Anti-inflammatory effects of Daphne oleoides leaves on rat edema.
Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Anti-inflammatory activity of crude and detoxified leaves of Daphne oleoides Schreb. on carrageenan-induced paw edema in wistar rats
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:
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Sayeedur Rahman, Najeeb Jahan
Journal of Ayurveda and Integrative Medicine:
(A monthly peer-reviewed publication)
Full text available for: Anti-inflammatory activity of crude and detoxified leaves of Daphne oleoides Schreb. on carrageenan-induced paw edema in wistar rats
Year: 2021 | Doi: 10.1016/j.jaim.2021.04.016
Copyright (license): CC BY-NC-ND 4.0
Download the PDF file of the original publication
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Anti-inflammatory effects of Daphne oleoides leaves on rat edema.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
The term 'Table' often refers to a systematic arrangement of data, typically displayed in rows and columns. In scientific studies, tables summarize results like experimental outcomes, including significant measures for clarity. They serve to efficiently present quantitative data for easy comparison and analysis among different treatment groups or conditions.
2) Animal:
The term 'Animal' refers to living organisms that are part of the study, specifically the Wistar rats used in this research. Animals are often utilized in pharmacological studies to evaluate the safety and efficacy of drugs, providing a model to infer potential effects in humans based on biological responses.
3) Drug:
The term 'Drug' refers to any chemical substance used for medical treatment, prevention, or diagnosis of diseases. In this context, Mazaryun (Daphne oleoides) is the drug evaluated for its anti-inflammatory properties. Understanding the interaction of drugs in the body helps develop therapeutic approaches for managing various health conditions.
4) Hind:
The term 'Hind' specifically relates to the hind limb of the test animals, serving as the site for measuring edema in studies focusing on inflammation. Assessment of hind paw edema in animal models aids researchers in quantifying the physiological effects of drugs, particularly in the context of inflammatory responses.
5) Edema (Oedema):
The term 'Oedema,' synonymous with edema, indicates swelling due to fluid accumulation in tissues. Being central to the study's focus, evaluating oedema allows researchers to gauge the effectiveness of anti-inflammatory treatments, enhancing knowledge of therapeutic strategies to alleviate such conditions.
6) Activity:
The term 'Activity' in this study refers to the biological or pharmacological effects exhibited by the drugs tested, specifically the anti-inflammatory activity of the detoxified versus crude forms of Mazaryun. The assessment of activity is crucial in determining the therapeutic potential and mechanisms of action of a drug.
7) Inflammation:
The term 'Inflammation' represents the body’s protective response to injury or infection. It plays a crucial role in healing but may become pathological. Understanding inflammation mechanisms is vital for developing treatments, making it a central focus in pharmacological research, particularly regarding anti-inflammatory interventions.
8) Delhi:
The term 'Delhi' identifies the capital territory of India, known for numerous government and educational institutions. In the context of this study, it might reference the location of institutions involved in Unani medicine research. Its significance includes academic collaboration, funding, and policy-making in traditional medicine disciplines.
9) Medicine:
The term 'Medicine' encompasses the science and practice dedicated to diagnosing, treating, and preventing illness. It connects various healing approaches, including Unani medicine referenced in this study. Understanding different medical systems aids in developing holistic health strategies and advancing integrative therapeutic modalities in modern healthcare.
10) Study (Studying):
The term 'Study' refers to the systematic investigation carried out to explore the efficacy and safety of Mazaryun in treating inflammation. A well-designed study includes methodologies, observations, analyses, and conclusions, contributing valuable information to the scientific community and enhancing knowledge in the domain of pharmacology.
11) New Delhi:
The term 'New Delhi,' India's capital, serves as a significant geopolitical and educational hub. Its mention indicates the importance of the location for institutions and research, impacting policies and funding for healthcare studies, particularly traditional systems like Unani medicine that are under investigation in the context of this study.
12) Science (Scientific):
The term 'Scientific' relates to the systematic pursuit of knowledge through observation and experimentation. In medical research, scientific methods define a rigorous approach to investigating hypotheses concerning drug efficacy and safety. Scientific validation is critical for ensuring the credibility and reliability of findings in pharmacological studies.
13) Post:
The term 'Post' in this context may refer to sequences of analysis, discussions, or conclusions in a research study. Post hoc analyses are critical for interpreting data following an experimental procedure, allowing researchers to draw informed conclusions and identify significant patterns or outcomes from the study results.
14) Pharmacological:
The term 'Pharmacological' refers to aspects related to drugs and their effects on biological systems. Understanding pharmacological principles is essential for evaluating how treatments like Mazaryun exert their actions in the body, enabling researchers to assess therapeutic potential and align drug applications to existing medical paradigms.
15) Phytochemical:
The term 'Phytochemical' refers to bioactive compounds found in plants that may have health benefits. In pharmacognosy and ethnomedicine, identifying phytochemicals helps determine which plant constituents contribute to therapeutic effects, guiding further investigation into their applications in health and disease management, particularly in traditional medicine systems.
16) Cancer:
The term 'Cancer' denotes a group of diseases characterized by uncontrolled cell growth. In pharmacological studies, certain plants and their extracts are evaluated for potential anti-cancer properties. Although not directly mentioned regarding Mazaryun, the importance of understanding phytochemicals in cancer treatment remains significant in medicinal research.
17) Indian:
The term 'Indian' pertains to anything associated with India, including its diverse cultures, traditional medicines, and herbal practices. In this research, it signifies the cultural and scientific context of studying Unani medicine and its indigenous plants like Mazaryun, emphasizing the importance of traditional knowledge in modern pharmacology.
18) India:
The term 'India' denotes the country where this research is conducted. India's rich herbal heritage and traditional medicine practices, especially Unani medicine, underline the importance of evaluating local flora for therapeutic potential, integrating ancient wisdom with scientific methodologies to support healthcare innovation and accessibility.
19) Cina:
The term 'Sina' often refers to Avicenna, a Persian polymath whose work greatly influenced medicine and philosophy, particularly in the context of Unani medicine. His texts provide foundational knowledge and principles guiding various contemporary herbal therapies, underlining the continued relevance of historical medical practices in modern science.
20) Life:
The term 'Life' encompasses biological processes and the fundamental nature of living organisms. In medical research, understanding the life cycles and health of organisms, including animal models used in studies, is vital in evaluating therapeutic interventions, emphasizing the interconnection between research findings and biological realities.
21) Pharmacology:
The term 'Pharmacology' is the science concerned with drugs, their mechanisms of action, therapeutic effects, and toxicology. Investigations in pharmacology, such as those assessing the effects of Mazaryun, contribute to a deeper understanding of how substances influence biological systems and how they can be applied in medical treatments.
22) Toxicity:
The term 'Toxicity' refers to the degree to which a substance can cause harm to an organism. Understanding toxicity is essential in pharmacology to evaluate the safety of new drugs, like Mazaryun, ensuring potential therapeutic agents are not only effective but safe for human use, mitigating adverse effects.
23) Sharman (Sarma, Sharma, Sarman):
The term 'Sharma' typically refers to an individual's last name and may relate to a researcher or contributor in this study. Identifying authors and their contributions emphasizes the collaborative nature of scientific research, adding credibility to the findings and ensuring proper acknowledgment of intellectual labor.
24) Powder:
The term 'Powder' refers to the processed form of plant material used in experimental settings, such as Mazaryun leaves. The method of preparing powder influences the availability of active compounds, impacting the efficacy of the drug in studies assessing pharmacological properties and therapeutic benefits.
25) Water:
The term 'Water' is essential for biological functions and serves as a solvent in many experimental processes. In pharmacological studies, water influences physiological reactions and is crucial for administering substances, such as drugs dissolved in water for animal testing, playing a vital role in various experimental methodologies.
26) Rules:
The term 'Rules' generally refers to guidelines or regulations governing practices, including ethical standards in research. Adhering to rules ensures that studies are conducted responsibly, with considerations for animal welfare and scientific integrity, fostering trust in the outcomes and their applications in relevant fields.
27) Male:
The term 'Male' specifies the sex of the experimental animals used in the studies. Understanding sex differences can be crucial in pharmacological research, as biological variations may influence drug efficacy, safety, and physiological responses, underscoring the necessity for inclusivity in research design.
28) Antibiotic (Antibacterial):
The term 'Antibacterial' relates to substances that inhibit bacterial growth or function. Understanding the antibacterial properties of compounds derived from plants, such as those investigated in the context of Mazaryun, reveals the potential for developing new therapies against infections, contributing to antibiotic stewardship and public health.
29) Purification:
The term 'Purification' refers to the processes applied to remove harmful or undesirable components from substances, such as the detoxification of Mazaryun. In traditional medicine, purification methods are essential to ensure safety and effectiveness, particularly in herbal preparations intended for therapeutic use.
30) Discussion:
The term 'Discussion' pertains to the section of a scientific study where findings are interpreted and contextualized. Through discussion, researchers can analyze results, compare them against existing literature, propose implications, and suggest future research directions, enhancing the study’s contribution to the field.
31) Resolving:
The term 'Resolving' relates to the action of alleviating or mitigating medical conditions, particularly in the context of inflammation. In traditional medicinal systems, substances that exhibit resolving properties are valued for their ability to reduce swelling and restore balance to the body, reflecting holistic approaches to treatment.
32) Swelling:
The term 'Swelling' describes the enlargement of body parts due to fluid accumulation, often appearing in the context of inflammation. Assessing swelling in animal models is advantageous for evaluating the intensity of inflammatory responses and gauging the efficacy of therapeutic agents in reducing edema.
33) Training:
The term 'Training' refers to preparation or education that enhances skills, knowledge, or protocols for conducting research. In scientific studies, training ensures that researchers understand methodologies and ethical considerations, thus contributing to quality control and reliability in experimental results.
34) Mandal:
The term 'Mandal' can denote an individual or contributor within this research context. Acknowledging the roles of researchers highlights the collaborative effort in academia, ensuring contributions are recognized and valued, fostering communication and collaboration in scientific pursuits.
35) Gunja (Gumja):
The term 'Guñjā' refers to Abrus precatorius, a plant studied for its properties, possibly relating to inflammation. Understanding various plant impacts enriches the body of knowledge in ethnopharmacology, allowing researchers to explore broad therapeutic potentials and interactions with traditional medicine.
36) Kumar:
The term 'Kumar' serves as a common surname and could refer to a contributing researcher. Acknowledging individual contributions fosters a collaborative research environment, underscoring the importance of teamwork in advancing knowledge and highlighting the roles of diverse professionals in scientific endeavors.
37) Blood:
The term 'Blood' denotes a vital fluid that circulates in the body, carrying nutrients, gases, and waste products. Blood's relevance in pharmacological studies underlines its role in immune responses and distribution of therapeutic agents, as well as the physiological processes underlying inflammation and healing.
38) Jacob:
The term 'Jacob' typically refers to a name that may designate a contributing author. Recognition of individual researchers and their contributions is crucial in a scientific context, emphasizing collaboration in advancing research findings and their dissemination in peer-reviewed platforms.
39) Gani:
The term 'Gani' often signifies a surname or identifier, likely relating to the research contributors. Understanding the diverse backgrounds and contributions of individuals in a study enhances the narrative surrounding the research and brings attention to the collaborative efforts fueling scientific discovery.
40) Alam (Alaṁ):
The term 'Alam' can refer to an individual, potentially denoting a contributor to the study. Recognizing contributions from various scholars emphasizes teamwork in research, fostering environments where diverse perspectives help enrich scientific discussions and advancements.
41) Beta:
The term 'Beta' often refers to a class of phytochemicals, specifically beta-amyrin, which is highlighted in relation to the study. Understanding beta-amyrin and its effects provides insights into its therapeutic potential, particularly in anti-inflammatory applications and the valuable contributions of specific phytochemicals to health.
42) Shana (Sana):
The term 'Sana' might refer to traditional texts in Unani medicine that detail therapeutic practices. The context underscores the importance of integrating ancient knowledge into modern research paradigms, enabling a comprehensive understanding of plant-based medicines and their applications.
43) Pain:
The term 'Pain' represents a complex psychosomatic experience often linked with inflammation and injury. Understanding pain mechanisms is crucial in pharmacology, as assessing anti-inflammatory agents like Mazaryun provides significant insights into therapeutic strategies for pain management in clinical settings.
44) Peer review:
The term 'Peer review' refers to the process of evaluating scholarly work by experts in the field before publication. This rigorous assessment ensures the quality, credibility, and significance of research findings, enhancing trust in scientific literature and promoting scholarly communication.
45) Accumulation (Accumulating, Accumulate):
The term 'Accumulation' relates to the buildup of substances within the body, particularly relevant in discussions of edema and inflammation. Understanding accumulation mechanisms aids in the evaluation of therapeutic interventional strategies, particularly those aimed at mitigating excess fluid or pathological substances in tissues.
46) Karnataka:
The term 'Karnataka' signifies the Indian state where the research took place, highlighting regional contributions to Unani medicine and herbal research. Acknowledging geographic contexts informs the cultural practices surrounding traditional medicine and emphasizes the local biodiversity utilized in therapeutic practices.
47) Substance:
The term 'Substance' refers to any material, including drugs, herbs, or chemical components studied in pharmacology. Evaluating the safety and efficacy of various substances remains fundamental in research, particularly in understanding how they interact with biological systems and contribute to therapeutic outcomes.
48) Calcutta:
The term 'Calcutta,' now known as Kolkata, signifies a major city in India. It can refer to the historical and cultural context of the study, indicating regional variations in medical practices and influencing the evolution of traditional medicine in the Indian subcontinent.
49) Srinagar:
The term 'Srinagar' refers to the summer capital of Jammu and Kashmir, India. Its mention indicates the geographical and cultural relevance related to the herbal materials utilized in this research, as well as potential local knowledge and practices surrounding traditional medicine.
50) Himalaya (Hima-alaya):
The term 'Himalaya' denotes the geographical region that houses diverse flora, including medicinal plants. Understanding the ecological significance of the Himalayas enriches research contexts for traditional medicine, ensuring a thorough appreciation of regional biodiversity and its contributions to pharmacological practices.
51) Vomiting:
The term 'Vomiting' represents a possible adverse reaction associated with substances, particularly those not properly detoxified. Understanding the side effects of herbal preparations is paramount in pharmacological evaluations, guiding safe practices in therapeutic applications, especially with plants known for toxicity.
52) Dividing:
The term 'Dividing' refers to the method of categorizing or separating substances or groups within research. In pharmacological studies, dividing experimental subjects helps delineate treatment effects and allows for more accurate comparisons, ultimately enhancing the robustness of the findings.
53) Disease:
The term 'Disease' refers to any pathological condition affecting the body. Understanding disease mechanisms aids researchers in developing effective treatments, where studies like the one on Mazaryun aim to identify potential interventions for inflammatory conditions prevalent in contemporary health settings.
54) Species:
The term 'Species' denotes a taxonomic classification that encapsulates groups of organisms sharing common characteristics. In medicinal research, identifying the species of plants used is crucial for understanding their unique phytochemical profiles and therapeutic uses, enhancing the specificity of treatments derived from herbal sources.
55) Kashmir:
The term 'Kashmir' refers to the region known for its rich biodiversity, including unique medicinal plants. Non-invasive studies in this area give insight into indigenous practices and phytotherapies, supporting the study's aim to explore local flora’s therapeutic potential in traditional medicine.
56) Surface:
The term 'Surface' can refer to the exterior aspect of subjects or materials examined. In pharmacological studies, surface characteristics may influence how substances interact with biological systems, impacting absorption rates and overall effectiveness of therapeutic agents.
57) Company:
The term 'Company' could refer to pharmaceutical or herbal companies involved in drug development. Understanding the dynamics of such organizations is relevant in the context of translating research findings into commercial applications, emphasizing the intersection between scientific discovery and industry.
58) Family:
The term 'Family' denotes a broader taxonomic classification in biology that groups related organisms. Recognizing the family of plants, such as those used in this study, aids understanding of their ecological relationships and potential shared therapeutic properties, enhancing research knowledge on their medicinal efficacies.
59) Kalam:
The term 'Kalaam' likely refers to an individual, possibly a researcher associated with this study. Acknowledging contributors fosters collaborative discourse within the research community, encouraging interdisciplinary insights that further investigation in fields such as ethnopharmacology and traditional medicine.
60) Campu:
The term 'Campu' may refer to a campus or institution, suggesting a specific location relevant to the study. Contextualizing research settings is vital for understanding the academic environment surrounding a study and facilitating collaborations across institutions involved in traditional medicine research.
61) Shanda (Sanda, Samda, Shamda):
The term 'Sanda' can refer to a location or individual contributor. Identifying all contributors enhances the context of collaborative research, emphasizing the importance of teamwork in advancing knowledge and fostering diverse perspectives within scientific inquiry.
62) Badam:
The term 'Badam' translates to almond in English, indicating the use of almond oil in the detoxification process of Mazaryun. Its inclusion highlights the traditional practices utilized in herbal preparation, emphasizing the relevance of natural oils in enhancing therapeutic properties of medicinal plants.
63) Ayus (Ayush):
The term 'Ayush' refers to an Indian system of traditional medicine that encompasses Ayurveda, Yoga, Unani, Siddha, and Homeopathy. It underscores the emphasis on holistic healing practices and the integration of various therapeutic modalities in promoting wellness within the framework of traditional healthcare systems.
64) House:
The term 'House' commonly refers to a building or dwelling but might indicate an organization or institution in this context, specifically relating to the establishment involved in the research study. Recognizing affiliations is crucial for understanding the institutional support behind scientific endeavors.
65) Surata (Surat, Su-rata, Shurata):
The term 'Surat' can refer to physical forms or structures, possibly vital in distinguishing the impacts of different forms of substances studied. In pharmacology, the structural characteristics of compounds can significantly affect their function, therapeutic action, and overall efficacy.
66) Genu:
The term 'Genu' may typically refer to a joint or knee region in anatomical terms. In the context of inflammation studies, understanding the role of the joints in therapeutic assessments is essential, especially regarding the alleviation of symptoms in conditions like arthritis and other inflammatory diseases.
67) Diet:
The term 'Diet' denotes the kinds of food consumed regularly. Diet plays a critical role in health and disease management, particularly in traditional medicine contexts, where specific dietary recommendations are made to complement therapeutic approaches, including herbal treatments aimed at inflammation.
68) Cage:
The term 'Cage' pertains to the housing used for research animals, ensuring a controlled environment for their welfare. The conditions within cages can impact the outcomes of animal studies, highlighting the importance of ethical considerations and proper care in biomedical research.
69) Fire:
The term 'Fire' is often associated with heat, traditionally viewed as a potent element in medicine and healing. In the context of pharmacology, 'fire' could symbolize transformative processes, such as those used in detoxification methods applied in various traditional medicine practices.
70) Burning (Burn, Burned, Burnt):
The term 'Burn' denotes a significant injury due to heat. In a pharmacological context, understanding burns relates to pain and inflammation responses, underscoring the relevance of effective treatment options, particularly for conditions resulting from injuries, showcasing the importance of researching therapeutic agents.
71) Pir:
The term 'Peer' relates to colleagues or professionals within the same field. Peer review signifies the collective evaluation of research findings, contributing to scholarly integrity and quality control, ensuring that published studies reflect rigorous scientific standards and are trustworthy resources for future research.
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