Neuroprotective effects of Myrica esulenta in Parkinson's model.

| Posted in: Science

Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Neuroprotective potential of Myrica esulenta in Haloperidol induced Parkinson’s disease
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:

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Author:

Atul Kabra, Uttam Singh Baghel, Christophe Hano, Natalia Martins, Mohammad Khalid, Rohit Sharma


Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: Neuroprotective potential of Myrica esulenta in Haloperidol induced Parkinson’s disease

Year: 2020 | Doi: 10.1016/j.jaim.2020.06.007

Copyright (license): CC BY-NC-ND 4.0


Download the PDF file of the original publication


Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Neuroprotective effects of Myrica esulenta in Parkinson's model.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Disease:
A disease is a pathological condition of a bodily part, an abnormal bodily condition characterized by various signs and symptoms. The research presented focuses on Parkinson's disease, a neurodegenerative disorder with a range of symptoms including motor and non-motor features, underscoring the need for effective treatments and innovative therapeutic agents.

2) Animal:
In this context, 'animal' refers to the Wistar rats used in the research to model Parkinson's disease in humans. Animal studies are essential for understanding disease mechanisms, testing new therapies, and assessing safety and efficacy before translating findings to human clinical trials, thus forming a crucial aspect of preclinical research.

3) Drug:
A drug is a substance used to diagnose, cure, treat, or prevent disease. The study investigates the neuroprotective properties of Myrica esculenta against haloperidol-induced neurotoxicity, highlighting the potential of this natural product as a safer therapeutic alternative to conventional drugs for managing Parkinson's disease symptoms and side effects.

4) Study (Studying):
A study systematically investigates a particular area of interest, in this case, the neuroprotective effects of Myrica esculenta in a rodent model of Parkinson's disease. The findings from such studies are crucial for advancing medical knowledge, leading to new therapeutic strategies and improved health outcomes for patients with Parkinson's.

5) Activity:
Activity in this context refers to the behavioral and pharmacological responses observed in the animal models during testing. Measuring activity provides insights into the efficacy of treatments, in this case the methanolic extract of Myrica esculenta, highlighting changes in symptoms of Parkinson’s disease and the overall neuroprotective effect of the extract.

6) India:
India is the region of origin for Myrica esculenta, a plant used in traditional medicine. The country has a rich heritage of herbal medicine and research on indigenous plants offers valuable insights into potential new therapies for diseases, spearheading initiatives that promote the integration of traditional knowledge with modern pharmacology.

7) Table:
In scientific documents, a table is often used to present data in a structured format, facilitating quick comparisons and analysis. The reference to a table in this study likely indicates a summary of biochemical parameters evaluated in the experiment, thereby effectively conveying experimental results regarding the impact of Myrica esculenta.

8) Sharman (Sarma, Sharma, Sarman):
Sharma is likely referenced as one of the authors of the study, suggesting a key role in conducting the research. Collaborations among authors with different expertise foster comprehensive investigations, contributing to the reliability of the findings and enhancing the validity of the research, as reflected in peer-reviewed literature.

9) Indian:
Referring to the geographical and cultural context, 'Indian' signifies the native heritage of Myrica esculenta. The formulation and application of treatments derived from indigenous knowledge contribute significantly to the understanding of local flora's therapeutic potential, encouraging further exploration of natural products in modern medicine.

10) Flavonoid:
Flavonoids are a class of polyphenolic compounds recognized for their antioxidant properties. In the study, flavonoids present in the methanolic extract of Myrica esculenta are hypothesized to play a vital role in mitigating oxidative stress, thus contributing to the neuroprotective effects observed in the animal models of Parkinson’s disease.

11) Toxicity:
Toxicity refers to the degree to which a substance can harm living organisms. The study highlights the importance of assessing the toxicity of Myrica esculenta’s extract in animal models, ensuring safety before potential therapeutic use. Understanding toxicity is critical for drug development and establishing safe dosage regimens.

12) Pharmacological:
Pharmacological relates to the study of drugs, their interactions, effects, and mechanisms of action. This research emphasizes the pharmacological potential of Myrica esculenta as an alternative treatment for Parkinson’s disease, exploring its capacity to alleviate symptoms and reduce drug-induced adverse effects in experimental models.

13) Phytochemical:
Phytochemicals are bioactive compounds derived from plants, often associated with health benefits. The study explores the phytochemical profile of Myrica esculenta, aiming to identify specific compounds responsible for the observed neuroprotective effects, potentially guiding the development of new natural medications for neurodegenerative diseases.

14) Srivastava (Sri-vastava, Shrivastava, Shri-vastava):
Similar to Sharma, Srivastava is likely an author involved in the study, contributing to its conceptualization and execution. The collaboration amongst researchers, each bringing unique insights and expertise, enriches the research quality, yielding findings that can influence therapeutic strategies in diseases like Parkinson's.

15) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine that emphasizes a holistic approach to health, using natural herbs and treatments. The study's focus on Myrica esculenta mirrors Ayurveda's principles, emphasizing the need to incorporate traditional knowledge into modern pharmacological research to discover effective, low-side-effect therapies.

16) Observation:
Observation refers to the systematic recording of behavioral and physiological responses during the study. In this context, accurate observations of the rats' behaviors in neurobehavioral tests are critical for assessing the efficacy of treatments, providing quantifiable data that supports the therapeutic potential of Myrica esculenta.

17) Himalaya (Hima-alaya):
The Himalayas are referenced in relation to the geographic origin of Myrica esculenta, linking the plant to a specific ecological and cultural context. This connection underscores the importance of local flora in developing therapies, enriching the pool of natural resources available in traditional medicine and pharmacognosy.

18) Species:
Species refers to a particular group of plants or animals that can interbreed. In this study, identifying Myrica esculenta as a specific species contributes to understanding its potential medicinal properties. Recognizing the species also aids in conservation efforts and encourages sustainable practices in harvesting medicinal plants.

19) Delhi:
Delhi may refer to a significant urban center in India where research institutions are located. This city likely plays a role in the advancement of scientific research in India, facilitating collaboration among researchers and supporting studies like the one on Myrica esculenta, enhancing accessibility to resources and funding.

20) Patel:
Patel is likely another contributing author of the study, indicative of the collaborative nature of research. Each author's contributions are essential for the integrity and completeness of the study, ensuring that diverse expertise is applied to explore the full potential of Myrica esculenta in therapeutic applications.

21) Roga:
In traditional Indian medicine, 'roga' translates to disease or disorder. This term indicates a focus on treating various ailments within the context of Ayurvedic practice, in this case, specifically pointing towards the neurological conditions the study aims to address through the use of Myrica esculenta.

22) Cage:
A cage refers to the environment in which the experimental animals were kept during the study. Providing a standardized and controlled environment is crucial for ensuring the well-being of the rats while allowing for accurate measurement of responses to treatments during neurobehavioral assessments.

23) New Delhi:
New Delhi enhances the context given its role as a major scientific and research hub in India. Researchers from this city likely have access to modern laboratory facilities and resources that facilitate innovative studies, contributing to advancements in health science and pharmacological research.

24) Inflammation:
Inflammation is a biological response to harmful stimuli and is often associated with various diseases. The study addresses inflammation in the context of neurodegeneration, exploring how Myrica esculenta may help regulate inflammatory processes, highlighting its therapeutic potential beyond simply addressing oxidative stress.

25) Water:
Water is essential for life and plays a crucial role in physiological processes and drug formulation. In the study, the use of water during the extraction and preparation of the methanolic extract of Myrica esculenta may affect the stability and efficacy of the extracted compounds being tested.

26) Sign:
In scientific research, a 'sign' relates to observable or measurable indications of effects or responses. In the context of this study, the absence of toxic signs after administering Myrica esculenta suggests a favorable safety profile, vital for establishing its therapeutic use for treating conditions like Parkinson’s disease.

27) Pharmacotherapy:
Pharmacotherapy refers to the treatment of disease through the administration of drugs. The study emphasizes the quest for alternatives to existing pharmacotherapies for conditions like Parkinson’s disease, illuminating the significance of Myrica esculenta as a potentially effective, natural therapeutic agent with acceptable efficacy and safety.

28) Pharmacology:
Pharmacology is the branch of medicine that focuses on drugs and their effects on human body systems. By exploring the pharmacological activities of Myrica esculenta, the study contributes to the understanding of how traditional remedies can be integrated with modern medicine to enrich treatment strategies for neurological diseases.

29) Agnimandya (Agni-mandya, Agnimamdya):
Agnimandhya is an Ayurvedic term referring to digestive impairment. Traditional uses of Myrica esculenta may include addressing digestive issues, highlighting the plant's broader therapeutic applications beyond neuroprotection. This link underscores the importance of integrating traditional knowledge into scientific research.

30) Performance:
Performance relates to the functioning of the experimental models in response to treatments. The evaluation of performance in neurobehavioral tests helps quantify the efficacy of Myrica esculenta extract, assisting researchers in determining its potential benefits and comparability to established therapies like levodopa.

31) Panduroga (Pandu-roga, Pamduroga):
Pandu-roga refers to a clinical condition in Ayurveda characterized by pale complexion and weakness, indicative of anemia. Highlighting the historical use of Myrica esculenta in treating such conditions connects traditional practices with contemporary therapeutic research, further supporting its relevance in modern pharmacotherapy.

32) Mukharoga (Mukha-roga):
Mukha-roga encompasses a set of diseases affecting the face or oral cavity in Ayurvedic medicine. The inclusion of such terms illustrates Myrica esculenta's diverse applications in traditional medicine, establishing it as a plant studied for varied health benefits beyond its potential neuroprotective properties.

33) Kantharoga (Kantha-roga):
Kantharoga refers to diseases related to the throat within Ayurvedic tradition, which may illustrate the historical therapeutic uses of Myrica esculenta. This connection emphasizes the broader medicinal scope of the plant and justifies the necessity for scientific studies exploring its diverse bioactive properties.

34) Meghalaya (Megha-alaya):
Meghalaya is a northeastern Indian state known for its biodiversity and traditional medicinal practices. The state’s rich flora may include Myrica esculenta, emphasizing the relevance of local plants in traditional medicine and their value for contemporary research seeking to identify natural therapeutic agents.

35) Gathering:
Gathering refers to the act of collecting or assembling information or resources. In the context of the study, this term could relate to collecting data on the effects of Myrica esculenta or gathering plant material for research purposes, exemplifying the systematic approach essential in scientific investigations.

36) Hrillasa (Hrllasa):
Hrillasa is an Ayurvedic term potentially related to respiratory and digestive health. Traditional uses of Myrica esculenta for such health issues underline its historical significance; understanding these connections can inform researchers in evaluating its broader therapeutic potential in modern medicine, particularly for respiratory conditions.

37) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing disease. This study positions Myrica esculenta within the realm of medicinal research, aiming to validate its use in traditional practices through scientific investigation and contribute to developing effective treatments for diseases like Parkinson’s.

38) Grahani:
Grahani is a traditional Ayurvedic term related to diarrhea and digestive disorders. The significance of this term in connection with Myrica esculenta suggests that the plant may have multiple therapeutic benefits, further warranting investigations into its holistic contributions to health and potential role in Ayurvedic medicine.

39) Village:
Village indicates a rural setting characterized by a small community. In the context of this study, it emphasizes the traditional knowledge and use of medicinal plants like Myrica esculenta among local communities, illustrating the importance of grassroots information in guiding scientific inquiries and validating traditional practices.

40) Anxiety:
Anxiety signifies a psychological condition marked by excessive worry. Understanding the impact of Myrica esculenta in treating anxiety could broaden its application beyond physical ailments and portray it as a comprehensive intervention in mental health, reflecting modern holistic approaches to medicine.

41) Science (Scientific):
Science is the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. In this context, the mention of science underscores the rigorous methodology employed in studying Myrica esculenta, fostering evidence-based conclusions that could enhance therapeutic approaches in healthcare.

42) Carati:
Saradhi may refer to a contributing author of the study, reflecting collaborative efforts in research. Such contributions help pool expertise and resources, ensuring that a comprehensive exploration of Myrica esculenta’s neuroprotective effects is conducted, leading to trustworthy and robust findings in the scientific literature.

43) Vaidya:
Vaidya refers to a practitioner of traditional Indian medicine, particularly Ayurveda. The mention of Vaidya exemplifies the historical framework within which Myrica esculenta has been utilized, encouraging collaboration between traditional healers and modern scientists to investigate the efficacy and safety of herbal medicines.

44) Mishra (Misra):
Mishra likely represents one of the authors or researchers involved in the study. Collaborative research efforts among individuals with diverse expertise augment the depth of scientific inquiry, facilitating the validation of the medicinal properties of Myrica esculenta through comprehensive analysis and peer-reviewed findings.

45) Prabhu:
Prabhu may also refer to an author or researcher contributing to the study. The active collaboration among various researchers enables a multifaceted approach to investigating the medicinal potential of plants, promoting comprehensive strategies that blend different scientific disciplines for enhanced outcomes in pharmacological research.

46) Dahiya:
Dahiya is likely another author in the research study. Author collaborations are critical in enhancing the reliability and validity of results, ensuring that a spectrum of expertise is applied to investigate the diverse pharmacological effects of Myrica esculenta, paving the way for new therapeutic discoveries.

47) Thomas:
Thomas may refer to one of the contributors to this study. The collaboration among diverse authors is instrumental in fostering interdisciplinary research that enriches studies of Myrica esculenta, ultimately advancing our understanding of how such natural products can be leveraged in modern therapies.

48) Punjab:
Punjab is a region in India known for its agricultural biodiversity. The cultivation and exploration of medicinal plants like Myrica esculenta in such areas highlight the potential for advancing the pharmaceutical industry through local resources, integrating traditional knowledge with modern agricultural practices to enhance public health.

49) Forest:
Forest refers to expansive areas characterized by dense vegetation and tree cover, often being biodiverse. The exploration of Myrica esculenta within forest ecosystems underscores the potential for utilizing naturally occurring plants in drug discovery and emphasizes the importance of habitat preservation for conserving medicinal resources.

50) Nature:
Nature relates to the physical world and its phenomena, including flora and fauna. This study emphasizes the role of natural products such as Myrica esculenta in medicine, advocating for a greater focus on environmentally sourced therapeutic agents and the conservation of biodiverse ecosystems for future health benefits.

51) Reason:
Reason signifies a cause or justification behind an action or phenomenon. In the context of this study, it could refer to the underlying rationale for researching Myrica esculenta, promoting its potential use in therapeutic applications and understanding its neuroprotective properties within the framework of modern science.

52) Aruci:
Aruchi refers to a loss of appetite, a condition addressed in Ayurveda. The potential of Myrica esculenta to alleviate symptoms associated with digestive disorders highlights the interconnectedness of traditional knowledge with contemporary health care, indicating that studies of such plants may unveil significant therapeutic benefits for wider health issues.

53) Mukha:
Mukha is a term associated with the face or mouth in Ayurvedic literature. By connecting Myrica esculenta to mukha roga, we see the plant's relevance not only as a neuroprotective agent but also within the context of holistic health practices aimed at treating various body ailments collectively.

54) Jvara:
Jvara means fever in traditional medicine systems. It indicates that Myrica esculenta may have roles in treating fevers, underscoring the diverse applications of the plant within Ayurvedic practices. This connection invites further research into its antipyretic properties alongside its neuroprotective effects against Parkinson's disease.

55) Gulma:
Gulma refers to a type of swelling or mass in the context of Ayurvedic medicine. This shows the historical usages of Myrica esculenta, emphasizing the need for scientific validation of these traditional claims, encouraging modern exploration of the plant's medicinal properties for various ailments.

56) Pandu (Pamdu, Pamde):
Pandu refers to a type of anemia or related symptoms in Ayurveda. This term indicates that Myrica esculenta may contribute to restoring vitality among users historically. The inclusion of such traditional usage reflects the need for scientific exploration of these claims in contemporary pharmaceutical research.

57) Shvasa (Svasa, Svasha):
Svasa means breath or respiration in Ayurvedic terminology, pointing toward respiratory conditions. This suggests the potential benefits of Myrica esculenta in treating respiratory ailments, emphasizing the uniqueness of the plant's applications in traditional medicine, encouraging investigations into the breadth of its therapeutic utility.

58) Dhanin (Dhani):
Dhani may refer to the author Dhani or connect to traditional uses within specific communities. This term signifies the importance of understanding local and traditional practices related to Myrica esculenta, informing scientific approaches to researching herbal medicines while integrating insights from community experiences and ethnobotanical knowledge.

59) Simha:
Sinha likely refers to another author contributing to the study. The diversity of authors suggests a collaborative approach, integrating various skills and knowledge areas necessary for a robust exploration of Myrica esculenta’s pharmacological properties and establishing more comprehensive insights into its medicinal uses.

60) Joshi (Josi):
Joshi represents a contributing author whose work forms part of the study on Myrica esculenta. Collaborative contributions from diverse authors enhance the research's credibility, ensuring thorough examination of the plant's therapeutic effects, ultimately enriching the scientific community's understanding of potential natural remedies.

61) Kumar:
Kumar likely refers to an author involved in the research study, illustrating the collaborative nature of scientific inquiry. The combined efforts of various researchers are essential in investigating Myrica esculenta, promoting interdisciplinary approaches and fostering innovative findings that advance medicinal plant research.

62) Chang:
Chang may be another author associated with the research effort. As in many scientific endeavors, the input and expertise of multiple contributors are vital for developing a comprehensive analysis of the effects of Myrica esculenta, leading to solid and reliable conclusions about its therapeutic potential.

63) Phani (Phanin):
Phani could refer to an author engaged in this study. The mention foreshadows collaborative research, emphasizing the necessity of bringing together various experts to examine the therapeutic aspects of Myrica esculenta, addressing both its advantages and potential limitations in pharmacotherapy.

64) House:
House likely ties to the research environment or institution involved in the study. The institutional backing provides important frameworks for conducting rigorous research, ensuring adherence to scientific standards, and fostering collaboration that can lead to significant advancements in the field of ethnobotanical studies.

65) Meha:
Meha refers to urinary disorders in Ayurvedic systems. The historical significance of Myrica esculenta in managing such conditions emphasizes its multifaceted applications within traditional medicine, prompting further examination of its potential health benefits in contemporary medical practice for various bodily functions.

66) Kasa (Kasha):
Kasa denotes cough or respiratory issues within Ayurvedic literature. Incorporating this term illustrates the plant's traditional uses for managing respiratory illnesses, suggesting potential avenues for research focused on the broader implications of Myrica esculenta in contemporary treatments for such ailments.

67) Beta:
Beta, as used in scientific contexts, may refer to a particular form of substances, such as beta-glucose or beta-carotene. In the context of this study, exploring beta compounds within Myrica esculenta could reveal additional pharmacological properties, enriching the exploration of its constituents for therapeutic applications.

68) Kala:
Kala refers to beauty or art in some contexts but may also relate to particular disciplines of study in traditional settings. The usage could signal the integration of cultural aspects into discussions about Myrica esculenta’s roles in maintaining health and its connection to traditional art and aesthetics.

69) Food:
Food signifies the substances consumed to sustain life, often tied to health. The traditional uses of Myrica esculenta may also intersect with dietary practices, where herbal consumption is linked to preventive healthcare and wellness, marking the intersection between nutrition and ethnomedicine.

70) Arshas (Arsa, Arsas, Arsha):
Arsa refers to dysentery or digestive disorders in Ayurveda. This term connects to the therapeutic investigations surrounding Myrica esculenta, reinforcing traditional knowledge of using specific plants to mitigate gastrointestinal issues, thus encouraging the need for scientific validation of such uses in modern contexts.

71) Wall:
Wall may represent a spatial barrier, but in scientific discussion, it can metaphorically denote barriers to knowledge or understanding regarding medicinal plants. It suggests the challenge of integrating traditional practices with modern scientific practices and the importance of overcoming such barriers in research.

72) Nagin (Nagi):
Nagi could refer to a species of plant, linking it to traditional medicine. This association emphasizes the use of indigenous plants in Ayurvedic practices, underlining the relevance of studying such plants to unlock therapeutic potentials derived from cultural approaches to healthcare.

73) Kota:
Koda may represent a term linked to traditional beliefs or practices regarding health, reinforcing the importance of understanding local names and characteristics of plants such as Myrica esculenta, connecting ethnobotanical knowledge with scientific exploration to unearth new therapeutic applications.

74) Peer review:
Peer review is a process where experts in a field evaluate research before publication. The mention of peer review underscores the rigorous standards of scientific research, emphasizing the need for validation and credibility in findings concerning Myrica esculenta, fostering trust in its proposed therapeutic applications.

75) Tribulus terrestris:
Tribulus terrestris is a plant noted for its medicinal properties, often studied alongside other natural products. Including it in the context of the study indicates comparisons may be drawn regarding its effects versus those of Myrica esculenta, enhancing understanding of alternative therapeutic strategies.

[Note: The above list is limited to 75. Total glossary definitions available: 100]

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