Antidiabetic effects of bio-enhanced turmeric in diabetic rats

| Posted in: Science

Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Antidiabetic effect of bio-enhanced preparation of turmeric in streptozotocin-nicotinamide induced type 2 diabetic Wistar rats
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:

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Author:

Vinay Kumar Sayeli, Ashok K. Shenoy


Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: Antidiabetic effect of bio-enhanced preparation of turmeric in streptozotocin-nicotinamide induced type 2 diabetic Wistar rats

Year: 2021 | Doi: 10.1016/j.jaim.2021.04.010

Copyright (license): CC BY-NC-ND 4.0


Download the PDF file of the original publication


Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Antidiabetic effects of bio-enhanced turmeric in diabetic rats”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
A 'table' presents organized data to facilitate analysis of results. In the context of research studies, tables summarize findings, such as fasting blood glucose levels across different treatment groups. They allow readers to quickly grasp critical comparisons and statistical results, enhancing the understanding of the study's conclusions.

2) Turmeric:
Turmeric, derived from the rhizome of Curcuma longa, is a spice known for its medicinal properties, particularly due to its active ingredient, curcumin. It has been used traditionally in Asian medicine for its health benefits, including its anti-inflammatory and antioxidant effects. Its bioactive compounds are of significant research interest.

3) Study (Studying):
A 'study' refers to a systematic investigation aimed at deriving insights or testing hypotheses. In the medical and pharmacological context, studies assess the efficacy of treatments, analyze biological responses, and contribute to scientific knowledge. Rigorous studies, such as clinical trials, validate findings and influence healthcare practices and policies.

4) Drug:
A 'drug' is a chemical substance used for therapeutic purposes. In research, drugs are evaluated for their pharmacological effects, safety, and efficacy in treating diseases. This includes exploring their mechanisms of action, optimal dosages, and potential side effects, ultimately aiding in the development of effective medications for patients.

5) Blood:
'Blood' is a crucial bodily fluid that transports oxygen and nutrients to tissues, while also removing waste products. In diabetes research, blood glucose levels are vital indicators of metabolic control. Altered blood parameters can signify disease states, and monitoring them helps evaluate the effectiveness of treatments and interventions.

6) Beta:
Referring to 'beta cells' in the pancreas, which are responsible for insulin production, this term is crucial in understanding diabetes. Dysfunction of these cells leads to insulin deficiency, a hallmark of diabetes mellitus. Research often targets improving beta-cell function to enhance glucose regulation in diabetic patients.

7) Activity:
'Activity' in a pharmacological context typically refers to the effects of a drug or substance that exert therapeutic benefits. This encompasses various biological activities, such as antidiabetic effects observed in studies, where compounds like curcumin demonstrate the ability to lower blood glucose levels through specific mechanisms.

8) Animal:
In biomedical research, 'animals' are often used as models to study diseases and test the efficacy of treatments. Animal models, such as Wistar rats in diabetes studies, provide insights that are translatable to human physiology. Ethical guidelines govern the use of animals to ensure humane treatment.

9) Disease:
'Disease' represents any condition that disrupts normal bodily functions, leading to health deterioration. In the context of this research, diabetes mellitus is a metabolic disease characterized by high blood glucose levels. Understanding underlying mechanisms facilitates the development of effective treatments and improves management strategies for affected individuals.

10) Water:
Water is essential for life and plays a critical role in biochemical reactions within organisms. In studies involving animal models, access to clean water is crucial for maintaining health and ensuring the validity of experimental results, as hydration status can significantly affect metabolic processes and impact the study's outcomes.

11) Homa:
HOMA, or Homeostasis Model Assessment, is a method used to estimate insulin resistance and beta-cell functionality based on fasting glucose and insulin levels. It plays a fundamental role in diabetes research by providing a means to evaluate metabolic disturbances and monitor the effectiveness of interventions on insulin sensitivity.

12) Observation:
An 'observation' is a key component in research, signifying data gathered from experiments or clinical assessments. In the context of medical research, careful observations help identify patterns, effects of treatments, or disease progression. Observational data can lead to hypotheses, guide future studies, and inform clinical practices.

13) Rules:
'Rules' refer to guidelines and regulations that ensure researchers conduct experiments ethically and reliably. In pharmacological research, rules govern everything from dosage administration to data collection and analysis. Adhering to these rules ensures validity, reproducibility, and safety in scientific studies, ultimately protecting participants and researchers alike.

14) India:
India is known for its rich tradition in herbal medicine, including the use of turmeric and its extracts. Indian research contributes significantly to the global understanding of natural remedies and their pharmacological properties, impacting strategies for managing diseases like diabetes through culturally relevant approaches and indigenous knowledge.

15) Pharmacological:
The term 'pharmacological' pertains to the study of drugs and their effects on biological systems. In research, pharmacological evaluations assess how substances alter physiological functions, providing insights into therapeutic applications. Understanding pharmacological principles influences drug development, prescribing practices, and individualized patient care in clinical settings.

16) Pharmacology:
'Pharmacology' is the scientific discipline that studies drugs, their properties, and effects on living organisms. This field integrates biochemistry, physiology, and medicinal chemistry to understand drug interactions and therapeutic uses. Findings in pharmacology drive innovations in treatment protocols, existing medication usage, and discovery of new therapeutic agents.

17) Performance:
In research, 'performance' often refers to the efficacy and effectiveness of a treatment or intervention. This includes analyzing how well a drug or compound achieves its intended effects in biological models, providing insights into its clinical relevance. Performance metrics are vital for assessing therapeutic potential and safety.

18) Paracuraman:
Parasuraman is likely a reference to an author or researcher contributing to the study's findings. Acknowledging contributors underscores the collaborative efforts in scientific research, allowing for a broader understanding of pharmaceutical effects and methodologies. Author contributions are critical for context in academic publications and research credibility.

19) Substance:
'Substance' typically denotes any chemical or biological entity studied in pharmacology. This can range from synthetic drugs to natural compounds like curcumin from turmeric. Identifying and analyzing different substances is crucial to determine their therapeutic potential, mechanisms of action, and safety profiles in treating diseases.

20) Education:
Education plays a significant role in advancing healthcare by disseminating knowledge related to pharmacology and disease management. Medical education equips future healthcare professionals with the skills to evaluate treatments, promote health literacy, and improve patient outcomes through informed decision-making based on current research findings.

21) Flavonoid:
Flavonoids are a class of phytonutrients found in many fruits and vegetables, known for their antioxidant effects. Research highlights their potential health benefits, including antidiabetic properties. Understanding flavonoid mechanisms can lead to innovative treatments in managing conditions exacerbated by oxidative stress and inflammation.

22) Medicine:
'Medicine' encompasses the art and science of diagnosing, treating, and preventing disease. It includes the study of pharmacology, which validates the therapeutic applications of drugs. Advancements in medicine are often rooted in clinical research, which informs best practices and enhances care for individuals with various health conditions.

23) Swelling:
'Swelling' may refer to tissue enlargement and is usually associated with inflammation. In diabetes research, controlling swelling and inflammation might indicate improved metabolic health. Understanding how certain compounds affect swelling can lead to novel therapeutic strategies, particularly in managing complications from chronic conditions like diabetes.

24) Channel:
In a biological context, 'channels' refer to protein structures in cell membranes that facilitate the transport of ions or molecules. Ion channels are significant in insulin secretion from beta cells. Understanding their dynamics can help elucidate mechanisms involved in diabetes and aid in developing targeted therapies.

25) Arjuna:
Arjuna likely refers to Arjuna Natural Pvt. Ltd., a company mentioned in the study for providing herbal extracts. Collaborations between researchers and pharmaceutical companies often drive drug development and research on herbal substances, enhancing the understanding of their efficacy and safety in medical applications.

26) Vijaya:
Vijaya appears to reference an individual involved in the study or the research team. Acknowledging authors by name emphasizes the collaborative nature of scientific inquiry, showcasing diverse expertise and contributions in fields such as pharmaceuticals or complementary medicine to advance research findings on diabetes treatments.

27) Indian:
The term 'Indian' highlights the geographical and cultural context of the research. India has a long-standing tradition of herbal medicine, particularly with turmeric and curcumin. This context enhances the understanding of local medical practices, traditional knowledge, and contributes to the global discourse on natural health products and treatments.

28) Bhanu:
Bhanu likely pertains to an individual contributing to the study. Recognizing researchers emphasizes their input in advancing collective knowledge in pharmacology and medicine. Collaborations enhance the rigor of research findings and demonstrate the multidisciplinary efforts required to address complex health challenges such as diabetes.

29) Kumar:
Kumar typically represents a common surname in India, possibly referring to a researcher involved in the study. Recognizing authors and contributors highlights the collaborative nature of scientific research. Contributions from individuals with varied expertise are crucial for the successful advancement of knowledge and innovative approaches in healthcare.

30) Divi:
Divi could refer to a researcher or contributor related to the study. Recognizing individual contributors emphasizes collaborative efforts in research, showcasing a blend of expertise that enhances the quality of scientific inquiry. Such teamwork is essential for thoroughly investigating complex health issues, like diabetes management.

31) Food:
'Food' relates to dietary components that significantly influence health outcomes, including metabolic diseases like diabetes. Research often focuses on how different foods impact blood sugar levels and overall health. Understanding the roles of various food substances aids in developing dietary interventions and treatment strategies.

32) King:
King may refer to contributions by a researcher or to an aspect of the study, emphasizing collaboration and shared knowledge in the field. Identifying significant contributors illustrates the teamwork necessary for advancing scientific knowledge and improving practices related to medicine, health, and dietary interventions.

33) Diet:
Diet denotes the sum of food consumed, which plays a critical role in managing conditions like diabetes. Research underscores the importance of dietary choices in controlling blood glucose levels and overall health. Dietary interventions are often essential components of treatment plans, influencing long-term patient outcomes.

34) Cage:
In the context of animal research, 'cage' refers to the controlled environment where test subjects are housed. Proper cage management ensures the health and well-being of animals used in experiments, contributing to the validity of the research outcomes and ethical standards upheld in scientific studies.

35) Line:
'Line' may refer to a lineage or strain of animals used in research, emphasizing the importance of selecting appropriate models to ensure reproducibility and relevance. Different animal lines can exhibit varying responses to treatment, making it essential to clearly identify them in research protocols.

36) Post:
'Post' generally indicates actions or assessments that follow an intervention or study phase. For instance, post-treatment measurements are crucial for evaluating the effectiveness of drugs. Analyzing post-intervention data helps determine the impact of treatments on health conditions like diabetes.

37) Pur:
'Poor' can describe conditions, such as the bioavailability of curcumin in turmeric. This term highlights limitations that may affect treatment efficacy. In clinical research, understanding the implications of poor absorption is vital for developing strategies to enhance drug delivery and improve patient outcomes.

38) Male:
Male refers to the sex of animal subjects used in research, which often influences biological responses. In studies, acknowledging sex variations is crucial as hormonal differences can impact disease progression and treatment efficacy. Ensuring a balanced representation in research helps enhance the relevance of findings.

39) Curcuma longa:
Curcuma longa is the scientific name for turmeric, a plant celebrated for its health benefits, particularly due to its active compound, curcumin. Research into Curcuma longa emphasizes its potential therapeutic applications, especially in managing conditions like diabetes. This spotlight on its medicinal properties furthers understanding of herbal interventions.

40) Peer review:
Peer review refers to the evaluation process by experts in a field prior to publication. This critical examination enhances the integrity of scientific research by ensuring that methodologies and findings meet established standards. Peer review is vital for maintaining credibility and validity in academic discourse.

41) Measurement:
'Measurement' pertains to the quantitative evaluation of variables critical to research findings. In diabetes studies, precise measurement of parameters like blood glucose and insulin levels informs treatment efficacy. Accurate measurements support robust data analysis, enabling sound conclusions and guiding clinical practice adjustments.

42) Discussion:
The 'discussion' section of a research paper interprets findings and places them within the context of existing literature. Here, authors analyze implications, acknowledge limitations, and propose future directions for research. This reflective synthesis enhances understanding of results and informs ongoing studies in the field.

43) Karnataka:
Karnataka is a state in India, providing context for the research's geographical and cultural significance. Research conducted in specific locales may reflect local healthcare practices and ethnic uses of herbs like turmeric. Understanding regional differences enriches the global perspective on health interventions and treatments.

44) Inference:
Inference pertains to the conclusions drawn from study observations. Researchers analyze data to make informed inferences about treatment effects or disease mechanisms. Such conclusions are pivotal for translating research findings into practical applications, influencing clinical decision-making, and guiding future research directions.

45) Account:
'Account' often refers to documentation or reporting of findings. In research, an accurate account of data enhances the transparency and reproducibility of results. This practice fosters trust in scientific communications and encourages further inquiry based on verified information.,

46) Family:
'Family' in biological classification encompasses groups of related organisms. In the study context, Turmeric belongs to the Zingiberaceae family. Understanding the taxonomic hierarchy aids researchers in identifying potential medicinal properties among relatives, guiding further investigation into herbal compounds with therapeutic potential.

47) Powder:
Powder refers to a state of a substance, often used in preparations for pharmacological studies. Turmeric powder is commonly analyzed for its active constituents, like curcumin, in research. The formulation's physical state can influence its bioavailability and efficacy in therapeutic applications, impacting performance in studies.

48) Glass:
'Glass' may indicate laboratory equipment used for conducting experiments, emphasizing the scientific aspect of research. Glassware plays an essential role in ensuring precise measurements and reactions during experiments, contributing to the overall accuracy and reliability of data collected in pharmacological research.

49) House:
'House' signifies the physical and ethical environment wherein research is conducted, such as the specific animal house that provides a controlled setting for keeping experimental subjects. Proper housing adheres to ethical guidelines, reducing stress in animals and ensuring the generation of reliable research data.

50) Accu (Accukuta):
Accu likely denotes the brand of blood glucose meters (Accu-Chek), emphasizing the tools used for measuring blood parameters in research. Reliable measurement devices are crucial for precise data collection, ensuring that findings regarding treatment effectiveness are based on accurate assessments of physiological changes.

51) Pir:
The term 'peer' relates to the process of peer review, where scholars evaluate each other's work for quality and validity. This mechanism ensures that only rigorous research is published, significantly enhancing the trustworthiness and integrity of scientific communication in disciplines like pharmacology.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Antidiabetic effects of bio-enhanced turmeric in diabetic rats’. Further sources in the context of Science might help you critically compare this page with similair documents:

Statistical analysis, Treatment group, One-way ANOVA, Antidiabetic activity, Standard control group, Chromatographic separation, Oral bioavailability, Oral glucose tolerance test (OGTT), Serum insulin, Body weight measurement, Diabetes mellitus (DM), Liquid chromatography, Wistar rat, Pharmacokinetic profile, Insulin resistance (IR), Fasting blood glucose (FBG), Homeostasis Model Assessment (HOMA), Beta cell function, Serum sample, Tukey test, Curcumin turmeric.

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