Boldine-loaded PLGA nanoparticles enhance drug delivery and reduce Cisplatin toxicity.
Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Improved drug carriage and protective potential against Cisplatin-induced toxicity using Boldine-loaded PLGA nanoparticles
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:
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Jesmin Mondal, Mousumi Patra, Ashis Kumar Panigrahi, Anisur Rahman Khuda-Bukhsh
Journal of Ayurveda and Integrative Medicine:
(A monthly peer-reviewed publication)
Full text available for: Improved drug carriage and protective potential against Cisplatin-induced toxicity using Boldine-loaded PLGA nanoparticles
Year: 2020 | Doi: 10.1016/j.jaim.2017.11.002
Copyright (license): CC BY-NC-ND 4.0
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Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Boldine-loaded PLGA nanoparticles enhance drug delivery and reduce Cisplatin toxicity.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
In scientific research, 'table' refers to a structured arrangement of data, typically displayed in rows and columns. Tables are crucial for summarizing complex information, making it easier to interpret findings, compare results, and draw conclusions. They provide a visual representation of data that facilitates analysis and enhances clarity.
2) Cancer:
Cancer is a group of diseases characterized by uncontrolled cell growth and division. It can arise in various tissues and organs, leading to tumors, metastasis, and systemic effects. Understanding cancer is vital for developing effective treatments and improving patient outcomes, as it remains one of the leading causes of death globally.
3) Drug:
The term 'drug' refers to any substance that, when introduced into the body, has a physiological effect. In medical contexts, drugs are utilized for diagnosis, treatment, or prevention of diseases. The study of drugs encompasses pharmacokinetics, pharmacodynamics, and their therapeutic applications, making it essential in healthcare and research.
4) Toxicity:
Toxicity describes the degree to which a substance can cause harm to organisms, including humans. It is a critical consideration in pharmacology and toxicology. Assessing toxicity is vital for drug development to ensure safety, establish dosage levels, and understand potential side effects that could impact patient health and treatment efficacy.
5) Study (Studying):
In a research context, 'study' signifies a systematic investigation aimed at answering specific questions or hypotheses. Studies are essential for advancing knowledge in various fields, particularly in medical research, where they help evaluate treatment efficacy, understand disease mechanisms, and contribute to evidence-based practices influencing patient care and policy.
6) Activity:
Activity often refers to the biological effect or function of a substance or process within an organism. In pharmacology, it relates to a drug's ability to produce a desired therapeutic effect. Understanding activity is crucial for drug design, development, and assessment of potential therapeutic benefits and risks in clinical applications.
7) Death:
Death is the cessation of all biological functions that sustain a living organism. In medical studies, understanding the causes and mechanisms leading to death, particularly in disease contexts, is essential for formulating prevention strategies, improving treatments, and informing public health policies, especially concerning life-threatening conditions like cancer and other serious illnesses.
8) Blood:
Blood is a vital fluid that circulates in the body's cardiovascular system, delivering nutrients and oxygen to tissues and removing waste products. In medicine, blood analysis is crucial for diagnosing diseases, monitoring health conditions, and guiding treatment decisions. It serves as a critical component in understanding many physiological and pathological processes.
9) Species:
In biological contexts, 'species' refers to a group of organisms that can interbreed and produce fertile offspring. Species classification is essential for biodiversity studies, conservation efforts, and understanding evolutionary relationships. In research, species selection impacts experimental outcomes, especially when studying disease mechanisms and therapeutic responses in preclinical models.
10) Ter:
The term 'ther' is an abbreviation associated with therapy, referring to treatment methods used for diseases or disorders. Understanding various therapeutic approaches is fundamental in medicine to improve patient outcomes and develop effective interventions. Research in therapy explores pharmacological, surgical, and other treatment modalities to manage health conditions.
11) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing diseases and injuries. It includes a wide range of health care practices and interventions aimed at improving patient well-being. The field is critical to public health and involves continuous advancements in research, technology, and treatment methodologies.
12) Arrow:
In medical and scientific research literature, 'arrow' is often used metaphorically to represent direction or indication, particularly in diagrams or flowcharts that illustrate processes, pathways, or relationships among variables. Arrows help clarify complex concepts by visually guiding readers through steps, connections, and causal relationships within studies.
13) Disease:
A disease is a pathological condition of a bodily part, an organ, or system resulting from various factors like infection, genetic defects, or environmental stressors. Understanding diseases is essential in medical research for developing effective treatments, preventive measures, and public health strategies to improve overall health and longevity in populations.
14) Biodegradable:
Biodegradable materials can be broken down by microorganisms into natural substances like water, carbon dioxide, and biomass. In pharmaceuticals, biodegradable drug delivery systems improve drug safety and efficacy while minimizing environmental impact. Their properties are crucial in designing therapies that ensure patient safety and effective treatment outcomes.
15) Transmission:
Transmission refers to the process by which a disease or infection spreads from one host to another, vital for understanding epidemiology. This includes modes of transmission such as airborne, vector-borne, or direct contact. Knowledge of transmission dynamics informs prevention strategies and public health interventions to control disease outbreaks.
16) Animal:
In research, 'animal' typically refers to non-human species used in experiments to study biological processes, disease mechanisms, and therapeutic interventions. Animal models are essential for understanding complex human conditions, testing new treatments, and ensuring safety before clinical trials, thus playing a critical role in biomedical research.
17) India:
India is a country in South Asia, known for its diverse culture, population, and significant contributions to science, medicine, and research. It has a growing healthcare system that includes extensive pharmaceutical research and development, making it a focal point for studies on diseases prevalent in its population and innovative therapeutic solutions.
18) Toxicology:
Toxicology is the study of the adverse effects of substances on living organisms. It combines aspects of biology, chemistry, and medicine to assess the risks and safety of drugs, chemicals, and environmental agents. Research in toxicology is essential for public health, regulatory standards, and understanding the mechanisms of toxicity.
19) Santa (Shanta, Samta, Shamta):
In the context of science and research, 'Santa' may refer to the name often associated with institutions or researchers. It can suggest significant contributions to specific studies. Understanding the contributions from various researchers is crucial for recognizing advancements and fostering collaboration in the scientific community.
20) Chemotherapy:
Chemotherapy is a type of cancer treatment that uses drugs to kill or inhibit the growth of cancer cells. Understanding chemotherapy's mechanisms, effectiveness, and side effects is crucial in oncology for developing effective treatment regimens, improving patient outcomes, and managing the overall treatment pathway for cancer patients.
21) Relative:
In a research context, 'relative' often refers to a comparison between groups, variables, or measurements. It helps determine the effectiveness or impact of a treatment or exposure by examining how one factor influences another, serving as a foundation for statistical analysis and drawing meaningful conclusions from data.
22) Nature:
Nature refers to the inherent qualities or characteristics of organisms, materials, or processes. Understanding the nature of substances and biological systems is fundamental in scientific research for developing accurate models, predicting behaviors, and informing the design of interventions in medicine, ecology, and environmental studies.
23) Observation:
In research, 'observation' is the act of monitoring and recording data related to a phenomenon or process. It is a critical step in scientific methods, enabling researchers to gather empirical evidence, analyze results, and draw conclusions. Accurate observations underpin reliable results and foster advancements in knowledge.
24) Transformation (Transform, Transforming):
Transformed describes a significant change or alteration, often in biological contexts such as cellular transformation due to an external factor like a drug or environmental influence. Understanding transformation processes is crucial for researching mechanisms underlying diseases, treatment responses, and cellular adaptation, ultimately guiding therapeutic strategies in medicine and biology.
25) Murugan (Murukan):
Murugan may refer to a specific researcher or study, often in the context of scientific contributions in pharmacology, medicine, or related fields. Recognizing key individuals in research helps contextualize findings and advances in knowledge, reflecting the collaborative nature of scientific inquiry and innovation.
26) Kalyani (Kalyanin):
Kalyani could relate to various entities, including educational institutions or geographical regions in India. In a research context, it may represent a location where studies are conducted, signifying the role of regional institutions in contributing to scientific advancement, especially in fields like medicine, toxicology, or pharmacology.
27) Prabha:
Prabha typically signifies a person's name and may relate to a contributor in the field of research, particularly in medicine or pharmacology. Acknowledging the roles of researchers named Prabha emphasizes the diverse collaboration and individual impact within scientific studies, enhancing the collective understanding of medical advancements.
28) Indian:
The term 'Indian' might refer to individuals from India or concepts related to Indian culture, medicine, and scientific research. It highlights the contributions from India in global scientific discussions, particularly in studies focused on local diseases, traditional medicine, and emerging therapeutic innovations relevant to diverse populations.
29) Shirna (Sirna):
siRNA (small interfering RNA) is a class of double-stranded RNA molecules that play a role in the RNA interference pathway, which regulates gene expression. In pharmacological studies, siRNA is significant for gene silencing, therapeutic interventions, and advancing treatment strategies for diseases like cancer, enhancing research opportunities in molecular medicine.
30) Water:
Water is essential for life and serves as a solvent in biological systems. In research, the role of water is critical in biochemical processes, drug delivery methods, and toxicity assessments. Understanding water's properties and interactions is vital for experimental design, particularly in pharmacological studies involving drug solubility and stability.
31) Rati:
Similar to Murugan and Prabha, Rathi may refer to an individual who has contributed to scientific research, particularly in health or biochemistry. Recognizing individual researchers is important for understanding the collaborative nature of scientific endeavors and attributing specific advancements to their respective contributions in studies and publications.
32) Saha (Shaha):
Saha may denote a researcher or scientist involved in medical or biochemical studies, highlighting the importance of individuals in contributing to scientific knowledge. Each researcher's unique insights and findings build upon the collective body of work necessary for advancing treatments and understandings in various medical fields.
33) Diet:
Diet encompasses the types of food consumed and significantly impacts overall health. In medical research, understanding diet helps inform studies on nutrition, disease prevention, and treatment efficacy. Research often correlates dietary patterns with health outcomes, elucidating nutrition's role in managing chronic conditions and improving quality of life.
34) Post:
In scientific discourse, 'post' often prefixes terms such as 'post-treatment,' indicating a phase after an intervention. It is crucial for analyzing long-term effects of treatments, their efficacy, and any side effects. Understanding post-intervention outcomes guides future research and clinical practice, enhancing patient care strategies.
35) Peer review:
Peer review is a critical evaluation process by experts in the field, assessing the quality and validity of research before publication. It helps ensure the integrity and credibility of scientific literature, fostering trust in research findings. Peer review is integral to upholding high standards in academic publishing.
36) New Delhi:
New Delhi, as India's capital, serves as a crucial hub for research, policy-making, and healthcare in the region. It is significant for governmental and academic institutions contributing to medical advancements, public health initiatives, and fostering collaborations in various scientific fields, making it vital for national and global health improvements.
37) Pharmacological:
Pharmacological studies examine drug interactions, mechanisms, and effects on biological systems. This field is essential for developing new treatments, understanding drug action principles, and evaluating therapeutic efficacy and safety. Research in pharmacology informs clinical practices and contributes to advancing healthcare strategies and drug development initiatives.
38) Accumulation (Accumulating, Accumulate):
Accumulation refers to the build-up of substances, often in biological systems, which can have pharmacological implications. Understanding accumulation processes is vital for assessing drug efficacy, toxicity, and potential side effects. It highlights the importance of dosage and administration routes in therapeutic contexts, influencing treatment decisions and patient outcomes.
39) Measurement:
Measurement is fundamental in scientific research, involving quantifying variables to collect data. Accurate measurement ensures reliability in experimental results, enabling valid comparisons and conclusions. In medicine, it encompasses assessing physiological parameters, drug concentrations, and response to treatments, critical for effective health interventions and scientific advancements.
40) Discussion:
Discussion is a critical section of scientific writing where researchers interpret results within the broader context of existing knowledge. It facilitates understanding of implications, limitations, and future research directions. A thorough discussion enhances the value of research findings, fostering informed debates and evolving scientific inquiry in relevant fields.
41) Reflecting:
Reflecting involves careful consideration or meditation on research findings, theories, or practices. In scientific contexts, reflection aids in understanding the implications of results and refining hypotheses or methodologies. It encourages researchers to connect their work to broader themes and considerations in their respective fields, promoting intellectual growth.
42) Observing:
Observing entails monitoring phenomena systematically to gather data and evidence. In scientific research, it is fundamental for experimentation, hypothesis testing, and data collection. Through observation, researchers can identify patterns, relationships, and causal factors, essential steps in the scientific method that lead to discoveries and advancements in various disciplines.
43) Science (Scientific):
Science represents systematic knowledge acquired through observation and experimentation. It encompasses various disciplines aimed at understanding natural phenomena, conducting research, and fostering innovation. The scientific method, characterized by hypothesizing, testing, and analyzing, underpins advancements in technology and medicine, influencing everyday life and societal progress.
44) Surface:
Surface often refers to the outer layer of a material or organism, important in various biological and chemical interactions. In medicine and pharmaceuticals, surface properties of drugs and drug delivery systems dictate absorption, bioavailability, and efficacy, influencing therapeutic outcomes and research directions in drug development.
45) Reason:
Reason pertains to logical justification or explanation for phenomena, critical in scientific inquiry. In research, articulating reasons for experimental design, methods, and conclusions fosters understanding of implications. It underlies peer review processes, enhances communication of findings, and strengthens the rationale for study advancements and innovations in various fields.
46) Medium:
Medium refers to the environment or substance through which interactions occur, essential for processes like drug delivery and biological reactions. In research, the choice of medium can influence outcomes, efficacy, and safety of treatments, making it a vital consideration in experimental designs and pharmaceutical applications.
47) Delhi:
Delhi, as a major city in India, is significant for science and healthcare research. It hosts various research institutions, hospitals, and universities that contribute to advancements in medicine, biotechnology, and public health. The city's role in collaborative research initiatives further emphasizes its importance in the global scientific community.
48) Rules:
Rules are established principles that govern conduct and procedures in scientific research. They ensure ethical standards, methodological rigor, and reproducibility in studies. Following rules enhances the integrity and credibility of research findings, building trust within the scientific community and promoting responsible practices in the pursuit of knowledge.
49) House:
In a metaphorical sense, 'house' may symbolize a collective space or institution where research and scientific inquiries are conducted. It represents the fostering of knowledge sharing and collaboration among researchers, creating an environment conducive to innovation and advancement in various scientific fields, especially in medical research.
50) Eagle:
Eagle, as a symbol of strength and vision, can metaphorically represent qualities desirable in scientific research such as clarity, insight, and the ability to stay focused on long-term goals. In more literal contexts, it may relate to specific studies involving the ecology of these birds and their habitats.
51) Food:
Food is essential for human survival, providing the necessary nutrients for health and bodily functions. In research, studies on nutrition and food impact public health, dietary guidelines, and prevention strategies for diseases. Understanding food's role in health informs effective dietary interventions and promotes nutritional awareness in communities.
52) Tree:
Trees symbolize life, growth, and ecological balance. In environmental studies, trees are critical for maintaining ecosystems, providing habitat, carbon sequestration, and oxygen production. Research focused on trees informs conservation efforts, climate change strategies, and sustainable practices, promoting the importance of biodiversity and environmental stewardship.
53) Sign:
In a scientific context, a 'sign' typically refers to an observable indication or marker of a biological condition or disease. Signs are vital in diagnosing medical conditions, guiding clinical decisions, and informing treatment plans. Accurate identification of signs improves patient management and enhances overall health outcomes.
54) Lamp:
In research, 'lamp' can metaphorically represent illumination or enlightenment, often signifying the introduction of new ideas, innovations, or discoveries. It emphasizes the role of research in shedding light on complex problems and guiding future inquiries, ultimately aiming to enhance understanding and promote progress in scientific fields.
55) Hand:
In biological and medical discussions, 'hand' often signifies action, intervention, or manipulation in experiments or treatments. It emphasizes the importance of human involvement in realizations of scientific concepts and healthcare practices, highlighting the direct relationship between researchers, practitioners, and the outcomes they strive to achieve.
56) Gold (Golden):
Gold symbolizes value and quality, often used metaphorically in research to represent highly desirable outcomes or successful results. In a more literal sense, gold nanoparticles are significant in biomedical applications, including targeted drug delivery and diagnostics, due to their unique properties that enhance efficacy and precision in therapeutic strategies.
57) Pir:
Peer refers to individuals at the same level or within the same field, particularly in academic and research contexts. Peer interactions, such as peer review, are fundamental for maintaining quality, fostering collaboration, and sharing knowledge, ultimately enhancing the credibility and reliability of scientific findings and advancements.
58) Life:
Life is the condition that distinguishes living organisms from inorganic matter, encompassing various biological phenomena. Understanding the principles of life is central to biology and medicine, driving research into health, disease mechanisms, and therapeutic interventions. It forms the foundation for studying diverse organisms and their interactions within ecosystems.