Anti-inflammatory effects of a herbomineral formula in rats with arthritis.
Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Evaluation of anti-inflammatory potential of the multidrug herbomineral formulation in male Wistar rats against rheumatoid arthritis
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
This page does not contain the article itself; See source (below) for actual content.
Original source:
This page only sums up technical details and meta-data hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Snehal S. Patel, Praboth V. Shah
Journal of Ayurveda and Integrative Medicine:
(A monthly peer-reviewed publication)
Full text available for: Evaluation of anti-inflammatory potential of the multidrug herbomineral formulation in male Wistar rats against rheumatoid arthritis
Year: 2013 | Doi: 10.4103/0975-9476.113869
Copyright (license): CC BY-NC-ND 4.0
Download the PDF file of the original publication
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Anti-inflammatory effects of a herbomineral formula in rats with arthritis.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Disease:
The term 'disease' refers to a pathological condition affecting the body, characterized by specific symptoms and signs. In the context of the study, rheumatoid arthritis (RA) is the primary focus as it is a chronic inflammatory disease that significantly impacts joint function and quality of life.
2) Animal:
In this study, 'animal' refers to the male Wistar rats used as experimental models to investigate the efficacy of the herbal formulation 'Rheuma off gold' (RG). Animal models are vital for understanding the biological mechanisms of diseases and testing potential therapeutic interventions before human application.
3) Inflammation:
'Inflammation' denotes a biological response to harmful stimuli, such as pathogens or damage. It is a hallmark feature of rheumatoid arthritis, resulting in pain, swelling, and joint destruction. The study evaluates how the RG formulation can ameliorate inflammatory markers and symptoms in induced arthritic rats.
4) Medicine:
'Medicine' encompasses the science and practice of diagnosing, treating, and preventing illnesses. The study explores the potential of a traditional Ayurvedic formulation as an alternative treatment for RA, highlighting the growing interest in integrating traditional medicine with modern pharmaceutical approaches.
5) Drug:
'Drug' refers to a substance used for medical treatment. While conventional pharmaceuticals like dexamethasone are standard for RA, this study investigates RG, an Ayurvedic formulation, as a potential alternative with fewer side effects, aiming to demonstrate its therapeutic benefits in inflammation reduction.
6) Table:
'Table' typically pertains to a structured representation of data. In the context of this study, tables summarize the composition of RG, experimental groups, and statistical results, aiding in comparing effects among treated and control groups to elucidate the formulation's efficacy in alleviating arthritis symptoms.
7) Pain (Paiṇ):
'Pain' is an unpleasant sensory experience often associated with tissue damage or inflammation. RA patients suffer chronic pain, underscoring the importance of finding effective anti-inflammatory treatments. The study measures pain reduction as a key endpoint to assess RG's therapeutic potential in managing arthritis.
8) Gold (Golden):
'Gold' relates to the 'Rheuma off gold' formulation. The term signifies the significance of the mineral aspect in traditional Ayurveda. This herbomineral formulation aims to provide an effective treatment for RA, harnessing the healing properties of both herbal constituents and the mineral gold.
9) Study (Studying):
'Study' refers to the systematic investigation conducted to assess the efficacy of RG in treating rheumatoid arthritis. Through rigorous experimental methodology, the research aims to provide scientific validation to traditional claims about Ayurvedic treatments in addressing chronic inflammatory diseases.
10) Ayurveda (Āyurveda, Ayus-veda):
'Ayurveda' is a traditional Indian system of medicine that emphasizes a holistic approach to health. It incorporates dietary practices, herbal formulations, and lifestyle recommendations. The study evaluates the Ayurvedic RG formulation as a possible alternative treatment for rheumatoid arthritis, highlighting its historical relevance.
11) Activity:
'Activity' denotes the physiological and pharmacological effects exerted by a substance. In this study, the 'activity' pertains to RG's anti-inflammatory and immunosuppressive actions evaluated against rheumatoid arthritis. Demonstrating this activity helps affirm the formulation's potential in clinical applications.
12) India:
'India' denotes the geographical context from which the Ayurvedic formulation originates. This cultural backdrop is essential in understanding the traditional practices, herbal knowledge, and medicinal use prevalent in Indian society. The study connects this rich heritage to modern scientific inquiry.
13) Blood:
'Blood' in this context refers to the biological fluid whose characteristics, such as cytokine levels, are analyzed to understand systemic effects of inflammation and treatment response. Measuring blood parameters helps validate RG's efficacy in regulating inflammatory processes in rheumatoid arthritis.
14) Commiphora mukul:
'Commiphora mukul' is a significant component of the RG formulation. It is known for its anti-inflammatory and healing properties. The presence of this herb underlines the formulation's potential benefits in treating arthritis and supports its use in traditional medicine practices.
15) Suvarna (Suvarṇā, Suvarṇa):
'Suvarna' refers to the gold used in Ayurvedic formulations for its perceived beneficial properties. It symbolizes purity and healing. In RG, it is believed to aid in enhancing the overall efficacy of the treatment for rheumatoid arthritis, potentially influencing immune response.
16) Bhasma (Bhasman):
'Bhasma' refers to an Ayurvedic preparation derived from minerals, processed through incineration to enhance bioavailability and medicinal efficacy. It plays a crucial role in RG, contributing to its therapeutic properties targeting rheumatoid arthritis and emphasizing Ayurveda's use of minerals in treatment.
17) Vata (Vāṭa, Vaṭa, Vāta, Vaṭā):
'Vata' is a fundamental concept in Ayurveda representing one of the three doshas or energies. It is associated with movement and physiological functions. Rheumatoid arthritis is linked to imbalance in Vata, and RG aims to restore equilibrium and alleviate related symptoms in patients.
18) Pharmacological:
'Pharmacological' pertains to the study of drug action. This term underscores the focus of the research in evaluating the pharmacological effects of RG. Demonstrating its pharmacological efficacy can lead to its acceptance as a viable treatment option for arthritis.
19) Gujarat:
'Gujarat' is the Indian state where the RG formulation was developed. Highlighting its geographical origin adds cultural context to the study. It connects the traditional medicines used in the local practice with the emerging interest in scientifically validating these practices.
20) Edema (Oedema):
'Edema' refers to the swelling caused by excess fluid accumulation, often a symptom in inflammatory conditions like rheumatoid arthritis. The study measures paw edema as a critical parameter to assess the effectiveness of RG in reducing inflammation and improving joint health.
21) Hind (Hiṇḍ):
'Hind' typically refers to the back or the eastern side in geographical terms. In this context, it may signify the Ayurvedic roots found in Eastern traditions or philosophies. Understanding this regional aspect is essential to appreciate the holistic approaches to health practiced here.
22) Sign:
'Sign' pertains to measurable indicators of a disease. In the study, signs of rheumatoid arthritis, including inflammation, edema, and arthritic index, are quantified to substantiate the therapeutic claims of RG and validate its efficacy through observable outcomes.
23) Rheumatoid arthritis:
'Rheumatoid arthritis' is a chronic autoimmune disorder characterized by inflammation and damage to joints. This study specifically investigates the Ayurvedic formulation RG as a treatment option aiming to alleviate the pain and inflammation associated with this debilitating condition.
24) Observation:
'Observation' refers to the systematic recording of data during experiments. In this study, numerous observations were made regarding the physical, biochemical, and histopathological parameters in rats, guiding conclusions about the efficacy of RG in treating rheumatoid arthritis effectively.
25) Measurement:
'Measurement' involves quantifying parameters to assess treatment effectiveness. The study focuses on measuring outcomes, such as paw swelling, inflammatory markers, and organ indices, to provide objective evidence of RG's impact compared to control treatments for arthritic conditions.
26) Developing:
'Developing' refers to the ongoing process of creating new therapies. In this study, the researchers aim to develop an understanding of how traditional Ayurvedic formulations can be scientifically validated and potentially integrated into modern treatments for rheumatoid arthritis.
27) Irritation:
'Irritation' relates to discomfort or exacerbated response tissues can exhibit during inflammation. While many conventional drugs used for RA may cause gastrointestinal irritation, RG is studied for its potential anti-inflammatory effects with reduced side effects, providing a safer alternative for long-term use.
28) Science (Scientific):
'Science' underscores the structured methodology employed in the study to explore the efficacy of RG. It indicates a commitment to evidence-based research to enhance understanding of how traditional remedies can offer viable alternatives in treating complex chronic diseases like arthritis.
29) Knowledge:
'Knowledge' encompasses the understanding acquired through experience and study. In this context, the researchers aim to expand existing knowledge regarding Ayurvedic treatments and their pharmacological validation, thereby contributing to the broader understanding of therapies for chronic inflammatory conditions.
30) Substance:
'Substance' refers to any material with distinct properties. In this research, various substances like herbal extracts, minerals, and their constituents in RG are investigated for their roles in alleviating arthritis symptoms, emphasizing the importance of compound interactions in therapeutic efficacy.
31) Stiffness:
'Stiffness' describes the limited range of motion often experienced in inflamed joints, a common symptom of rheumatoid arthritis. The study seeks to assess the impact of RG on stiffness, aiming to demonstrate its potential to improve joint function and overall mobility in patients.
32) Swelling:
'Swelling' signifies the enlargement of tissues due to inflammatory responses commonly seen in rheumatoid arthritis. The study focuses on reducing swelling in the paws of arthritic rats as a primary outcome measure, indicative of the anti-inflammatory efficacy of the RG formulation.
33) Kashaya (Kāṣāya, Kāśaya, Kāsāya, Kaṣāya, Kaśāya, Kāsaya, Kaṣāyā, Kasāya, Kasaya):
'Kashaya' refers to a category of herbal formulations in Ayurveda characterized by their astringent properties. This terminology emphasizes the therapeutic approaches taken in traditional medicine, where formulations might be designed to manage symptoms associated with conditions like rheumatoid arthritis through balanced herbs.
34) Dealing:
'Dealing' refers to the systematic approach toward addressing a particular issue. In this study, the focus on dealing with the challenges posed by rheumatoid arthritis through innovative treatment approaches reflects the importance of both traditional knowledge and modern scientific evaluation.
35) Mineral:
'Mineral' concerns the inorganic elements found in formulations, which are believed to have health benefits. In RG, the inclusion of minerals like gold signifies the Ayurvedic principle of using mineral-based therapies as integral to providing anti-inflammatory and restorative effects in treatment.
36) Sandhi (Shandhi, Samdhi):
'Sandhi' in Ayurveda refers to joints, reinforcing the connection between traditional Ayurvedic practices and modern scientific research. Studying the effects of RG focuses on joint health, particularly in addressing conditions characterized by inflammation in the sandhi, such as rheumatoid arthritis.
37) Water:
'Water' often represents a fundamental element in herbal preparations. In Ayurveda, it plays a crucial role as a solvent for herbal extracts and can influence the bioavailability of active constituents in formulations. The study may explore how hydration impacts treatment outcomes.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Anti-inflammatory effects of a herbomineral formula in rats with arthritis.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Erythrocyte sedimentation rate, C-Reactive Protein, Anti-inflammatory effect, Dexamethasone, Herbomineral formulation, Inflammatory mechanism, Rheumatoid Arthritis (RA), Histopathological examination, Splenomegaly, Maharasnadi Kwath, Plant Steroids, Plant-based therapies, Pannus formation, Serum rheumatoid factor, Immunological mechanism.