Allium cepa protects retinal ganglion cells in PPA-ligated mice.

| Posted in: Science

Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Allium cepa exerts neuroprotective effect on retinal ganglion cells of pterygopalatine artery (PPA) ligated mice
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:

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Author:

Saurabh Kumar, Shweta Modgil, Sridhar Bammidi, Gillipsie Minhas, Richa Shri, Sushmita Kaushik, Varinder Singh, Akshay Anand


Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: Allium cepa exerts neuroprotective effect on retinal ganglion cells of pterygopalatine artery (PPA) ligated mice

Year: 2020 | Doi: 10.1016/j.jaim.2019.08.002

Copyright (license): CC BY-NC-ND 4.0


Download the PDF file of the original publication


Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Allium cepa protects retinal ganglion cells in PPA-ligated mice.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
The term 'Table' refers to a systematic arrangement of data in rows and columns, facilitating comparative analysis. In scientific research, tables summarize findings, such as gene expression values in various experimental conditions. Tables help readers quickly grasp complex information and identify trends or differences across experimental groups, enhancing the clarity of results.

2) Study (Studying):
A 'Study' implies a systematic investigation aimed at discovering or verifying facts. In research contexts, it commonly refers to a structured inquiry into a specific field, such as the effects of herbal extracts on retinal injury. A study's rigor determines its credibility and potential contributions to scientific knowledge within a discipline.

3) Disease:
The term 'Disease' describes a pathological condition characterized by an abnormal physiological process that affects part or all of an organism. In the context of the presented research, diseases like glaucoma lead to retinal ganglion cell damage, necessitating neuroprotective investigations using herbal compounds. Understanding disease mechanisms is crucial for developing effective treatments.

4) Animal:
In research, 'Animal' refers to non-human species used for experimental purposes. Animal models, such as mice, help scientists study disease mechanisms and test potential therapies in vivo. These studies provide insights that can translate to human health outcomes, allowing researchers to assess neuroprotective effects of treatment interventions on living organisms.

5) Drug:
A 'Drug' is a chemical substance used to prevent, diagnose, or treat illness. The research context emphasizes evaluating various compounds, particularly herbal extracts, for their therapeutic effects on retinal injuries. Investigating the efficacy and safety of drugs is essential in clinical settings to optimize treatment strategies and minimize adverse effects.

6) Blood:
The word 'Blood' denotes the fluid circulating within an organism's vascular system, crucial for transport of nutrients, gases, and waste products. In the study of ischemic conditions, blood supply is critical since its restriction leads to cell damage. Understanding blood flow dynamics helps researchers assess therapeutic interventions aimed at restoring adequate circulation.

7) India:
India is a country where traditional medicine plays a significant role in healthcare, with a large portion of the population relying on herbal remedies. The context of the study highlights the scientific exploration of herbal treatments like Allium cepa, reflecting the integration of traditional practices with modern scientific inquiry to enhance therapeutic regimes.

8) Family:
The term 'Family' can denote a taxonomic group of organisms, hierarchically ranked. In the context of herbal medicine, it often relates to plant families from which specific medicinal plants are derived. Understanding plant families assists in identifying beneficial compounds derived from plants, enhancing research endeavors in pharmacognosy and drug discovery.

9) Sharman (Sarma, Sharma, Sarman):
In the context of the research, 'Sharma' is likely a reference to one of the authors of the study. Author affiliations lend credibility to the research, and their expertise contributes to the study's design, methodological rigor, and interpretation of findings. Individual contributions can significantly influence a study's impact within the scientific community.

10) Death:
The term 'Death' is used to signify the termination of life processes. In the context of retinal damage, the study examines how conditions like ischemia may lead to the death of retinal ganglion cells. Understanding mechanisms leading to cell death is critical for developing neuroprotective strategies to preserve vision.

11) Shri (Sri, Sr):
The honorific 'Shri' is commonly used in Indian culture to denote respect. In academic contexts, authors often include titles or honorifics to acknowledge their contributions formally. The inclusion of 'Shri' underscores the cultural context of the research and may reflect the author's professional status or experience within the field.

12) Food:
The term 'Food' refers to any substance that can be consumed to provide nutritional support. In the context of the study, the investigation into Allium cepa emphasizes its role not only as a dietary staple but as a potential therapeutic agent, linking nutritional science and health benefits derived from food sources.

13) Post:
The word 'Post' refers to the period following an event. In the research context, it often refers to follow-up assessments after treatment interventions or surgeries. Understanding post-treatment outcomes is essential for evaluating the efficacy and safety of therapeutic approaches, including recovery trajectories in models of retinal damage.

14) Life:
The term 'Life' denotes the state of being alive and encompasses various biological processes. In research, it often pertains to the study of living organisms' responses to interventions. Understanding life processes is crucial for investigating cellular health, survival mechanisms, and potential therapies aimed at enhancing organismal well-being.

15) Toxicity:
Toxicity refers to the degree to which a substance can cause harm to organisms. In pharmacological studies, assessing the toxicity of compounds is essential to ensure their safety for human use. Evaluating toxicity profiles helps in determining safe dosage ranges and understanding potential side effects associated with therapeutic agents.

16) Biodegradable:
The term 'Biodegradable' signifies substances that can break down naturally in the environment without causing harm. In the context of medical research, biodegradable materials are significant for drug delivery systems. They provide a safer alternative that minimizes environmental and biological impact, enhancing the sustainability of therapeutic interventions.

17) Antibiotic (Antibacterial):
Antibacterial refers to substances that inhibit the growth of bacteria. In a pharmacological context, exploring the antibacterial properties of herbal extracts, like Allium cepa, can lead to advancements in treatment strategies for infections. Understanding antibacterial mechanisms is critical for developing effective antimicrobial therapies and addressing public health challenges.

18) Measurement:
The term 'Measurement' denotes the process of quantifying characteristics or attributes. In scientific research, precise measurements are essential for data integrity, enabling researchers to assess outcomes and draw valid conclusions. Accurate measurement techniques enhance the reliability of results, allowing for reproducibility and comparison across studies.

19) Substance:
A 'Substance' signifies any material or matter, typically referring to a chemical compound within a research study. In the context of pharmacology, substances may include active compounds derived from natural sources aimed at therapeutic applications, emphasizing the importance of biochemical characteristics and interactions in health-related research.

20) Blindness:
Blindness refers to the condition of having impaired or total loss of vision. The study addresses diseases like glaucoma, which can lead to blindness due to retinal damage. Understanding the underlying mechanisms of vision loss is vital for developing prevention and treatment strategies to preserve sight and improve quality of life.

21) Medicine:
The term 'Medicine' encompasses the field dedicated to the diagnosis, treatment, and prevention of illnesses. Investigation into herbal medicines, like Allium cepa, reflects a growing interest in integrating traditional knowledge with scientific inquiry to explore potential therapeutic applications. Advancements in herbal medicine can lead to innovative approaches in healthcare.

22) Chauhan:
In the context of the research article, 'Chauhan' is likely one of the authors contributing to the study. Author credentials, including their affiliations and expertise, augment the validity of the research. Recognizing individual contributions fosters collaboration within scientific fields and helps in disseminating knowledge effectively.

23) Vijaya:
The name 'Vijaya' refers to one of the authors involved in the study. Author recognition is important for attributing research findings accurately and acknowledging contributions in scientific literature. Author roles can influence the direction of research, highlighting the collaboration among individuals with diverse expertise.

24) Gupta:
In the article, 'Gupta' refers to an author involved in the research. The name signifies a contributor's role in the study, emphasizing collaboration in scientific inquiry. The involvement of multiple authors enhances the credibility of research findings and indicates shared expertise within the relevant field.

25) Patel:
The name 'Patel' likely denotes an author associated with the research study. Author identification is significant in scholarly work, aligning contributions with professional backgrounds and enhancing accountability. The collaborative nature of research is highlighted by multiple authors working together to explore complex scientific questions.

26) Ayus (Ayush):
The term 'Ayush' pertains to the Ministry of AYUSH in India, which promotes traditional medicine systems, including Ayurveda, Yoga, Unani, Siddha, and Homoeopathy. Its emphasis on research and development underscores the importance of integrating traditional and modern medical practices, providing a holistic approach to healthcare and enhancing therapeutic options.

27) Water:
Water is an essential substance for life, serving multiple roles in biological systems. In pharmacological research, water is often used as a solvent for dissolving substances before administration. Its role in maintaining homeostasis and facilitating biochemical reactions underscores its importance in studies involving animal models and drug formulations.

28) Rules:
The term 'Rules' refers to established guidelines or principles that govern scientific research. Following rules enhances the integrity of studies by ensuring ethical standards, methodological rigor, and accuracy in data collection and analysis. Compliance with rules is essential for gaining trust within the scientific community and for public health regulations.

29) House:
In research studies, 'House' pertains to the controlled environment in which animals are kept. Maintaining appropriate housing conditions ensures the welfare of experimental animals, influencing behavioral and physiological outcomes. Housing conditions can impact research validity by affecting the health and stress levels of the animal subjects.

30) Kara:
In the context of the article, 'Kara' likely represents an author contributing to the research study. Identifying authors is important in academic publishing, as it attributes credit and enhances accountability for the research findings. Collaborative works showcase the integration of collective expertise across diverse scientific disciplines.

31) Bora:
The term 'Bora' refers to one of the authors of the research paper. Acknowledging authorship is pivotal in scientific discourse, as it provides transparency about contributors' backgrounds and obligations in the study. Collaborations among multiple authors enhance the rigor and depth of research inquiries across disciplines.

32) Sam (Sham):
The word 'Sham' signifies a type of control in experimental designs, particularly in studies investigating therapeutic effects. A sham control is employed to account for placebo effects and ensure that observed outcomes can be attributed to the experimental treatment rather than other factors, enhancing the clarity and validity of study findings.

33) Line:
In scientific research, 'Line' may refer to a lineage or strain of organisms used for experimentation. Lineage-specific studies enable researchers to assess genetic or phenotypic variability and assess treatment responses across diverse biological contexts. Understanding lineage attributes enhances the replicability and relevance of findings in broader applications.

34) Peer review:
Peer review is a critical process in academic publishing where manuscripts undergo evaluation by experts in the field before publication. This system ensures the research quality, integrity, and validity of findings. Peer review fosters accountability and supports the advancement of scientific knowledge by maintaining high publication standards.

35) Allium sativum:
Allium sativum, commonly known as garlic, is a widely researched species noted for its numerous health benefits. In studies investigating neuroprotective properties, Allium sativum is explored for its potential therapeutic effects due to its bioactive compounds. Its role highlights the intersection of dietary influences and pharmacological applications in health.

36) Pharmacology:
Pharmacology is the branch of medicine focused on the study of drug action and effects. This field investigates how substances interact with biological systems and informs the development of therapeutic agents. Understanding pharmacological principles is essential for optimizing treatments, minimizing adverse effects, and maximizing therapeutic benefits in clinical contexts.

37) Discussion:
The 'Discussion' section of a research article interprets and contextualizes findings within the broader scientific literature. It evaluates study implications, proposes future directions for research, and addresses limitations. This analytical approach fosters critical engagement with the results, enhancing understanding of underlying mechanisms and guiding subsequent investigations in the field.

38) Detachment:
Detachment in a research context typically refers to the separation of biological tissues or structures, such as retinal layers during injury studies. Understanding the impacts of detachment aids researchers in assessing recovery processes and evaluating therapeutic interventions aimed at promoting adhesion, healing, and functional restoration in affected tissues.

39) Science (Scientific):
Science encompasses the systematic study of the natural world through observation and experimentation. It seeks to explain phenomena through rigorously tested hypotheses. Scientific inquiry drives advancements in medicine, biology, and pharmacology, fostering understanding of complex processes and informing interventions that enhance health outcomes and quality of life.

40) Incision:
An 'Incision' refers to a surgical cut made in tissues during procedures such as experiments inducing ischemia. Proper technique in making incisions ensures minimal tissue trauma and precise interventions. Understanding incision impacts helps researchers maintain integrity in surgical models while assessing treatment effects on healing and recovery processes.

41) Repair:
Repair refers to the biological processes involved in restoring tissue structure and function after injury. Understanding repair mechanisms is crucial in studies investigating therapeutic agents, as promoting effective healing can minimize lasting damage. Research often explores interventions that enhance natural repair processes, particularly in contexts of degenerative diseases.

42) Indian:
The term 'Indian' signifies a cultural or geographical context, particularly regarding traditional practices and regional healthcare approaches. It often relates to the significant reliance of the Indian population on herbal medicines, influencing the exploration of indigenous plants for therapeutic efficacy in contemporary scientific research.

43) Hara:
In the context of the research, 'Hara' likely refers to an author noted for contributions to the study. Recognizing individual authors is important in academic work as it associates expertise and influences the study's credibility. The collaborative nature of research helps elucidate complex questions and develop comprehensive findings.

44) Miṇi (Mini):
The term 'Mini' likely refers to a specific context or a characteristic such as a smaller scale in experimental setups. In research contexts, miniaturization techniques can enhance efficiency and reduce resource consumption. Understanding the implications of 'mini' approaches contributes to innovative developments in areas like drug delivery and testing.

45) Beta:
In a scientific context, 'Beta' often refers to a specific form or version of a substance, or a factor indicating variability or comparison within models. In pharmacological studies, beta forms are used to assess efficacy, safety, and dosage responses, essential for understanding treatment dynamics and optimizing therapeutic parameters.

46) Diet:
The term 'Diet' pertains to food consumption patterns that significantly influence health and disease outcomes. In the context of the research, dietary constituents like those from Allium cepa highlight how nutrition can impact therapeutic efficacy. Understanding the relationship between diet and health can guide preventive strategies and therapeutic interventions.

47) Rich (Rch):
The word 'Rich' typically denotes abundance or high concentration of certain components. In nutritional contexts, it refers to foods containing significant amounts of beneficial compounds. A diet rich in antioxidants or bioactive substances is often emphasized for its role in promoting health and preventing diseases, particularly in dietary studies.

48) Pir:
The term 'Peer' refers to colleagues in a particular field. In academic contexts, peer interactions foster collaborative research efforts, enhance knowledge exchange, and contribute to the overall rigor of scientific inquiry. Peer collaborative efforts are crucial for producing credible research outcomes and advancing collective understanding in various domains.

49) Pur:
The term 'Poor' often describes inadequate or deficient conditions. In research, it can refer to suboptimal health, nutritional levels, or environmental factors impacting biological processes. Understanding the implications of poor conditions in experimental models is essential for assessing treatment efficacy and developing strategies to address health disparities.

50) Male:
The term 'Male' denotes the biological sex of an organism, specifically in the context of research involving animal models. Gender differences can significantly influence biological responses to treatments, necessitating careful consideration in experimental design and analysis to ensure that findings are relevant and applicable across genders.

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