SA medicinal plants with ACE inhibition for managing preeclampsia

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Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: South African medicinal plants displaying angiotensin-converting enzyme inhibition: Potential use in the management of preeclampsia
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:

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Author:

Rebecca Reddy, Sooraj Baijnath, Roshila Moodley, Jagidesa Moodley, Thajasvarie Naicker, Nalini Govender


Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: South African medicinal plants displaying angiotensin-converting enzyme inhibition: Potential use in the management of preeclampsia

Year: 2022 | Doi: 10.1016/j.jaim.2022.100562

Copyright (license): CC BY-NC-ND 4.0


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Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “SA medicinal plants with ACE inhibition for managing preeclampsia”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Blood:
Blood is essential for transporting nutrients, oxygen, and waste products throughout the body. It plays a critical role in maintaining homeostasis and immune function. In the context of pregnancy-related diseases like preeclampsia, monitoring blood pressure and composition is crucial for understanding and managing hypertensive disorders that can lead to severe complications for both mother and child.

2) Table:
In the context of scientific literature, a table organizes data systematically, making it easier to present and interpret complex information. In this review, tables summarize the properties of various medicinal plants and their effects on blood pressure, highlighting their potential role in addressing hypertensive disorders in pregnancy, particularly in resource-limited settings.

3) Activity:
Activity refers to the biological or pharmacological effects exerted by compounds found in plants or drugs. This includes inhibiting angiotensin-converting enzyme (ACE), which is relevant for managing blood pressure in hypertensive disorders of pregnancy. Understanding these activities is vital for developing effective and safe treatment alternatives using natural products.

4) Toxicity:
Toxicity assesses the adverse effects caused by substances, including medicinal plants and pharmaceutical drugs. It's crucial to evaluate the safety of traditional remedies in pregnancy, where both maternal and fetal health are at risk. Determining toxicity helps ensure that herbal therapies do not pose significant harm, particularly regarding potential teratogenic effects.

5) Drug:
Drugs are compounds used for therapeutic benefits, including treating diseases and conditions. In the context of hypertensive disorders, various pharmacological agents are relevant as they manage blood pressure. This narrative review discusses the need for cost-effective alternatives, emphasizing herbal medicines over synthetics in resource-constrained settings.

6) Phytochemical:
Phytochemicals are bioactive compounds found in plants that contribute to their medicinal properties. The review discusses various phytochemicals, such as flavonoids and saponins, which can have antihypertensive effects. Understanding how these compounds interact with biological systems informs the therapeutic potential of traditional medicines in managing conditions like preeclampsia.

7) Anishata (Anisata):
Anisata, specifically referring to Clausena anisata, is a medicinal plant noted for its use in traditional medicine. Its extracts have demonstrated potential antihypertensive activities, making it relevant in the management of hypertension, especially in pregnancy. Exploring its efficacy and safety can lead to improved health outcomes in low-resource settings.

8) Study (Studying):
A study refers to a systematic investigation intended to establish facts or principles. In this context, studies focus on the efficacy of medicinal plants and synthetic drugs in managing hypertensive disorders during pregnancy. Evidence from such research is crucial for informing clinical practices and guiding treatment strategies in vulnerable populations.

9) Medicine:
Medicine encompasses the science of diagnosing, treating, and preventing diseases. This term is particularly relevant when discussing the management strategies for hypertensive disorders in pregnancy. Both traditional and modern medicine play pivotal roles in improving maternal-fetal health, particularly in resource-limited settings where access to conventional treatments may be restricted.

10) Flavonoid:
Flavonoids are a group of phytochemicals abundant in fruits, vegetables, and herbs, often associated with numerous health benefits, including antihypertensive effects. Many South African medicinal plants rich in flavonoids show promising ACE inhibitory activity, suggesting their potential as natural treatments for managing hypertension during pregnancy.

11) Pharmacological:
Pharmacological refers to the effects and mechanisms of drugs in the body. Understanding pharmacological properties is vital for assessing the safety and efficacy of treatments for hypertensive disorders in pregnancy. This knowledge is crucial for ensuring that both synthetic drugs and herbal therapies provide therapeutic benefit with minimal adverse effects.

12) Disease:
Disease refers to any condition that disrupts the normal functioning of the body. In this review, hypertensive disorders such as preeclampsia are highlighted as significant contributors to maternal and neonatal morbidity and mortality. Addressing these diseases through effective management strategies is crucial for improving health outcomes.

13) Species:
Species denotes a group of organisms with similar characteristics capable of interbreeding. The study highlights various plant species with potential antihypertensive properties. Identifying and classifying these species is essential for exploring their medicinal uses and potential contributions to health, particularly in managing pregnancy-related hypertension.

14) Death:
Death is the cessation of life, often influenced by disease processes. In the context of hypertensive disorders of pregnancy, understanding the risk factors leading to maternal and neonatal deaths is critical for developing effective interventions. Evidence-based strategies are necessary to lower the incidence of preventable maternal mortality.

15) Rich (Rch):
Rich typically refers to an abundance of a particular substance or quality. In this context, it describes the range of phytochemicals available in South African medicinal plants. These rich sources of bioactive compounds can be harnessed for therapeutic uses, particularly in addressing the challenges of managing hypertension in pregnancy.

16) Animal:
Animal models are used in research to study the effects of substances on biological systems. This review highlights studies using animal models to test the antihypertensive properties of various medicinal plants, providing insights into their potential applications in human health, particularly for pregnant women experiencing hypertension.

17) Fever:
Fever is a common symptom indicating an underlying infection or disease. The review discusses traditional medicinal plants that are used to treat conditions like fever, alongside hypertension. Recognizing the integrated use of herbal medicine in addressing various health issues is important for understanding traditional healthcare practices in resource-limited settings.

18) Pain:
Pain is a subjective experience often linked to injury or disease. Managing pain effectively is crucial for patient comfort, particularly in the context of pregnant women experiencing hypertensive disorders. Understanding how traditional remedies can alleviate pain alongside hypertension can lead to holistic treatment approaches to improve maternal health.

19) Male:
Male refers to the gender of organisms. Although the focus is on maternal health in this context, understanding sex differences in health responses is important. Research findings often extrapolate findings from male animal models to females, necessitating awareness of gender-specific responses to treatments, particularly in pregnancy-related conditions.

20) Toxicology:
Toxicology studies the effects, mechanisms, and detection of toxic substances, often in relation to drug safety. In the review, toxicology is significant for evaluating the safety profiles of both synthetic drugs and herbal medicines used for managing hypertension in pregnancy, particularly concerning potential adverse effects on maternal and fetal health.

21) Pregnant:
Pregnant refers to the state of carrying a fetus. Pregnancy is a critical period in women’s health, necessitating careful management of conditions such as hypertension. This review emphasizes the importance of understanding how both synthetic and traditional treatments can be safely administered during pregnancy to mitigate health risks.

22) Account:
In scientific literature, an account typically refers to a detailed report or narrative of observations and findings. This review provides an account of the efficacy of traditional herbal remedies, emphasizing the importance of documenting these findings to inform healthcare practices concerning hypertension management during pregnancy.

23) Water:
Water is essential for life, serving as a solvent in biological processes. In herbal medicine, water is commonly used for extracting bioactive compounds from plants. This review highlights the importance of aqueous extracts in demonstrating the antihypertensive properties of various South African medicinal plants, contributing to traditional healthcare practices.

24) Ulcer:
Ulcers are sores that can occur in various body areas, often due to infection or inflammation. In traditional medicine, some plants are used for treating ulcers, highlighting their broad therapeutic applications. Understanding the relationship between ulcer treatment and hypertension management could lead to better integrated healthcare strategies.

25) Food:
Food provides the necessary nutrients for body function. In the context of medicinal plants, some herbs are consumed as food sources that also have therapeutic properties. The dual role of food and medicine underscores the importance of dietary choices in managing conditions like hypertension during pregnancy.

26) Sign:
Sign denotes an indicator or symptom of a condition. In the context of pregnancy, signs of hypertension or preeclampsia are critical for timely diagnosis and management. Understanding these signs can lead to improved outcomes for mothers and children by facilitating early intervention and monitoring during pregnancies.

27) Garlic:
Garlic is noted for its medicinal properties, including potential antihypertensive effects. This review explores the role of garlic as a traditional remedy in managing high blood pressure, particularly in low-resource settings. Its integration into dietary practices reflects a holistic approach to health and disease management.

28) Rules:
Rules in scientific research define the guidelines and principles governing study designs, data interpretation, and ethical considerations. Adhering to rules in conducting pharmacological studies ensures the reliability of findings. This is essential in exploring the safety and efficacy of traditional medicinal plants for treating hypertensive disorders.

29) Rana:
Rana refers to a prominent author within the domain of maternal health, particularly regarding hypertensive disorders. Their contributions to understanding the prevalence and management of conditions like preeclampsia provide valuable insights that inform current research and guide clinical practices aimed at improving maternal and neonatal outcomes.

30) Ras (Rash):
Raas stands for the renin-angiotensin-aldosterone system, a critical hormonal system that regulates blood pressure. In pregnancy, its dysregulation can contribute to hypertensive disorders. Understanding the role of RAAS aids in developing effective treatments, illustrating the connection between hormonal regulation and the management of hypertension in pregnant women.

31) Antibiotic (Antibacterial):
Antibacterial refers to substances that inhibit bacterial growth or kill bacteria. In traditional medicine, many plants are used for their antibacterial properties, addressing infections that can complicate health during pregnancy. Researching these properties can contribute to developing safe and effective treatments for common infectious diseases in pregnant women.

32) Pharmacology:
Pharmacology is the study of drugs and their effects on biological systems. Understanding pharmacology is essential in evaluating the therapeutic potential and safety of both synthetic and herbal remedies in managing hypertensive disorders during pregnancy, ensuring that treatment strategies align with best practices in maternal health.

33) Tuberculosis:
Tuberculosis (TB) is a contagious bacterial infection affecting the lungs and other body parts, posing significant health risks. In the context of maternal health, TB can complicate pregnancy outcomes, necessitating awareness of its prevalence and management strategies, especially when considering the interaction of traditional and modern therapies.

34) Inflammation:
Inflammation is the body's response to injury or infection. Chronic inflammation is implicated in various diseases, including hypertensive disorders in pregnancy. Understanding the relationship between inflammation and hypertension helps inform treatment strategies that address underlying pathophysiological mechanisms and could integrate the use of anti-inflammatory herbal remedies.

35) Science (Scientific):
Scientific refers to the systematic study of the natural world based on empirical evidence and observation. In the context of traditional medicine, scientific validation of herbal remedies is crucial for establishing their efficacy and safety in managing conditions like hypertension during pregnancy, leading to evidence-based practices in healthcare.

36) Bleeding:
Bleeding represents a significant health concern, particularly during pregnancy when it can indicate serious complications. Understanding the causes and management of bleeding is critical for ensuring maternal and fetal safety, especially in conjunction with hypertensive disorders where blood pressure regulation can impact bleeding risks and overall outcomes.

37) Epilepsy:
Epilepsy is a neurological disorder characterized by recurrent seizures. While not directly related to hypertension, understanding epilepsy is crucial in a comprehensive approach to maternal health, considering that certain antihypertensive medications may have interactions with epilepsy treatments, necessitating careful management in pregnant patients with both conditions.

38) Channel:
The term channel often refers to protein structures that facilitate the movement of ions across cell membranes. In the context of pharmacology, understanding these channels is important for developing drugs that target specific physiological mechanisms, such as calcium channels, which play critical roles in regulating cardiovascular function and blood pressure.

39) Thomas:
Thomas may refer to a researcher or a contributor within the medical literature pertaining to hypertensive disorders. Recognizing contributions from various authors and researchers is important for building on shared knowledge to advance understanding and treatment approaches related to hypertension, particularly in the context of maternal health.

40) Nausea:
Nausea is a common symptom during pregnancy, often linked to hormonal changes and various conditions. It can influence dietary choices and overall health, particularly in women with hypertensive disorders. Understanding nausea management is essential for ensuring the well-being of pregnant women and can intersect with treatment approaches.

41) Indian:
Indian may refer to traditional practices or herbs utilized in Indian medicine that relate to hypertension management. The relevance of Indian medicinal practices can provide insight into the broader applications of herbal remedies, emphasizing the importance of cultural approaches to treating health conditions, including hypertension during pregnancy.

42) Megha:
Megha may refer to a contributor in the field of maternal health research, particularly concerning hypertension. Contributions by various authors enrich the body of literature, enhancing understanding of preeclampsia and interventions necessary for improving maternal and neonatal outcomes in vulnerable populations.

43) Campu:
Campu likely relates to a context associated with research institutions or settings where studies are conducted. Recognizing the role of academic institutions in fostering advancements in maternal health research is vital for addressing public health challenges, including the management of hypertensive disorders in pregnancy.

44) Edema (Oedema):
Edema refers to the accumulation of fluid in tissues, often indicative of underlying health issues. In pregnancy, edema can relate to hypertensive disorders, making its identification and management crucial in assessing maternal health. Understanding the implications of edema is vital for health professionals caring for pregnant women.

45) Vega:
Vega could refer to a researcher within the field of hypertension during pregnancy. Recognition of contributions from various authors illustrates the collaborative nature of medical research, particularly in exploring effective management strategies for conditions like preeclampsia that significantly affect maternal and neonatal health.

46) Mena:
Mena might reference a contributor to the research of hypertensive disorders, emphasizing the importance of a multidisciplinary approach. Recognizing diverse perspectives and contributions is crucial in developing comprehensive treatment strategies for managing conditions affecting women during pregnancy, leading to improved health outcomes.

47) Raji:
Raji denotes a researcher contributing to studies related to hypertension or traditional medicine. Understanding the breadth of research and individual contributions is vital for a comprehensive approach to maternal health, particularly in developing effective strategies to address complications like hypertensive disorders during pregnancy.

48) Koya:
Koya may refer to a prominent figure or researcher within the medical field, particularly concerning studies on maternal health. Recognizing the work of various contributors helps build a comprehensive picture of advancements made in addressing hypertensive disorders and improving maternal and neonatal health outcomes.

49) Beta:
Beta usually refers to beta-blockers, a class of antihypertensive medications. Understanding their role in managing hypertension is crucial, especially in the context of pregnancy, where their use may necessitate consideration of safety and efficacy to avoid adverse effects on maternal and fetal health.

50) Cham:
Cham could reference an author or contributor relevant to the discussion of hypertensive disorders. Contributions from different researchers inform clinical guidelines and treatment strategies, ultimately enhancing understanding and management of maternal health issues, especially in the context of pregnancy and associated complications.

51) Diet:
Diet refers to the nutritional intake of individuals, which plays a crucial role in managing health conditions. In the context of hypertension during pregnancy, understanding dietary choices and integrating functional foods with medicinal properties can lead to better health outcomes for mothers and their children.

52) Cock:
Cock likely refers to an author or scholar associated with the exploration of traditional medicinal practices. Acknowledging diverse contributions enhances the understanding of domestic plant use and its effectiveness in managing health conditions such as hypertension, particularly in pregnant women relying on traditional remedies.

53) Worm:
Worm might relate to parasitic infections that are of concern in maternal health. Understanding the potential impact of such infections is essential in providing comprehensive care for pregnant women, particularly in resource-limited settings where traditional remedies may be employed for treatment.

54) Salt (Salty):
Salt intake plays a significant role in regulating blood pressure. In the context of managing hypertension in pregnancy, understanding dietary sodium consumption is imperative for developing guidelines that promote cardiovascular health and reduce complications related to hypertensive disorders such as preeclampsia.

55) Peer review:
Peer review is a vital process in academic publishing that ensures research quality and integrity. This review process is particularly critical in the scientific community for validating findings related to hypertensive disorders of pregnancy, which informs healthcare practices and treatment protocols aimed at improving maternal health.

56) Developing:
Developing refers to emerging countries or regions where healthcare access and solutions may be limited. In the context of this review, understanding the challenges faced by developing regions helps tailor effective treatment strategies for managing hypertension in pregnancy, leveraging accessible traditional remedies to improve health outcomes.

57) Substance:
A substance refers to any form of matter, including pharmaceutical drugs and natural compounds. Understanding the distinct properties of various substances, especially concerning their therapeutic effects and interactions, is essential for developing effective treatment strategies for managing hypertensive disorders during pregnancy.

58) Attending:
Attending refers to patients who are regularly visiting healthcare facilities for prenatal care. Understanding the patterns of patients attending clinics is crucial for identifying at-risk populations, ensuring timely interventions and management of conditions like hypertension during pregnancy to prevent severe complications.

59) Composite:
Composite refers to the combination of various elements to form a whole. In the context of herbal medicine, understanding the composite nature of plant extracts, which contain multiple bioactive compounds, highlights the complexities involved in evaluating their safety and efficacy in managing health conditions during pregnancy.

60) Worry (Worried, Worrying):
Worrying reflects concerns about safety, particularly regarding the use of traditional medicines and their potentials for adverse effects. In maternal health, understanding the implications of using unverified remedies can lead to caution in recommending such treatments for managing hypertensive disorders during pregnancy.

61) Family:
Family can refer to a group of related organisms, including various medicinal plants. Recognizing the taxonomic relationships among plants provides essential insights into their potential uses and functions in traditional medicine, particularly when considering compounds that may have antihypertensive properties.

62) Reason:
Reason refers to a justification or rationale behind particular actions or beliefs. In the context of this narrative review, explicitly articulating the reasons for investigating traditional medicines' efficacy sets the foundation for future research into alternative therapies for managing hypertensive disorders in pregnancy, emphasizing cultural contexts.

63) Labour (Labor):
Labor involves the process of childbirth and is critical in the context of maternal health. Understanding how conditions like hypertension affect labor and delivery is crucial for developing effective management strategies that ensure safety for both mothers and infants during the birthing process.

64) House:
House may refer to legislation or institutions concerned with public health. Understanding health policies and regulations is critical in improving maternal health outcomes and ensuring that safe practices are upheld regarding the treatment of conditions like hypertension in pregnant women.

65) Line:
Line could refer to methodological approaches in research, denoting the importance of structure in studies addressing hypertensive disorders. Research design established by defined lines ensures that findings are credible and can be effectively translated into clinical practices for managing health issues during pregnancy.

66) Post:
Post may refer to the follow-up or review of cases after treatment. In maternal health, understanding post-treatment outcomes, particularly regarding hypertensive disorders, informs ongoing management strategies and enhances overall care for pregnant women facing complications.

67) Pir:
Peer indicates a colleague or someone of equal standing in the academic field. Collaboration among peers in research is essential for developing comprehensive approaches to understanding and addressing health disparities, especially as they relate to maternal care and effective treatment of hypertensive disorders.

68) Lily:
Lily likely refers to plants within the genus Lilium or related species. Such plants may have traditional uses in various cultures, especially concerning their potential medicinal properties. Exploring their applications in managing health conditions adds to the understanding of the diversity of medicinal flora.

69) Pur:
Poor refers to limited access to health resources and services, often seen in developing regions. Understanding the implications of poor healthcare access is crucial for tailoring effective interventions aimed at managing conditions like hypertension during pregnancy, ensuring vulnerable populations receive appropriate care.

70) Life:
Life refers to the biological state of organisms. In the context of maternal health, understanding the conditions supporting a healthy life is critical, especially in managing diseases such as hypertension during pregnancy. This highlights the importance of interventions that improve the quality of life for mothers and infants.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘SA medicinal plants with ACE inhibition for managing preeclampsia’. Further sources in the context of Science might help you critically compare this page with similair documents:

Medicinal plant, Traditional medicine, Phytotherapy, Traditional healer, Socioeconomic background, Angiotensin Converting Enzyme inhibitor, ACE inhibitory activity, Herbal therapy, Neonatal mortality, Maternal mortality, Preeclampsia, Renin Angiotensin Aldosterone System, Hypertensive Disorders of Pregnancy, Pre-clinical trial.

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