Aspartate aminotransferase in gingival fluid: Initial therapy study.
Journal name: Journal of Indian Society of Periodontology
Original article title: Analysis of aspartate aminotransferase in gingival crevicular fluid: A study with initial therapy
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Tejal S. Sheth, Sharmila J Verma
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Analysis of aspartate aminotransferase in gingival crevicular fluid: A study with initial therapy
Year: 2011 | Doi: 10.4103/0972-124X.85666
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The conventional diagnostic indicators in periodontal disease are often insufficient in differentiating between active and inactive disease phases, as they primarily reflect past tissue destruction. A precise and accurate periodontal diagnosis is crucial for developing effective treatment and preventive strategies, as well as for identifying at-risk sites. This study aimed to investigate the relationship between gingival crevicular fluid (GCF) levels of aspartate aminotransferase (AST) and the progression of periodontal disease. It also sought to analyze AST levels in GCF before and after initial therapy in patients with chronic periodontitis, examining the association between AST and conventional measures of periodontal health.
Relationship Between AST Levels and Periodontal Health
The study involved 20 patients diagnosed with chronic periodontitis, with sampling conducted at both diseased and healthy sites. Specifically, two sites with active disease and one healthy site were selected from each patient. The periodontal health status, along with GCF levels of AST, was assessed at baseline and again three months following initial therapy. The findings revealed a statistically significant difference in AST levels between diseased and healthy periodontal sites, suggesting a potential role for AST as a biomarker in gauging periodontal disease activity.
Conclusion
The results of this longitudinal study indicate that GCF levels of AST may serve as a relevant diagnostic indicator in chronic periodontitis, providing insight into the disease's ongoing activity. The significant variation in AST levels between healthy and diseased sites underscores the necessity for further research in this area. Establishing AST as a reliable biomarker could enhance clinical approaches to periodontal diagnosis and management, ultimately aiding in the prevention of disease progression.
FAQ section (important questions/answers):
What is the focus of the study on periodontal disease?
The study examines the relationship between aspartate aminotransferase (AST) levels in gingival crevicular fluid and the progression of chronic periodontitis, evaluating AST before and after initial therapy.
How many patients participated in the periodontal study?
A total of 20 patients with chronic periodontitis were randomly selected for the study, with specific sites chosen for evaluation.
What were the key findings regarding AST levels?
Results indicated a statistically significant difference in AST levels between diseased periodontal sites and healthy sites, suggesting AST could be a potential indicator of periodontal disease activity.
What is the importance of a proper periodontal diagnosis?
A proper periodontal diagnosis is essential for rational treatment planning, preventive strategies, and identifying sites at risk for disease progression.
What measures were taken at baseline and after therapy?
The periodontal status and GCF-AST levels were recorded at baseline and again three months after initial therapy, allowing for a comprehensive analysis of treatment effects.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Aspartate aminotransferase in gingival fluid: Initial therapy study.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Disease:
Disease refers to a pathological condition affecting the normal function of the body, particularly in this study, chronic periodontitis. Understanding the disease is vital for identifying indicators that reveal its presence and extent, guiding clinicians in diagnosing and effectively treating periodontal conditions to mitigate further tissue destruction.
2) Activity:
Activity in this context denotes the active phase of periodontal disease, characterized by inflammation and tissue destruction. Distinguishing between active and inactive disease states is crucial for periodontal diagnosis and treatment planning, allowing clinicians to focus on improving patient outcomes through targeted therapies aimed at reducing disease activity.
3) Study (Studying):
Study pertains to the systematic investigation undertaken to explore the relationship between gingival crevicular fluid levels of aspartate aminotransferase (AST) and periodontal disease progression. It encompasses methodology, materials, and objectives, contributing to the scientific understanding of periodontal disease and identifying potential biomarkers for assessing disease status and treatment efficacy.
4) Post:
Post signifies the timeframe after initial therapy, emphasizing the importance of longitudinal analysis in assessing the effects of treatment on periodontal disease. Monitoring outcomes ‘post’ intervention helps evaluate the effectiveness of therapeutic strategies and the changes in biochemical markers, which can determine the overall success of periodontal treatment.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘Aspartate aminotransferase in gingival fluid: Initial therapy study.’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
Statistically significant difference, Aspartate Aminotransferase, Gingival crevicular fluid, Initial therapy, Periodontal disease progression, Chronic periodontitis patients, Periodontal status.