Clinical evaluation of GlucoCare in non-insulin dependent diabetes.
Journal name: Journal of Ayurveda and Integrative Medicine
Original article title: Double-blind, placebo-controlled clinical evaluation of an Ayurvedic formulation (GlucoCare capsules) in non-insulin dependent diabetes mellitus
The Journal of Ayurveda and Integrative Medicine (JAIM) is an open-access publication promoting collaboration between Ayurveda, traditional medicine, and biomedicine, publishing research on integrative health sciences
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Original source:
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R. K. Sharma, Pralhad S. Patki
Journal of Ayurveda and Integrative Medicine:
(A monthly peer-reviewed publication)
Full text available for: Double-blind, placebo-controlled clinical evaluation of an Ayurvedic formulation (GlucoCare capsules) in non-insulin dependent diabetes mellitus
Year: 2010 | Doi: 10.4103/0975-9476.59827
Copyright (license): CC BY-NC-ND 4.0
Download the PDF file of the original publication
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Clinical evaluation of GlucoCare in non-insulin dependent diabetes.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Study (Studying):
The study refers to the clinical trial evaluating the efficacy and safety of GlucoCare capsules in managing non-insulin dependent diabetes mellitus (NIDDM). This investigation is crucial to assess the potential benefits of Ayurvedic formulations in treating a prevalent metabolic disorder, contributing to overall understanding of alternative diabetes therapies.
2) Activity:
Activity in this context pertains to the pharmacological effects exhibited by the components of GlucoCare capsules, especially their antihyperglycemic and therapeutic properties against diabetes. The term emphasizes the significance of these effects in controlling blood sugar levels and alleviating symptoms associated with NIDDM, thus supporting clinical outcomes.
3) Blood:
Blood is central to diabetes management, as it carries glucose and indicates metabolic health through parameters like fasting blood sugar and postprandial glucose levels. Monitoring blood glucose is vital for diagnosing and managing diabetes, guiding treatment decisions and evaluating the effectiveness of interventions like GlucoCare capsules.
4) Prakriti (Prakṛti):
Prakriti refers to the Ayurvedic concept of individual constitution or body type that influences health and treatment responses. The study specifically included patients identified with 'Pitta-Kapha' prakriti, indicating the tailored approach of Ayurveda, where treatments are aligned with a person's unique balance of doshas for optimal efficacy.
5) Kapha:
Kapha is one of the three doshas in Ayurveda, representing qualities such as stability, moisture, and heaviness. In the context of the study, Kaphaja diabetes refers to a specific type characterized by excess Kapha dosha, indicating the importance of balancing doshas through tailored herbal formulations like GlucoCare for effective diabetes management.
6) India:
India is highlighted as a key geographic location with a high prevalence of diabetes cases, particularly NIDDM. The study’s context within India reflects the need for research in traditional Ayurvedic therapies, addressing the growing health crisis in the country and exploring culturally relevant treatment options.
7) Drug:
The term drug signifies therapeutic agents utilized for medical treatment. GlucoCare capsules are presented as an Ayurvedic drug aiming to provide a natural alternative for managing NIDDM symptoms, showcasing a shift towards holistic and integrative approaches in diabetes care among clinicians and patients.
8) Pitta (Pītta, Piṭṭā):
Pitta is another of the three doshas in Ayurveda, associated with metabolism and transformation qualities like heat and intensity. The study emphasizes Pitta's role in certain diabetes types, guiding the formulation of remedies that balance metabolic functions optimally, aligning treatment with metabolic profiles of individuals.
9) Table:
Table serves as a structured presentation of data within the study, such as the composition of the GlucoCare capsules or baseline characteristics of participants. Tables organize complex information, making it easier for readers to comprehend and analyze key findings regarding treatment efficacy and participant demographics.
10) Sugar:
Sugar refers to glucose levels in the blood, which are critical in diagnosing and managing diabetes. The study measures blood sugar parameters to assess the effectiveness of GlucoCare capsules. Controlling sugar levels is paramount for preventing complications and maintaining overall health in diabetic patients.
11) Prameha:
Prameha is a Sanskrit term in Ayurveda that categorizes metabolic disorders involving excessive urination, including diabetes mellitus (Madhumeha). Understanding Prameha is essential for practitioners for diagnosing and treating conditions like NIDDM, providing a framework for symptomatology and therapeutic approaches in Ayurveda.
12) Disease:
Disease signifies a pathological condition characterized by specific signs and symptoms. NIDDM, as the focus of the study, reflects the broader issue of metabolic disorders affecting millions, highlighting the necessity for effective management strategies and the exploration of alternative treatments like GlucoCare.
13) Pittaja (Pitta-ja):
Pittaja is a subtype of Prameha categorized under Ayurvedic classifications referring to diabetes linked to Pitta dosha imbalances. By processing patient characteristics and symptoms, understanding Pittaja aids in creating targeted treatment protocols, including dietary and herbal interventions aimed at restoring balance in Pitta-related conditions.
14) Momordica charantia:
Momordica charantia, or bitter melon, is a key ingredient in GlucoCare, known for its blood glucose-lowering effects. Its presence in the formulation illustrates Ayurveda's reliance on botanical compounds with scientific backing, emphasizing its role in enhancing pancreatic function and improving glucose uptake, vital for diabetic management.
15) Attending:
Attending indicates the recruitment process for patients participating in the study. It reflects the clinical setting where individuals with NIDDM were observed, emphasizing the importance of real-world contexts in evaluating therapeutic interventions, solidifying the link between Ayurvedic practices and patient outcomes.
16) Flavonoid:
Flavonoid refers to a diverse group of plant metabolites known for their antioxidant properties. In the context of the study, flavonoids present in Ayurvedic herbs enhance the therapeutic profile of GlucoCare capsules by contributing to overall metabolic health and potentially mitigating oxidative stress in diabetes.
17) Himalaya (Himālaya, Hima-alaya):
Himalaya refers to The Himalaya Drug Company, the manufacturer of GlucoCare capsules. The company plays a significant role in traditional herbal medicine and research, bridging Ayurveda with modern science, enhancing the credibility of their formulations in addressing public health concerns like diabetes.
18) Kaphaja:
Kaphaja is a classification of diabetes associated with excess Kapha dosha. Identifying patients with Kaphaja characteristics allows for tailored treatments that consider dosha imbalances, underpinning Ayurvedic principles that promote personalizing healthcare strategies rooted in individual constitutions for effective management of diabetes.
19) Diet:
Diet is a fundamental aspect of diabetes management, comprising lifestyle choices that directly impact blood glucose levels. The study underscores the combination of diet, Ayurvedic treatment, and lifestyle modifications as essential elements for achieving effective control of NIDDM and enhancing quality of life among patients.
20) Burning sensation:
Burning sensation is a common symptom reported in diabetes, often due to neuropathy or poor circulation. The study's focus on alleviating this symptom through GlucoCare highlights the formulation's potential to improve not only glycemic control but also overall patient comfort and quality of life.
21) Pharmacological:
Pharmacological pertains to the science of drug action and how formulations exert physiological effects. The study evaluates the pharmacological mechanisms of GlucoCare capsules, providing insights into their efficacy for NIDDM and positioning Ayurveda within a scientific framework for understanding therapeutic actions.
22) Observation:
Observation is critical in clinical studies as it involves close monitoring of patients’ responses to interventions. The study relied on careful observations of symptom relief and glucose level changes, ensuring a thorough evaluation of GlucoCare capsules, thereby grounding the research on evidence-based assessments.
23) Suffering:
Suffering reflects the health challenges and symptoms faced by individuals with NIDDM. The study aims to address this suffering by providing an alternative treatment through GlucoCare, underscoring the necessity of effective management to reduce the burden of diabetes on patients' well-being.
24) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing diseases. The study explores Ayurvedic medicine's role in effectively managing NIDDM, emphasizing the integration of alternative therapies into modern healthcare to enhance the scope of disease management for practitioners and patients.
25) Relative:
Relative, in this context, pertains to the comparison of the effects of the GlucoCare capsules against a placebo. The study highlights the importance of relative efficacy in clinical trials to determine whether the Ayurvedic formulation provides statistical advantages in managing NIDDM symptoms over traditional treatments.
26) Company:
Company refers to The Himalaya Drug Company, which is integral to this research as the developer of GlucoCare capsules. The company's involvement signifies the collaboration between traditional knowledge systems and modern health practices, fostering the legitimacy and potential acceptance of Ayurvedic treatments among healthcare professionals.
27) Burning (Burn, Burned, Burnt):
Burning, specifically in the context of this study, is often associated with neuropathic symptoms in diabetes. Addressing burning sensations through treatment is indicative of the comprehensive approach in diabetes management, targeting both metabolic control and symptomatic relief through interventions like GlucoCare capsules.
28) Kshaya (Kṣaya):
Kshaya refers to a progressive depletion or deficiency, a term used to describe the depletion of doshas in Ayurveda. In the context of diabetes, identifying Kshaya in patients may sharpen the focus on necessary dietary and lifestyle modifications alongside treatment to restore dosha balance for improved health outcomes.
29) Vataja (Vātaja, Vata-ja):
Vataja is a classification of diabetes related to Vata dosha imbalances. Understanding Vataja helps practitioners customize Ayurvedic treatments that consider unique patient characteristics, ensuring holistic management of symptoms while addressing the specific doshic imbalances that could exacerbate diabetic conditions.
30) Family:
Family implies the broader impact diabetes has on familial structures. In the context of the study, recognizing family participation in management discussions or affecting patient compliance with treatments reinforces the significance of addressing health challenges collaboratively, maximizing support and adherence in diabetes management.
31) Vata (Vāṭa, Vaṭa, Vāta, Vaṭā):
Vata represents one of the three key doshas in Ayurveda, governing motion and bodily functions. Its involvement in diabetes classifications is crucial as it seeks to understand how imbalances affect metabolic processes, promoting targeted interventions that reflect the holistic nature of Ayurvedic treatments for diabetes.
32) Beta (Bēṭa, Beṭa):
Beta refers to beta cells in the pancreas responsible for insulin production. The study's focus on enhancing beta cell function through ingredients like Gymnema sylvestre underscores the biochemical mechanisms targeted by Ayurvedic formulations in improving insulin sensitivity and managing blood sugar levels effectively.
33) Male (Mālē):
Male denotes gender specifications within the patient population analyzed in the study. Including both male and female participants emphasizes the study's goal of providing comprehensive insights into the effectiveness of GlucoCare capsules and asserting its applicability across demographic variations in diabetes management.
34) Pain (Paiṇ):
Pain refers to the discomfort that may occur in diabetic patients, often linked to neuropathy or circulation issues. Addressing pain relief in the context of GlucoCare highlights the formulation's role in improving quality of life for individuals with NIDDM, showcasing holistic management strategies.
35) Hand:
Hand represents a common site where symptoms like numbness or burning may be experienced in diabetic patients due to neuropathy. This focus on symptoms in the hands further informs the treatment efficacy of GlucoCare capsules, aiming to enhance overall well-being among individuals affected by NIDDM.
36) Post:
Post signifies the postprandial (after eating) measurement of blood glucose levels, critical in assessing diabetes control. The study observes glucose levels both fasting and post-prandial to evaluate the overall effectiveness of GlucoCare in managing blood sugar fluctuations inherent in diabetes.
37) Tinospora cordifolia:
Tinospora cordifolia, also known as Guduchi, is an Ayurvedic herb known for its immunomodulating and hypoglycemic properties. Its incorporation into GlucoCare capsules supports enhanced glucose metabolism and overall metabolic function in managing diabetes, illustrating Ayurveda's rich botanical heritage in contemporary health solutions.
38) Zingiber officinale:
Zingiber officinale, or ginger, is recognized for its anti-inflammatory and antioxidant effects. In GlucoCare capsules, ginger may support digestive health and contribute to overall wellbeing, enhancing the formulation's capacity to address various symptoms associated with diabetes while promoting metabolic balance.
39) Emblica officinalis:
Emblica officinalis, also known as Amla, is a potent antioxidant known for its hypoglycemic effects. Found in GlucoCare capsules, its inclusion emphasizes Ayurveda's reliance on herbal constituents that can boost metabolic health and enhance immune function in patients dealing with diabetes.
40) Glycyrrhiza glabra:
Glycyrrhiza glabra, or licorice, possesses anti-inflammatory and hypoglycemic properties. Its presence in GlucoCare capsules underscores the formulation’s holistic approach to managing diabetes and improving patients' metabolic profiles, showcasing how traditional herbs with therapeutic potential are integrated into contemporary treatment strategies.
41) Terminalia chebula:
Terminalia chebula, commonly known as Haritaki, is regarded for its gastrointestinal benefits and metabolic regulation. As a component of GlucoCare, it contributes to the formulation's effectiveness in managing blood sugar levels, highlighting Ayurveda's comprehensive strategy toward promoting digestive health alongside blood glucose control.
42) Commiphora wightii:
Commiphora wightii, or Guggulu, is primarily known for its cholesterol-lowering and anti-inflammatory properties. Its incorporation into GlucoCare capsules emphasizes the formulation's multi-faceted approach to managing diabetes by addressing lipid profiles and overall metabolic health while exhibiting cultural significance within Ayurveda.
43) Ocimum sanctum:
Ocimum sanctum, or Tulsi, is revered in Ayurveda for its medicinal properties, including stress reduction and blood sugar management. Its inclusion in GlucoCare capsules enhances the formulation's potential to support holistic improvement in health outcomes, emphasizing Ayurveda’s focus on integrating stress response with diabetes management.
44) Curcuma longa:
Curcuma longa, or turmeric, is acclaimed for its anti-inflammatory properties and benefits in metabolic disorders. In GlucoCare capsules, it plays a role in improving inflammatory markers tied to diabetes, advocating for the inclusion of Ayurvedic herbs in synergistic management approaches for metabolic health.
45) Piper longum:
Piper longum, or long pepper, is recognized for its role in enhancing bioavailability and supportive effects on digestion. In GlucoCare capsules, it may facilitate the absorption of other herbs, ensuring that the therapeutic effects on glucose metabolism are maximized, aligning with Ayurveda's holistic practices.
46) Asparagus racemosus:
Asparagus racemosus, known as Shatavari, is valued for its adaptogenic and nutritive properties. In GlucoCare capsules, it contributes to balancing hormonal functions, which can positively influence diabetic patients' overall well-being, reinforcing Ayurveda's focus on individualized care through plant-based solutions.
47) Tribulus terrestris:
Tribulus terrestris, or Gokshura, is recognized for its potential role in reducing blood glucose levels. Its inclusion in GlucoCare capsules highlights the formulation’s overall efficacy, reflecting Ayurveda's integration of diverse plants into therapeutic regimens for addressing complications associated with diabetes.
48) Gmelina arborea:
Gmelina arborea is noted for its traditional use and hypoglycemic effects in managing diabetes. Its incorporation into GlucoCare capsules signifies urgent research into lesser-known yet effective Ayurveda-derived compounds, aiding in holistic interventions designed for improving blood sugar management in diabetic populations.
49) Syzygium cumini:
Syzygium cumini, known as jambolan, is acclaimed for its blood glucose-lowering effects and antioxidant properties. By including this herb in GlucoCare, the formulation aims to enhance overall efficacy in managing diabetes, exemplifying the utilization of traditional knowledge in contemporary health practices.
50) Kaphadosha (Kaphadoṣa, Kapha-dosha):
Kapha-dosha refers to the body constitution associated with qualities such as stability and heaviness underlying certain types of diabetes. Understanding Kapha-dosha helps practitioners relate doshic balance to health outcomes, enabling targeted treatments that address both the grounded nature of patients and their metabolic needs.
51) Developing:
Developing indicates the ongoing research and advancements in understanding diabetes and its management. The study contributes to the growing body of knowledge regarding Ayurvedic formulations, supporting the evolution of effective treatment strategies that integrate traditional medicine with modern scientific insights.
52) Science (Scientific):
Scientific pertains to the evidence-based approach used to evaluate the efficacy and safety of GlucoCare capsules. The application of scientific methods reinforces the credibility of alternative therapies like Ayurveda, fostering broader acceptance and integration into mainstream healthcare practices for conditions such as diabetes.
53) Punarnava (Punarnavā, Punarṇava, Punar-nava):
Punarnava, or Boerhaavia diffusa, is valued for its detoxifying and diuretic properties. Inclusion in GlucoCare capsules emphasizes its role in managing diabetically induced complications, showcasing the multifaceted nature of Ayurvedic formulations in addressing both blood sugar control and associated health challenges.
54) Composite:
Composite describes the overall arrangement of various herbal components within GlucoCare capsules. Each ingredient's unique properties work synergistically to tackle symptoms of NIDDM, illustrating Ayurveda's philosophy of holistic healing through carefully formulated combinations of plants addressing complex health issues efficiently.
55) Ayurveda (Āyurveda, Ayus-veda):
Ayurveda is an ancient system of medicine emphasizing holistic health, balance, and preventive care. The study on GlucoCare capsules highlights Ayurveda's relevance in contemporary health, showcasing its potential as a safe, natural alternative in managing chronic conditions like diabetes through targeted herbal interventions.
56) Shilajit (Śilājit, Shila-jit):
Shilajit, a natural exudate from rocks, is revered in Ayurvedic medicine for its energizing properties and therapeutic potential. Its incorporation into GlucoCare capsules highlights the holistic approach to diabetes management, capitalizing on traditional treasures to bolster health and improve outcomes for diabetic patients.
57) Triphala (Triphalā, Tri-phala):
Triphala, a well-known Ayurvedic formulation derived from three fruits, is noted for its digestive and detoxifying properties. In GlucoCare, its inclusion signifies a focus not only on blood sugar control but also overall digestive health, aligning with Ayurveda's comprehensive treatment philosophy.
58) Tamalaki (Tāmalakī, Tamālaki):
Tamalaki, or Phyllanthus amarus, is acknowledged for its liver protective and hypoglycemic effects. Its presence in GlucoCare capsules emphasizes the herbal formulation's scope in managing diabetes, highlighting Ayurveda’s extensive repository of medicinal plants with therapeutic benefits for metabolic health.
59) Gokshura (Gokṣura, Go-kshura):
Gokshura, also known as Tribulus terrestris, is utilized in Ayurveda for its adaptogenic properties and its potential effects on blood glucose. Its addition to GlucoCare capsules reflects the integration of scientifically supported herbal remedies to enhance diabetes management and reduce complications associated with the condition.
60) Shatavari (Śatāvarī, Satāvarī):
Satavari or Asparagus racemosus is recognized in Ayurveda as a rejuvenative herb. In GlucoCare capsules, its calming and nourishing properties are leveraged to support hormonal balance, thereby further contributing to holistic diabetes management by addressing underlying stresses that affect metabolic health.
61) Toxicity:
Toxicity refers to the potential adverse effects of a drug or supplement. In the context of the study, ensuring low toxicity levels for GlucoCare capsules emphasizes the safety aspect, establishing trust and reliability in Ayurvedic formulations as viable therapeutic options for managing NIDDM.
62) Mountain:
Mountain signifies the geographical origin of certain Ayurvedic herbs, including Shilajit, which is sourced from mountainous regions. This connection highlights the natural environmental components key to traditional herb-based medicine, underpinning the unique properties these plants may have on health and disease management.
63) Turmeric:
Turmeric, or Curcuma longa, is notable for its active compound curcumin, recognized for potent anti-inflammatory effects. Its inclusion in GlucoCare capsules adds significant therapeutic potential, reinforcing Ayurveda's principles by offering natural solutions to manage inflammatory pathways implicated in diabetes.
64) Pregnant:
Pregnant indicates a specific exclusion criterion in the study, recognizing that certain treatments or formulations may not be suitable during pregnancy. This precaution emphasizes the need for safety protocols in clinical research to ensure the health of both the mother and the developing fetus.
65) Liquorice (Licorice):
Licorice, or Glycyrrhiza glabra, is important for its soothing and anti-inflammatory properties. Its role in GlucoCare capsules illustrates how Ayurvedic formulations leverage herbal profiles to promote not only glycemic control but also overall well-being, effectively addressing the multifaceted challenges of diabetes.
66) Guggulu:
Guggulu, derived from Commiphora wightii, is noted for its lipid-modulating properties. In GlucoCare, its inclusion accentuates the formulation’s comprehensive approach to diabetes management by not only addressing blood sugar levels but also contributing to better lipid profiles and metabolic health.
67) Atibala (Atibalā, Atibālā):
Atibala, or Abutilon indicum, is recognized for its beneficial effects, particularly in wound healing and managing diabetic complications. Including this herb in GlucoCare capsules showcases Ayurveda’s extensive benefits and the careful selection of herbal constituents targeted at enhancing health outcomes for diabetes.
68) Karpasa (Kārpāsa, Karpāsa):
Karpasa, or Gossypium herbaceum, is traditionally known to assist in managing blood sugar levels. Its presence in GlucoCare underlines the formulation's holistic and synergistic properties, reflecting Ayurveda's medicinal plant knowledge in addressing complex health issues like diabetes effectively.
69) Trikatu (Trikaṭu, Tri-katu):
Trikatu, a traditional blend of three spices (Piper longum, Piper nigrum, Zingiber officinale), enhances bioavailability and digestive functions. This formulation aspect within GlucoCare caters to better absorption of active compounds, ensuring the therapeutic benefits are maximized, a key principle of Ayurvedic practices.
70) Vriddhi (Vṛddhi):
Vriddhi refers to the state of increase or enhancement in Ayurveda, important in understanding health improvements over time. Evaluating Vriddhi in patients taking GlucoCare capsules signifies ongoing efforts to enhance therapeutic outcomes and overall well-being in diabetes management.
71) Chennai:
Chennai is a major city in India highlighted in the context of diabetes epidemiology, where studies have captured the rising prevalence rates. The city's demographic significance informs healthcare strategies, prompting exploration of effective treatments like GlucoCare to mitigate diabetes challenges in urban populations.
72) Allergy:
Allergy indicates potential reactions to medications or formulations, underscoring the need for comprehensive patient evaluations in studies. The study’s exclusion of patients with known allergies to ingredients ensures participant safety while validating the inclusion criteria aligned with ethical research practices.
73) Itching:
Itching is often associated with skin conditions that can complicate diabetes management. Addressing itching in diabetic patients through GlucoCare emphasizes the holistic approach of the formulation, aiming not only at glycemic control but also alleviating associated skin issues for improved quality of life.
74) Tulasi (Tulasī):
Tulasi (Ocimum sanctum) is an important herb in Ayurveda known for its numerous health benefits, including blood sugar regulation. In GlucoCare capsules, Tulasi reinforces the formulation’s potential to address various metabolic health concerns, exemplifying the significance of traditional herbs in managing diabetes.
75) Marica (Marīca, Mārīca, Mārica):
Marica or black pepper (Piper nigrum) is included in Ayurvedic formulations for its calorific processes and enhancing absorption of other herbs. Its addition to GlucoCare capsules underscores the formulation’s strategy to maximize therapeutic effects while aligning with Ayurvedic principles of synergistic healing.
[Note: The above list is limited to 75. Total glossary definitions available: 87]
Other Science Concepts:
Discover the significance of concepts within the article: ‘Clinical evaluation of GlucoCare in non-insulin dependent diabetes.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Madhumeha, Medicinal herb, Clinical examination, Adverse effect, Diabetes mellitus, Statistical analysis, Symptomatic relief, Ayurvedic formulation, Patient withdrawal, Placebo group, Insulin resistance, Combination therapy, Hypoglycemic activity, Glycemic control, Glycosylated hemoglobin, Pitta Kapha Prakriti, Types of Diabetes mellitus, Prevalence of diabetes, Non Insulin Dependent Diabetes Mellitus (NIDDM), Fasting Plasma Glucose (FPG), Microvascular and Macrovascular Complications, Acute manifestation, Post-prandial glucose (PPG), Compliance with medication.