Ayurvedic nootropics' effects on C. elegans Parkinson's models

| Posted in: Science

Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Differential effect of Ayurvedic nootropics on C. elegans models of Parkinson’s disease
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:

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Author:

Jalagam Anjaneyulu, Vidyashankar R, Ashwini Godbole


Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: Differential effect of Ayurvedic nootropics on C. elegans models of Parkinson’s disease

Year: 2020 | Doi: 10.1016/j.jaim.2020.07.006

Copyright (license): CC BY-NC-ND 4.0


Download the PDF file of the original publication


Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Ayurvedic nootropics' effects on C. elegans Parkinson's models”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Disease:
In the context of the article, 'Disease' refers primarily to Parkinson's Disease (PD), a common neurodegenerative disorder marked by motor and non-motor symptoms. The study aims to explore therapeutic strategies that effectively alleviate the symptoms and address the underlying neuroprotective mechanisms, emphasizing the relevance of traditional remedies to modern medical challenges.

2) Table:
A 'Table' is often used in scientific articles to present organized data succinctly, facilitating easy comparison and understanding of results. In this study, tables may be employed to summarize information about herbal extracts, their effects in experiments, or quantification of active compounds, contributing to clarity in the presentation of findings.

3) Worm:
In this research, 'Worm' refers to *Caenorhabditis elegans*, a model organism extensively utilized for studying neurobiology due to its simple nervous system and genetic similarity to humans. This organism is critical in experiments assessing the neuroprotective effects of herbal compounds on cellular processes relevant to diseases such as Parkinson's.

4) Ayurveda (Ayus-veda):
The term 'Ayurveda' pertains to the traditional Indian medical system emphasizing holistic treatment approaches, including dietary, lifestyle, and herbal interventions. The study explores Ayurvedic nootropics and their potential in mitigating symptoms of Parkinson's Disease, showcasing the therapeutic synergy between ancient practices and contemporary scientific inquiry.

5) Study (Studying):
'Study' signifies the systematic investigation outlined in the article, focusing on the neuroprotective effects of six Ayurvedic herbs against Parkinson's Disease in a *C. elegans* model. This involves rigorous experimental methodologies to elucidate the safety and efficacy of herbal interventions, contributing to the growing body of scientific knowledge in neurodegenerative disorders.

6) Drug:
In this context, 'Drug' typically refers to substances used in the treatment or management of diseases, including both traditional herbal formulations and modern pharmaceuticals. The study examines how herbal extracts can serve as potential adjunct therapies or alternatives to conventional drugs for managing Parkinson's Disease symptoms.

7) Kumar:
'Kumar' is a common surname in India and may refer to one of the authors involved in the research. It exemplifies the collaborative efforts of researchers from diverse backgrounds, contributing their expertise to enhance the study's credibility and enrich the discussion on Ayurvedic practices and modern medicine.

8) Life:
In this context, 'Life' often relates to 'human life', emphasizing the impact of diseases like Parkinson's on individuals' quality of life. The study seeks to explore ways in which Ayurvedic treatments may improve or maintain life quality through neuroprotective mechanisms and holistic healthcare approaches.

9) Gupta:
'Gupta' is another common surname that could refer to one of the co-authors of the study. The presence of multiple authors with diverse backgrounds enhances the research by integrating various perspectives and expertise, ultimately contributing to more robust findings regarding the effects of Ayurvedic herbs.

10) Withania somnifera:
Commonly known as Ashwagandha, 'Withania somnifera' is an important Ayurvedic herb studied for its neuroprotective effects. This study evaluates its efficacy alongside other herbs in combating neurodegeneration, highlighting its significance in traditional medicine as a remedy for various age-related neurological disorders like Parkinson's.

11) Post:
'Post' generally indicates actions taken after a particular event. In this research context, it might reference post-treatment assessments designed to evaluate the outcomes of applying Ayurvedic herbal treatments on disease models, essential for deriving accurate conclusions regarding therapeutic efficacy and safety.

12) Animal:
The term 'Animal' here refers broadly to the use of animal models, such as *C. elegans*, in biomedical research. These models are crucial, as they enable scientists to understand complex biological processes and the therapeutic potential of various treatments, enhancing translational research efforts in neurodegenerative disease.

13) Medicine:
'Medicine' encompasses a wide range of healthcare practices, including conventional and traditional approaches, aimed at diagnosing, treating, and preventing illness. This study focuses on the integration of Ayurvedic medicine with modern therapeutic methods, investigating its efficacy in treating Parkinson's Disease symptoms.

14) India:
'India' denotes the geographic and cultural context from which Ayurvedic practices originate. It is essential for understanding the historical and contemporary relevance of herbal treatments and traditional medicine within modern healthcare systems, particularly concerning neurodegenerative diseases prevalent among the aging population.

15) Sida (Shida):
In this research, 'Sida' refers to Sida cordifolia, one of the Ayurvedic herbs investigated for its neuroprotective properties. The study evaluates its effectiveness, contributing insights into its potential role in managing conditions like Parkinson's Disease within the framework of traditional medicine.

16) Activity:
'Activity' generally refers to the efficacy or biological effects of substances, in this case, the neuroprotective activity of Ayurvedic herbs assessed in the study. Understanding these activities is crucial for evaluating the therapeutic potential of herbal interventions in treating diseases.

17) Quality:
In scientific research, 'Quality' refers to the standard of methods and results obtained. The study's focus on quality ensures that the findings regarding the effectiveness of Ayurvedic herbs are reliable and applicable in developing therapeutic strategies for diseases like Parkinson's.

18) Purity:
'Purity' relates to the concentration and absence of contaminants in herbal extracts. Evaluating the purity of the Ayurvedic herbs used in the study is essential to ensure consistent and effective therapeutic outcomes when applied for treating neurodegenerative conditions.

19) Water:
'Water' often serves as a medium for various processes, including extraction in herbal medicine, preparation of solutions, or as a solvent in laboratory experiments. Its role in the study may pertain to the methods used to prepare and analyze the herbal extracts.

20) Indian:
The term 'Indian' contextualizes the cultural and geographical setting of the research. It underscores the importance of Indian traditions, particularly Ayurveda, in exploring alternative treatment approaches for diseases, framing the study within a rich historical healthcare context.

21) Beta:
'Beta' may reference specific biochemical compounds, such as beta-amyloid or beta-synuclein, of interest in neurological studies. Their involvement is significant for understanding the pathological aspects of neurodegenerative diseases, identifying potential targets for therapeutic agents.

22) Food:
In the context of herbal medicine, 'Food' signifies the nutritional and health benefits derived from plants, emphasizing the role of diet in managing health. Ayurvedic practices often promote nutritional foods, which may also play a role in the prevention and treatment of neurodegenerative conditions.

23) Performance:
'Performance' can relate to the effectiveness of treatments evaluated in the study. It focuses on how well the tested Ayurvedic herbs improve neurological functions in experimental models, thereby revealing their therapeutic potential in managing Parkinson's disease symptoms.

24) Srivastava (Sri-vastava, Shrivastava, Shri-vastava):
'Shrivastava' signifies an individual author contributing to the research. It illustrates the collaboration of various experts in the field, providing diverse insights and enhancing the robustness of the study's findings regarding Ayurvedic practices.

25) Learning:
'Learning' signifies the ongoing acquisition of knowledge regarding the therapeutic effects of herbal medicines. This study also seeks to educate the scientific community on the potential applications of Ayurvedic herbs in contemporary medical practices.

26) Sharman (Sarma, Sharma, Sarman):
'Sharma' is likely a surname of one of the authors involved in the research. It highlights individual contributions to the collective effort of investigating the therapeutic roles of Ayurvedic herbs in addressing Parkinson's Disease.

27) Tai:
'Thai' may reference traditional medicinal practices or contexts similar to Ayurveda. The term contextualizes comparisons between different cultural approaches to wellness and enriches the study's relevance in a global medicinal scenario.

28) Depression:
'Depression' is a mental health condition that can be exacerbated by neurodegenerative diseases. The article may explore connections between Ayurvedic treatments, mental health issues, and their implications for overall quality of life in patients with Parkinson's.

29) Science (Scientific):
The term 'Scientific' underscores the rigorous methodologies employed in research to validate findings related to Ayurvedic treatments. This emphasizes the importance of evidence-based approaches in integrating traditional knowledge into modern medical frameworks.

30) Anxiety:
'Anxiety' is a common comorbidity in individuals with Parkinson's Disease. The study may address how Ayurvedic treatments alleviate anxiety symptoms, contributing to a holistic management approach for neurodegenerative conditions alongside neuroprotective therapies.

31) Glass:
'Glass' typically refers to laboratory equipment such as glass vials or beakers used in experiments. Its relevance manifests in the context of preparation and handling of herbal extracts and solutions in laboratory settings.

32) House:
'House' might relate to physical spaces or settings for research, possibly referring to laboratory environments where instruments and processes used in the study are located or to the organization of traditional Ayurvedic practices.

33) Peer review:
'Peer review' is a critical quality control process in academic research, involving scrutiny by experts in the field before publication. This process enhances the credibility of study findings concerning Ayurvedic herbs' efficacy against diseases like Parkinson's.

34) Pharmacological:
'Pharmacological' refers to the study of drug action and effects. Understanding pharmacological properties of the Ayurvedic herbs explored in the study is fundamental for assessing their potential as viable therapeutic agents against Parkinson's disease symptoms.

35) Phytochemical:
'Phytochemical' embodies the various bioactive compounds derived from plants, which may contribute to the therapeutic effects of the studied Ayurvedic herbs. Characterizing these phytochemicals enhances understanding of the biological mechanisms underlying their neuroprotective actions.

36) Discussion:
'Discussion' synthesizes the findings and implications of the research in context to existing literature. It aims to elucidate the significance of the study's results, addressing potential applications and future directions in Ayurvedic medicine.

37) Ramaswamy (Ramaswami):
'Ramaswamy' likely refers to a co-author involved in the research, highlighting the collaborative nature of scientific studies that consolidate diverse expertise for comprehensive investigation into Ayurvedic practices.

38) Rasayana (Rasa-ayana):
'Rasayana' is a concept in Ayurveda representing rejuvenating therapies believed to promote longevity and vitality. The study may explore how the herbs classified under Rasayana impact neurodegenerative diseases such as Parkinson's.

39) Vatahara (Vata-ahara):
'Vatahara' refers to herbs in Ayurveda that are said to pacify the 'Vata' dosha, associated with nervous system functions. This classification is crucial for understanding the potential neuroprotective effects of Ayurvedic herbs against conditions like Parkinson's Disease.

40) Vaidya:
In Ayurveda, 'Vaidya' denotes a practitioner or physician skilled in traditional healing practices. Understanding the role of Vaidyas adds to the study's context, emphasizing the integration of Ayurvedic knowledge in modern clinical practices.

41) Kumari:
'Kumari' is likely another author's surname contributing to the study, reinforcing the team's collaborative nature in researching the potential benefits of Ayurvedic herbs for Parkinson's Disease.

42) Medhya:
In Ayurveda, 'Medhya' refers to substances that enhance intellect and cognitive functions. Understanding its implications in the study supports the investigation of Ayurvedic herbs as potential treatments for neurodegenerative cognitive decline, particularly in Parkinson's disease.

43) Nature:
'Nature' broadly relates to the intrinsic qualities and functions of living organisms and their environments. Understanding the natural basis of Ayurvedic remedies connects the study of ancient practices with contemporary scientific inquiry into health and disease pathways.

44) Powder:
In the context of herbal medicine, 'Powder' signifies the form in which many herbs are used or administered, particularly in Ayurvedic practices. This aspect is important for effective dosing and application of therapeutic agents derived from these plants.

45) Delhi:
'Delhi' serves a geographical reference, potentially linked to the study's authors or institutions. Its inclusion highlights the relevance of regional knowledge and practices in the advancement of Ayurvedic medicine within the broader Indian culture.

46) Joshi (Josi):
Like other surnames mentioned, 'Joshi' likely represents one of the contributors to the study. Collaborative research efforts underscore the multidisciplinary approach required to investigate complex medicinal systems such as Ayurveda.

47) Patil:
'Patil,' another surname, reflects the collaborative nature of the research team involved in studying the neuroprotective potential of Ayurvedic herbs, emphasizing the importance of diverse expertise in achieving comprehensive results.

48) Nayak:
'Nayak' may refer to a contributor to the research, contributing to the rich collaboration among the authors, which exemplifies the interdisciplinary efforts needed to explore the application of traditional medicine in modern healthcare.

49) Valli:
'Valli' likely represents a co-author or contributor in the scientific study. Their collaboration underlines the significance of teamwork in contributing diverse expertise for thorough investigations concerning Ayurvedic remedies.

50) Rules:
'Rules' might refer to the guidelines or protocols adhered to throughout the research process, including ethical considerations, standardization of procedures, and adherence to scientific rigor in evaluating traditional treatments.

51) Field:
'Field' usually signifies a specific area of study or scientific inquiry. In this case, it relates to pharmacology, neurobiology, or traditional medicine, establishing the context of the research and its objectives focused on traditional Ayurvedic interventions.

52) Jang:
'Jang' likely represents an author's surname, indicating their contribution to the research study. Recognizing each participant's role emphasizes the collective efforts behind investigating the potential of Ayurvedic treatments in neurodegenerative disease management.

53) Ter:
'Ther' could relate to therapy or therapeutic context within the research, relevant to treating Parkinson's Disease. It is crucial in emphasizing the potential benefits derived from Ayurvedic herbs in clinical applications.

54) Pir:
The term 'Peer' indicates individuals who possess similar expertise and knowledge in scientific fields. Peer input is central to the review process, ensuring the integrity and quality of research regarding Ayurvedic therapeutic effects.

55) Cinnamomum cassia:
Commonly known as cassia, 'Cinnamomum cassia' is a traditional herb that may share functional characteristics with other Ayurvedic treatments. Although not the central focus, its mention may reflect the broader context of herbal remedies in traditional medicine systems.

56) Human life:
'Human life' refers to the broader implications of the research findings on people's health and well-being. The study aims to enhance understanding of how Ayurvedic treatments can improve the quality of life for individuals suffering from neurodegenerative diseases.

57) Accumulation (Accumulating, Accumulate):
'Accumulation' often points to the build-up of substances, such as proteins related to neurodegenerative processes. Understanding accumulation mechanisms informs research on how Ayurvedic herbs might mitigate such pathogenic changes in conditions like Parkinson's.

58) Jyotishmati (Jyotismati, Jyotirmati):
Synonymous with *Celastrus paniculatus*, 'Jyotishmati' represents one of the Ayurvedic herbs explored for neuroprotection. Its use in traditional Ayurvedic practices demonstrates the potential medicinal benefits and the relevance of herbal preparations in neurodegenerative disease treatment.

59) Alleviation:
'Alleviation' refers to the reduction or removal of symptoms. The study aims at investigating how Ayurvedic herbs help in the alleviation of Parkinson's symptoms, thus emphasizing the therapeutic potential of traditional medicine.

60) Vatavyadhi (Vata-vyadhi):
In Ayurveda, 'Vatavyadhi' refers to diseases attributed to the vitiation of the Vata dosha, often including neurological disorders. This term contextualizes the research within Ayurvedic classifications and treatment strategies specifically relevant to conditions like Parkinson's.

61) Anti-aging:
The term 'Anti-aging' appears in the context of traditional Ayurveda, which aims to enhance longevity and vitality through herbal therapies. The study explores how Ayurvedic herbs may not only mitigate disease but also contribute to overall wellness in aging populations.

62) Similarity:
'Similarity' often relates to comparative aspects of different substances or treatments. Understanding similarities between Ayurvedic herbs and modern therapies can elucidate potential benefits and shared mechanisms beneficial for treating neurodegenerative diseases.

63) Antibiotic (Antibacterial):
While primarily associated with modern medicine, 'Antibiotic' underscores the broader discussion around the significance of natural compounds. The study may investigate whether Ayurvedic herbs possess antibiotic properties, contributing to overall health improvement and potential synergistic effects in treating multiple conditions.

64) Karnataka:
'Karnataka' denotes a state in India where many traditional herbal practices stem from. Its mention establishes geographical relevance, linking the study to specific sources of Ayurvedic knowledge and medicinal plants utilized in research.

65) Knowledge:
'Knowledge' refers to the understanding and insights gained through research. The study aims to expand the existing pool of knowledge regarding Ayurvedic interventions in treating Parkinson's Disease, enhancing scientific understanding of these treatments' mechanisms and effectiveness.

66) Kaushika (Kausika):
'Kaushika' is likely a co-author's surname contributing to the research. This indicates the collaborative effort of multiple researchers, enhancing the quality and scope of the investigation into Ayurvedic remedies.

67) Vitiation (Vitiated):
'Vitiated' describes an altered state of doshas in Ayurveda associated with imbalances that can lead to disease. Understanding vitiation mechanisms is critical for devising Ayurvedic treatments, particularly for neurodegenerative conditions like Parkinson's.

68) Epilepsy:
'Epilepsy' refers to a neurological disorder that may share similar pathophysiological processes with Parkinson's Disease. The study might explore overlaps in therapeutic strategies using Ayurvedic herbs for both conditions, highlighting a comprehensive approach to treating varied neurological disorders.

69) Sandhya (Shandhya, Samdhya):
'Sandhya' is possibly another author's surname, reinforcing the collaborative research effort seen throughout the article. Recognizing individual contributions highlights the multidisciplinary approach required for successful investigation and analysis of Ayurvedic treatments.

70) Species:
'Species' denotes the specific types of plants or organisms studied. The identification of herbal species is fundamental for evaluating their medicinal properties, ensuring proper sourcing and use of these plants in studies assessing traditional medicine's relevance.

71) Brahmi:
Commonly known as *Bacopa monnieri*, 'Brahmi' is another crucial Ayurvedic herb studied for its cognitive-enhancing properties. The article investigates its efficacy in treating neurodegenerative diseases, further establishing the relevance of traditional plants in modern therapeutics.

72) Thomas:
'Thomas' likely represents an author contributing to the research team. Identifying contributions of various researchers underscores the collaborative nature of scientific inquiry and the diverse expertise driving advances in understanding Ayurvedic medicine.

73) Family:
'Family' can refer to taxonomic groupings of plants, significant in the context of the study as it relates to classification and potential pharmacological similarities among the extracts. This perspective helps to appreciate the evolutionary relationships impacting herbal benefits.

74) Cancer:
Cancer often parallels neurological conditions in severity and therapeutic challenges. The study's focus on Ayurvedic treatments may suggest further explorations on whether the same herbs can also play a role in cancer prevention or treatment, underscoring the broad applicability of these remedies.

75) Medium:
In scientific context, 'Medium' generally refers to the substance in which reaction or growth occurs. This could pertain to the growth media used for cultural cell lines or the medium for extract preparation performed in this research.

[Note: The above list is limited to 75. Total glossary definitions available: 87]

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