Nano-crystalline hydroxyapatite and collagen for periodontal defects
Journal name: Journal of Indian Society of Periodontology
Original article title: Nano-crystalline hydroxyapatite bone graft combined with bioresorbable collagen membrane in the treatment of periodontal intrabony defects: A randomized controlled clinical trial
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Vijendra P. Singh, Dilip G. Nayak, Ashita S. Uppoor, Dipen Shah
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Nano-crystalline hydroxyapatite bone graft combined with bioresorbable collagen membrane in the treatment of periodontal intrabony defects: A randomized controlled clinical trial
Year: 2012 | Doi: 10.4103/0972-124X.106912
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The study aims to assess the clinical effectiveness of using nanocrystalline hydroxyapatite (NcHA) bone graft in combination with a collagen membrane (PerioCol®) compared to open flap debridement (OFD) alone for treating intrabony periodontal defects. The research involved 16 systemically healthy patients, who were tracked over a period of six months, with various periodontal health indicators including plaque index, gingival index, probing pocket depth (PPD), and clinical attachment level (CAL) being evaluated. The implementation of NcHA, known for its osteoconductive properties and ability to enhance bone healing, combined with a bioresorbable collagen membrane, forms the basis for exploring improved periodontal regeneration techniques.
Enhanced Periodontal Regeneration
An important aspect of the study is the synergistic effect of combined regenerative procedures in comparison to traditional methods. Clinical outcomes demonstrated that the test group, which received the NcHA graft and collagen membrane, showed a significant reduction in probing pocket depth (PPD) of 4.33 mm and a clinical attachment level (CAL) gain of 3.78 mm after six months. In contrast, the control group that underwent only OFD displayed a mean PPD reduction of 3.22 mm and a CAL gain of 2.78 mm. These results highlight the potential of applying NcHA with PerioCol® as a more effective treatment strategy for enhancing periodontal regeneration in patients with intrabony defects.
Conclusion
The findings from this study suggest that the use of nanocrystalline hydroxyapatite bone graft in conjunction with a collagen membrane results in superior clinical outcomes in treating intrabony periodontal defects compared to open flap debridement alone. The combination of these regenerative materials not only improves the probing pocket depth and clinical attachment levels but also supports the ongoing development of more effective periodontal treatments. This research contributes to the broader understanding of regenerative approaches in periodontics and emphasizes the importance of combining graft materials and membranes to facilitate optimal healing and regeneration.
FAQ section (important questions/answers):
What is the aim of the study involving NcHA and collagen membranes?
The study aims to evaluate the clinical outcomes of nanocrystalline hydroxyapatite (NcHA) bone graft combined with a collagen membrane compared to open flap debridement in treating intrabony periodontal defects.
What were the key findings regarding PPD and CAL in the groups?
In the control group, the mean reduction of probing pocket depth (PPD) was 3.22 mm, and clinical attachment level (CAL) gain was 2.78 mm. In the test group, PPD reduction was 4.33 mm with a CAL gain of 3.78 mm.
What is the significance of using NcHA in periodontal defects?
Nanocrystalline hydroxyapatite (NcHA) promotes faster healing and shows improved osseointegration, which enhances bone regeneration in critical size defects, making it beneficial in periodontal treatments.
What is the role of the collagen membrane in combination with NcHA?
The collagen membrane supports the bone graft and helps maintain its position, preventing undesirable cell entry, which is crucial for effective guided tissue regeneration in periodontal defects.
What criteria were used for patient selection in the study?
Patients were chosen based on their health, presence of specific intrabony defects, good oral hygiene, and no recent antibiotic use or periodontal surgery in the last 12 months.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Nano-crystalline hydroxyapatite and collagen for periodontal defects”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Study (Studying):
Study refers to the research investigation conducted to evaluate the clinical outcomes of using nanocrystalline hydroxyapatite (NcHA) bone grafts combined with collagen membranes in treating intrabony periodontal defects. It involves systematic observation, data collection, and analysis, contributing to advancements in periodontal regenerative techniques and providing evidence-based conclusions about treatment efficacy.
2) Antibiotic (Antibacterial):
Antibiotic pertains to the exclusion criteria established for patient selection. Patients in the study could not have taken antibiotics within six months before the examination. This requirement ensures that the presence of antibiotics does not interfere with healing processes or the study's outcomes, hence maintaining the integrity of treatment evaluations.
3) Fish:
Fish is significant as it relates to the source of the collagen membrane used in the study (PerioCol®). The development of bioresorbable collagen membranes from non-mammalian sources like fish is particularly relevant for guided tissue regeneration applications in periodontal therapy, offering alternative materials that might have distinct biological advantages.
4) Activity:
Activity in this context refers to the physiological processes involved in bone healing and regeneration. Specifically, the study highlights the osteoblast activity stimulated by NcHA, which contributes to the successful integration of the graft and collagen membrane, ultimately leading to improved clinical outcomes in periodontal defect treatments.
5) Surface:
Surface plays a critical role regarding nanostructured materials, particularly in NcHA. The increased surface area of nanosized particles enhances the material's bioactivity, osseointegration, and interaction with surrounding tissues, thus facilitating more effective regeneration processes. This property is integral to the effectiveness of the proposed grafting techniques in the study.
6) Hygiene (Hygienic):
Hygiene can refer to the study's criteria related to the participants' oral health. A good level of oral hygiene was necessary for inclusion, emphasizing its importance in periodontal health and treatment outcomes. Maintaining proper oral hygiene is essential for the success of periodontal therapies and minimizing complications during treatment.
7) Science (Scientific):
Science encompasses the systematic approach taken in this clinical study. It represents the methodologies, statistical analyses, and underlying principles used to evaluate the effectiveness of new materials and techniques. Scientific inquiry helps validate findings in periodontology, advancing clinical practices and informing future research in dental treatments.
8) Animal:
Animal references previous experimental studies mentioned in the text that tested nanocrystalline hydroxyapatite (NcHA) in various applications, including bone healing. These studies provided foundational evidence supporting the use of NcHA in human subjects. Animal studies are critical for assessing the safety and effectiveness of medical materials before human trials.
9) Male (Mālē):
Male indicates the demographic distribution of subjects included in the study, with nine male participants out of sixteen total. Including a balanced gender distribution in clinical trials is important to ensure that findings are generalizable and applicable across the broader population, thereby improving the reliability of research outcomes.
10) Pur (Pūr):
Poor applies to the description of potential issues with collagen membranes when dampened by biological fluids. Such membranes may exhibit decreased resistance and structural integrity, which could hinder successful regeneration. The study addresses this concern by exploring the combined technique of using a bone graft to support the membrane effectively.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘Nano-crystalline hydroxyapatite and collagen for periodontal defects’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
Randomly assigned, Probing pocket depth, Mann–Whitney U-test, Clinical attachment level, Wilcoxon signed rank–sum test, Controlled clinical trial, Gingival Recession, Clinical outcome, Collagen membrane, Open flap debridement, Guided tissue regeneration.