Elephantopus scaber and Phaleria macrocarpa extracts enhance anticancer effects.

| Posted in: Science

Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: The combination of Elephantopus scaber and Phaleria macrocarpa leaves extract promotes anticancer activity via downregulation of ER-α, Nrf2 and PI3K/AKT/mTOR pathway
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:

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Author:

Yuyun Ika Christina, Muhaimin Rifa’i, Nashi Widodo, Muhammad Sasmito Djati


Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: The combination of Elephantopus scaber and Phaleria macrocarpa leaves extract promotes anticancer activity via downregulation of ER-α, Nrf2 and PI3K/AKT/mTOR pathway

Year: 2022 | Doi: 10.1016/j.jaim.2022.100674

Copyright (license): CC BY-NC-ND 4.0


Download the PDF file of the original publication


Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Elephantopus scaber and Phaleria macrocarpa extracts enhance anticancer effects.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Cancer:
Cancer refers to a group of diseases characterized by uncontrolled cell growth and division, leading to the formation of tumors. This condition poses significant health risks and requires effective therapeutic strategies for management. The relevance of cancer in the study lies in exploring novel treatments, particularly from naturally occurring compounds as alternatives to chemotherapeutic agents.

2) Table:
In scientific literature, tables are often utilized to present data in a clear, organized format. They summarize research findings, experimental results or characteristics of compounds in an easily interpretable manner. They facilitate comparison and analysis by allowing readers to quickly grasp key information and draw conclusions from the data presented.

3) Study (Studying):
A study typically refers to a systematic investigation aimed at discovering new knowledge or understanding a phenomenon. In the context of this research, it represents the exploration of the anticancer effects of plant extracts. Scientific studies are crucial for validating hypotheses, informing new treatments, and guiding clinical practices in medicine.

4) Line:
In the context of cancer research, a 'line' often refers to a cell line, which is a standardized population of cells used in experiments. These cell lines are essential for understanding cancer biology, testing drug efficacy, and investigating the mechanisms of action of treatments in a controlled environment, leading to advancements in clinical applications.

5) Activity:
Activity in pharmacology refers to the biological effect or impact of a compound on living organisms, often measured in terms of therapeutic efficacy. In cancer research, it represents how a particular treatment or plant extract influences cancer cell behavior, such as inhibiting growth, inducing apoptosis, or altering signaling pathways vital for cell survival and proliferation.

6) Drug:
A drug is a chemical compound designed to alter physiological functions with therapeutic intent. In cancer treatment, drugs are vital for managing disease progression, alleviating symptoms, and improving quality of life. The investigation of plant-based drugs in this study aims to explore potential natural alternatives to conventional cancer treatments, highlighting their therapeutic promise.

7) Relative:
Relative refers to a comparison between entities, particularly in experimental studies where various treatments or outcomes are evaluated against each other. In the context of this research, relative comparisons of treatment effects on cell viability or apoptosis provide insights into the efficacy of different combinations of plant extracts versus control treatments like chemotherapy.

8) Pregnant:
Pregnant pertains to the condition of carrying a developing fetus, highlighting special considerations in medical studies. In the context of this research, it emphasizes the relevance of studying safe and effective treatments that do not adversely affect maternal or fetal health. This is crucial for developing cancer therapies that are safe for use during pregnancy.

9) Arrow:
In scientific diagrams and illustrations, arrows are used to indicate direction or flow, often representing processes like signaling pathways or cellular responses. In the context of pharmacological studies, arrows visually guide readers through complex interactions or effects observed during experiments, aiding in the understanding of mechanisms underlying drug actions or side effects.

10) Phytochemical:
Phytochemicals are bioactive compounds derived from plants, known for various health-promoting properties, including anticancer effects. Understanding their role is essential in pharmacological studies, as many therapeutic candidates originate from plant sources. This study investigates the phytochemical properties of certain plants to evaluate their efficacy against cancer, potentially leading to new treatment options.

11) Science (Scientific):
Science is the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. In the context of this research, it highlights the integral role of rigorous scientific methods in understanding complex biological phenomena, particularly in discovering new therapeutic strategies against diseases like cancer.

12) Ter:
Ther is often an abbreviation for therapy or therapeutic, referring to treatments aimed at alleviating symptoms or curing diseases. The relevance lies in exploring therapeutic strategies to combat cancer, particularly the effectiveness of natural extracts in promoting apoptosis and inhibiting cancer cell proliferation as a holistic approach to treatment.

13) Pharmacological:
Pharmacological refers to the study of drugs and their effects on biological systems. In this context, it emphasizes the importance of understanding how different substances, particularly plant-derived compounds, can affect cancer cells. Pharmacological research can lead to new drug discoveries and inform treatment options based on the bioactivity of those substances.

14) Medium:
In the laboratory context, medium refers to the nutrient solution used to support the growth of cells in culture. It plays a critical role in experiments involving cell lines, as it provides the necessary environment for maintaining cellular functions and allowing researchers to assess the effects of different treatments on cell behavior.

15) Death:
In a biological context, death often refers to cellular death, which can occur through various mechanisms like apoptosis (programmed cell death) or necrosis (unprogrammed death). In cancer research, understanding the mechanisms leading to cancer cell death is essential for evaluating the effectiveness of treatments and the development of new therapeutic strategies.

16) Chemotherapy:
Chemotherapy is a type of cancer treatment that uses drugs to kill cancer cells or stop their growth. While effective, it often has severe side effects because it can also affect healthy cells. This study explores alternative therapies with potentially less toxicity and improved efficacy against cancer, particularly focusing on plant-derived compounds.

17) Accumulation (Accumulating, Accumulate):
Accumulation refers to the buildup or increase of substances within cells or tissues. In the context of cancer research, understanding the accumulation of drugs or bioactive compounds within cancer cells is essential for evaluating therapeutic efficacy and optimizing treatment regimens, particularly in assessing the effectiveness of natural extracts against tumor cells.

18) Ayurveda (Ayus-veda):
Ayurveda is a traditional system of medicine originating from India, emphasizing the use of natural products and holistic approaches to promote health and well-being. It plays a role in this research as it provides insight into the potential of traditional plant-based treatments in modern oncology, focusing on the efficacy of extracts in cancer management.

19) Writing:
Writing in a scientific context refers to the process of documenting research findings, methodologies, and interpretations in a structured format. Clear writing is crucial for communicating results to the scientific community and stakeholders, ensuring that research contributes to existing knowledge and informs future studies or clinical applications in cancer treatment.

20) Disease:
Disease refers to a pathological condition characterized by a set of clinical symptoms. In this study, cancer is the primary disease of focus, and the exploration of effective treatments is critical for improving patient outcomes. Understanding disease mechanisms and potential therapeutic interventions can significantly impact public health and patient care.

21) Antibiotic (Antibacterial):
Antibiotics are substances that inhibit bacterial growth or kill bacteria. While not the primary focus in cancer research, the potential antibacterial properties of plant extracts could be beneficial adjuncts in therapy, particularly in preventing infections in cancer patients undergoing immunosuppressive treatments, thus enhancing overall management of the disease.

22) Radiotherapy:
Radiotherapy is a treatment that uses high doses of radiation to kill or damage cancer cells while minimizing damage to surrounding tissue. Its relevance lies in combination treatment strategies; understanding how natural compounds may enhance or mitigate the effects of existing therapies like radiotherapy offers potential for improved treatment outcomes for cancer patients.

23) Medicine:
Medicine encompasses the science of diagnosing, treating, and preventing disease. The relevance in this study revolves around exploring new therapeutic options through plant extracts, integrating traditional knowledge with modern scientific approaches to develop safer and more effective cancer treatments, ultimately advancing medical practice and patient care.

24) Killing (Killed):
Killing in a biological context often refers to the eradication of cells, particularly in cancer research targeting tumor cells. The objective of anticancer treatments is to achieve effective killing of malignant cells while sparing healthy cells, thereby enhancing survival and minimizing adverse effects. This study assesses how plant extracts induce cell death in cancer cells.

25) Toxicity:
Toxicity refers to the degree to which a substance can harm organisms. In cancer treatment, understanding the toxicity of drugs and alternative therapies is crucial for patient safety and treatment efficacy. This research evaluates the toxicity profiles of plant extracts to identify safe and effective alternatives to traditional chemotherapeutic agents.

26) Mutation:
Mutation refers to changes in the DNA sequence that may lead to cancer development or progression. Understanding mutations is essential for cancer biology, particularly in identifying targets for therapy. This study's investigation of plant extracts may reveal mechanisms of action that address mutational effects and improve treatment outcomes in affected patients.

27) Karshani (Karsani):
Karsani likely refers to a relevant researcher or contributor to the field of study mentioned within the context. Understanding the contributions of various collaborators and authors is essential in recognizing diverse perspectives and expertise that enrich the research process, ultimately leading to more robust and comprehensive scientific outcomes.

28) Sharman (Sarma, Sharma, Sarman):
Sharma seems to indicate an author or researcher pertinent to the study or relevant work discussed in the research paper. Highlighting contributions from various authors contributes to the credibility of the research findings and acknowledges the collective effort in advancing knowledge in cancer treatment and related fields.

29) Animal:
In research, animal studies are often conducted to evaluate the effects of treatments before human trials. They serve as intermediaries in translational research, providing insights into efficacy and safety profiles. In this context, examining the impacts of plant extracts in animal models can assist in understanding their potential therapeutic applications.

30) Kumar:
Kumar likely references another author or researcher involved in the study. Collaborations among various researchers are vital to the integrity of the research process and fostering innovation in cancer research, integrating different areas of expertise to maximize the understanding and potential applications of their findings.

31) Water:
Water's relevance in research concerns its importance as a solvent in biological systems and laboratory settings. It is critical for maintaining cellular integrity and is often involved in extraction processes of bioactive compounds from plants. Understanding how water interacts with these compounds can influence their effectiveness in treating diseases.

32) Fever:
Fever generally denotes an elevated body temperature often associated with infection, inflammation, or other illnesses. Understanding how fever interacts with treatment regimens, particularly for patients undergoing cancer therapy, contributes to holistic patient care and can guide decisions regarding supportive treatments amidst cancer management.

33) Pada:
Pada refers to a term often used in various contexts, including descriptions relevant to traditional knowledge or systems such as Ayurveda. In this study, it may highlight aspects of plant use or therapeutic applications, emphasizing the integration of local knowledge in understanding the benefits of natural extracts in health care practices.

34) Diet:
Diet plays a significant role in overall health and the management of diseases, including cancer. Research exploring dietary components, particularly in conjunction with natural therapies, provides insights into holistic approaches for improving treatment outcomes and the quality of life for cancer patients, emphasizing the importance of nutrition.

35) Chan:
Chan appears to reference a contributor or author linked to the research. Acknowledging individuals involved in the study is important for recognizing diverse contributions and fostering collaboration across various fields, leading to a more comprehensive understanding of research outcomes and their applications in medicine.

36) Life:
Life in this context may pertain to the biological foundations of living organisms, emphasizing the importance of scientific research in understanding life processes, particularly in the context of health, disease, and treatment. Research aimed at improving health outcomes ultimately serves to enhance the quality of life for individuals affected by conditions like cancer.

37) Peer review:
Peer review is a critical process in scientific publishing where research is evaluated by experts in the field before publication. This process enhances the quality and validity of research findings. It ensures that studies meet rigorous scientific standards, thereby contributing to the credibility and reliability of research in cancer treatment.

38) Purification:
Purification refers to the process of isolating specific compounds or substances from mixtures, often used in pharmacological studies to extract bioactive components from plants. Understanding purification techniques is crucial for ensuring the quality and efficacy of extracts used in treating diseases like cancer, as it affects the concentration and bioavailability of active ingredients.

39) Observation:
Observation in scientific research involves closely monitoring phenomena or results during experiments. It helps identify trends, effects, and outcomes of treatments tested. This study emphasizes observation as a key method for assessing the impact of plant extracts on cancer cells, contributing to understanding their therapeutic potential and guiding future research directions.

40) Discussion:
Discussion sections in research papers provide a platform to interpret findings, situate them within the broader context of existing literature, and propose implications for future studies. This segment is vital for synthesizing data, evaluating the significance of results, and suggesting practical applications in the ongoing search for effective cancer treatments.

41) Developing:
Developing typically refers to the process of creating or enhancing something, such as new treatments or therapies in research. In cancer studies, developing effective interventions is crucial, particularly those that improve patient outcomes and minimize side effects. The focus on developing novel plant extract-based therapies reflects the ongoing search for more effective cancer treatments.

42) Knowledge:
Knowledge encompasses the understanding gained through experience, education, and research. In the context of scientific inquiry, it refers to accumulated information that contributes to advancing fields such as medicine and pharmacology. This study aims to expand existing knowledge regarding effective cancer treatment approaches, particularly through exploring plant-derived compounds.

43) Fixation:
Fixation in biology often refers to the process of preserving cells or tissues for analysis. It is a critical step in preparing samples for microscopy or other analytical techniques. In cancer research, fixation is important for maintaining the integrity of cellular structures, enabling accurate observation of treatment effects and cellular responses.

44) Family:
Family typically refers to groups of related organisms in biological classification. In plant research, identifying the family of a plant is essential for understanding its characteristics and potential uses. This study may explore the therapeutic properties of specific plant families, linking traditional uses with scientific validation and modern applications.

45) Repair:
Repair refers to the restoration of cellular structures or functions after damage or injury. In the context of cancer, understanding repair mechanisms is vital as they relate to tumor progression and treatment resistance. Research into how treatments influence repair processes informs strategies to enhance cancer therapy effectiveness and mitigate recurrence.

46) Reason:
Reason usually pertains to justification based on rational understanding. In research, valid reasons underpin hypotheses, experimental designs, and interpretations of data. Establishing well-founded reasons for specific choices enhances the credibility of scientific arguments, especially in studies exploring complex phenomena like cancer therapeutics and their mechanisms of action.

47) India:
India is significant for its rich biodiversity and traditional medicinal practices, such as Ayurveda. The country's extensive use of herbal medicine provides a foundation for exploring plant-based treatments in modern research. This study may leverage India's traditional knowledge to investigate the efficacy of indigenous plants in treating diseases, particularly cancer.

48) Rules:
Rules establish guidelines or principles governing conduct or procedures within a particular context. In scientific research, rules dictate ethical standards, experimental protocols, and publication practices. Adhering to established rules ensures the integrity and reliability of research findings, promoting trust in the scientific community and among the public.

49) Miṇi (Mini):
Mini typically refers to something small in size or extent. In a scientific context, 'mini' may relate to smaller-scale studies or experimental setups, such as micro-scale assays that assess biological activity or efficacy of compounds. Utilizing miniaturized systems can enhance efficiency and reduce resource consumption in drug discovery and research.

50) Mada:
Mada appears to reference a specific term, potentially relating to regional knowledge or practices relevant to the study. Understanding local terminology enriches the research process, providing insights into culturally significant uses of plants in medicine. This contextual knowledge might influence the interpretation of findings and guide future applications of the research.

51) Genu:
Genu can refer to genus in biological classification, signifying a group of species sharing common characteristics. Identifying the genus of plants studied helps contextualize their biological properties and potential therapeutic applications. Understanding botanical classifications supports the study of plant-derived compounds in research, assisting in the development of novel treatments.

52) Post:
Post often signifies a subsequent process or phase, particularly in research contexts. It refers to activities or analyses conducted after an experiment or study concludes, such as data interpretation, writing findings, and peer review. Understanding the post-study processes ensures comprehensive communication of research outcomes and facilitates knowledge dissemination.

53) Pir:
Peer often refers to colleagues or equals in a professional or academic setting. In scientific research, peer interactions are crucial for collaboration, validation, and feedback processes, particularly in the peer review system that ensures the integrity and quality of published studies. Recognizing peer contributions enhances the credibility and impact of research.

54) Pur:
Poor denotes a lack of something, such as resources or health outcomes. In a medical context, addressing the issues faced by low-income populations is crucial for equitable healthcare. The relevance in this research lies in exploring accessible and effective treatments for underprivileged communities, ensuring that all patients benefit from advances in cancer therapy.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Elephantopus scaber and Phaleria macrocarpa extracts enhance anticancer effects.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Cell viability, Cell proliferation, DNA fragmentation assay, In Silico, Molecular docking analysis, Anticancer effect, Flow cytometry assay, Human breast cancer cell, T47D cell, Novel Anticancer Agent.

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