Toxicological study of udayabhaskara rasa

Summary of article contents:

Udayabhaskara rasa is a herbomineral preparation that contains Gandhakamarita Tamra Bhasma, Shu. Vatsanabha and Maricha explained in RasendraSara Sangraha in Kushtaroga Chikitsa adhyaya 1 Despite having therapeutic utility there is hesitation in accepting the usage of heavy metals like Copper ( Tamra ), a poisonous drug like Aconitum ferox ( Vatsanabha ) and Sulphur ( Gandhaka )also can cause poisonous effects if it is used in more quantity. As Rasashastra holds a valid response of drugdesigning and analysing with a vision to produce safe drugs. This yoga also has the necessity of proving its safety in the global scenario of recent times. So, this research work is an attempt to perform an acute and subacute toxicity study of Udayabhaskara rasa . An acute toxicity study of the test drug was carried out at the dose of 2000 mg/kg,550 mg/kg.175 mg/kh bw po orally in albino mice. For subacute toxicity udayabhaskara rasa was administered at therapeutic equivalent dose (TED) (0.35 mg/kg bw po), TEDx 2(0.70 mg/kg bw po), TEDx 5(1.75 mg/kg bw po) for 28 days. Acute toxicity results showed that the drug produces signs and symptoms of toxicity and mortality up to an oral dose of 550 mg/kg BW Po. The data generated during the subacute oral toxicity study indicated that udayabhaskara rasa is mildly toxic in the administration of the TED dose level. Keywords: Udayabhaskara rasa , Acute toxicity study, Sub Acute study INTERNATIONAL AYURVEDIC MEDICAL JOURNAL Amritha Surendran