Comparative antitussive activity of kantakari avaleha and its granules in swiss albino mice – in vivo study

Summary of article contents:

Kantakari Avaleha (KA) is used for respiratory systemrelated diseases in Ayurveda. Kantakari Kwatha (Decoction of Solanum xanthocarpum ) and other 15 herbal ingredients are included in this formulation. KA was converted into Kantakari Avaleha granules (KAG) to increase its palatability. Most of the ingredients included in this formula are shown in Antiasthmatic effects which have been pharmacologically proven. But there are no published Pharmacological details regarding the antitussive activity of Kantakari Avaleha as one medicine. Furthermore, KAG is a modified dosage form, it needs a comparative study of both dosage forms. Aim and Objectives: To evaluate the antitussive activity of (KA) and its Granules (KAG) in Swiss albino mice. Method: KA and KAG were prepared in the laboratory of Bhaishajya Kalpana and Swiss albino mice of either sex were obtained from the Animal house attached to the Pharmacology laboratory of ITRA, GAU, Jamnagar, after taking the approval of Institutional Animal Ethical Comity (IAEC/25/2019/04). Experimental Models were antitussive activity against SO 2-induced cough reflexes. The dose selection was done based on the body surface area ratio using the table of Paget and Barnes (1969). Results: Both the groups of KA and KAG treated produced a statistically significant (P<0.05) decrease in cough reflex in comparison to the control group. There was no significant difference in efficacy between the two test drugs treated groups. Conclusion: Both the medicine KA and KAG have an antitussive effect and hence Kantakari Avaleha granules can be substituted for Kantakari Avaleha. Keywords: Antitussive effect, Bronchial asthma, Kantakari Avaleha , Kantakari Avaleha Granule , Swiss albino mice INTRODUCTION Kantakari Avaleha