treatment efficacy.
8) Dressing:
The dressing used post-surgery, specifically Coe-Pak™, serves to protect the surgical site and maintain graft stability during the healing process. Periodontal dressings are critical in ensuring favorable outcomes by preventing disturbances to the grafted area, minimizing complications like postoperative bleeding or infection, and fostering a conducive environment for healing.
9) Incision:
Incisions are surgical cuts made to access periodontal defects, critical in executing procedures like flap debridement. The study employed intrasulcular incisions to facilitate access while preserving soft tissue. Incision techniques directly affect surgical outcomes, influencing healing time, tissue recovery, and the success of grafting interventions in periodontal therapy.
10) Grafting:
Grafting involves transplanting biomaterials, in this case, Bio-Oss™, into osseous defects to promote bone regeneration. This study focuses on the effectiveness of grafts compared to traditional surgery in improving periodontal conditions. Grafting is critical in achieving successful outcomes, as it aims to restore alveolar bone integrity and enhance clinical attachment levels.
11) Mineral:
Mineral refers to the inorganic components of bone, specifically in the context of Bio-Oss™, which is derived from bovine sources. Understanding the mineral composition is crucial, as it mirrors human bone characteristics, promoting biocompatibility and effective integration during the healing process. This reinforces the viability of Bio-Oss™ as a grafting material.
12) Male (Mālē):
This term denotes the demographic aspect of the study participants, with 5 males included among the 12 patients treated. Understanding gender distribution is important in clinical research as it may influence treatment response and outcomes. Addressing gender-related factors ensures comprehensive evaluations of therapeutic interventions in diverse patient populations.
13) Surrounding:
Surrounding refers to the tissues adjacent to the surgical site, which play a crucial role in the healing process post-surgery. The compatibility of graft materials with surrounding tissues is essential for successful regeneration. Assessing the response of these tissues to graft placement aids in understanding overall treatment outcomes and patient recovery.
14) Antibiotic (Antibacterial):
Antibiotic refers to the systemic therapy provided post-operatively to prevent infection following surgical procedures. In the study, tetracycline was administered to facilitate healing and minimize complications. The use of antibiotics underscores the importance of infection control in periodontal surgeries and highlights comprehensive approaches to ensure patient safety and treatment efficacy.
15) Swelling:
Swelling is a potential postoperative complication in surgical procedures, reflecting inflammation around the surgical site. The study reported no instances of excessive swelling, indicating favorable healing conditions. Monitoring for swelling is essential in postoperative care, informing clinicians about potential complications and ensuring that healing progresses as expected.
16) Company:
Company refers to Geistlich Biomaterials, the manufacturer of Bio-Oss™, which is a crucial aspect of the product's credibility and reliability in clinical applications. Understanding the source of graft materials emphasizes the importance of quality assurance in biomaterial development, influencing choices made by dental professionals in regenerative periodontal therapies.
17) Surface:
Surface pertains to the characteristics of Bio-Oss™, particularly its porous and crystalline structure that enhances osteoconductivity and bone integration. The surface properties of graft materials are significant in promoting cellular interactions and growth, ultimately affecting the efficacy of bone regeneration procedures in periodontal therapy.
18) Repair:
Repair refers to the restorative processes initiated after periodontal surgery, aiming to restore lost tissue architecture and function. The study evaluates the effectiveness of Bio-Oss™ in facilitating repair by promoting new bone formation and clinical attachment gain, critical components for successful periodontal rehabilitation and improved patient outcomes.
19) Nature:
Nature signifies the inherent characteristics and biological properties of Bio-Oss™ as a graft material. Recognizing the natural origin enhances understanding of its compatibility and function in human tissues, emphasizing the potential for achieving successful regenerative outcomes due to the design and biological suitability of the graft in periodontal defects.
20) Reason:
Reason pertains to the rationale behind selecting Bio-Oss™ for this study, focusing on its reported biocompatibility and effectiveness in enhancing periodontal regeneration. Establishing a clear reason for graft selection informs clinical decision-making processes, ensuring that treatment choices are grounded in evidence-based practice to optimize patient care.
21) Visit:
Visit refers to the regular follow-up appointments scheduled for patients post-surgery to monitor healing and assess treatment outcomes. These visits are integral in permitting clinicians to evaluate the success of interventions, make necessary adjustments, reinforce oral hygiene instructions, and ensure optimal recovery and long-term maintenance of periodontal health.
22) Silk:
Silk relates to the type of sutures used in the study, specifically non-absorbable black silk sutures. Selecting appropriate sutures is essential in ensuring effective closure of surgical sites, reducing the risk of complications such as dehiscence, and contributing to favorable outcomes by providing adequate support for healing tissues during postoperative recovery.
23) Line:
Line denotes accuracy in surgical procedure execution, and maintaining a consistent approach throughout the study. In the surgical context, achieving a precise line during incisions and suturing is crucial for proper healing, influencing both aesthetic results and functional outcomes in periodontal treatments involving soft and hard tissue regeneration.
24) Pain (Paiṇ):
Pain is a common concern following surgical interventions, and managing it effectively is essential for patient comfort. The study monitored postoperative pain levels to ensure that the surgical procedures remained within acceptable limits. Addressing pain through appropriate analgesics contributes to overall patient satisfaction and successful recovery in periodontal surgeries.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘Use of Bio-Oss™ in infrabony periodontal defects.’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
Healing properties, Antibiotic therapy, Informed consent, Systemic disease, Probing pocket depth, Long-term Clinical Studies, Surgical technique, Random assignment, Clinical parameter, Bone fill, Open flap debridement, Adult periodontitis, Baseline scores.