Hepatoprotective effects of detoxified Plumbago zeylanica and rosea.
Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Comparative hepatoprotective activity of detoxified roots of Plumbago zeylanica L. and Plumbago rosea L. in Wistar rats
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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A.R. Akhilraj, Sudhakar Bhat, B. Priyalatha, K.S. Vimala
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Journal of Ayurveda and Integrative Medicine:
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Full text available for: Comparative hepatoprotective activity of detoxified roots of Plumbago zeylanica L. and Plumbago rosea L. in Wistar rats
Year: 2021 | Doi: 10.1016/j.jaim.2021.04.002
Copyright (license): CC BY-NC-ND 4.0
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Hepatoprotective effects of detoxified Plumbago zeylanica and rosea.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
In the context of this study, 'Drug' refers to substances used for diagnosis, treatment, or prevention of diseases. Here, it specifically pertains to the hepatoprotective compounds derived from the roots of two species of Citraka, which were tested for their ability to mitigate liver damage caused by paracetamol toxicity.
2) Citraka:
'Citraka' is the name of two medicinal plants, Plumbago rosea and Plumbago zeylanica, known for their usage in traditional Ayurvedic medicine. These plants are recognized for their potential hepatoprotective properties, making them relevant in studies focusing on treating liver ailments, thus forming the cornerstone of this research.
3) Table:
'Table' in a scientific context typically refers to a structured arrangement of data. In this study, it likely represents the summarized data on biochemical parameters that outline the effects of the various treatments on liver function, helping researchers to compare results across different test groups effectively.
4) Activity:
'Activity' in this research refers to the pharmacological effects exhibited by the herbal extracts and drugs tested. Specifically, it denotes hepatoprotective activity, indicating the ability of these extracts to protect the liver from damage caused by toxic substances like paracetamol, underscoring the therapeutic relevance of the study.
5) Animal:
'Animal' references the subjects used in the experiments, specifically male Wistar albino rats in this study. They serve as models to evaluate the hepatoprotective efficacy of Citraka extracts, allowing researchers to assess the biological and biochemical effects of potential liver protective substances in a controlled environment.
6) India:
'India' is significant as it indicates the geographic and cultural context within which the study is conducted, particularly regarding Ayurveda, a traditional medicinal system native to the region. The plants being studied, Citraka, are integral to Ayurvedic practices, emphasizing the importance of regional medicinal knowledge.
7) Study (Studying):
'Study' marks the scientific endeavor aimed at exploring and validating the hepatoprotective effects of two species of Citraka. This systematic research not only evaluates their biochemical impacts on liver function but also contributes to understanding their potential as safer alternatives to conventional hepatoprotective drugs in medicine.
8) Species:
'Species' pertains to the classification of living organisms, in this case, referring to Plumbago rosea and Plumbago zeylanica. Understanding species differences is crucial as this study aims to compare their diverse hepatoprotective effects, leading to insights on which species might offer superior therapeutic benefits for liver health.
9) Toxicity:
'Toxicity' denotes the degree to which a substance can harm living organisms, which is central to this research. Studying the hepatic toxicity of paracetamol provides the basis for assessing the protective effects of Citraka extracts against such damage, establishing a foundation for evaluating potential treatments for liver disorders.
10) Water:
'Water' is utilized in the study for various processes, such as preparing the decoction (or Kvatha) from Citraka roots. It plays a vital role in extraction methods to obtain active compounds from plants, reflecting the importance of solubility in determining the efficacy of herbal preparations.
11) Yakrit (Yakrt):
'Yakrt' is the Sanskrit term for 'liver' in Ayurvedic texts. Understanding its role is vital as the study focuses on liver disorders and the efficacy of Citraka in detoxifying and healing liver tissues, thus aligning the research with traditional concepts of organ-specific treatments in Ayurveda.
12) Plumbago zeylanica:
'Plumbago zeylanica' refers to one of the two species of Citraka being investigated. Its efficacy in traditional medicine, particularly in treating liver ailments, underscores its importance as a subject of scientific research, shedding light on its potential health benefits and therapeutic applications.
13) Ayurveda (Ayus-veda):
'Ayurveda' is the ancient Indian system of medicine that emphasizes the use of herbal remedies and holistic treatments. This study is rooted in Ayurvedic principles, exploring the effectiveness of herbal medicines like Citraka in the management of liver disorders, connecting traditional practices with modern scientific validation.
14) Varanasi (Varanashi):
'Varanasi' is a historical city in India, often associated with significant contributions to Indian culture, philosophy, and traditional medicine. Its mention may reflect the geographical origin of certain Ayurvedic texts or practices, giving context to the herbal components of the study and their traditional uses.
15) Samhita:
'Samhita' refers to classical Ayurvedic texts that compile medicinal knowledge and practices. This term signifies the rich history of herbal medicine which supports the formulations used in the study, providing a foundational source for understanding the therapeutic roles of Citraka's plant compounds.
16) Vikara:
'Vikara' means disease or disorder in Sanskrit, central to Ayurveda’s framework of diagnosis and treatment. Recognizing 'vikara' helps contextualize the study within Ayurvedic diagnoses of liver diseases and the therapeutic options researchers are targeting through the exploration of Citraka extracts.
17) Family:
'Family' signifies the biological classification of plants, which is relevant in determining the medicinal properties associated with specific groups. Plumbago species belong to the Plumbaginaceae family, indicating shared characteristics that may play a role in their pharmacological effects as studied in this research.
18) Blood:
'Blood' refers to the biological fluid analyzed in this study to assess liver function through various biochemical markers. Evaluating blood parameters provides insight into the physiological impact and efficacy of Citraka, making it a crucial element in determining hepatoprotective activity.
19) Science (Scientific):
'Science' represents the systematic study of theories and principles through empirical observations. This term signifies the methodology adopted in the research, connecting traditional knowledge with scientific validation to enhance the credibility and efficacy of herbal treatments like Citraka.
20) Ratnakara (Ratna-akara, Ratna-kara):
'Ratnakara' likely refers to 'Nighantu Ratnakara,' a classical text in Ayurveda detailing medicinal plants. The inclusion of this term underscores the reliance on traditional documentation for identifying the properties and uses of plants like Citraka, integrating ancient wisdom with contemporary research methodologies.
21) Shrikantha (Srikantha, Shri-kantha, Shrikamtha):
'Srikantha' is probably a reference to a classical Ayurvedic author or scholar, indicating the study’s intellectual lineage rooted in historical medicinal texts. This connection signifies the importance of historical context when examining traditional medicinal practices in relation to modern scientific research.
22) Nighantu (Nighamtu):
'Nighantu' pertains to botanical lexicons or dictionaries used in Ayurveda to classify and describe plants and their medicinal properties. Understanding these texts is integral to validating the therapeutic uses of plants like Citraka, emphasizing their role in bridging ancient knowledge with current scientific practices.
23) Madhyama:
'Madhyama' translates to 'middle' or 'moderate,' possibly referring to a section of Ayurvedic texts. This highlights the organized structure within Ayurvedic literature, indicating the systematic elaboration of medicinal practices and principles that guide current research on herbal remedies.
24) Shodhana (Sodhana):
'Sodhana' refers to the purification processes in Ayurveda that make substances safe for consumption by eliminating toxins. This term is pivotal in this study, emphasizing how detoxification affects the hepatoprotective efficacy and safety of the tested herbal remedies derived from Citraka.
25) Kerala:
'Kerala' is a state in India known for its rich tradition of Ayurveda and numerous medicinal plants. Its mention reinforces the cultural and geographic context of the study, suggesting the local utilization and significance of Citraka in traditional healing practices prevalent in this region.
26) Sharman (Sarma, Sharma, Sarman):
'Sharma' may refer to a common surname in Ayurveda, possibly linked to a respected Ayurvedic practitioner or author. This underscores the collaborative nature of scientific inquiries, connecting historical figures and their contributions to the current understanding and exploration of herbal medicines.
27) Khanda (Khamda):
'Khanda' typically means 'section' or 'chapter' in Sanskrit. In the context of Ayurvedic texts, it indicates the structure and organization of knowledge, showcasing the systematic approach to documenting medicinal information, which is vital for the methodology of contemporary research.
28) Kapha:
'Kapha' is one of the three doshas in Ayurveda, representing elements of earth and water. Its relevance in this study highlights the holistic view of health, where restoring balance among doshas is crucial for treating ailments, particularly in conjunction with the therapeutic effects of Citraka.
29) Pliha:
'Pliha' is the term for spleen in Ayurveda, often connected with illnesses affecting the digestive system. Its importance in this study underscores the holistic view of bodily functions, integrating the role of the spleen in liver health and the interconnectedness of Ayurvedic diagnosis and treatment.
30) Inflammation:
'Inflammation' is a biological response triggered by tissue damage, and its assessment is crucial in this study to evaluate the extent of liver injury. Analyses of inflammation provide insights into the effectiveness of treatments in protecting liver tissue from toxic substances like paracetamol.
31) Curnodaka:
'Curnodaka' refers to lime water used in the detoxification process in Ayurveda. Its role in the study highlights traditional purification methods employed to make herbal remedies safer and more effective, demonstrating the integration of ancient practices with modern scientific applications.
32) Medicine:
'Medicine' encompasses the practices and substances used for healing. This research intersects with medicinal studies aimed at exploring the efficacy of herbal treatments, signifying the significance of validating traditional remedies like Citraka through empirical scientific methods.
33) Indian:
'Indian' references the cultural and contextual backdrop of Ayurveda, showcasing the traditional practices inherent to the region's medicinal systems. This establishes the significance of local knowledge systems in developing treatments that efficiently address health concerns, particularly in ethnomedicine.
34) Pitta:
'Pitta' is an Ayurvedic dosha representing fire and water elements, crucial for metabolism. Its mention highlights the need for balance within the body, showcasing how various remedies aim to regulate pitta for optimal health, thereby linking traditional beliefs with current therapeutic practices.
35) Rakta:
'Rakta' means blood in Sanskrit and is one of the dhatus (tissues) in Ayurveda. Its significance in this study is paramount as evaluating blood parameters offers insights into hepatic function, demonstrating the interrelationship between blood health and liver detoxification processes.
36) House:
'House' refers to housing facilities for animal subjects in the study. Maintaining controlled environments for experiments is crucial for obtaining reliable results, ensuring the well-being of the animals, which is fundamental in scientific research ethics and methodologies.
37) Life:
'Life' typically signifies the vitality or essence of living beings, and in Ayurveda, it correlates to a holistic approach to health. This concept underpins the study's objective of enhancing life quality through effective medicinal interventions that target critical health issues sustainably.
38) Raktacitraka (Rakta-citraka):
'Rakta-citraka' refers to Plumbago rosea, a specific species of Citraka known for its medicinal properties. The relationship between this name and liver health emphasizes the targeted study of herbal remedies in Ayurvedic medicine for correcting, treating, and rejuvenating liver functions.
39) Pharmacology:
'Pharmacology' is the branch of medicine concerned with drugs and their effects on living systems. Its relevance to this research lies in examining the therapeutic properties of Citraka extracts, showcasing how studying herbal constituents contributes to developing safer, effective treatments for health conditions.
40) Purification:
'Purification' denotes the process of removing impurities from substances, which is critical in Ayurveda. This study emphasizes purification methods as applied to Citraka extracts, highlighting the traditional approaches to enhance safety and effectiveness in herbal treatments for liver diseases.
41) Observation:
'Observation' refers to the act of monitoring and documenting experimental results. In scientific research, observation is imperative for gathering data that confirm hypotheses. This study relies heavily on observations made during experiments to validate the hepatoprotective effects of Citraka.
42) Kaphadosha (Kaphadosa, Kapha-dosha):
'Kapha-dosa' refers to the Ayurvedic concept of balance relating to the earthy and watery elements within the body. This reinforces the study's aim of assessing how herbal treatments assist in correcting imbalances related to kapha, particularly in relation to liver and systemic health.
43) Adhikara:
'Adhikara' signifies a chapter or division in traditional Ayurvedic texts that expounds on specific disease concepts or treatments. It illustrates how ancient classifications and knowledge foundations are instrumental when examining contemporary uses of herbal remedies in medicine.
44) Calcutta:
'Calcutta', now known as Kolkata, is a significant city in India, rich in cultural and historical context. Its mention could pertain to traditional or modern Ayurvedic practices established in this region, paralleling the ethnobotanical relevance of herbs like Citraka in local treatments.
45) Vasudeva (Vasu-deva):
'Vasudeva' likely refers to an important figure in Ayurvedic scholarship. Highlighting such prominent references connects the present study with foundational Ayurvedic wisdom, establishing credibility for empirical research based on historical grounding in medicinal practices and principles.
46) Vitiation (Vitiated):
'Vitiated' indicates a condition where doshas (bio-energies) become imbalanced or disturbed, leading to diseases. This term is essential in the study as it aims to explore how treatments may restore the balance against conditions like liver damage, drawing on concepts crucial to Ayurvedic medicine.
47) Kalpana:
'Kalpanā' means preparation or formulation, denoting the methods used to create Ayurvedic medicines. Highlighting this term emphasizes the meticulous processes involved in preparing herbal extracts, reinforcing the importance of traditional knowledge in modern pharmacological studies.
48) Nirnaya:
'Nirnaya' denotes the process of determination or decision-making, often used in Ayurvedic texts to describe diagnostic procedures. Its context in the study underlines the importance of clear methodologies for developing effective treatments through comprehensive understanding of herbs like Citraka.
49) Krishna (Krsna):
'Krishna' could refer to a prominent figure within the framework of Ayurveda, possibly contributing to historical texts or practices. Such references emphasize how integrating traditional philosophies aids in underpinning scientific validations and therapeutic applications relevant to the research.
50) Vitthal:
'Vitthal' might refer to a revered deity in local culture or context, reflecting the intersection of spirituality and medicine in Ayurveda. Such cultural ties show how traditional beliefs impact the perception and acceptance of herbal remedies in clinical settings.
51) Quality:
'Quality' pertains to the standard or grade of medicines, highlighting the importance of using verified sources and preparation methods in studies. Ensuring the quality of herbal remedies is crucial for valid research outcomes, establishing the efficacy and safety of those tested.
52) Vimala:
'Vimala' might be a reference to influential individuals in Ayurveda or specific formulations. Citing such references underscores the historical significance of various figures and their contributions to the heritage of herbal medicine, significantly impacting current research practices.
53) Kvatha:
'Kvatha' is an alternative spelling of 'Kvātha', illustrating the traditional method of preparing herbal medicines in Ayurveda. The term reiterates the practical application of this preparation in the study, underscoring its importance in enhancing the potency of the plant extracts used.
54) Maurya:
'Maurya' likely denotes a surname or reference to a contributor in the Ayurvedic field, signifying collaborative efforts within the discipline. Such connections highlight the collective knowledge that supports research on the efficacy of traditional medicinal plants like Citraka.
55) Arogya:
'Arogya' means health or well-being in Sanskrit, embodying the ultimate goal of Ayurvedic practices. This concept captures the essence of the study, which seeks to explore how herbal remedies can enhance liver health and overall well-being by addressing specific ailments.
56) Prabhu:
'Prabhu' might refer to a respected figure in the Ayurveda domain or a scholarly contributor. Such placements reinforce the integration of historical perspectives and collective experiences shaping modern Ayurvedic research and its adaptations in contemporary healthcare approaches.
57) Bombay:
'Bombay,' now Mumbai, is an Indian city with a rich history of trade and cultural exchange. Mentioning this city may reflect its role in the dissemination of Ayurvedic knowledge and practices, highlighting the broader geographic context of traditional medicines studied.
58) Powder:
'Powder' refers to the form in which herbal materials, like those from Citraka, are taken after processing. The mention of powders underscores the practical aspects of medicinal preparation, indicating its use in creating decoctions and formulations for therapeutic applications.
59) Karma (Karman):
'Karma' in Ayurveda refers to the actions and processes that influence healing and health. This term illustrates the holistic nature of Ayurvedic healing and the interconnectedness of body processes, emphasizing the relevance of such ideas within the study design.
60) Gupta:
'Gupta' is a common surname in India, potentially linking to a researcher or figure in Ayurvedic studies. This reference exemplifies the scholarly lineage supporting modern turmeric research, showing the interconnectedness of historical practices with current scientific explorations.
61) Priya:
'Priya' translates to 'beloved' in Sanskrit, often appearing as a common name. Its relevance here may refer to an author or individual recognized in the Ayurvedic texts, signifying continuity in scholarly work and the tradition's impact on modern studies.
62) Dhatu:
'Dhatu' refers to the fundamental bodily tissues in Ayurveda, including the liver. Its importance in the study reflects the necessity to evaluate how herbal preparations interact with different dhatus, linking traditional Ayurvedic knowledge with the physiological processes examined in this research.
63) Shveta (Sveta):
'Sveta' translates to 'white' in Sanskrit and relates to Plumbago zeylanica, referred to as Sveta Citraka. This differentiation highlights the distinct properties attributed to different species within Ayurvedic practices, emphasizing unique qualities important when investigating their therapeutic value.
64) Sagar (Sagár):
'Sagar' is a name often associated with water or oceans, potentially linking to Ayurvedic traditions connecting nature and healing. Its mention may underline a broader ecologically aware approach to herbal medicine, emphasizing how context influences the medicinal properties studied.
65) Kumar:
'Kumar' signifies 'son' or 'youth' in Hindi, sometimes used as a part of names. Its reference here may point to contributors in the field of Ayurveda, reflecting the passing of traditional knowledge and practices through generations to contemporary study frameworks.
66) Rules:
'Rules' encompasses the guidelines or regulatory frameworks governing scientific studies and Ayurvedic practices. Understanding the established procedure is essential for ensuring valid results and maintaining ethical standards within the research undertaken on herbal medicines.
67) Ravi (Ravin):
'Ravi' translates to 'Sun' in Sanskrit and may refer to a common name in India. Its relevance in the study could include associations with health and vitality linked to Ayurvedic interpretations of natural elements, underlying the holistic perspective embraced in the research.
68) Daya:
'Daya' denotes compassion or kindness in Sanskrit, which may underline the traditional ethos guiding Ayurvedic practices. Its mention indicates a perspective on health that prioritizes benevolence and healing, enhancing the understanding of the intent behind using herbs for therapeutic purposes.
69) Dosha (Dosa):
'Dosa' refers to the three primary energies in Ayurveda - Vata, Pitta, and Kapha - that govern physiological functions. Understanding dosha imbalances is critical to the study, demonstrating how Citraka's healing properties align with Ayurvedic concepts of restoring health through herbal remedies.
70) Ghat (Gham):
'Ghat' may refer to a term used in the context of Ayurveda or its traditional settings. Its relevance may include cultural practices associated with purification or holistic processes that support overall health status and the therapeutic intent of the study.
71) Vrat:
'Vrat' denotes a vow or religious observance in Hinduism. Its mention may highlight the cultural and spiritual context of the study, indicating how traditional practices and beliefs influence approaches to health and the acceptance of herbal remedies in Ayurveda.
72) Seth:
'Seth' is another common surname in India, which may refer to an influential figure in Ayurvedic literature or practice. This name depicts the depth of intellectual contributions from various scholars, reinforcing traditional knowledge's importance in modern research initiatives.
73) Fish:
'Fish' indicates the animal studied in context, or it represents another branch of research in understanding biochemical interactions. Its mention could suggest comparative studies looking at hepatoprotective effects in various species beyond the primary study focus on rats.
74) Post:
'Post' may refer to the publication or dissemination of research findings. In academic contexts, timely sharing of results is vital for advancing knowledge and fostering dialogue about the implications of studies like those examining Citraka’s therapeutic effects.
75) Male:
'Male' refers to the sex of the animal subjects in the study, specifically male Wistar albino rats used for experiments. This differentiation is important in experimental design, as biological factors can influence the outcomes of pharmacological studies.
[Note: The above list is limited to 75. Total glossary definitions available: 108]
Other Ayurveda Concepts:
Discover the significance of concepts within the article: ‘Hepatoprotective effects of detoxified Plumbago zeylanica and rosea.’. Further sources in the context of Ayurveda might help you critically compare this page with similair documents:
Plumbago zeylanica, Statistical analysis, Hepatoprotective activity, Comparative effect, Serum biochemical parameters, Animal house, Silymarin, Histopathological assessment, Biochemical parameter, Paracetamol toxicity, Ayurveda Classic, Wistar albino rat, Liver Disorder, Plumbago rosea.