Neuropharmacological evaluation of Shankhpushpi herbs in India.

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Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Neuropharmacological evaluation on four traditional herbs used as nervine tonic and commonly available as Shankhpushpi in India
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:

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Author:

Neeraj K. Sethiya, Alok Nahata, Pawan Kumar Singh, S.H. Mishra


Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: Neuropharmacological evaluation on four traditional herbs used as nervine tonic and commonly available as Shankhpushpi in India

Year: 2019 | Doi: 10.1016/j.jaim.2017.08.012

Copyright (license): CC BY-NC-ND 4.0


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Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Neuropharmacological evaluation of Shankhpushpi herbs in India.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
In research, a 'Table' presents complex data in a structured format, making it easier for readers to understand results. It summarizes key findings, comparisons, and statistics, often including measurements and test outcomes relevant to the experiments. Tables enhance clarity by organizing information systematically, aiding in the quick comprehension of experimental outcomes and conclusions.

2) Activity:
In scientific research, 'Activity' typically refers to the biological effects exhibited by substances, such as plants or drugs, on cellular or physiological targets. Measuring activity helps determine efficacy, such as neuropharmacological effects or enzyme inhibition, guiding further exploration of therapeutic potential for treating diseases. Activity is critical in pharmacological evaluation.

3) Mishra (Misra):
Mishra is a surname commonly found in India, often associated with individuals engaged in scholarly or scientific research, notably in the fields of pharmacology and herbal medicine. Researchers with this surname may contribute to studies exploring traditional medicine, including Ayurvedic practices, and the benefits of local flora for health and wellness.

4) Water:
Water is a vital component in biological and chemical processes. In experimental research, it acts as a solvent, facilitating the extraction of phytochemicals from plants, and is also used for hydration in animal studies. Additionally, 'Water' in studies involving animals often relates to testing cognitive performance in tasks like the Morris water maze.

5) India:
India, rich in biodiversity, is renowned for its traditional Ayurvedic medicine. The country's rich heritage of medicinal plants and remedies promotes studies aimed at discovering biological activities and health benefits of indigenous species. Research focusing on Indian herbs contributes significantly to global understanding of natural products and their pharmacological properties.

6) Pole:
The term 'Pole' in experimental contexts often refers to apparatus used in behavioral studies to assess animal cognition. For instance, in the Cook and Weidley’s pole climbing apparatus, it helps measure learning and memory retention in animal models. The pole serves as a test environment fostering behavioral investigation in neurological research.

7) Drug:
A 'Drug' refers to any substance that produces a physiological effect when introduced into a biological system. In pharmacology, drugs are pivotal for therapeutic interventions, including those derived from plants in traditional medicine. Research studies assessing the effectiveness of herbal drugs contribute to the understanding of medicinal properties and clinical applications.

8) Indian:
The term 'Indian' often relates to the cultural, historical, and geographical context of India, especially regarding its diverse flora used in traditional medicine. In research, studies focused on Indian medicinal plants explore their efficacy, safety, and potential applications in modern therapeutics, bridging traditional practices and contemporary science.

9) Animal:
In scientific research, 'Animal' typically refers to laboratory specimens used in experiments to evaluate the effects of drugs, treatments, or interventions. Animal studies provide invaluable insights into physiological responses, behavior changes, and effectiveness in preclinical trials. They are essential for understanding complex biological systems before human trials.

10) Study (Studying):
A 'Study' is a systematic investigation aimed at answering specific research questions or testing hypotheses. In the scientific context, it often involves experiments, observations, or analyses that yield results useful for expanding knowledge in areas such as pharmacology, botany, and medicine. Studies underpin advancements in scientific understanding and health interventions.

11) Performance:
In research, 'Performance' refers to the outcomes or capabilities exhibited by subjects during tests or experiments. It can pertain to cognitive tasks, physical abilities, or behavioral responses assessed through various methodologies. Performance metrics help evaluate the effects of treatments on improving or impairing functions, particularly in neuroscience and pharmacology.

12) Learning:
In the context of psychology and neuroscience, 'Learning' describes a process whereby subjects acquire new information or skills through experience. Research often explores learning mechanisms, particularly in animal models, to assess cognitive enhancement or memory retention effects of specific compounds, thereby contributing to understanding memory-related disorders and therapeutics.

13) Phytochemical:
'Phytochemical' refers to biologically active compounds found in plants that can have medicinal properties. In research, phytochemicals are investigated for their potential health benefits, including antioxidant, anti-inflammatory, and neuroprotective effects. Understanding the role of phytochemicals informs the use of herbal medicine and the development of new therapeutic agents.

14) Training:
Training typically refers to the process of teaching or conditioning subjects to perform specific tasks or behaviors. In experimental contexts, training protocols are crucial for enabling subjects, especially animals, to learn and demonstrate memory or cognitive functions necessary for assessing the effects of various treatments in research methodologies.

15) Disease:
'Disease' signifies a pathological condition affecting the normal functions of an organism. Research into diseases often seeks to identify causative factors, explore therapeutic interventions, and evaluate treatment efficacies. Studies focusing on specific diseases, especially neurodegenerative disorders, are vital to develop effective pharmacological and non-pharmacological approaches to treatment.

16) Patil:
Patil is a common surname in India, typically found among individuals involved in academia and research. Notable researchers with this surname may focus on pharmacological studies, traditional medicine, and related fields, contributing to the understanding and development of therapeutic applications derived from indigenous plants and traditional Ayurvedic practices.

17) Line:
'Line' in biological research often refers to cell lines, which are cultures derived from a specific type of cells maintained under controlled conditions. Cell lines are essential for investigating cellular responses, including drug effects and toxicity studies. Research involving cell lines allows for detailed exploration of mechanistic pathways in pharmacology.

18) Rasayana (Rasa-ayana):
'Rasayana' pertains to a category in Ayurveda emphasizing rejuvenation and longevity. Rasayana therapy aims to enhance physical and mental vitality, improve memory, and promote overall health. Research in this area explores the efficacy of various herbs deemed 'Rasayana,' investigating their biochemical properties and potential for therapeutic use in modern medicine.

19) Toxicity:
'Toxicity' refers to the degree to which a substance can cause harm to organisms. In pharmacological studies, assessing toxicity is crucial to determine the safety profile of drugs or extracts. Evaluating both acute and chronic toxicity enables researchers to understand potential adverse effects and establish safe dosing guidelines for therapeutic agents.

20) Post:
'Post' in research contexts often refers to the aftermath of an experiment or treatment phase. It can represent data collection or observations made after an intervention, allowing researchers to assess effects, changes, or outcomes resultant from experimental conditions. Post-experimental analysis is key to drawing conclusions from scientific investigations.

21) Medicine:
'Medicine' entails the science and practice of diagnosing, treating, and preventing disease. Research in medicine spans various fields, including pharmacology, where studies explore herbal remedies and pharmaceutical formulations. Understanding medicinal properties aids in developing effective treatments and promoting holistic health approaches, often derived from traditional practices like Ayurveda.

22) Kumar:
Kumar is a common surname in India, frequently associated with academic and scientific professionals. Individuals with this surname often engage in extensive research in areas such as pharmacology, botany, and traditional medicine, contributing to the scientific investigation of medicinal plants and their therapeutic efficacy in treating various health conditions.

23) Rules:
In the context of scientific research, 'Rules' pertains to established guidelines and protocols that govern experimental procedures, ensuring integrity, reproducibility, and ethical considerations. Adhering to these rules is essential for valid results and acceptance in peer-reviewed journals. Rules shape the framework within which scientific inquiry operates, facilitating trust in research findings.

24) Food:
'Food' refers to any substance consumed to provide nutritional support to organisms. In research, food sources can influence health outcomes and be studied for their impact on diseases. The role of food in health, particularly functional foods containing bioactive compounds, bridges nutrition and medicine, informing dietary recommendations.

25) Ayurveda (Ayus-veda):
'Ayurveda' is an ancient Indian system of medicine focusing on holistic health through balancing bodily energies. It employs various herbs and therapies to promote wellness and prevent diseases. Research into Ayurveda investigates its pharmacological efficacy, validating its practices and integrating traditional knowledge into modern healthcare paradigms.

26) Medhya:
'Medhya' in Ayurveda refers to herbs or substances that enhance intellect and cognitive function. Research aims to identify plants classified as 'Medhya,' explore their potential neuropharmacological effects, and validate traditional claims. Understanding the properties of 'Medhya' substances is crucial for developing cognitive enhancers and addressing neurodegenerative disorders.

27) Medium:
In biological experiments, 'Medium' often refers to the liquid or environment in which cells or tissues are cultured. It provides essential nutrients and conditions for growth, impacting the outcomes of studies involving drug effects or cellular behavior. The medium must be optimized for specific experimental goals ensuring accurate results.

28) Death:
'Death' signifies the cessation of biological functions crucial for sustaining life. In pharmacological studies, understanding the mechanisms leading to cell death, particularly in neurodegeneration or toxicity, is vital. Research explores ways to prevent or mitigate cell death through therapeutic interventions, influencing treatment strategies for various diseases.

29) Pharmacognostical:
'Pharmacognostical' relates to the study of medicinal drugs derived from natural sources, particularly plants. Research in this area explores the identification, characterization, and evaluation of plant-based compounds for their therapeutic potential. Understanding pharmacognostical properties fosters the development of new medicines and validates traditional healing practices in modern contexts.

30) Controversy:
'Controversy' indicates disagreement or dispute often arising from differing opinions or interpretations within scientific communities. In herbal medicine, controversies may exist over the efficacy, safety, and identification of species used in traditional practices. Addressing controversies is crucial for establishing trust in research findings and promoting evidence-based practices.

31) Flavonoid:
'Flavonoid' refers to a diverse group of phytochemicals known for their antioxidant properties. Present in fruits and vegetables, flavonoids exhibit numerous health benefits, including anti-inflammatory and neuroprotective effects. Research into flavonoids focuses on their role in preventing diseases and enhancing health, reinforcing the significance of dietary sources in wellness.

32) Gujarat:
Gujarat is a state in western India known for its rich biodiversity and traditional herbal practices. Research in Gujarat often explores local flora for pharmacological properties, contributing to studies on herbs like 'Shankhpushpi' for their medicinal efficacy. The state's wealth of flora enhances the understanding of traditional remedies in modern pharmacology.

33) Botany:
'Botany' is the scientific study of plants, focusing on their structure, properties, and biochemical processes. Research in botany is foundational for understanding plant-based medicines, essential for developing and utilizing herbal therapies. It encompasses the identification and classification of plants, contributing knowledge crucial for pharmacognostical studies.

34) Malik:
Malik is a surname predominantly found in South Asian cultures, associated with individuals in research and academia. Researchers with this name may contribute to fields such as pharmacology and herbal medicine, providing valuable insights into traditional medicinal practices, exploring bioactive properties of indigenous plants, and advancing knowledge in health sciences.

35) Patel:
Patel is another common surname in India, particularly within the Gujarati community. Individuals with this name often engage in various scientific fields, including pharmacology and traditional medicine, contributing to studies exploring the health benefits of herbal remedies. Their research efforts focus on the intersection of culture, tradition, and science.

36) Raja:
'Raja' is a title in India, often denoting royalty or leadership. In research contexts, it may be associated with academics or experts contributing to fields such as pharmacology or medicine. Contributions from individuals with this title may focus on indigenous knowledge systems and their relevance in addressing contemporary health issues.

37) Beta:
'Beta' often refers to the beta form of various compounds or biological markers in research. In pharmacology, it can denote Beta-amyloid peptides, involved in Alzheimer's disease research. Understanding the roles and implications of beta forms is crucial for exploring pathways of neurodegenerative disorders and therapeutic interventions.

38) Seth:
Seth is a common surname in India, primarily associated with scholars and professionals in various fields, including pharmacognosy and medicine. Notable researchers with this name may focus on traditional healing practices, exploring pharmacological properties, and contributing significantly to studies assessing herbal remedies for cognitive enhancement and overall health.

39) Fear:
'Fear' in psychological research often denotes a natural emotional response to perceived threats or danger. It can be studied in the context of behavioral experiments, especially in evaluating animal responses to stress or aversive stimuli. Understanding fear mechanisms is important for exploring cognitive processes and potential anxiolytic treatments.

40) Cage:
In experimental contexts, a 'Cage' typically refers to enclosure housing laboratory animals. Cages are designed to provide a controlled environment for housing subjects during behavioral studies. They are critical for assessing responses to stimuli, learning tasks, and evaluating pharmacological interventions in neuroscience and behavioral research.

41) Gold (Golden):
'Gold' usually signifies high value and significance in various fields, including medicine and pharmacology. In research, it may refer to 'Gold standard' protocols or treatments that are widely accepted and recognized for their efficacy. Moreover, it may indicate valuable insights derived from studies contributing to knowledge advancement.

42) Peer review:
'Peer review' is a critical process in scientific publishing where experts evaluate research for quality and credibility. This practice ensures that findings meet rigorous academic standards, fostering trust and integrity in scientific literature. Peer review is essential for advancing knowledge and validating research methodologies and conclusions.

43) New Delhi:
New Delhi, the capital of India, is a hub for scientific and academic research. Many institutions and organizations are based here, contributing to advancements in various fields including pharmacology and traditional medicine. Research conducted in New Delhi often influences public health policies and integrates traditional practices with modern science.

44) Pharmacological:
'Pharmacological' pertains to the study of drugs and their interactions within biological systems. Research in this field investigates the effects of substances on physiological functions, contributing to the development of therapeutic agents. Understanding pharmacological mechanisms is pivotal for translating traditional medicine into clinically effective treatments for various diseases.

45) Antibiotic (Antibacterial):
'Anti-bacterial' denotes properties of agents that inhibit or kill bacterial growth. Research focuses on identifying and testing natural compounds, including those derived from plants, with anti-bacterial activities, to develop effective treatments. Anti-bacterial studies are crucial in addressing infection-related diseases and resistance issues faced in contemporary healthcare.

46) Discussion:
In research, 'Discussion' is a critical section where authors interpret their findings, relating them to existing literature. It allows for exploration of implications, strengths, limitations, and future research directions, providing context and depth to the study. The discussion fosters dialogue in the scientific community, enhancing understanding and knowledge sharing.

47) Depression:
'Depression' refers to a mental health disorder characterized by persistent sadness and loss of interest. In pharmacological contexts, research focuses on understanding its neurobiological mechanisms and evaluating therapeutic interventions, including natural remedies from plants. Exploring depression's impact informs the development of effective treatment strategies for mental health disorders.

48) Lighting:
'Lighting' can refer to environmental conditions affecting behavior in animal studies. Proper lighting conditions are critical to ensure animal welfare and influence the outcomes of behavioral experiments targeting cognitive function. Lighting impacts emotional states, which may indirectly affect learning and memory assessments during scientific research.

49) Relative:
'Relative' often pertains to comparative assessments made during evaluations. In research contexts, relative measures are vital for interpreting results concerning changes or differences observed in experimental conditions. Understanding relative outcomes helps researchers contextualize data, fostering more substantial insights into the biological significance or therapeutic potential of interventions.

50) Lucknow:
Lucknow, a city in India, is notable for being an academic and cultural center. It houses research institutions that contribute to studies on traditional medicine, pharmacognosy, and botanical research. Research conducted in Lucknow often investigates the pharmacological properties of local plants, integrating ancient wisdom with modern scientific approaches.

51) Science (Scientific):
'Science' is the systematic study of the natural world through observation and experimentation. It encompasses various fields, including biological sciences, where research explores life processes and interactions. Scientific inquiry drives advancements in technology and medicine, shaping understanding of health, environment, and broadly influencing human knowledge.

52) Surface:
'Surface' may relate to the physical boundaries of biological samples or cells in research contexts. Analyzing the surface properties can inform researchers about the interactions with drugs, solvents, or environments. Surface characteristics are crucial for understanding mechanisms of action in pharmacological studies and developing effective delivery systems for therapies.

53) Smriti (Smrti):
'Smriti' can refer to the traditional memory or remembrance in the context of Indian philosophy. In research, 'Smriti' may symbolize the importance of retaining knowledge from ancient practices, particularly Ayurvedic medicine. Integrating traditional wisdom with modern scientific inquiry can impact contemporary health practices and therapeutic approaches.

54) Baroda:
Baroda, also known as Vadodara, is a city in Gujarat, India, recognized for its educational institutions and research facilities. Studies conducted in Baroda often focus on traditional medicinal plants and pharmacological research, contributing to the understanding and promotion of herbal remedies in modern medicine and health care.

55) Gupta:
Gupta is a widespread surname in India, often associated with individuals in various fields, including research and academia. Those with this surname may contribute significantly to studies exploring medicinal plants and traditional practices, merging indigenous knowledge with scientific inquiry to validate and understand therapeutic uses in health sciences.

56) Delhi:
Delhi, as India’s capital, serves as a central location for education and research. It hosts numerous institutions dedicated to medical and scientific research, fostering studies on traditional medicine, modern therapies, and public health. Research outcomes from Delhi significantly influence health policy and academic discourse across various domains.

57) Ulcer:
'Ulcer' denotes a sore or lesion typically formed on internal or external body surfaces due to various factors, including infection or stress. Research into ulcer treatments explores pharmacological interventions, including herbal remedies, aiming to understand mechanisms and efficacy, contributing to improved therapeutic practices and patient care.

58) Eagle:
Eagle, as a term, might relate to the bird species but in research contexts, it may refer to 'Eagle’s Minimum Essential Medium,' crucial for cell culture applications in laboratory settings. The medium assists in providing necessary nutrients for sustaining cell lines, vital for various biological research pursuits, including drug development.

59) Pune:
Pune is a city in India recognized for its educational institutions and research initiatives. It houses laboratories and universities focusing on pharmacological and botanical research, exploring traditional medicine and its applications in modern healthcare. Research from Pune often advances understanding of local flora's medicinal potential and broader therapeutic frameworks.

60) Ghat (Gham):
Ghat refers to a series of steps leading to a water body in India, often significant in cultural practices. In research, especially related to ethnobotany, 'ghats' may symbolize areas where specific medicinal plants are found, providing context for studies exploring their uses and pharmacological properties in traditional medicine.

61) Lamp:
'Lamp' usually refers to a light source. In research environments, proper lighting, including from lamps, influences working conditions and animal behaviors. The use of lamps ensures that studies are conducted in well-lit environments, essential for tasks that involve observation, learning, and cognitive assessments in experimental settings.

62) Wall:
In experimental research, 'Wall' refers to barriers in various settings used for spatial cues or conditioning environments. It plays a role in behavioral studies where walls may define areas for learning or memory tasks. Understanding how walls influence experimentation is crucial for accurate analyses of animal behavior and responses.

63) Salt (Salty):
'Salt' can refer to a common substance used in various biological applications, including as an electrolyte in culture media or during experiments. In pharmacological studies, certain salts may affect the solubility and absorption of drugs, playing a critical role in the formulation and evaluation of therapeutic agents.

64) Pir:
In research contexts, 'Peer' often refers to individuals within the same field or discipline who evaluate and assess work through peer review processes. This assessment fosters quality research and scientific integrity, ensuring that findings are scrutinized and validated by experts before publication in academic journals.

65) Pur:
The term 'Poor' can be used in multiple contexts, often referring to insufficient quality or lack of resources. In scientific evaluations, it may describe suboptimal conditions affecting experiments or the efficacy of therapeutic agents. Understanding poor outcomes in studies can lead to improved methodologies and better resource allocation in research.

66) Male:
'Male' refers to the gender of organisms typically used in biological research, particularly in animal studies. Gender influences growth, behavior, and physiological responses in experimental settings. Studies often consider male specimens to understand sex-specific responses to treatments or interventions in pharmacological and psychological research.

Other Ayurveda Concepts:

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