Amelioration of Nicotine-Induced Damage of Blood Cells in Protein...

[Full title: Amelioration of Nicotine-Induced Damage of Blood Cells in Protein Malnourished Female Rats by Curcumin]

(A) (B) (C)

0.6 0.5 0.4 0.3 0.2 0.1 0.0 Optical density N (500 µM) N+C (16.6 µM) N+C(36.6 µM) N+C(56.6 µM) N+C (66.6 µM) N+C(76.6 µM) N+C(86.6 µM) N+C(96.6 µM) 230 240 250 260 270 280 290 300 Wavelength (nm) 0.01 0.012 0.013 0.015 0.018 0.021 0.027 0.037 1/C (µM¯ 1 ) 10 8 6 4 2 0 1/ ∆ A ° (A) DNA DNA+N(50 nM) DNA+N(100 µM) DNA+N(1 mM) DNA+N(500 µM) 0.45 0.35 0.25 0.15 0.05 0.00 230 240 250 260 270 280 290 300 Wavelength (nm) DNA DNA*+C(100 µM) DNA*+C(76.6 µM) DNA*+C(36.6 µM) DNA*+C(3.3 µM) DNA+N(500 µM) 0.45 0.35 0.25 0.15 0.05 0.00 230 240 250 260 270 280 290 300 Wavelength (nm) Optical density Optical density (B) (C) θ ( mdeg) 5 4 3 2 1 0 -1 -2 -3 -4 -5 -6 -7 -8 200 220 240 260 280 300 320 340 Wavelength (nm) (DNA) Curcumin 5 4 3 2 1 0 -1 -2 -3 -4 -5 -6 -7 -8 201 220 240 260 280 300 320 340 Wavelength (nm) θ ( mdeg) 5 4 3 2 1 0 -1 -2 -3 -4 -5 -6 -7 -8 202 220 240 260 280 300 320 340 Wavelength (nm) θ ( mdeg) DNA DNA +500 µM nicotine DNA+100 µM nicotine DNA+1 µM nicotine DNA DNA+1 mM nicotine +78 µM curcumin DNA+1 mM nicotine +37 µM curcumin DNA+1 mM nicotine (A) (B) (C) Nicotine

p 53 consensus sequence Nicotine Pseudo bonds (A) Pseudo bonds p 53 consensus sequence Free energy: -163.74 kcal Free energy: -272.74 kcal Curucumin Nicotine Curucumin Pseudo bonds Free energy change: -129.02 kcal (B) (C) (D) Free energy change: -175.18 kcal Pseudo bonds Nicotine Chain A Chain B Albumin Pseudo bonds Chain B Chain A Curucumin Pseudo bonds Free energy change: -310.65 kcal (E) Albumin

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