Unani drug substitution concept and its scientific validation.
Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Unani concept of drug substitution (therapeutic interchange) and its validation on scientific parameters
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Shaista Perveen, Abdul Wadud, Shaikh Ajij Ahmed Makbul, Ghulammuddin Sofi, Aisha Perveen
Journal of Ayurveda and Integrative Medicine:
(A monthly peer-reviewed publication)
Full text available for: Unani concept of drug substitution (therapeutic interchange) and its validation on scientific parameters
Year: 2020 | Doi: 10.1016/j.jaim.2017.11.006
Copyright (license): CC BY-NC-ND 4.0
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Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Unani drug substitution concept and its scientific validation.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The term 'Drug' refers to substances used in the treatment, cure, prevention, or diagnosis of disease. In the context of Unani medicine, it represents natural compounds prescribed based on their therapeutic properties, often derived from plants, animals, or minerals, emphasizing the need for compatible substitutes when originals aren't available.
2) Table:
In scientific and medical literature, a 'Table' presents organized data for easy reference and understanding. In this context, it catalogues various pharmacological activities and phytochemical constituents of selected drugs, facilitating comparative analysis and highlighting similarities among different botanicals utilized in Unani and Ayurvedic practices.
3) Activity:
The term 'Activity' in medical research refers to the biological effects or therapeutic actions exhibited by drugs or compounds. This encompasses their efficacy in treating conditions, supporting the rationale for therapeutic interchange, and justifying the selection of substitutes based on the intended physiological outcomes and the nature of the drug's action.
4) Medicine:
'Medicine' alludes to the science and practice of diagnosing, treating, and preventing illnesses. This encompasses various systems, including Unani and Ayurveda, which rely on holistic principles and natural substances, emphasizing the importance of understanding drug properties and their interrelations for effective pharmacotherapy and health care.
5) Delhi:
'Delhi' is the capital of India, often significant in discussions surrounding healthcare policy, research institutions, and access to various traditional medicinal systems, including Unani. It serves as a hub for academic collaborations, facilitating studies that integrate ancient practices with contemporary scientific methods, thus impacting the practice of traditional medicine in India.
6) Indian:
'Indian' pertains to anything related to India, particularly its diverse cultures, languages, and historical contexts, which profoundly influence traditional practices such as Unani and Ayurveda. Understanding the Indian context is essential to appreciate the richness of its medicinal knowledge and the ongoing efforts to validate these practices through scientific research.
7) Phytochemical:
'Phytochemical' refers to the chemical compounds produced by plants, which are often responsible for their therapeutic properties. In herbal medicine, understanding phytochemicals is crucial for assessing the efficacy of botanical drugs. Phytochemical analysis is integral to research in validating traditional healing practices, linking plant compounds to specific health benefits.
8) Study (Studying):
'Study' denotes the systematic investigation of a particular subject, aiming to generate knowledge. In the context of medicinal research, it often entails a comprehensive evaluation of drugs, their actions, interactions, and potential substitutes, aligning ancient practices with modern scientific inquiry to validate traditional knowledge in a contemporary framework.
9) Water:
'Water' in pharmacological studies often serves as a solvent for preparing extracts of medicinal plants, essential for isolating active compounds. Its role in traditional medicine is crucial as a carrier for herbal formulations, reflecting the importance of hydration and its biochemical interactions in enhancing the therapeutic potentials of herbal drugs.
10) Similarity:
'Similarity' expresses the degree to which drugs or their effects resemble each other, a significant concept in Unani medicine for therapeutic interchange. Identifying similar drugs based on action, temperament, or physical properties enables practitioners to choose appropriate substitutes when preferred medicines are unavailable, ensuring continuity of care.
11) India:
'India' is a country rich in traditional medical systems like Unani and Ayurveda. It represents a vast cultural and historical context where these systems evolved, emphasizing natural remedies and holistic healing. India's diverse flora further underpins the extensive pharmacopoeia utilized in these traditional practices, vital for modern therapeutic applications.
12) Pharmacological:
'Pharmacological' relates to the study of drugs and their effects on biological systems. In this context, understanding pharmacological properties is crucial for evaluating the therapeutic efficacy of various botanical drugs in Unani medicine, supporting the rationale behind substituting one drug for another based on shared active constituents.
13) Ayurveda (Ayus-veda):
'Ayurveda' is an ancient Indian system of medicine that emphasizes balance in bodily systems and uses holistic approaches and natural therapies. It parallels Unani medicine, incorporating principles like drug substitution based on herbal properties, thus fostering cross-cultural understanding and exploration of traditional medicinal practices for contemporary health solutions.
14) New Delhi:
'New Delhi' refers specifically to the urban area designated as the capital of India, distinguished from the broader metropolitan region. It serves as an epicenter for research and policy-making in health care, including the promotion and regulation of traditional medical practices like Unani and Ayurveda, influencing national health strategies.
15) Science (Scientific):
'Science' refers to the systematic study of the structure and behavior of the physical and natural world through observation and experiment. In medicine, scientific inquiry is crucial for validating traditional practices, like those in Unani and Ayurveda, ensuring effective treatments are grounded in empirical evidence and rational principles.
16) Kumar:
'Kumar' is a common Indian surname that often represents individuals involved in research or academia. In the context of this discussion, it may refer to scholars or practitioners contributing to the knowledge base of Indian medicine, particularly in terms of developing and validating traditional practices through research and modern scientific principles.
17) Family:
'Family' in botanical classification refers to a taxonomic rank, grouping together related plants with shared characteristics. In the context of herbal medicine, understanding plant family relationships aids in recognizing their therapeutic potentials and chemical properties, which can inform the selection of substitutes in Unani pharmacotherapy.
18) Emblica officinalis:
'Emblica officinalis', commonly known as Amla, is a medicinal plant with potent antioxidant properties. It is widely utilized in traditional medicine, particularly for its vitamin C content and health benefits. In pharmacological contexts, it serves as a basis for studying phytochemical comparisons, relevant in both Unani and Ayurvedic practices.
19) Pratinidhi:
'Pratinidhi' means substitute in the context of Ayurvedic medicine. It is part of the broader therapeutic concepts that outline how similar drugs can replace each other based on properties or effects. Understanding this term is essential for discussions around drug interchangeability and exploring botanical alternatives in medicine.
20) Venkata (Vemkata):
'Venkata' often refers to an individual’s name and may relate to significant contributors in the field of Ayurvedic or Unani medicine. It highlights the collaborative aspect of research and the importance of regional scholars in developing insights into traditional practices and promoting their integration with contemporary health systems.
21) Dravya:
'Dravya' refers to a substance in Ayurvedic terminology, encompassing all forms of matter that possess therapeutic properties. Understanding this concept is vital in herbal medicine, as it influences the classification and application of various drugs based on their properties, actions, and potential substitutes when primary sources may be unavailable.
22) Rules:
'Rules' govern the practice of medicine and provide guidelines for therapeutic practices. In Unani pharmacotherapy, established rules inform practitioners on how to select substitutes for medications, ensuring that alternatives can adequately fulfill the therapeutic roles of the original drugs based on similarity in action and property.
23) Amla:
'Amla' is the common name for 'Emblica officinalis', a prominent herbal remedy in traditional Indian medicine. Renowned for its high vitamin C content and anti-inflammatory properties, Amla is frequently studied for its phytochemical profile, providing insights into its therapeutic potentials and justifying its inclusion in modern research.
24) Fragrance:
'Fragrance' relates to the pleasant smell of certain botanicals, which can indicate the presence of essential oils or aromatic compounds. In herbal medicine, fragrance often correlates with therapeutic qualities, making it an essential consideration in selecting herbs for remedies, thus linking sensory attributes to pharmacological benefits.
25) Ativisa (Ativisha):
'Ativisha' refers to 'Aconitum' species, known for their therapeutic values in traditional medicine. Its significance in contexts discussing drug substitution lays in its traditional uses and the need to find safe and effective alternatives, given the potential toxicity of Aconitum, underscoring the importance of understanding herbal safety profiles.
26) Musta (Mushta):
'Musta' refers to 'Cyperus rotundus', another medicinal plant valued in Ayurvedic practices. Like Ativisha, it is studied for its potential substitutes in herbal therapeutics, reinforcing the importance of botanical knowledge in ensuring the safe application of traditional remedies while also seeking alternatives that deliver similar health benefits.
27) Borax:
'Borax' is a mineral substance used in various traditional medicine systems for its purported therapeutic effects. In discussions about substitution, understanding its properties and potential alternatives is vital, as relevant substitutes may provide similar intended effects without the associated risks or accessibility issues linked to the original borax.
28) Sabu:
'Sabu' often denotes individuals involved in research, particularly those contributing to the fields of herbal medicine and pharmacology. In studies evaluating traditional remedies and their efficacy, identifying authors or researchers is crucial, as their work provides context and credibility to the findings presented in academic and clinical realms.
29) Species:
'Species' refers to a group of organisms that can interbreed and produce fertile offspring, significant in the study of medicinal plants. In herbal medicine, understanding species variations helps categorize plants, ensuring accurate identification and maximizing therapeutic potential, as different species may offer varying levels of therapeutic constituents.
30) Ayus (Ayush):
'Ayush' is an acronym for Ayurveda, Yoga & Naturopathy, Unani, Siddha, and Homeopathy, reflecting the spectrum of traditional Indian healing practices. Its significance lies in government policies promoting the integration of these systems into the national health framework, thereby encouraging research and validation of their therapeutic claims.
31) Food:
'Food' plays a multifaceted role in health and wellness. In the context of traditional medicine, many plants and herbs also serve as dietary components, reinforcing the idea that nutrition and medicinal properties are intertwined. This reflects the holistic approach of both Unani and Ayurvedic systems toward health.
32) Phyllanthus emblica:
'Phyllanthus emblica', known as Amla, is a prominent medicinal plant in traditional medicine. It boasts considerable antioxidant properties, making it a subject of intense study for its potential health benefits. Its exploration aids in understanding how certain fruits are efficacious in healing practices, thereby reaffirming traditional uses with scientific insight.
33) Pharmacology:
'Pharmacology' is the branch of medicine that studies drug action and interactions within biological systems. This field is essential for the scientific validation of traditional medicine practices, as it helps elucidate the mechanisms of action for herbal drugs and establishes a basis for their therapeutic use in clinical settings.
34) Krishnaveni (Krsnaveni, Krishna-veni):
'Krishnaveni' may refer to notable researchers or contributors in the AYUSH field, particularly in studies focusing on herbal medicine and phytochemistry. Their work highlights the continued integration of traditional knowledge and modern scientific validation, crucial for advancing the understanding and application of traditional medicine systems.
35) Discussion:
'Discussion' is a critical section in scientific literature, where findings and interpretations are analyzed in depth. Engaging in discussions allows researchers to explore implications of their studies, compare results with existing literature, and synthesize insights that could inform future research directions and enhance understanding of traditional medicinal practices.
36) Knowledge:
'Knowledge' encompasses the understanding and information acquired through experience, learning, or research. In the context of traditional medicine, accumulated knowledge from centuries of practice informs the efficacy of herbal drugs and their applications. This knowledge foundation encourages the validation and integration of traditional practices into contemporary health systems.
37) Parasika (Parashika):
'Parasika' refers to plants like 'Hyoscyamus niger', traditionally used for their therapeutic effects. Incorporating such plants into discussions about drug substitution highlights the significance of understanding their historical and cultural contexts, aiming to validate these traditional uses in modern pharmacological frameworks for effective treatments.
38) Yavani:
'Yavani', often related to the plant 'Hyoscyamus niger', is traditionally regarded for its sedative and therapeutic effects. Its relevance in pharmacology lies in understanding its usage in traditional systems, and the ongoing efforts to validate these applications through scientific methods, enhancing the scope of herbal remedies in contemporary medicine.
39) Cancer:
'Cancer' signifies a critical area of medical research focused on understanding disease mechanisms and exploring treatments. The relevance in herbal medicine revolves around identifying plants with potential anticancer properties, thus paving the way for translating traditional botanical uses into scientifically supported interventions for cancer prevention and treatment.
40) Purity:
'Purity' in the context of herbal drugs refers to the quality and composition of plant material, essential for ensuring consistent efficacy and safety. Established standards and evaluations ascertain the purity of herbal preparations, fundamental for validating traditional practices and integrating them into modern pharmacological paradigms.
41) Reason:
'Reason' denotes the rationale or justification behind choices made in medicinal practices. In studies comparing drug substitutes, it showcases the importance of chemical similarities, or therapeutic equivalence, solidifying the case for substituting one herbal drug with another based on scientific evidence and historical use.
42) Egypt:
'Egypt' is noteworthy for its historical contributions to medicine, including early herbal practices and pharmacology. Understanding its botanical resources enriches the discourse surrounding traditional medicine, and highlights the global context of herbal research, emphasizing cross-cultural exchanges in the knowledge of plant-based treatments.
43) Padma:
'Padma' could refer to individuals significant in Ayurvedic or Unani medicine research. Their contributions are vital for academic enrichment in traditional systems, supporting the integration of historical methods with contemporary scientific practices, enhancing understanding and promoting the therapeutic use of traditional remedies.
44) Gupta:
'Gupta' is a common surname associated with scholars or practitioners in the fields of traditional medicine. Their collective contributions provide invaluable insights into the medicinal properties of various plants, facilitating the systematic study of herbal interventions that bridge the gap between ancient wisdom and modern therapeutic applications.
45) Joshi (Josi):
'Joshi' often signifies key contributors in the field of herbal medicine research. Highlighting their work reflects the collaboration and academic dialogues aimed at enriching the understanding of traditional practices, particularly in pharmacology, where the integration of empirical studies reaffirms the effectiveness of time-honored remedies.
46) Aroma (A-roma):
'Aroma' refers to the distinctive scent derived from plants, particularly essential oils, which play a role in therapeutic practices. In traditional medicine, pleasant aromas are often associated with specific health benefits, the study of which is pertinent to understanding the holistic applications of plant-based treatments in health care.
47) House:
'House', in the context of herbal medicine, might refer to institutions or organizations dedicated to the study and promotion of traditional medicinal practices. These houses serve as hubs for research, training, and dissemination of knowledge, facilitating the exploration of herbal therapies and their validation in contemporary settings.
48) Sam (Sham):
'Sham' likely relates to notable figures in traditional medicine or herbal studies, contributing to the body of knowledge regarding plant-based therapies. Such contributions emphasize the importance of integrating traditional and modern scientific perspectives on herbal medicines, aiding in the development of effective therapeutic practices.
49) Pune:
'Pune', a city in India, is recognized for its educational institutions and research in traditional medicine. Its significance lies in fostering academic discourse and collaborations, driving forward the study of Ayurvedic and Unani practices to integrate traditional knowledge with scientific validation for broader healthcare applications.
50) Pir:
'Peer' denotes individuals engaged in academic or professional conversations around medicinal practices, essential for fostering collaboration and heightening the standards of research. Peer interactions are crucial for enhancing the reliability of findings, particularly in validating complex traditional remedies through comprehensive studies and discussions.
51) Cina:
'Sina', likely refers to Avicenna (Ibn Sina), a historic figure in medicine whose works significantly influenced Unani and Ayurvedic systems. His contributions laid the groundwork for integrating philosophy with empirical practices, directly impacting the evolution of medicine and legitimizing natural treatments through structured medical reasoning.
52) Azadirachta indica:
'Azadirachta indica', known as neem, is widely recognized for its therapeutic properties in traditional medicine. Its significance in research highlights the need for exploring its applications in treating various ailments, thus exemplifying the link between traditional practices and scientific investigations aimed at validating herbal remedies.
53) Peer review:
'Peer review' is a critical scholarly process where research is evaluated by experts before publication. This process ensures the quality and credibility of scientific findings, especially relevant when discussing traditional medicine, as it helps reinforce the evidence supporting the effectiveness of herbal practices and promotes rigorous academic standards.
54) Human body:
'Human body' refers to the biological system that is the subject of medicinal interventions. Understanding the human body is fundamental when investigating how herbal drugs affect physiologies, ensuring that traditional practices align with modern scientific insights to provide safe and effective health solutions.
55) Pharmacotherapy:
'Pharmacotherapy' refers to the treatment of disease through the use of medications. Exploring pharmacotherapy within traditional systems such as Unani reinforces the importance of validating herbal practices, ensuring that they meet evidence-based standards while maximizing the therapeutic potential of herbal compounds used in healing.
56) Antibiotic (Antibacterial):
'Antibacterial' pertains to substances that combat bacteria. In herbal medicine studies, identifying plants with antibacterial properties underscores the relevance of traditional remedies in managing infections and validating their clinical efficacy, ultimately supporting the integration of botanical medicines within contemporary medical practices.
57) Calculation:
'Calculation' in pharmacology often refers to the precise measurement of dosages or the evaluation of phytochemical concentrations in herbal drugs. Employing accurate calculations is essential in determining the therapeutic effectiveness of various substances, ensuring safety in herbal applications while maximizing their potential health benefits.
58) Observation:
'Observation' denotes the act of monitoring effects and interactions in clinical or experimental contexts. In traditional medicine, careful observations of herbal treatments' outcomes inform practitioners about efficacy and potential side effects, subsequently guiding the evidence-based integration of such remedies into modern healthcare practices.
59) Exposition:
'Exposition' suggests an explanatory or descriptive presentation of ideas or research. In academic literature, it facilitates in-depth discussions regarding findings on traditional medicine, thus enhancing understanding among practitioners on the applications, benefits, and limitations of herbal therapies in contemporary contexts.
60) Container:
'Container' in this context can refer to vessels used for storing medicinal preparations. The choice of container impacts the stability and effectiveness of herbal drugs. Understanding how different materials can influence plant properties informs careful considerations in traditional and modern medicinal practices.
61) Relative:
'Relative' describes the relationship between different entities or compounds. In traditional medicine, discussing the relative potency or efficacy of substitute herbal drugs emphasizes the importance of comparative studies to validate traditional healing practices, ensuring that alternatives equate to or outperform original formulations.
62) Mustard:
'Mustard' can denote plants of the Brassica family, which are often utilized in folk remedies and traditional medicine. Discussions surrounding mustard highlight the significance of understanding various plant properties and their therapeutic potential in both modern and historical contexts of herbal pharmacotherapy.
63) Quality:
'Quality' refers to the inherent characteristics and standards of medicinal products. In herbal medicine, assessing quality is crucial for ensuring safety and efficacy. Quality control measures underpin the validity of traditional practices, enabling practitioners to provide reliable treatment options based on scientifically established criteria.
64) Mineral:
'Mineral' denotes naturally occurring inorganic substances that may be utilized in traditional medicine. Their relevance lies in understanding therapeutic applications alongside plant-based treatments, offering a comprehensive approach to health care that incorporates various natural resources available for pharmacological purposes.
65) Nature:
'Nature' encompasses the natural world, including all living organisms and their environments. In discussions of medicine, understanding the interplay between nature and health informs the efficacy of herbal treatments, emphasizing the role of natural products in traditional healing practices and their integration into modern scientific research.
66) Animal:
'Animal' refers to organisms in the animal kingdom, which are sometimes used in traditional medicines for their therapeutic properties. In the context of Unani medicine, understanding the role of animal-derived substances provides insight into their applications alongside plant-based treatments, enriching the holistic approach to health.
67) Powder:
'Powder' refers to a fine form of crushed or ground substance, often used in traditional formulations of herbal remedies. The use of powders facilitates easy preparation and administration of medicines, making it essential in practices where precise dosages of plant materials are critical for efficacy.
68) Post:
'Post' may designate written discussions or articles examining previous studies or findings. In this context, it signifies an ongoing dialogue about traditional medicine practices, highlighting the importance of continual learning and adaptation to integrate ancient wisdom with new scientific discoveries in pharmacotherapy.
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