Evaluation of immunomodulatory activity of the hydroalcoholic extracts of pterospermum acerifolium flowers in wistar rats

Summary of article contents:

Background: Pterospermum acerifolium Linn ous parts of this tree have been traditionally used as ethno medicine for a number of disorders including cancer. Most of immunostimulants and immunosuppressants in There is a growing interest to use herbal medicines as multi in the prevention of infections rather than treating the immune plant origin as new leads for development of potent and safe immunomodulator agents is gaining much major research interest. Aims and Objectives: The present study was conducted to evaluate the immunolic flower extract of Pterospermum acerifolium in Wistar ratstracts of Pterospermum acerifolium flower were subjected to preliminary phyto 500 mg/kg oral dose were selected for the study after conducting the acute dose toxicity study. We have used neutrophil adhesion test, haem agglutination antibody titre test, delayed standard immunomodulatory agent and Distilled water served as a control in all the tests. the successive methanol extract was found to exhibit a dose related increase in the hypersensitivity reaction, to the SRBC antigen, at concentrations of 200 and 500 mg/kg. It also resulted in a significant increase in the antibody titre value, to SRBC, at doses of 200 and 500 mg/kg in animal studies. There was an increment in WBC, lymphocyte, and neutrophil counts at a dose of 500 mg/kg body weight similar to the levamisole. The neutrophil adhesion was statistically significant (p ≤ 0.05) for treatment groups that received 200 mg/kg bwt (25.73%) and 500 mg/kg bwt at 29.05%. The mean incr ment in footpad thickness was high (3.60±0.064 mm) af mg/kg bwt and this later reduced to (1.52±0.28 mm) after 24 h. There was a dose agglutination antibody titre to sheep red blood cells (SRBC) from 17.50±1. 24.35±1.36 HA units/μL for the 500 mh/kg body weight. standard drug levamisole. Pterospermum acerifoliumand prevention of selected human diseases such as cancer, allergic disorders, and may also serve as immunoadjuvant for vaccine therapy. Keywords: hemagglutination, immunostimulant, sterculiaceae, wistar albino rats INTRODUCTION System of medicines like Ayurveda gives emphasis on promotion of health through strengthening host defences against different diseases