Immunomodulatory effects of Andrographis paniculata in adults

| Posted in: Science Health Sciences Hinduism Ayurveda Journals

Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Immunomodulatory effects of Andrographis paniculata extract in healthy adults – An open-label study
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:

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Author:

M. Rajanna, B. Bharathi, B.R. Shivakumar, M. Deepak, D'Souza Prashanth, D. Prabakaran, T. Vijayabhaskar, B. Arun


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Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: Immunomodulatory effects of Andrographis paniculata extract in healthy adults – An open-label study

Year: 2021 | Doi: 10.1016/j.jaim.2021.06.004

Copyright (license): CC BY-NC-ND 4.0


Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Immunomodulatory effects of Andrographis paniculata in adults”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
A table is a systematic arrangement of data in rows and columns, which is often used in research to present findings clearly and concisely. In the context of this study, tables summarize key data relating to immune cell counts, cytokine levels, and participant demographics, enhancing comprehension and facilitating comparison across treatment periods.

2) Study (Studying):
A study refers to a systematic investigation aimed at discovering or verifying facts. It is crucial in research to test hypotheses and explore effects or outcomes. In this context, the study aims to evaluate the immunomodulatory effects of Andrographis paniculata extract on healthy adults, contributing valuable clinical evidence to herbal medicine.

3) Activity:
Activity, particularly in a biological or medical context, refers to the functioning or action of cells, organisms, or systems. In this research, assessing immune activity serves to determine how the extract influences immune response, providing insights into its efficacy in enhancing or suppressing immune functions in individuals taking the supplement.

4) Viru:
Although it appears incomplete, 'viru' likely references 'virus' within the context of immunology or infectious diseases. Studying virus interactions with immune responses is important, especially for evaluating how Andrographis paniculata might enhance protective immunity against viral infections, contributing to the understanding of potential therapeutic applications.

5) Saxena (Sakshena, Saksena):
Saxena likely references one of the researchers or authors involved with this study. Crediting researchers is essential in academic writing for transparency and attribution of contributions to the research findings. As part of a collaborative effort, Saxena's involvement aligns with the study’s credibility in exploring Andrographis paniculata’s effects.

6) Pharmacology:
Pharmacology is the science concerned with the study of drugs, their actions, effects, and usage in medical treatment. This study ties into pharmacology by investigating how the Andrographis paniculata extract can modulate immune responses, thereby informing potential therapeutic uses and contributing to knowledge of herbal pharmacology.

7) Disease:
Disease refers to a pathological condition of a bodily part, an abnormal impairment of physiological function, or a systematic disturbance. Understanding diseases and their interactions with the immune system is critical, particularly in evaluating whether Andrographis paniculata might provide therapeutic benefits in preventing or managing such conditions.

8) India:
India is significant in this context as the location where the study was conducted. It hosts diverse flora, including medicinal plants like Andrographis paniculata. The geographical and cultural aspects of herbal medicine in India are crucial for understanding local practices and the significance of studying its herbal pharmacology.

9) Animal:
In biomedical research, animal studies often serve as preliminary investigations before human trials, providing insights into biological processes and potential therapeutic effects. This study references prior animal research on Andrographis paniculata, establishing a foundational understanding of its immunomodulatory effects, which can inform human applications.

10) Drug:
A drug is a chemical substance administered to achieve a therapeutic effect. The study examines a herbal supplement, standardized extract from A. paniculata, similarly classifiable as a drug due to its biopharmacological activity on immune modulation. Investigating herbal medicines' drug-like properties enhances therapeutic exploration in traditional medicine.

11) Ter:
Ther likely abbreviates ‘therapy’ or ‘therapeutic’, relevant to the study's focus on exploring the therapeutic effects of Andrographis paniculata extract. Evaluating such therapies is critical in understanding how herbal interventions may improve immune function and overall health, laying groundwork for potential treatments for immune-related conditions.

12) Measurement:
Measurement in research refers to the process of obtaining data on particular variables, often involving quantification for analysis. Within this study, precise measurement of immune cell types and cytokine levels is crucial to ascertain the immunomodulatory effects of the extract clearly, ensuring reliable scientific conclusions.

13) Ashvagandha (Asvagandha, Ashwagandha, Ashvagamdha, Ashva-gandha):
Ashwagandha, a well-regarded adaptogenic herb, is mentioned in the context of immunomodulatory studies. Like Andrographis paniculata, it's researched for its potential benefits to immune function and stress response. Comparing and contrasting different herbs like Ashwagandha and Andrographis can enrich understanding in the realm of herbal medicine.

14) Bharathi:
Bharathi references one of the authors and contributors of the study, indicating their involvement in conceptualizing and designing the research. Author attribution is vital in academic writing to acknowledge contributions to the research framework, methodologies, findings, and interpretations surrounding the matters at hand.

15) Rules:
Rules typically refer to established guidelines or principles governing conduct or procedures in research. In this context, adherence to ethical standards and study protocols ensures validity and reliability, as well as protection for participant health and safety while investigating the immunomodulatory effects of the herbal extract.

16) Food:
In research related to health and pharmacology, food plays a crucial role in influencing physiological responses and outcomes. The study may examine dietary factors as they relate to participants' health and assess how the extract may interact with typical diets, potentially influencing immune response and overall well-being.

17) Rice (Rce):
Rice is a staple food that might be referenced in the study regarding its nutritional aspects, especially in relation to other dietary components that can impact immune health. The study might explore how rice- or grains-based fermentation influences health benefits when assessing dietary interactions with supplements.

18) Post:
The term 'post' usually refers to conditions or measurements taken after an intervention in a study. In the context of the research, 'post' relates to the assessments conducted after administering the extract to evaluate its effects, marking the transition from baseline to potential changes in immune function.

19) Life:
Life pertains to the state of living organisms and their biological processes. In this study, the premise revolves around enhancing life quality by improving immune function through the supplementation of herbal extracts, stressing the importance of natural medicinal approaches to foster a healthier lifestyle among individuals.

20) Withania somnifera:
Withania somnifera, commonly known as Ashwagandha, is recognized for its adaptogenic properties. Mentioning it emphasizes the interrelationship between different herbs in herbal medicine and their collective role in enhancing immune function, stress resilience, and overall wellness, thus adding context to the study on Andrographis paniculata's effects.

21) Ocimum sanctum:
Ocimum sanctum, widely known as Tulsi or Holy Basil, is revered for its health benefits. Its mention alongside Andrographis paniculata highlights the significance of various herbs in traditional medicine and their roles in studying immunomodulatory effects, as well as their use in enhancing overall health and well-being.

22) Srivastava (Sri-vastava, Shrivastava, Shri-vastava):
Srivastava most likely refers to a contributor or co-author of the research, highlighting the collaborative nature of scientific investigations. Acknowledging individuals like Srivastava is crucial for transparency in research, as each person plays a role in conducting experiments, analyzing data, or interpreting results.

23) Container:
A container in research may refer to the packaging used to store investigational products, such as the capsules containing standardized A. paniculata extract in this study. Proper containment ensures product integrity, user instructions, and efficacy during the clinical phase while assessing potential health benefits.

24) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing diseases. This study's focus on a herbal extract underscores its classification as a complementary form of medicine, exploring traditional remedies' roles in health, wellness, and immune modulation to bolster recognized medicinal practices.

25) Pregnant:
The term pregnant likely pertains to the exclusion criteria for study participants. Understanding the effects of herbal interventions on pregnancy is critical, prompting caution in including such groups to protect the health of both mothers and developing fetuses during clinical research on immunomodulatory properties.

26) Quality:
Quality relates to the standard or caliber of the intervention being tested. In clinical research, ensuring the quality of the extract, dosing, and adherence to protocols is vital for producing reliable results. High-quality assessments bolster scientific evidence on the efficacy of herbal supplements for immune support.

27) Mishra (Misra):
Mishra is referenced as a contributing author to the study, indicating their involvement in conceptual discussions, methodology design, or data analysis. Attribution is essential in scholarly work, acknowledging individual contributions to the collective effort in understanding Andrographis paniculata's immunomodulatory effects.

28) Bitter:
Bitter often references the taste profile of specific herbs, such as Andrographis paniculata, known as the 'king of bitters.' Recognizing taste profiles can contribute to understanding their traditional usage in medicine and impact patient acceptance and compliance in herbal supplementation.

29) Gupta:
Gupta likely names an author of the study, underscoring the collaborative effort in conducting the research. Author names are crucial in establishing credibility and accountability in research publications, as it highlights the individuals who contributed to investigating Andrographis paniculata's health effects.

30) Joshi (Josi):
Joshi, as an author, conveys the contributions of individuals involved in the research. Recognizing Joshi alongside co-authors reflects the collaborative nature of scientific inquiry, encompassing various expertise needed to conduct clinical studies such as the one investigating Andrographis paniculata's effects.

31) Kumar:
Kumar refers to an individual likely involved in the research team. Including authors’ names is essential for transparency in academic writing, allowing interested readers to attribute the study's findings to the respective researchers, thereby validating the investigation of Andrographis paniculata’s immunomodulatory properties.

32) Tulsi:
Tulsi, also known as Ocimum sanctum, symbolizes a significant herb in traditional medicine. It demonstrates the extensive research surrounding the effects of herbal remedies on health. Its mention highlights the broader context of understanding plant-based therapies with potential immunomodulatory effects, beneficial for health.

33) Cina:
China is often viewed in the realm of herbal medicine and pharmacology due to its extensive tradition in utilizing medicinal plants. Its inclusion in the study context emphasizes a comparative understanding of herbal practices globally, identifying similarities or differences in the use of plants like Andrographis paniculata.

34) Miṇi (Mini):
Mini might refer to a mini-review or scholarly summary focusing on a specific aspect of research. Mini-reviews provide concise insights into current findings, trends, or methods, making complex topics more accessible while contributing to ongoing discussions around herbal medicine and its applications.

35) Puri:
Puri is indicated as an author, essential for recognizing the contributions of the research team in the study. Acknowledgment of each author involves transparency and credibility, validating their roles in the research process examining the health effects associated with Andrographis paniculata.

36) Paik:
Paik likely names a collaborative researcher contributing to the investigative work. Recognition of each co-author is important in research publications to maintain transparency and accountability, allowing readers to understand who is responsible for different elements of the study and its findings.

37) King:
King may reference its use as a title in describing Andrographis paniculata, known as the 'king of bitters.' Such epithets emphasize the significance of the herb in traditional therapeutic practices, marking its substantial efficacy, especially concerning immune modulation in natural health practices.

38) Diet:
Diet refers to the intake of food that influences health and immune response. Understanding participants' diets is critical in clinical trials, as nutritional contexts can significantly affect the outcomes of herbal supplementation studies, thereby influencing the evaluation of the Andrographis paniculata extract’s effectiveness.

39) Wall:
Wall may reference the author of the classification of Andrographis paniculata or related literature. Recognizing contributions and classifications in academic contexts is essential. This situates the studied herbs within scientifically valid frameworks, enhancing understanding and discussions of their therapeutic potentials.

40) Male:
Male references the demographic distribution of participants in the study. Understanding gender differences in immune response and herbal efficacy is critical in clinical research, as variations can influence the outcomes and applicability of findings related to supplements and their effects on health.

41) Zingiber officinale:
Zingiber officinale, or ginger, is often mentioned in studies exploring complementary and alternative medicine. Highlighting it allows comparison between herbs regarding their potential therapeutic attributes. Understanding these comparisons enriches discussions surrounding immunomodulatory effects and diversifies knowledge on traditional herbal medicine.

42) Peer review:
Peer review is a critical process in academic publishing where experts evaluate research for quality, credibility, and contribution to the field. This ensures that studies, like the one on Andrographis paniculata, meet scientific standards before publication, fostering integrity and trust in findings.

43) Antibiotic (Antibacterial):
Anti-bacterial refers to substances or functions that inhibit bacterial growth or kill bacteria. Highlighting this aspect in studies concerning Andrographis paniculata supports the exploration of its multifaceted potentials not only in immune modulation but also as a treatment against bacterial infections.

44) Discussion:
Discussion in a research paper is where interpretations of findings take place, analyses are examined, and implications for future research are proposed. This section critically evaluates the study’s results on Andrographis paniculata’s immunomodulatory effects, reinforcing findings and suggesting avenues for additional inquiry.

45) Flavonoid:
Flavonoids are bioactive compounds often found in plants, renowned for their antioxidant properties. Their reference in the context of A. paniculata indicates the interest in understanding how these compounds might contribute to the herbal extract's immunomodulatory effects and overall health benefits.

46) Pesticide:
In studies concerning natural products, pesticide refers to the assessment of any chemical residues that could affect safety and quality. Ensuring A. paniculata extracts remain free from pesticides upholds integrity in research findings, promoting consumer trust regarding herbal safety and efficacy.

47) Attacked:
The term attacked is likely used to describe the immune system's continuous challenge by pathogens. Understanding this dynamic is crucial in evaluating the effectiveness of herbal interventions like Andrographis paniculata, which plays a role in strengthening immune responses against constant pathogenic threats.

48) Allergy:
Allergy refers to hypersensitivity reactions that occur in response to otherwise harmless substances. This condition highlights the importance of prudent research parameters in studies like this one, assessing if herbal extracts exhibit any potential adverse effects in individuals with allergies, ensuring participant safety.

49) Cancer:
Cancer is a critical area of investigation where immune modulation plays a role in treatment strategies. Mentioning cancer emphasizes the need to explore the potential benefits of Andrographis paniculata extracts not only for preventing infections but also for aiding in immune responses related to cancer therapies.

50) Reason:
Reason signifies the underlying scientific rationale for conducting a study, such as exploring immunomodulatory effects. In this context, elucidating the reasons why A. paniculata might enhance immune function deepens understanding and informs further research directions in herbal medicine.

51) Filling (Filled):
Filled specifically refers to how capsules or containers are prepared with the investigational product, ensuring that participants receive accurate dosing. This detail is critical for maintaining the study's integrity, ensuring safety, and facilitating the analysis of outcomes related to the herbal supplementation.

52) Surya (Shurya):
Surya is likely a reference to a site, organization, or individual involved in the clinical trial. Recognizing stakeholders is important for validating research efforts, as they ensure proper coordination and execution of methodologies surrounding the investigation into A. paniculata’s health properties.

53) Blood:
Blood is fundamental in immunological studies, as it facilitates immune monitoring through various indicators like immune cell profiles and cytokines. Analyzing blood samples before and after treatment provides crucial insights into how A. paniculata extract influences immune responses, contributing to overall study conclusions.

54) Pati (Patin):
Padhi appears to refer to an author or contributor in the study, fundamental for recognizing collective research efforts. Author attribution in academic works supports transparency and highlights the collaborative input in understanding the causes, effects, and benefits of herbal interventions on health.

55) Pir:
Peer signifies the collaborative and evaluative process in academic research, ensuring that findings are scrutinized by experts in the field. Emphasizing the importance of peer involvement enhances the credibility of studies, like examining the immunological effects of Andrographis paniculata on healthy adults.

Other Ayurveda Concepts:

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Discover the significance of concepts within the article: ‘Immunomodulatory effects of Andrographis paniculata in adults’. Further sources in the context of Ayurveda might help you critically compare this page with similair documents:

Andrographis paniculata, Adverse effect, Statistical analysis, Clinical trial, Pilot study, Immunomodulatory effect, Open-label study, T cell, T-helper cells, Phagocytic activity, Immune cells, Interleukin-4, Interferon gamma, Lymphocyte proliferation, Treatment-emergent adverse events, Absolute Lymphocyte Count, Investigational product, Serum Cytokines, Lifestyle habit, T cytotoxic cells, Interleukin-2.

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