Trial on GandhakaRasayana for post-op pain in ano-rectal disorders.
Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: A randomised controlled trial to evaluate the effect of GandhakaRasayana rectal suppository in post operative pain management in ano-rectal disorders
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:
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Ranjani Deshpande, Shilpa Prakash N, Manjunath Swaroop, Mahalakshmi Muralimohan, Ashwin Shetty
Journal of Ayurveda and Integrative Medicine:
(A monthly peer-reviewed publication)
Full text available for: A randomised controlled trial to evaluate the effect of GandhakaRasayana rectal suppository in post operative pain management in ano-rectal disorders
Year: 2022 | Doi: 10.1016/j.jaim.2021.07.001
Copyright (license): CC BY-NC-ND 4.0
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Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Trial on GandhakaRasayana for post-op pain in ano-rectal disorders.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
In the context of this document, 'Table' refers to organized data that presents comparative results and findings from the study, often showcasing statistical information related to the effectiveness of the treatments administered to patients. Tables enhance the clarity and accessibility of complex data in scientific research.
2) Pain:
Pain is a sensory and emotional experience often associated with tissue damage or injury, and is a primary concern post-surgery. This study focuses on evaluating post-operative pain management methods, highlighting the significance of effective pain relief in improving patient quality of life and facilitating recovery.
3) Post:
The term 'Post' usually modifies a noun and refers to aspects occurring after surgery. In this study, it is most commonly associated with post-operative scenarios where patient recovery, pain assessment, and treatment methods are evaluated to ascertain the efficacy of the administered therapies.
4) Drug:
In this study, 'Drug' refers to the medicinal substances used for pain relief during the post-operative period. The effectiveness of various drugs, particularly comparing the traditional Ayurvedic preparation 'Gandhaka Rasayana' and the modern synthetic 'Diclofenac Sodium', is a central theme of the research.
5) Gandhaka (Gamdhaka):
Gandhaka, or sulfur in Ayurvedic medicine, is recognized for its therapeutic properties. In the context of this study, Gandhaka's formulation as a rectal suppository aims to leverage its analgesic and anti-inflammatory effects to treat post-operative pain in patients undergoing various surgical procedures.
6) Rasayana (Rasa-ayana):
Rasayana is a concept in Ayurveda referring to rejuvenating compounds that promote health and longevity. The study utilizes 'Gandhaka Rasayana,' emphasizing its role in enhancing therapeutic outcomes post-surgery, particularly in alleviating pain and facilitating recovery through traditional Ayurvedic practices.
7) Study (Studying):
The term 'Study' refers to the systematic investigation conducted to understand the effects of 'Gandhaka Rasayana' on post-operative pain management. It involves rigorous methodologies, participant assessments, and analysis of results, contributing to the body of knowledge in both Ayurveda and modern medicine.
8) Activity:
Activity in a pharmacological context refers to the effects a substance has on biological systems. In this study, the focus is on the analgesic activity of 'Gandhaka Rasayana' in reducing pain and promoting healing compared to conventional drug options.
9) Bhavana (Bha-vana):
Bhavana refers to the process of trituration or mixing of medicinal herbs with a liquid medium, which is vital in Ayurveda to enhance the bioavailability and efficacy of drugs. This study underscores the importance of bhavana in preparing 'Gandhaka Rasayana' for optimal therapeutic effectiveness.
10) Sharman (Sarma, Sharma, Sarman):
Sharma is a common surname in India, usually associated with scholars or practitioners in fields like Ayurveda. In this study, it may refer to references, scholars, or contributors to Ayurvedic literature that informs the methodology or rationale behind the treatments being evaluated.
11) Vata:
Vata is one of the three doshas in Ayurveda, representing air and ether qualities. Imbalance in Vata is associated with various health issues, including pain and discomfort. This study focuses on balancing Vata through rectal administration of 'Gandhaka Rasayana' to manage post-operative pain effectively.
12) Dravya:
Dravya translates to substances or materials used in Ayurvedic formulations. In this research, 'Dravya' pertains to the ingredients that constitute 'Gandhaka Rasayana,' emphasizing the significance of using quality substances in traditional remedies for alleviating pain and enhancing healing post-surgery.
13) Vatadosha (Vatadosa, Vata-dosha):
Vatadosha pertains to the Vata element in Ayurveda, representing one of the three doshas integral to an individual's constitution. Elevated levels of Vatadosha can lead to conditions like pain, making its balance essential for effective postoperative pain management in this study.
14) Disease:
Disease refers to a pathological condition that disrupts normal bodily functions. Within the context of this study, it relates to surgical conditions like fissures, hemorrhoids, and fistulas, focusing on effective management of pain arising from such diseases through traditional and modern therapies.
15) Dosha (Dosa):
Dosha is a fundamental concept in Ayurveda referring to biological energies that govern physiological functions. The study emphasizes understanding Tridosha (Vata, Pitta, Kapha) balance in pain management, advocating treatments that address doshic imbalances, particularly Vata's role in post-operative pain.
16) Kumar:
Kumar is a common Indian surname often denoting a male individual. In research contexts, it may refer to authors, contributors, or subjects involved in the study who provide insights or data pertaining to the effectiveness of Ayurvedic treatments versus conventional methods.
17) Triphala (Tri-phala):
Triphala is an Ayurvedic herbal formulation composed of three fruits: Amalaki, Bibhitaki, and Haritaki. Known for its digestive and rejuvenating properties, its mention in the study may relate to its potential role as a complementary treatment in managing post-operative conditions.
18) Karma (Karman):
Karma refers to actions or deeds and is an essential concept in Ayurveda related to the patient's lifestyle and treatment methods. The study discusses 'Shastra Karma' (surgical procedures) and their aftermath, emphasizing the importance of effective post-operative care to manage resultant pain.
19) Basti:
Basti is an Ayurvedic treatment modality involving the administration of medicated oils or decoctions through the rectum to alleviate Vata-related disorders. This study explores the alternative use of rectal suppositories, specifically 'Gandhaka Rasayana,' to provide similar therapeutic benefits in managing post-surgical pain.
20) Pharmacological:
Pharmacological pertains to the study of drugs and their effects on living systems. In this research, it relates to the assessment of 'Gandhaka Rasayana' and 'Diclofenac Sodium' concerning their analgesic properties, highlighting the role of traditional herbal treatments in contemporary pain management.
21) Godugdha:
Godugdha refers to cow's milk, considered a nourishing and therapeutic substance in Ayurveda. This study may address its properties in relation to formulations such as 'Gandhaka Rasayana,' reinforcing the idea that natural ingredients cultivate healing and recovery post-surgery.
22) Medicine:
Medicine broadly encompasses all substances used to diagnose, treat, or prevent illness. This study focuses on both traditional Ayurvedic medicines, such as 'Gandhaka Rasayana', and modern pharmaceuticals, such as 'Diclofenac Sodium', providing comparative insights into their therapeutic efficacy.
23) Rules:
In a research context, 'Rules' may refer to the guidelines and protocols governing the study's design and methodology, including ethical considerations, treatment administration, participant selection, and data analysis, ensuring the legitimacy and reliability of the findings.
24) Antibiotic (Antibacterial):
Anti-bacterial refers to substances that can kill or inhibit the growth of bacteria. In this study, the mention of anti-bacterial properties may relate to the potential benefits of 'Gandhaka Rasayana' in preventing infections during post-operative recovery, enhancing overall healing.
25) Ayurveda (Ayus-veda):
Ayurveda is an ancient Indian system of medicine focused on holistic health, utilizing natural herbs and practices. This study explores Ayurvedic principles, highlighting the efficacy of traditional remedies in addressing modern medical issues like post-operative pain management.
26) Samskara:
Samskara is a term describing the preparatory processes involved in crafting herbal formulations in Ayurveda. In this context, it informs the meticulous preparation of 'Gandhaka Rasayana' as a dedicated effort to ensure its therapeutic potency and effectiveness in treating pain.
27) Shastra (Sastra):
Shastra refers to texts or scriptures containing teachings, laws, or wisdom, often linked to Ayurvedic principles. In this study, it suggests that traditional texts guide the formulation and therapeutic application of 'Gandhaka Rasayana' in managing post-operative pain.
28) Quality:
Quality pertains to the standard or effectiveness of a product, particularly concerning its therapeutic benefits. The study emphasizes the importance of high-quality ingredients and preparation methods in ensuring that 'Gandhaka Rasayana' achieves its desired effects in pain relief.
29) Animal:
In research, 'Animal' typically refers to studies conducted on animal subjects for understanding drug efficacy and pharmacodynamics. While this study primarily focuses on human subjects, prior animal studies may provide essential insights into the pharmacological aspects of 'Gandhaka Rasayana.'
30) Indian:
Indian pertains to anything that originates from India, including cultural, medicinal, and philosophical practices. This term is significant in the study as it contextualizes the Ayurvedic methods explored within the frame of Indian traditional practices, enhancing the relevance of the findings.
31) Varti (Vartin):
Varti is a term used for a rectangular or conical form of medicated suppository in Ayurveda. The study focuses on the application of 'Gandhaka Rasayana' in varti form to effectively deliver herbal medicinal properties to manage post-operative pain.
32) Water:
Water plays a crucial role in Ayurvedic formulations and healing practices, often used as a solvent, medium, or vehicle for drugs. Its significance in this study may relate to the preparation methods of 'Gandhaka Rasayana' and the post-operative care regimen.
33) Hara:
Hara refers to the action of removing or pacifying, particularly concerning afflictions or doshic imbalances in Ayurveda. Its mention in the study underscores the role of 'Gandhaka Rasayana' in alleviating pain and promoting healing post-surgery.
34) Rasa (Rasha):
Rasa translates to taste in Ayurveda, but also refers to the inherent quality or property of medicinal substances. In this context, it may highlight the effectiveness of 'Gandhaka Rasayana' based on its rasa, enhancing its therapeutic application for pain management.
35) Diet:
Diet refers to the food and nutrition consumed by individuals. This study may indicate the importance of dietary modifications in conjunction with treatment of pain to ensure cohesive management and overall well-being in the post-operative period.
36) Milk:
Milk, particularly cow's milk, is valued in Ayurveda for its nourishing properties and used as a base in many formulations. In this study, references to milk may relate to its role as an ingredient or therapeutic medium in 'Gandhaka Rasayana.'
37) Pur:
Poor describes a suboptimal condition or result. In this study, poor outcomes may refer to inadequate pain relief or ineffective treatment responses observed in either of the drug therapies, highlighting areas for improvement in future research.
38) Cinnamomum zeylanicum:
Cinnamomum zeylanicum, commonly known as true cinnamon, is known for its culinary and medicinal properties. In this study, its medicinal applications may be included among the ingredients referenced for their anti-inflammatory and therapeutic properties related to pain management.
39) Tinospora cordifolia:
Tinospora cordifolia, or Guduchi, is revered in Ayurveda for its immunomodulatory and restorative properties. This study may explore its inclusion in formulations like 'Gandhaka Rasayana,' showcasing its benefits in promoting post-operative recovery and pain management.
40) Zingiber officinale:
Zingiber officinale, commonly known as ginger, has anti-inflammatory and analgesic properties. Its relevance in this study may focus on its inclusion in ayurvedic formulations, emphasizing its benefits in mitigating pain associated with surgical recovery.
41) Phytochemical:
Phytochemical refers to the bioactive compounds found in plants that have health benefits. This study likely references phytochemicals in 'Gandhaka Rasayana' and other ingredients, emphasizing their role in providing therapeutic effects for pain relief and healing.
42) Irritation:
Irritation refers to the local reactions that may occur due to certain medications. This term’s relevance in the study may indicate concerns regarding the side effects of treatments like Diclofenac Sodium, promoting the exploration of safer alternatives like 'Gandhaka Rasayana.'
43) Abhighata:
Abhighata indicates injury or trauma within Ayurvedic terminology. In this study, it applies to the context of post-operative conditions, emphasizing the need for effective pain management strategies to address the discomfort following surgical procedures.
44) Sadananda (Sadanamda, Sada-ananda):
Sadananda commonly refers to individuals in Ayurvedic literature. In this study, it may indicate references to text, authors, or contributors that provide foundational knowledge or frameworks supporting the therapeutic applications discussed.
45) Cinnamon:
Cinnamon is a spice derived from the inner bark of certain trees, recognized for its medicinal properties including anti-inflammatory and antimicrobial effects. Its presence in this study may underscore its value in Ayurvedic formulations aimed at improving health and managing pain.
46) Dressing:
Dressing refers to the medical covering or treatment applied to wounds. In this study, dressing techniques illustrate the importance of wound care in post-operative patient management, enhancing healing while simultaneously assessing the efficacy of pain-relief strategies.
47) Bleeding:
Bleeding indicates the loss of blood, which may be a concern following surgeries or injuries. The assessment of bleeding in this study emphasizes monitoring for post-operative complications and ensuring effective management of safety during treatments.
48) Sanskrit:
Sanskrit is the classical language of India and the medium of many ancient texts, including Ayurvedic scriptures. This study may reference Sanskrit terms to uphold the heritage and traditional knowledge underlying contemporary Ayurvedic practices.
49) Shodhana (Sodhana):
Sodhana refers to the purification processes in Ayurveda that enhance the quality and efficacy of medicinal substances. In this study, sodhana emphasizes the importance of preparing 'Gandhaka Rasayana' to obtain maximum therapeutic benefits for post-surgical pain alleviation.
50) Bandari (Bamdari):
Bandari can refer to individuals or scholarly references in Ayurvedic research. In this context, it possibly references the author or researcher contributing insights on the pharmacological properties or traditional uses of 'Gandhaka Rasayana.'
51) Samana (Shamana):
Shamana signifies the act of pacifying or reducing conditions, especially pertaining to doshic imbalances in Ayurveda. This study highlights shamana as an objective, focusing on the ability of 'Gandhaka Rasayana' to alleviate discomfort and restore balance post-surgery.
52) Filling (Filled):
Filling references the process involved in preparing suppositories where the herbal mixture is placed into molds. The technique ensures that the 'Gandhaka Rasayana' is adequately administered, reflecting the importance of precise preparations in effective Ayurvedic treatments.
53) Vaidya:
Vaidya refers to a practitioner or physician of Ayurveda. This term in the study may pertain to the expertise required in traditional healing practices, emphasizing the roles of vaidya in creating effective treatment plans for patients in post-operative care.
54) Shukla (Sukla):
Shukla is a surname often found in India and commonly associated with scholars in Ayurveda. In this text, it could refer to individuals who either contributed to the research or are noteworthy in the context of Ayurvedic studies and literature.
55) Shveta (Sveta):
Shveta may denote individuals involved in the Ayurvedic field or texts that provide insights into traditional practices. In the context of this study, it could refer specifically to practitioners or researchers who have contributed to the findings.
56) Anjali (Amjali):
Anjali is another common Indian name often associated with scholarly contributions in Ayurveda. This name could reference an author or contributor to the body of work informing the study or its outcomes.
57) Medium:
Medium refers to the substances or methodologies employed to enhance drug formulations. The study emphasizes the use of a specific medium, such as cocoa butter in 'Gandhaka Rasayana,' that facilitates effective drug delivery and absorption through rectal administration.
58) Mitra:
Mitra is a surname that may refer to individuals contributing to Ayurvedic research or texts. In context, it’s relevant to showcasing the collaboration among various contributors, highlighting their shared commitment to furthering the understanding of Ayurvedic treatments.
59) Delhi:
Delhi is the capital of India, often mentioned concerning research and academic settings. In this study context, it may denote the location of related institutions, highlighting the contribution of Delhi-based research in advancing Ayurvedic practices.
60) Vrana:
Vrana refers to wounds in Ayurveda, focusing on healing processes and treatments. This term underscores its importance in this study, emphasizing the effectiveness of 'Gandhaka Rasayana' and traditional methods on the healing of post-operative wounds.
61) Kesa (Kesha):
Kesha is a common Indian surname or name that may refer to individuals contributing to Ayurvedic scholarship. In the context of the research, it highlights notable authors or practitioners pertinent to the discourse or findings presented.
62) Shuci (Suci, Sucin, Shucin):
Suchi is often a name found in Indian culture and may relate to Ayurvedic scholars or practitioners. Associating such names in research reiterates the importance of individuals aim committed to studying and preserving the Ayurvedic knowledge base.
63) Raji:
Raji may refer to specific contributors or scholars within the discipline of Ayurveda or this study. Its mention serves to acknowledge individuals who have influenced Ayurvedic practices and research methodologies within contemporary contexts.
64) Sam (Sham):
Sham typically refers to peacefulness or tranquility, possibly pointing to the objective of achieving balance and alleviation in pain treatments. Its significance may reflect the aim of Ayurvedic practices to restore calmness amid distressing health issues.
65) Sah:
Shah is a common surname in India that may indicate contributors to this study. Referencing the name denotes the collaborative efforts amongst various professionals working in the space of Ayurvedic health and medicinal research.
66) Sign:
In research, 'Sign' portrays observable indicators that reflect clinical improvements or conditions. This study assesses various signs of recovery and healing, investigating the impact of treatments on physical symptoms and patient quality of life.
67) Ghi (Ghee):
Ghee, a clarified butter made from cow's milk, is utilized in Ayurvedic practices for its health benefits. In this study, it's likely referenced as an ingredient that enhances the efficacy and absorption of herbal formulations like 'Gandhaka Rasayana.'
68) Pir:
Peer refers to professionals or researchers within the same discipline who evaluate or review work. In this study, peer involvement underscores the importance of scrutiny and validation of findings to establish reliable and effective therapeutic practices in Ayurveda.
69) Life:
Life is a term referring to the condition of living organisms. This study emphasizes quality of life improvements through effective pain management, showcasing the profound impact adequate treatment has on patient recovery and general well-being following surgery.
70) Cow milk (Cow's milk):
Cow's milk is significant in Ayurveda for its nutritional value and health benefits. This study may highlight the use of cow's milk as an ingredient in 'Gandhaka Rasayana,' reinforcing its role in enhancing therapeutic outcomes and patient nourishment.
71) Rheumatoid arthritis:
Rheumatoid arthritis is an autoimmune disorder characterized by chronic inflammation of joints. While generally not the focus of the study, its mention may be relevant when evaluating patients' health status as part of determining eligibility for post-operative research.
72) Phyllanthus emblica:
Phyllanthus emblica, also known as Amla, is an Ayurvedic herb recognized for its numerous health benefits, including its anti-inflammatory and antioxidant properties. Its inclusion in discussions may refer to adjunct therapies that complement 'Gandhaka Rasayana' for managing post-operative care.
73) Terminalia chebula:
Terminalia chebula is another key herb in Ayurveda, valued for its therapeutic properties. Its relevance in the study may relate to its combination with other medications to enhance overall effectiveness in managing post-operative pain and promoting healing.
74) Cinnamomum tamala:
Cinnamomum tamala, known as Indian bay leaf, is utilized in Ayurveda for its fragrances and potential medicinal properties. Referencing this herb within the study might highlight its role in improving formulations or synergistic effects in treatments for post-operative pain.
75) Mesua ferrea:
Mesua ferrea, or nutmeg flower, is another significant herb in traditional medicine known for its soothing properties. In the context of the present study, it may emphasize its inclusion in the formulations aimed at alleviating pain or aiding recovery.
[Note: The above list is limited to 75. Total glossary definitions available: 122]