GEM 21S® vs. collagen membrane for root coverage in gingival recession.
Journal name: Journal of Indian Society of Periodontology
Original article title: Clinical evaluation of GEM 21S® and a collagen membrane with a coronally advanced flap as a root coverage procedure in the treatment of gingival recession defects: A comparative study
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Preetinder Singh, D. K. Suresh
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Clinical evaluation of GEM 21S® and a collagen membrane with a coronally advanced flap as a root coverage procedure in the treatment of gingival recession defects: A comparative study
Year: 2012 | Doi: 10.4103/0972-124X.106919
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
This clinical evaluation aimed to assess the efficacy of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) combined with beta-tricalcium phosphate (GEM 21S®) and a collagen membrane in enhancing root coverage through a coronally advanced flap technique. The study's significance arises from the increasing demand for effective periodontal procedures that address aesthetic concerns linked to gingival recession, hypersensitivity, and root caries. The research highlights the potential of incorporating growth factors and osteoconductive scaffolds in regenerative periodontal therapy, which is crucial for achieving predictable and aesthetic outcomes.
Growth Factor and Matrix in Periodontal Regeneration
A key aspect of the study is the innovative use of GEM 21S®, which merges rhPDGF-BB and beta-tricalcium phosphate, to stimulate the body's inherent healing processes. This growth-factor-enhanced matrix is designed to not only facilitate wound healing but also promote bone regeneration and enhance gingival attachment in challenging periodontal conditions. By recruiting periodontal progenitor cells, the treatment aims to create a functional tissue environment that can effectively cover exposed roots. With the study comparing the outcomes of GEM 21S® paired with a collagen membrane against a collagen membrane alone, it underscores the advancements in tissue engineering and regenerative therapies that could redefine periodontal treatment paradigms.
Conclusion
The findings from this case series indicate a favorable clinical and esthetic outcome when utilizing GEM 21S® combined with a collagen membrane in recession defect management through a coronally advanced flap technique. Statistically significant reductions in gingival recession depth highlight the potential of integrating growth factors in periodontal surgery. As interest in esthetic periodontal procedures continues to grow, the importance of exploring and validating effective regenerative techniques becomes paramount, reinforcing the need for further research in this field to optimize treatment outcomes and enhance patient satisfaction.
FAQ section (important questions/answers):
What is the purpose of this study on rhPDGF-BB?
The study aims to evaluate the efficacy of rhPDGF-BB combined with beta tricalcium phosphate in root coverage procedures using a coronally advanced flap, comparing it against a collagen membrane alone.
What are the main treatments compared in the study?
The study compares two treatments: one using GEM 21S® (rhPDGF-BB plus beta-tricalcium phosphate) along with a collagen membrane, and another using only a collagen membrane for root coverage.
How was the surgical procedure conducted for Group A?
Group A underwent a coronally advanced flap with GEM 21S®, where the exposed root surface was treated with rhPDGF-BB, beta-tricalcium phosphate, and a collagen membrane.
What clinical parameters were assessed post-surgery?
Clinical parameters included recession depth, clinical attachment level, probing depth, and width of keratinized tissue, recorded at 1, 3, and 6 months after surgery.
What were the findings regarding tissue responses to treatments?
The study found that both GEM 21S® and collagen membrane showed favorable tissue responses, indicating positive clinical and aesthetic outcomes in regenerative periodontal surgery.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “GEM 21S® vs. collagen membrane for root coverage in gingival recession.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Beta (Bēṭa, Beṭa):
Beta-tricalcium phosphate (β-TCP) is an osteoconductive material used in regenerative periodontal surgery. It serves as a scaffold for bone and tissue regeneration, facilitating healing and providing structural support. In this study, it works synergistically with recombinant human platelet-derived growth factor (rhPDGF-BB) to enhance tissue recovery post-surgery.
2) Incision:
Incisions are critical surgical cuts made to access the tissue underlying a gingival recession defect. The design and placement of these incisions can affect healing and the success of root coverage procedures. Proper incisional techniques promote tissue adaptation and minimize scars, enhancing clinical outcomes.
3) Study (Studying):
This clinical study evaluates the efficacy of a novel treatment modality involving rhPDGF-BB, β-TCP, and collagen membranes for root coverage. The findings contribute to evidence-based periodontal therapy, influencing future regenerative techniques and informing best practices in clinical periodontal surgery.
4) Surface:
The root surface, which becomes exposed due to gingival recession, is the target area for treatment. Proper conditioning and application of biologic materials on this surface are essential for successful healing and attachment gain. The study emphasizes the importance of managing the root surface effectively.
5) Transformation (Transform, Transforming):
Transforming growth factor (TGF) is another crucial cytokine involved in tissue regeneration. Although not the primary focus of this study, factors like TGF are important in wound healing and cellular responses, complementing the effects of PDGF in periodontal regeneration and overall tissue healing processes.
6) Surrounding:
The term 'surrounding' refers to the tissues, bone, and supporting structures adjacent to the treated gingival recession area. Understanding the surrounding environment is vital in periodontal therapy; the success of treatments often depends on how well these surrounding tissues respond to surgical interventions.
7) Measurement:
Measurement of clinical parameters such as recession depth, attachment level, and keratinized tissue width is essential for evaluating treatment effectiveness. These measurements provide objective data, allowing comparisons between treatment modalities, which informs future clinical decisions and enhances understanding of regenerative techniques.
8) Science (Scientific):
The advancements and techniques in this study reflect the integration of science into clinical practice. Understanding biological processes, surgical methodologies, and the use of growth factors are vital for evolving periodontal therapy, ultimately enhancing patient outcomes and improving the quality of periodontal treatments.
9) Antibiotic (Antibacterial):
Antibiotics, such as amoxicillin and cloxacillin, are administered post-surgery to prevent infections. Their role is critical in ensuring successful healing of surgical sites. The prudent use of antibiotics is also necessary to mitigate potential complications, thus promoting better clinical outcomes in periodontal procedures.
10) Swelling:
Swelling is a common postoperative symptom following surgical procedures. Monitoring for swelling allows clinicians to assess the healing process and identify potential complications such as infection or improper healing. Managing swelling is essential for patient comfort and overall treatment success.
11) Dressing:
Dressing is applied post-operatively to protect the surgical site and promote healing. In the context of this study, periodontal dressing serves to stabilize the flap and prevent displacement while allowing initial healing. Dressing changes aid in maintaining hygiene and observing the surgical area.
12) Bleeding:
Bleeding is a potential complication during and after surgical procedures. Evaluating bleeding postoperative is crucial for assessing the success of hemostasis and overall surgical technique. Managing bleeding effectively can prevent unwanted complications and ensure a smoother recovery for patients undergoing periodontal procedures.
13) Ambala:
Ambala, a district in Haryana, India, is the locale from which study participants were drawn. The geographical context may influence patient demographics and health profiles, contributing to the study's findings and providing insight into regional variations in periodontal health and treatment outcomes.
14) Reason:
The underlying reason for conducting this study is to explore the efficacy of innovative periodontal treatment strategies. As patients increasingly seek better esthetic outcomes and functional recovery, identifying effective techniques becomes vital in addressing gingival recession and enhancing periodontal therapy.
15) Animal:
Referring to prior research, animal studies play a crucial role in understanding the biological actions of growth factors and materials used in human therapies. This study builds on previous animal research findings, validating their translational potential to clinical settings within human periodontal therapy.
16) Desire:
The desire for improved esthetic outcomes drives the need for effective root coverage procedures. Patient expectations regarding the appearance of their dentition influence treatment decisions, underlining the necessity for clinicians to provide innovative and predictable surgical options in periodontal care.
17) Blood:
Blood is critical for the wound healing process, supplying cells and growth factors vital for tissue regeneration. The study highlights the importance of growth factors released by platelets in blood during healing, emphasizing their role in successful periodontal regeneration strategies.
18) Pain (Paiṇ):
Pain management is a vital aspect of postoperative care following periodontal surgeries. Proper assessment and alleviation of pain contribute to patient comfort and satisfaction, influencing recovery experiences. Effective pain control strategies can aid in ensuring success in periodontal surgical interventions.
19) Post:
The term 'post' signifies the period after surgical procedures, which is crucial for monitoring healing and recovery. Postoperative evaluations allow clinicians to assess the effectiveness of interventions and ensure patients are informed on proper care to achieve optimal outcomes.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘GEM 21S® vs. collagen membrane for root coverage in gingival recession.’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
Wound healing, Clinical study, Clinical evaluation, Surgical Procedure, Clinical outcome, Periodontal therapy, Periodontal regeneration, Biological barriers, Platelet-derived growth factor, Growth factor, Clinical parameter, Collagen membrane, Stem cell, Root coverage, Edentulous area, Keratinized tissue, Tissue response, Split mouth design, Antibiotic coverage.