Evaluation of biodegradable tetracycline fiber in periodontitis
Journal name: Journal of Indian Society of Periodontology
Original article title: Evaluation of commercially available biodegradable tetracycline fiber therapy in chronic periodontitis
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Surinder Sachdeva, Vipin Agarwal
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Evaluation of commercially available biodegradable tetracycline fiber therapy in chronic periodontitis
Year: 2011 | Doi: 10.4103/0972-124X.84381
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Chronic periodontitis is an inflammatory disorder primarily caused by the presence of mixed microbial flora in dental plaque. Treatment strategies focus on removing microorganisms through mechanical debridement, such as scaling and root planing (SRP), alongside systemic or localized antimicrobial agents. This study investigates the efficacy of combining SRP with tetracycline fibers, administered locally in periodontal pockets, versus SRP alone in improving periodontal health over a three-month observation period in patients with significant periodontal issues.
Enhanced Treatment with Local Antibiotics
The study utilized a split-mouth design involving 35 patients, each presenting with two non-adjacent periodontal pockets measuring ≥5 mm and exhibiting bleeding on probing. The patients were treated at selected sites either with SRP alone or SRP combined with tetracycline-impregnated collagen matrix. Clinical assessments, including plaque index, gingival index, probing pocket depth, and clinical attachment level, revealed that while both treatment modalities resulted in improvements, the combination of local drug delivery with SRP demonstrated superior results. This suggests that localized antibiotic treatment may be more effective in targeting residual microbes, particularly in challenging anatomical areas, and in enhancing clinical outcomes in chronic periodontitis.
Conclusion
The findings indicate that the application of tetracycline in a collagen matrix following scaling and root planing can provide significant benefits in managing chronic periodontitis. By effectively reducing plaque accumulation, improving gingival health, and promoting clinical attachment gain, the combination therapy may offer a more comprehensive approach to periodontal treatment. These results support the inclusion of local antibiotic delivery methods in periodontal therapy regimens to optimize patient outcomes and further manage this complex inflammatory condition.
FAQ section (important questions/answers):
What is the main cause of chronic periodontitis?
Chronic periodontitis is primarily caused by dental plaque containing mixed microbial flora, leading to an inflammatory disorder affecting the supporting structures of the teeth.
What is the purpose of using tetracycline in periodontal treatment?
Tetracycline is used as a local antimicrobial agent to reduce bacteria in periodontal pockets, especially in hard-to-reach areas where traditional mechanical debridement may not be sufficient.
What are the main methods of treating chronic periodontitis?
Treatment typically involves scaling and root planing to remove plaque and calculus, and may be augmented by local or systemic antimicrobial agents to enhance effectiveness.
How was the study on tetracycline fibers designed?
The study involved 35 patients with chronic periodontitis, comparing the effectiveness of scaling and root planing combined with tetracycline fibers to scaling and root planing alone over three months.
What were the main outcomes measured in the study?
The study evaluated changes in plaque index, gingival index, probing depth, and clinical attachment level at baseline and during the three-month follow-up period.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Evaluation of biodegradable tetracycline fiber in periodontitis”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Disease:
Disease refers to chronic periodontitis in this context, an inflammatory disorder resulting from an interaction between host mechanisms and microbial factors, primarily from dental plaque. Understanding the disease's pathogenesis is crucial for developing effective treatment strategies aimed at managing the infection and preserving periodontal health.
2) Drug:
The term drug, specifically tetracycline, highlights its role as a localized antimicrobial agent used in treating chronic periodontitis. The advantages of localized drug delivery include targeting infected sites directly, minimizing systemic exposure, and improving treatment outcomes, particularly in conjunction with mechanical therapies like scaling and root planing.
3) Study (Studying):
The study represents a clinical investigation designed to assess the effectiveness of treating chronic periodontitis with a combination of scaling and root planing alongside tetracycline delivery. It employs a split-mouth design, allowing for direct comparisons of therapeutic outcomes, ultimately contributing to evidence-based clinical practices in periodontology.
4) Post:
Post indicates the timeframe for evaluating treatment efficacy after initial therapeutic interventions. In this study, clinical parameters are measured at intervals after therapy to determine the sustained effects and improvements in periodontal health, facilitating an understanding of how treatment impacts disease progression over time.
5) Measurement:
Measurement is essential in clinical studies to quantify the effectiveness of treatments. In this case, parameters such as plaque index, gingival index, probing pocket depth, and clinical attachment level are systematically evaluated before and after therapy, providing objective evidence of treatment outcomes in managing chronic periodontitis.
6) Visit:
Visit refers to the clinical interactions where patients are assessed, treated, and monitored. Each visit allows for the collection of data on periodontal health parameters, enabling practitioners to track improvements or changes due to the implemented treatment, thereby informing future therapeutic decisions and patient care.
7) Biodegradable:
Biodegradable pertains to the tetracycline-impregnated collagen used in the study as a localized drug delivery system. This characteristic ensures safe and effective treatment in periodontal therapy, as the material gradually breaks down naturally within the periodontal pocket, reducing the risk of complications associated with non-resorbable alternatives.
8) Observation:
Observation indicates the timeline and approach used to gather data on patient responses to treatment over the study period. Continuous observation allows researchers to document changes in periodontal parameters, thereby assessing the effectiveness and longevity of the therapeutic interventions employed in managing chronic periodontitis.
9) Antibiotic (Antibacterial):
Antibiotic refers to the classification of tetracycline, a key component of the study aimed at reducing microbial load in periodontal pockets. Its bacteriostatic properties help inhibit bacterial growth, making it a valuable adjunct therapy when combined with mechanical treatments for chronic periodontitis.
10) Bleeding:
Bleeding signifies a significant clinical symptom associated with periodontal disease, indicating inflammation and tissue destruction. Clinically measuring bleeding on probing helps assess the severity of periodontal disease and the effectiveness of treatments applied, as a reduction in bleeding is a primary goal of periodontal therapy.
11) Pregnant:
Pregnant highlights a specific exclusion criterion within the study population, indicating the need to exclude expectant mothers from participation due to potential risks associated with antibiotic use and periodontal treatments. This ensures the safety of both the mother and the developing fetus during treatment.
12) Chennai:
Chennai denotes the geographical location where the study was conducted, emphasizing the context in which the research took place. Understanding the local population and healthcare environment is crucial for interpreting study results and for future applications of findings in similar or different demographic settings.
13) Hygiene (Hygienic):
Hygiene refers to the essential aspect of oral care emphasized in the study. Proper oral hygiene practices are vital in preventing and managing periodontal disease, and educating patients on these practices is crucial for achieving long-term therapeutic success alongside clinical interventions and treatments.
14) Allergy:
Allergy refers to the exclusion criterion related to patients with known hypersensitivity to tetracycline or other materials used during the study. This consideration is crucial for patient safety and ensuring that adverse effects do not confound the results of the study concerning treatment efficacy.
15) India:
India is the country where the study was conducted, providing important context about the healthcare landscape, socioeconomic factors, and cultural attitudes towards dental health. This context is essential for understanding the applicability and generalizability of the study findings to diverse populations and regions.
16) Male (Mālē):
Male denotes one gender represented within the study population, reflecting an emphasis on inclusivity in clinical research. In studies such as this, gender distribution is important for analyzing potential differences in treatment responses or outcomes, thereby enhancing the overall understanding of chronic periodontitis.
17) Pur (Pūr):
Poor emphasizes a situation characterized by inadequate access or effectiveness in previous periodontal therapies, highlighting that mechanical cleaning methods alone often fail in certain scenarios. The study aims to address such shortcomings by testing a combined approach utilizing both mechanical and localized antibiotic therapies.