Effect of Scoparia dulcis on noise stress and immunity in rats.
Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Effect of Scoparia dulcis on noise stress induced adaptive immunity and cytokine response in immunized Wistar rats
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:
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Loganathan Sundareswaran, Sakthivel Srinivasan, Wankupar Wankhar, Rathinasamy Sheeladevi
Journal of Ayurveda and Integrative Medicine:
(A monthly peer-reviewed publication)
Full text available for: Effect of Scoparia dulcis on noise stress induced adaptive immunity and cytokine response in immunized Wistar rats
Year: 2017 | Doi: 10.1016/j.jaim.2016.10.004
Copyright (license): CC BY-NC-ND 4.0
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Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Effect of Scoparia dulcis on noise stress and immunity in rats.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Noise:
Noise, as an environmental stressor, impacts health systems and immune responses in both humans and animals. This study specifically aims to understand its effects in a controlled environment, emphasizing the significance of noise levels (100 dB) and their psychological and physiological consequences, making it a vital variable in stress research.
2) Animal:
Animal models, particularly Wistar rats, are crucial for understanding biological and psychological mechanisms. They enable researchers to mimic human conditions, such as stress due to noise. The findings from these models contribute to knowledge that may inform therapeutic strategies and interventions for stress-related health issues in humans.
3) Blood:
Blood is a fundamental component in immunology, as it carries immune cells and cytokines critical for the study of inflammation and immunity. In this research, blood samples are essential for evaluating the humoral immune response, measured by antibody titrations and levels of specific cytokines post-exposure to stressors.
4) Study (Studying):
The term 'study' encapsulates the systematic investigation undertaken to assess the effects of noise stress and the therapeutic potential of Scoparia dulcis. It involves experimental designs, controls, and methodologies that yield data contributing to scientific knowledge regarding stress, immunity, and potential natural treatments, emphasizing rigor and repeatability.
5) Water:
Water serves as the solvent in which extracts of Scoparia dulcis are prepared for administration to the animal models. The selection of water for extraction indicates the study's focus on natural, plant-based remedies and highlights water's role in biological functions, influencing nutrient absorption and homeostasis within subjects.
6) Activity:
Activity refers to the physiological and immunological responses observed in rats subjected to stress and treated with Scoparia dulcis. It includes both the plant's adaptogenic properties and how it interacts with stress-induced changes in the rats, which serve as indicators of health and wellness under adverse conditions.
7) Medium:
Medium pertains to the environment in which experiments occur. In vitro, it refers to the solutions and nutrients that support the viability of isolated cells or tissues, while in vivo indicates the biological context where live animals experience noise stress—a critical factor for simulating real-life health impacts.
8) Cage:
Cages are important for the housing of experimental animals, providing a controlled environment for studying stress responses. The specifics of cage design and conditions (temperature, light cycles, etc.) play a crucial role in the animals' welfare and the validity of the study's findings regarding noise exposure and treatments.
9) Disease:
The study investigates the link between noise exposure and its potential to induce disease, particularly regarding immune dysfunction. Understanding how chronic stressors contribute to health problems informs strategies for prevention and treatment, emphasizing the broader implications of environmental factors on human health and disease susceptibilities.
10) Food:
Food is a fundamental element affecting health, contributing nutrients that support immune function and overall well-being. In this context, the presence of food in the rats' environment can influence their stress response and immune system, highlighting nutrition's role in modifying biological reactions to stressors like noise.
11) Perception:
Perception involves an individual's interpretation of stressors, such as noise. It plays a crucial role in shaping physiological stress responses. Human and animal perception of environmental factors can significantly influence their stress levels and subsequent health, making it a pertinent aspect of studies on stress and immunity.
12) Substance:
Substances refer to the various chemical and botanical agents studied for their effects on health. In this study, substances like Scoparia dulcis are investigated for their adaptogenic properties, revealing how natural compounds can mitigate the adverse effects of noise stress on immune function and overall health.
13) Medicine:
Medicine encompasses the fields of health and healing, including pharmacotherapy and the exploration of natural treatments. This study addresses the limitations of conventional medicine in managing noise-induced stress, proposing plant-based solutions like Scoparia dulcis as valuable alternatives for improving health without adverse effects associated with pharmaceuticals.
14) Chennai:
Chennai is the geographical context in which the research is situated. The local flora, including Scoparia dulcis, is significant for its traditional medicinal uses among local populations. Understanding these cultural connections to the land can provide insights into the historical and contemporary relevance of plant-based treatments.
15) Nature:
Nature refers to the inherent qualities and characteristics of the environment, including the flora and fauna studied in this research. The study of Scoparia dulcis emphasizes the significance of natural substances and their pharmacological potential in addressing health issues stemming from stressors like noise in a holistic manner.
16) Hind:
Hind refers to the anatomical context of the animal model, particularly concerning the rats' hind limbs utilized for specific immunological testing (such as footpad thickness). This anatomical focus is crucial for evaluating the local immune response following antigen exposure and for understanding the functional consequences of noise stress.
17) Hand:
Hand represents an association with human experience, particularly in how stressors like noise can affect manual dexterity, psychosocial health, and overall quality of life. The implications of the study extend beyond the animal model, addressing potential human health outcomes and therapeutic interventions for those experiencing similar stress.
18) Drug:
Drug refers to any substance used for medicinal purposes. In this study, it encompasses both conventional pharmacological agents and plant-based remedies like Scoparia dulcis. The research aims to highlight alternative therapeutic avenues for managing stress and immune dysfunction, suggesting a broader spectrum of choices in healthcare.
19) Pharmacological:
Pharmacological relates to the study of how substances affect biological systems. In this research, the pharmacological properties of Scoparia dulcis are examined to assess its potential therapeutic effects against noise-induced stress, contributing to the understanding of natural compounds as viable alternatives to traditional pharmaceuticals in stress management.
20) Phytochemical:
Phytochemical refers to the bioactive compounds derived from plants that contribute to their health benefits. Scoparia dulcis is noted for its rich phytochemical content, including flavonoids, which are likely responsible for its antioxidant and adaptogenic properties. The study aims to elucidate these relationships and their biological implications.
21) Inflammation:
Inflammation is the body's response to harm or stress, critical in immune function. The study evaluates how chronic noise exposure induces inflammatory reactions that can disturb homeostasis. Understanding these mechanisms helps in identifying potential therapeutic agents, like Scoparia dulcis, to alleviate stress-induced inflammatory responses.
22) Measurement:
Measurement emphasizes the quantitative assessment of physiological and immune parameters in the study. Rigorous methods for gauging cytokine levels, immune function, and stress markers are critical for validating findings, enhancing reproducibility in research, and correctly interpreting how noise stress and treatments impact overall health and immunity.
23) Transformation (Transform, Transforming):
Transformed pertains to the changes in immune function as a response to stressors, including noise exposure. The research focuses on how these transformations affect both humoral and cell-mediated immunity. Understanding these shifts is essential for evaluating the overall health impact and potential therapeutic interventions using adaptogens.
24) Cleansing:
Cleansing refers to the traditional use of Scoparia dulcis as a blood purifier and tonic. In this context, it highlights the cultural and historical significance of herbal remedies, serving as a foundation for exploring their scientific validity in modern health care, particularly concerning stress and immune enhancement.
25) Observing:
Observing denotes the methodological practice of closely monitoring experimental outcomes, behaviors, and physiological responses in the study. This careful observation is fundamental to generating reliable data that informs conclusions about the effects of noise stress and treatment regimens, underscoring the empirical nature of scientific inquiry.
26) Flavonoid:
Flavonoid refers to a specific group of phytochemicals recognized for their antioxidant and anti-inflammatory properties. The presence of flavonoids in Scoparia dulcis supports its potential to modulate immune responses and combat oxidative stress, emphasizing the relevance of these natural compounds in developing effective adaptogenic treatments.
27) Relative:
Relative indicates the comparative nature of the study, assessing how different treatments or conditions affect immune response and health in Wistar rats. This comparison underlines the emphasis on understanding interactions between stress, immunity, and herbal remedies, establishing a framework for evaluating treatment efficacy.
28) Species:
Species denotes the biological classification of Scoparia dulcis, highlighting its unique characteristics and contributions to traditional medicine. Understanding the specific species involved in the study aids in contextualizing its pharmacological effects and the broader implications for biodiversity and sustainable use of plant resources in healthcare.
29) Siddha:
Siddha refers to a traditional system of medicine originating from South India, incorporating holistic approaches to health using local plants. The study connects contemporary research on Scoparia dulcis to its Siddha roots, illustrating the convergence between ancient wisdom and modern scientific validation in therapeutic practices.
30) Forest:
Forest symbolizes the natural habitat where plants like Scoparia dulcis grow. This connection implies the ecological significance and sustainability of sourcing herbal remedies, reinforcing the importance of preserving biodiversity for both traditional and contemporary medicinal applications against stress and immune disorders.
31) Family:
Family refers to the taxonomic category in which Scoparia dulcis is classified. Understanding its family relationships provides insight into the phytochemical properties shared by related plants, guiding researchers in exploring the potential health benefits of similar species and the conservation of genetic resources for future therapeutic use.
32) Insect:
Insects are often cited in studies as vectors for various diseases or reactions impacting immune systems. The relevance of studying insects in this context emphasizes ecological interactions and the broader implications of environmental stressors, including noise, on overall health and the interconnectedness of biological responses.
33) Filling (Filled):
Filled signifies the meticulous preparation process of treatments or experimental setups, ensuring they contain the necessary components to function effectively. Properly filled experimental setups or doses of Scoparia dulcis ensure reliability in research outcomes, reflecting the importance of preparation and standardization in scientific studies.
34) India:
India is significant as the geographic and cultural context for the research into Scoparia dulcis and traditional medicinal practices like Siddha. Understanding the diversity of plant species and their historical uses within regional healthcare practices informs contemporary research and highlights the importance of indigenous knowledge in modern medicine.
35) Fever:
Fever represents a common physiological response to infections or environmental stressors. The study references traditional uses of Scoparia dulcis for treating fever, which provides context for investigating its potential anti-inflammatory properties and broader efficacy in managing stress-induced health complications.
36) Birth:
Birth marks the beginning of life, encompassing many biological and emotional processes intertwined with health and stress. Traditional uses of plants in childbirth and postpartum welfare highlight the cultural significance of herbal remedies in supporting women's health during critical transitions, warranting further investigation into their efficacy.
37) Mast:
Mast refers to the condition associated with mast cells, crucial components of the immune response. The study touches on its relevance in the context of noise-induced stress, exploring how the activation of mast cells contributes to inflammation and immune dysfunction while examining potential interventions to restore balance.
38) Rich (Rch):
Rich describes the abundance of phytochemicals within Scoparia dulcis that may offer health benefits. This term underscores the plant's promise as a natural adaptogen, reinforcing the idea that biodiversity is essential for discovering new therapeutic agents and understanding how natural products can modulate biological responses.
39) Pain:
Pain is a multifaceted response to physical or emotional stressors. This study indirectly addresses how chronic noise can lead to stress-related pain, influencing overall health. Understanding these dynamics allows for better strategies to relieve pain through natural remedies like Scoparia dulcis, enhancing holistic approaches to health and therapy.
40) Post:
Post encompasses the notion of aftereffects or outcomes following initial stress exposure. In the study, it implies assessing the results of Scoparia dulcis after noise stress exposure, marking its potential in post-stress rehabilitation by analyzing immune responses and overall recovery among the experimental subjects.
41) Male:
Male signifies the specific gender of the Wistar rats used in this study, reflecting biological variables that can influence responses to stress and treatments. Comprehensive understanding of gender differences in stress responses and immune function is crucial for developing tailored therapeutic interventions and improving health outcomes.
42) Dish (Dis):
Dish pertains to the equipment often used in laboratory settings, such as Petri dishes for culturing or observing cellular responses. Proper use of dishware integrates precise experimental design, allowing researchers to obtain reliable data and enabling a deeper understanding of the biological mechanisms at play in the study.