Anticancer effects of Momordica charantia seed fat on liver cancer in rats

| Posted in: Science Health Sciences Hinduism Ayurveda Journals

Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: In vivo anticancer effects of Momordica charantia seed fat on hepatocellular carcinoma in a rat model
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Author:

K.N.K. Ranasinghe, A.D. Premarathna, T.A.N. Mahakapuge, K.K. Wijesundera, A.T. Ambagaspitiya, A.P. Jayasooriya, S.A.M. Kularatne, R.P.V.J. Rajapakse


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Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: In vivo anticancer effects of Momordica charantia seed fat on hepatocellular carcinoma in a rat model

Year: 2021 | Doi: 10.1016/j.jaim.2021.03.001

Copyright (license): CC BY-NC-ND 4.0


Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Anticancer effects of Momordica charantia seed fat on liver cancer in rats”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
A table organizes and presents data or results in a systematic format, providing a clear visual representation of information for easier comprehension and comparison. In scientific papers, tables often summarize key findings or experimental data, allowing researchers to communicate complex information effectively to their audience.

2) Cancer:
Cancer is a group of diseases characterized by the uncontrolled growth of abnormal cells in the body. This uncontrolled growth can lead to the formation of tumors and spread to other parts of the body. Numerous studies explore effective treatments, prevention, and the biological mechanisms behind cancer development.

3) Bitter:
The term 'bitter' often describes a sharp, unpleasant taste and can refer to certain foods, plants, or medicinal properties. In the context of medicinal herbs like bitter melon, the bitterness is associated with health benefits, including potential anti-cancer properties and metabolic regulation in various therapeutic applications.

4) Study (Studying):
A study refers to a systematic investigation of a subject intended to establish facts or principles. In the context of scientific research, studies are critical for generating knowledge, testing hypotheses, and validating findings. Research studies can vary in design, including clinical trials, observational studies, and laboratory experiments.

5) Momordica charantia:
Momordica charantia, commonly known as bitter melon, is a tropical fruit known for its medicinal properties. It is widely used in traditional medicine for its potential health benefits, including blood sugar regulation and anticancer effects. Research focuses on its bioactive compounds, including antioxidants and phytonutrients beneficial for health.

6) Lanka (Lamka, Lànkà):
Lanka, more specifically Sri Lanka, is a South Asian island nation known for its rich biodiversity, including various plant species with medicinal properties. Research conducted in Sri Lanka on local plants, like bitter melon, highlights their potential benefits in traditional medicine and encourages studies on their pharmacological effects.

7) Surface:
In biological contexts, 'surface' often refers to the outer layer of an organism or tissue, relevant in studies of cellular structure or interactions. For instance, in cancer research, the surface of tumors or affected organs is observed for changes that indicate disease progression, influence treatment approaches, or reflect treatment efficacy.

8) Animal:
Animals are a kingdom of living organisms that can be utilized in research, especially in biomedical studies. Animal models play a crucial role in testing hypotheses related to human diseases, pharmacological interventions, and understanding disease mechanisms, including studies on effectively modeling cancer to assess new treatments.

9) Death:
Death refers to the cessation of all biological functions that sustain a living organism, and in the context of research, it often relates to mortality rates in studies focusing on disease impact. In cancer research, understanding causes of death helps improve treatment strategies and patient outcomes by targeting mortality factors.

10) Medicine:
Medicine is the science and practice of diagnosing, treating, and preventing diseases. It encompasses a wide range of healthcare practices, including pharmacotherapy, surgical interventions, and the use of natural remedies. Innovative treatments are continuously researched to improve patient care, particularly in managing chronic conditions like cancer.

11) Disease:
Disease refers to a pathological condition that results from various factors, including infections, genetic defects, or environmental impacts. In medical research, understanding disease mechanisms, pathophysiology, and progression is critical to develop effective treatments and preventive measures, particularly for complex diseases, including various cancers and metabolic disorders.

12) Relative:
The term 'relative' denotes a comparative relationship between entities. In scientific research, it often appears in data analysis, such as relative expression levels of genes, relative risk in epidemiological studies, or relative viability in treatment evaluations, providing context to quantify observations and inform conclusions drawn from results.

13) Food:
Food refers to any substance consumed to provide nutritional support for the body. It plays a vital role in health and disease prevention, with various diets impacting overall wellness. Research often explores the nutritional composition of foods, their effects on health, and the role of specific foods in treating diseases.

14) Rich (Rch):
Rich in this context often describes a high concentration or abundance of specific nutrients or compounds. In relation to food or medicinal plants, 'rich' signifies the presence of beneficial bioactive components, such as vitamins, minerals, or phytochemicals, which are linked to health benefits, such as antioxidant activities or anticancer effects.

15) Science (Scientific):
Scientific refers to methods, principles, or approaches based on empirical evidence and rigorous testing. In research, scientific methodologies are essential for ensuring the validity and reliability of findings. Adhering to scientific principles promotes factual understanding and facilitates technological and medical advancements that benefit society.

16) Rules:
Rules, in a research context, are established guidelines or principles that govern scientific procedures, ethical conduct, and data interpretation. Adhering to rules ensures consistency, replicability, and validity of scientific findings. Researchers must follow rules to maintain the integrity of their work and advance mutual understanding in the scientific community.

17) Activity:
Activity refers to the level of engagement or action within biochemistry or pharmacology, often related to the efficacy of a compound in inducing biological responses. In studies, measuring the activity of a substance helps ascertain its therapeutic potential, safety, and effectiveness, especially in the context of drug development.

18) Nature:
Nature encompasses the physical world and its phenomena, including plants, animals, ecosystems, and their interactions. In scientific research, understanding nature is critical for developing natural medicines and therapies. Studies often leverage natural compounds to uncover potential health benefits, especially those with reduced side effects compared to synthetic alternatives.

19) Water:
Water is an essential component for living organisms, playing critical roles in biological processes like nutrient transportation, thermoregulation, and cellular reactions. In research, water’s role is often examined in relation to hydration, physiological functions, and as a solvent in which biochemical reactions occur, impacting health and disease.

20) Blood:
Blood is a vital fluid in organisms, responsible for transporting nutrients, gases, hormones, and waste products. In medical research, studying blood components—such as cells, plasma, and platelets—provides insights into physiological responses, disease states, and treatment efficacy. Blood parameters are crucial for diagnosing and monitoring health conditions.

21) Drug:
A drug is any chemical substance used for diagnosing, curing, or preventing disease, or for altering physiological functions. In pharmaceuticals, research focuses on drug efficacy, mechanisms of action, and safety profiles. Advances in drug development aim to create targeted therapies with minimal side effects for various health conditions.

22) Veterinary medicine:
Veterinary medicine is a branch of healthcare focusing on the prevention, diagnosis, and treatment of diseases in animals. It plays a crucial role in public health, food safety, and animal welfare. Research in veterinary medicine often relates to zoonotic diseases and the development of effective treatments for pets and livestock.

23) Bitter gourd:
Bitter gourd, also known as bitter melon, is a tropical fruit recognized for its health benefits, particularly its use in traditional medicine. Its bitter taste is associated with medicinal properties, including potential anti-diabetic and anticancer effects. Research on bitter gourd helps explore its bioactive compounds and therapeutic applications.

24) Phytochemical:
Phytochemicals are bioactive compounds produced by plants, often associated with various health benefits. They play crucial roles in human health, such as antioxidant, anti-inflammatory, and anticancer properties. Research on phytochemicals aims to isolate and understand their mechanisms, offering potential for developing natural remedies and functional foods.

25) Chemotherapy:
Chemotherapy is a prevalent cancer treatment regimen using drugs to kill or inhibit the growth of cancer cells. It works by targeting rapidly dividing cells, but can cause side effects due to its impact on healthy tissues. Research focuses on improving chemotherapy effectiveness and minimizing adverse effects for better patient outcomes.

26) Inflammation:
Inflammation is the body’s immune response to injury or infection, characterized by redness, swelling, and pain. In chronic diseases, including cancer, inflammation can contribute to tumor progression. Research studies explore the relationship between inflammation and disease mechanisms, seeking approaches to manage or reduce inflammation for therapeutic benefits.

27) Dharmadasa:
Dharmadasa may refer to a researcher or contributor in the context of a study or analysis. Individuals in academia often play critical roles in advancing knowledge through their research efforts and findings. The contributions of researchers help shape understanding in their respective fields and impact future studies and innovations.

28) Developing:
Developing refers to the process of advancing, evolving, or maturing over time. In research, it often implies creating new methodologies, treatments, or understanding of diseases. This process encompasses investigating new compounds, improving existing therapies, or discovering innovative approaches to enhance health outcomes in diverse populations.

29) Evolution:
Evolution describes the gradual development or change of species over time. In scientific terms, it encompasses biological adaptations and transformations that enhance survival and reproduction. Understanding evolution helps researchers comprehend biodiversity and the interactions within ecosystems, as well as informs medical studies related to genetic disorders and disease resistance.

30) Species:
Species are groups of organisms that can interbreed and produce fertile offspring. Understanding species diversity is essential for comprehending ecosystems and their functions. In biological research, species are often the focus of studies examining genetic variations, adaptations, and the impact of environmental changes on survival and proliferation.

31) Mineral:
Minerals are naturally occurring inorganic substances vital for various biological processes. They play significant roles in numerous physiological functions, including bone health, metabolism, and cellular processes. Research on the health benefits of minerals helps inform dietary recommendations and therapeutic interventions aimed at preventing or treating deficiencies.

32) Prabha:
Prabha may refer to a researcher, author, or contributor in studies related to the subject matter, particularly in the field of medical or biological research. The efforts of individuals like Prabha contribute significantly to the academic and scientific community, enriching knowledge and fostering innovation within their specialized areas.

33) Karela:
Karela is another name for bitter melon, a plant known for its medicinal properties. It has been traditionally used in various cultures for treating ailments such as diabetes and digestive problems. Research on karela focuses on its phytochemical composition and therapeutic efficacy, particularly in relation to its health benefits.

34) Sharman (Sarma, Sharma, Sarman):
Sharma could refer to a key researcher or author relevant to the topics in the document, particularly those focusing on medicinal studies, dietary impacts, or effectiveness of natural products. Contributions from authors like Sharma are vital in advancing research and understanding in their respective fields.

35) Gupta:
Gupta may denote an author or researcher involved in studies regarding medicinal plants or pharmacological effects. Such individuals often contribute to the scientific body of work, investigate new treatments, and enhance our understanding of natural compounds, promoting health and disease management strategies.

36) Arrow:
In academic publications, 'arrow' may be used metaphorically to indicate directionality or a point of focus in discussion diagrams. It could also symbolize observational techniques in research that guide inquiries. Understanding symbols in scientific communications aids clarity in presenting complex information effectively.

37) Miṇi (Mini):
Mini may refer to miniature models or setups used in experiments, particularly in laboratory contexts. Miniaturization aids in reducing resource consumption and enhancing efficiency in experimental protocols. Researchers often utilize miniaturized systems in studies to explore reactions and interactions with limited sample quantities.

38) Alam (Alaṁ):
Alam may signify an individual contributing to the scientific knowledge base through research on beneficial aspects of different compounds, especially in the field of health sciences. The role of researchers like Alam is critical for advancing drug development, natural products research, and enhancing understanding of treatment mechanisms.

39) Jang:
Jang might refer to a researcher known for contributions to studies in pharmacology, plant-based therapies, or disease mechanisms. The work of researchers recognized in studies often addresses specific health challenges, revealing insights that guide future research and create pathways for innovations in medical treatments.

40) Diet:
Diet refers to the array of food and drink consumed by individuals or groups, significantly impacting health outcomes and disease prevention. Research on diet examines how different nutritional components influence overall health, risk factors for diseases, and the effectiveness of dietary interventions in managing chronic health conditions.

41) Milk:
Milk is a nutrient-rich liquid produced by mammals, containing essential nutrients that support growth and maintenance of health. In dietary studies, milk is often assessed for its role in nutrition, its health benefits, and potential adverse effects related to lactose intolerance or allergies, influencing public health recommendations.

42) Pur:
Poor can describe conditions relating to low socioeconomic status, limited access to healthcare, or suboptimal living conditions, impacting overall health and well-being. In public health research, understanding the implications of poverty helps advocate for interventions and policies aimed at improving health equity and access to medical care.

43) Life:
Life encompasses the existence and biological processes of living organisms. Understanding biological life is crucial in many scientific fields, including medicine, biology, and ecology, as it drives research into health, longevity, evolution, and the impact of environmental interactions on living organisms and their survival strategies.

44) Curcuma longa:
Curcuma longa, commonly known as turmeric, is a flowering plant popular for its rhizome, which contains bioactive compounds with proven anti-inflammatory and antioxidant properties. Scientific research on curcuma longa focuses on its health benefits, especially in chronic diseases, exemplifying its potential as a natural therapeutic agent.

45) Peer review:
Peer review is an essential component of the scientific process where experts in the field evaluate research before publication. This process enhances the credibility, accuracy, and quality of scientific literature, ensuring that findings meet rigorous standards and contribute valuably to the existing knowledge base.

46) Malnutrition:
Malnutrition refers to deficiencies, excesses, or imbalances in nutrient intake, posing significant health challenges. It can arise from poor dietary choices, socioeconomic factors, or underlying health issues. Research on malnutrition explores its impact on health outcomes and feeds into public health strategies aimed at improving nutrition and dietary habits.

47) Calculation:
Calculation involves determining numerical values through systematic methods. In research, accurate calculations are vital for data analysis, statistical evaluations, and ensuring reliable results. Robust calculations underpin scientific outcomes and influence conclusions drawn from experimental data, guiding further inquiries and applications in real-world contexts.

48) Measurement:
Measurement refers to the process of determining the size, quantity, or degree of something using established standards. In scientific research, accurate measurements are critical for maintaining consistency, validity, and accuracy in experiments. Measurements create the foundation for understanding phenomena, driving conclusions, and allowing effective comparisons across studies.

49) Agriculture:
Agriculture is the practice of cultivating the soil, growing crops, and raising animals for food, fiber, and other products. It plays a crucial role in food security and economic development. Research in agriculture explores sustainable practices, crop improvement, and the impact of environmental factors on food production and nutrition.

50) Discussion:
Discussion in scientific articles presents interpretations of research findings and situates them within the existing body of knowledge. It facilitates the examination of implications, limitations, and future research directions, fostering deeper insights into the subject matter. A comprehensive discussion enhances the contribution of the study to scientific understanding.

51) Flavonoid:
Flavonoids are a class of phytochemicals known for their antioxidant properties and health benefits, including anti-inflammatory effects. Found in various fruits, vegetables, and herbs, flavonoids play a significant part in plant defense mechanisms and are subject to extensive research concerning their role in promoting human health and preventing chronic diseases.

52) Toxicity:
Toxicity refers to the degree to which a substance can damage biological tissue or disrupt physiological functions. Toxicity assessments are critical in pharmacology, environmental science, and toxicology, ensuring that compounds used in treatments or found in environments do not pose significant harm to human health or ecological systems.

53) Mutation:
Mutation refers to a change in the DNA sequence of an organism, which can lead to alterations in protein function and contribute to various diseases, including cancer. Research on mutations focuses on understanding their origins, effects on health, and potential implications for treatment strategies, especially in personalized medicine.

54) Bandara (Bamdara):
Bandara may refer to a researcher or contributor within the field of biomedical studies or agricultural sciences. Individuals like Bandara often provide insights that enrich the academic literature, enabling advancements in understanding subjects like plant properties or health impacts, impacting both scientific discourse and practical applications.

55) Account:
In research contexts, 'account' may refer to a record or report detailing scientific findings or observations. Accurate accounts are critical for reproducibility and validation of results within the scientific community, serving to inform further research, policy-making, and applications in real-world scenarios.

56) Family:
Family refers to a group of related organisms categorized in biological classifications. In the context of plants, family grouping is crucial for understanding evolutionary relationships and shared characteristics. Research on plant family characteristics informs agricultural practices, conservation efforts, and the discovery of potential medicinal benefits.

57) Powder:
Powder refers to a finely ground substance, often used in food, medicine, or industrial applications. In pharmacology, powdered forms of herbs or drugs can enhance bioavailability and absorption. Research assesses the efficacy, safety, and applications of powdered medications, particularly in herbal remedies and dietary supplements.

58) House:
House typically refers to a physical structure, but in scientific contexts, it can indicate laboratory or agricultural settings where research is conducted. Proper facilities, such as animal houses or greenhouses, are crucial for ensuring controlled environments for experiments and studies, impacting the quality and integrity of research findings.

59) Cina:
China often represents a significant entity in discussions related to agriculture, traditional medicine, and herbal products. It is known for its extensive research on various plants and natural compounds, contributing to understanding medicinal properties and fostering global interest in herbal remedies, biological resources, and sustainable practices.

60) Kalu:
Kalu may refer to a local variety or specific term related to plant species in specific regions. Identifying local varietals contributes to understanding biodiversity and the potential uses of native plants in medicine and agriculture, highlighting the relevance of traditional knowledge in contemporary scientific research.

61) Rice (Rce):
Rice is a staple food crop vital to food security for billions globally. As a research subject, rice encompasses studies on genetics, agronomy, and nutritional value. Understanding rice cultivation, varietal differences, and sustainable agricultural practices is essential for improving yield and addressing food production challenges.

62) Line:
Line may refer to a lineage or specific classification in genetic studies, particularly in breeding programs or strain identification. In research, defining lines helps elucidate relationships, inheritance patterns, and potential for targeted selection in agriculture or biomedical studies, enhancing knowledge within various fields.

63) Pain:
Pain is a complex phenomenon representing a subjective experience resulting from injury, disease, or psychological factors. Understanding pain mechanisms is crucial for developing effective treatments and therapies. Research studies focus on pain management strategies, exploring pharmacological and non-pharmacological interventions to improve patient quality of life.

64) Post:
Post could refer to a publication or statement regarding particular findings in scientific literature, often used to share research advancements or insights with the academic community. It is also associated with discussions that facilitate collaborative learning and knowledge dissemination concerning various scientific topics.

65) Pir:
Peer refers to an individual with similar standing or expertise within a field. Peer interactions promote knowledge exchange and collaboration in research. Peer evaluations, such as peer reviews, maintain the integrity of scientific literature, ensuring that research findings meet high standards of quality and validity.

66) Soil:
Soil is a critical environmental component that supports plant life and agricultural practices. It functions in nutrient cycling, water retention, and ecological balance. Research on soil health includes examining its physical, chemical, and biological properties, focusing on sustainable management practices to enhance productivity and environmental conservation.

67) Male:
Male typically refers to the sex of an organism that produces small, mobile gametes (sperm) and often presents specific anatomical or behavioral traits. In studies, understanding male biological characteristics or differences is crucial for research on reproduction, health disparities, and behavioral studies across species.

Other Ayurveda Concepts:

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Discover the significance of concepts within the article: ‘Anticancer effects of Momordica charantia seed fat on liver cancer in rats’. Further sources in the context of Ayurveda might help you critically compare this page with similair documents:

Bitter melon, Therapeutic action, Ayurvedic medicine, Control group, Treatment group, Statistically significant reduction, Biochemical analysis, Hematological analysis, Gene expression analysis, Anticancer properties, Histopathological analysis, Hepatocellular Carcinoma, Wistar rat, Morphological analysis.

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