Studying Tinospora cordifolia and Phyllanthus emblica for memory in mice.

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Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Exploring Bhavana samskara using Tinospora cordifolia and Phyllanthus emblica combination for learning and memory in mice
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:

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Author:

Harshad Onkarrao Malve


Journal of Ayurveda and Integrative Medicine:

(A monthly peer-reviewed publication)

Full text available for: Exploring Bhavana samskara using Tinospora cordifolia and Phyllanthus emblica combination for learning and memory in mice

Year: 2015 | Doi: 10.4103/0975-9476.157953

Copyright (license): CC BY-NC-ND 4.0


Download the PDF file of the original publication


Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Studying Tinospora cordifolia and Phyllanthus emblica for memory in mice.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
A drug is a substance used for medical purposes to prevent, diagnose, treat, or alleviate symptoms of diseases. In the context of this study, drugs like Tinospora cordifolia, Phyllanthus emblica, and Rivastigmine are evaluated for their effects on learning and memory, highlighting the search for effective treatments for cognitive disorders.

2) Learning:
Learning refers to the process of acquiring new information or skills, a core component of cognition. This study investigates how different Ayurvedic formulations influence learning in mice, contributing to the understanding of potential treatments for cognitive impairments associated with conditions like dementia.

3) Study (Studying):
Studying denotes the process of learning or rigorous investigation into a subject. This study systematically explores how traditional medicines can influence cognitive functions, contributing to advancing knowledge in both Ayurveda and modern pharmacological practices.

4) Water:
Water serves as a solvent and vehicle for the administration of drug formulations in this study. Distilled water is used to dissolve medications for oral administration to mice, ensuring accurate dosing and facilitating the evaluation of the effects of various treatments on learning and memory.

5) Samskara (Saṃskāra):
Samskara in Ayurvedic texts refers to the processes that purify or transform substances to enhance their therapeutic properties. The concept is examined in this study through the 'Bhavana samskara', exploring how this transformation affects the effectiveness of herbal formulations in improving cognitive functions.

6) Bhavana (Bhāvanā, Bhāvana, Bha-vana):
Bhavana is a specific type of Samskara that involves the treatment of herbal powders with liquid mediums to enhance their pharmacological effects. This study explores its implications using Tinospora cordifolia and Phyllanthus emblica, assessing whether Bhavana improves the nootropic properties of these drugs.

7) Table:
In the context of this study, tables are used to present data clearly and systematically. They summarize findings, drug treatments, and corresponding effects, facilitating easier comparison and analysis of the results obtained from different experimental groups during memory evaluations.

8) India:
India is the birthplace of Ayurveda, a traditional system of medicine that emphasizes the use of natural herbs and holistic treatments. The study's investigation into Ayurvedic formulations underscores the significance of India as a source of alternative medicinal practices for cognitive enhancement.

9) Ayurveda (Āyurveda, Ayus-veda):
Ayurveda is an ancient Indian system of medicine focused on balance in bodily systems and uses herbal treatments. The study investigates Ayurvedic formulations' potential to enhance learning and memory in animal models, highlighting the relevance of traditional knowledge in modern pharmacology.

10) Animal:
The term 'animal' refers to the subjects of this experimental study, specifically mice used for testing the effects of Ayurvedic formulations. Animal models provide essential insights into the potential efficacy and safety of treatments before considering clinical applications in humans.

11) Maharashtra (Mahārāṣṭra, Maha-rashtra):
Maharashtra is a state in India where this study was conducted at Seth G. S. Medical College and K. E. M. Hospital. Its significance lies in providing a context for the research, which utilizes local resources and traditional medicinal practices inherent to the region's culture.

12) Training:
Training refers to the processes used to condition animals for memory tests in this study. Mice are subjected to specific procedures to assess their learning and memory abilities, essential for scientifically evaluating the impact of various treatments on cognitive performance.

13) Indian:
Indian refers to the cultural and traditional context from which Ayurveda and its medicinal practices emerge. This descriptor emphasizes the geographical and ideological origins of the treatments explored in the study, linking them to a rich heritage of holistic health practices.

14) Seth:
Seth refers to Seth G. S. Medical College, where the study was conducted. The institution's role is significant as it provides a structured environment for scientific research, ensuring ethical practices and rigorous methodology in investigating the effects of Ayurvedic formulations.

15) Tinospora cordifolia:
Tinospora cordifolia is a medicinal plant extensively used in Ayurveda, known for its potential neuroprotective and memory-enhancing properties. The study evaluates its efficacy in improving cognitive functions in mice, contributing to the exploration of its therapeutic potential in modern medicine.

16) Phyllanthus emblica:
Phyllanthus emblica, commonly known as Amla, is renowned for its health benefits, particularly in enhancing memory and cognitive performance. This study assesses its effects in combination with other Ayurvedic herbs, contributing to the understanding of its role in cognitive health and dementia treatment.

17) Ocimum sanctum:
Ocimum sanctum, also known as Tulsi, is a significant herb in Ayurveda associated with various health benefits, including stress reduction and cognitive enhancement. The study explores its synergistic effects when combined with other herbs in improving learning and memory in mice.

18) Pharmacology:
Pharmacology is the scientific study of drug action and interaction within biological systems. This study employs pharmacological principles to evaluate the effectiveness of traditional Ayurvedic herbs, contributing knowledge to the field by bridging ancient practices and modern therapeutic approaches.

19) Performance:
Performance refers to the results obtained from the learning and memory tests conducted on mice. It is a key metric for evaluating the efficacy of different treatment formulations, helping to determine which combinations yield the best cognitive-enhancing effects.

20) Medicine:
Medicine encompasses the practices of diagnosis, treatment, and prevention of diseases. The study investigates traditional medicinal systems, particularly Ayurveda, examining its herbal formulations as potential alternatives or adjuncts to modern pharmacotherapy for cognitive disorders.

21) Tulsi:
Tulsi, or Ocimum sanctum, is a sacred plant in Indian tradition known for its various health benefits. It is included in the study to assess its impact on learning and memory, providing insight into its role in enhancing cognitive abilities through Ayurvedic practices.

22) Food:
Food in this study refers to the diet provided to the mice as they undergo testing. Nutrition and dietary components can influence cognitive function, making it a relevant factor in the evaluation of herbal formulations’ effectiveness in enhancing memory and learning.

23) Cage (Cāge):
Cage refers to the housing for the mice in the study, essential for maintaining controlled conditions that are conducive to the well-being of the animals. Proper housing ensures that environmental variables do not affect the results of the behavioral assessments.

24) Pharmacological:
Pharmacological relates to the study and evaluation of drugs and their effects. This research focuses on the pharmacological actions of Ayurvedic formulations, assessing their potential to enhance memory and learning while contrasting with conventional pharmacological agents like Rivastigmine.

25) Rasayana (Rasa-ayana, Rasāyana, Rāsāyana):
Rasayana is a category in Ayurveda denoting rejuvenation therapies aimed at promoting longevity and cognitive function. The study investigates Rasayana herbs for their nootropic effects, emphasizing their significance in enhancing learning and memory within traditional medicinal frameworks.

26) Activity:
Activity refers to the biological action of the herbal formulations tested in this study. Understanding the activity of specific compounds is crucial for determining their efficacy in enhancing cognitive functions, thus guiding future research directions in both traditional and modern medicine.

27) Disease:
Disease encompasses the medical conditions addressed by the study, particularly neurodegenerative disorders affecting memory and learning. By exploring the efficacy of Ayurvedic formulations, the research aims to identify potential treatments for diseases like dementia that currently lack effective medications.

28) Anxiety:
Anxiety refers to a state of heightened concern that can affect cognitive performance. The study acknowledges anxiety's role in learning and memory by utilizing the elevated plus maze test, providing a behavioral model to evaluate how treatments can mitigate anxiety-induced cognitive deficits.

29) Powder:
Powder pertains to the form in which the herbal drugs are processed before administration. The study evaluates the powdered form of specific Ayurvedic herbs, considering how their preparation and potential transformation through Bhavana can influence their effectiveness in enhancing cognitive functions.

30) Shri (Śri, Śrī, Śṝ, Sṛ, Sṝ):
Shri is an honorific title used in naming and crediting organizations or persons, indicating respect. In this context, it refers to Shri Dhootpapeshwar Ltd., the provider of herbal formulations, emphasizing the collaborative effort in researching traditional remedies for modern medical challenges.

31) Zingiber officinale:
Zingiber officinale, commonly known as ginger, is another significant herb studied for its health benefits. Although not the primary focus in this research, its associations with cognitive enhancement like other Ayurvedic herbs highlight the broader potential of traditional medicines in promoting cognitive wellness.

32) Glycyrrhiza glabra:
Glycyrrhiza glabra, or licorice, possesses various health benefits, including anti-inflammatory properties. This study's reference to it aligns with the exploration of multiple herbs within ayurvedic traditions that can contribute to cognitive health, reflecting potential synergistic effects when combined with other herbs.

33) Withania somnifera:
Withania somnifera, or Ashwagandha, is an adaptogenic herb known to enhance cognitive function and reduce stress. The study's mention of it underscores its relevance in examining the broader scope of Ayurvedic treatments for cognitive disorders and their potential role in enhancing memory.

34) Mental disorder:
Mental disorder refers to cognitive impairments that can adversely impact daily functioning. The study addresses the rising concern of such disorders, particularly dementia, and evaluates traditional Ayurvedic formulations as potential agents for improving cognitive function and alleviating symptoms related to memory loss.

35) Butea frondosa:
Butea frondosa, also known as 'flame of the forest,' is recognized for its medicinal properties and role in Ayurveda. Its mention in this study broadens the research scope to include multiple herbs with potential effects on learning and memory within traditional or integrative approaches.

36) Vitis vinifera:
Vitis vinifera, or grapevine, is noted for its antioxidant properties and benefits to health. The inclusion of this herb relates to the study's broader investigation into various plant compounds traditionally used to enhance cognitive function and potentially combat neurodegenerative diseases.

37) Transformation (Transform, Transforming):
Transformation refers to the process of altering the inherent properties of substances, such as herbs, to enhance their therapeutic effects. This study particularly examines how the transformation through Bhavana can impact the pharmacological efficacy of Ayurvedic formulations in cognitive enhancement.

38) Observation:
Observation in research refers to the systematic assessment of effects, behaviors, and results during experiments. This study's observations focus on measuring the impacts of various treatments on learning and memory in mice, driving conclusions about the efficacy of Ayurvedic formulations.

39) Ahmednagar:
Ahmednagar is a city in Maharashtra, India, noted for its relevance in the study's context as the source of the Rivastigmine drug evaluated for memory enhancement. The inclusion of local locales emphasizes the geographical ties that influence traditional and modern treatment approaches.

40) Alcoholism:
Alcoholism refers to the chronic disease of alcohol dependence, often leading to cognitive impairments among other health issues. The study acknowledges factors like alcoholism that can contribute to dementia, thereby highlighting the importance of effective treatments for cognitive dysfunction in affected individuals.

41) Science (Scientific):
Scientific refers to the systematic study and application of knowledge through empirical methods and evidence. This research adopts scientific methodologies to evaluate traditional Ayurvedic treatments, reinforcing the importance of rigorous testing in determining the efficacy of herbal formulations on memory and learning.

42) Container:
Container refers to the vessels used for preparing, storing, or administering Ayurvedic formulations. This study emphasizes the significance of proper containing techniques to maintain the quality and effectiveness of herbal drugs, ensuring accurate dosing in experimental assessments.

43) Cleansing:
Cleansing refers to the process of purifying or preparing substances for use by removing impurities. In the context of Ayurvedic formulations, it highlights the traditional practices involved in ensuring that herbs are prepared correctly, thus preserving their active properties for therapeutic efficacy.

44) Fragrance:
Fragrance relates to the aromatic qualities of the herbs studied. The scent not only influences palatability in consumption but also can play a role in therapeutic applications, as certain fragrances are believed to have calming or cognitive-enhancing effects, aligning with Ayurveda's holistic approach to medicine.

45) Language:
Language refers to the means of communication, particularly in the context of presenting research findings or conveying traditional Ayurvedic knowledge. The study employs precise language and terminology to ensure clear understanding of methodologies, results, and implications for cognitive health.

46) Samhita (Saṃhitā, Saṃhita):
Samhita refers to the ancient texts of Ayurveda that document knowledge about health, herbal medicine, and practices. The study leverages insights from these texts to frame the investigation of specific herbs, reinforcing the historical and cultural foundations of the treatments being tested.

47) Gujarat:
Gujarat is a state in India where diverse herbal plants grow and traditional practices thrive. Though not the primary setting for this study, its mention reflects the geographic diversity of Ayurvedic resources and the broad applicability of the research focus within India.

48) Nirmala (Nirmalā):
Nirmala refers to Dr. Nirmala N. Rege, a contributing supervisor in the study. Her guidance underscores the importance of scholarly mentorship in conducting research effectively and ensuring the integrity and rigor of the scientific findings presented.

49) Heating:
Heating is a process involved in the preparation of herbal formulations, particularly in Ayurveda. This signifies a method used in Bhavana that may change the properties of the herbs, potentially improving their efficacy, a key component of the study's investigation into these transformations.

50) Nature:
Nature signifies the natural origins of the Ayurvedic herbs studied. Understanding how these materials interact with biological systems reflects a holistic view consistent with Ayurvedic philosophy, emphasizing the integration of natural remedies into modern health discussions, particularly in cognitive enhancement.

51) Paddy:
Paddy refers to the rice husk bedding used for housing the experimental mice. Ensuring proper bedding contributes to the comfort and health of the animals, which is essential for maintaining stable conditions throughout behavioral and pharmacological assessments.

52) Vapi (Vāpī, Vāpi, Vapī):
Vapi is another city in India, known for its industrial activities. Its mention alongside studies reflects the broader landscape of traditional medicines' integration with contemporary practices, emphasizing the importance of diverse geographical contributions to the field of Ayurveda.

53) Amla (Amlā, Āmlā):
Amla, or Phyllanthus emblica, is highlighted for its potent health benefits and significant role in enhancing cognitive functions as per Ayurvedic tradition. This study investigates its effects in contributing to memory improvement, reinforcing its established reputation within both traditional and modern contexts.

54) Viti (Vīti, Viṭi, Vīṭi, Vīṭī):
Viti refers to Vitis vinifera, or grapes, a plant recognized for its benefits, particularly its antioxidant properties. Its inclusion broadens the research understanding by recognizing various plants traditionally used for enhancing cognitive health, showcasing the efficacy of a diverse range of herbal remedies.

55) Life:
Life signifies the biological processes and health considerations underpinning the study of cognitive function and the impact of treatment on quality of life. The research aims to enhance life quality by improving cognitive health through the application of traditional medicinal practices.

56) Sign:
Sign refers to the indicators or markers of cognitive performance, such as transfer latency in the learning tests used in this study. Identifying these signs is crucial for evaluating the efficacy of treatments and their potential to reverse memory impairments.

57) Salt (Salty):
Salt in this context refers to the chemical compounds that may be involved in the biochemical processes affected by the studied herbs. Though not a primary focus, it highlights the complexity of herbal interactions which can influence efficacy in cognitive enhancement strategies.

58) Post:
Post refers to the analysis or assessment conducted after the treatment phase or tests, emphasizing the importance of evaluating outcomes following the administration of formulations. This temporal aspect is critical in determining the effects and sustained benefits of treatments applied.

59) Pole:
Pole relates potentially to the method of experimental design used in the study of animals, particularly regarding locations or areas within the elevated plus maze. Understanding spatial and environmental interactions is relevant for evaluating behavioral responses to cognitive tasks.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Studying Tinospora cordifolia and Phyllanthus emblica for memory in mice.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Phyllanthus emblica, Tinospora cordifolia, Cognitive impairment, Elevated Plus Maze, Plant drug, Short-term memory, Long-term memory, Neuroprotective effect, Bhavana Samskara, Biological evaluation, Neurodegenerative disease, Traditional medicinal system, Institutional animal ethics.

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