Open controlled clinical study evaluating the therapeutic effect of bakuchi rasayana in shwitra

Summary of article contents:

Objective: To evaluate the therapeutic efficacy of Bakuchi Rasayana in the remission of the symptoms of Shwitra /Vitiligo, to evaluate the therapeutic efficacy of Shashilekha Vati in the remission of the symptoms of Shwitra/Vitiligo and to compare the effect of Bakuchi Rasayana and Shashilekha Vati in bringing symptomatic relief in the patients of Shwitra /Vitiligo. Design: Open controlled clinicalstudy with pre and posttest design. Setting: I.P.D. of Shri Dharmasthala Manjunatheshwara College of Ayurveda & Hospital, Udupi. Participants: 27 patients diagnosed with Shwitra. Interventions: The patients selected were randomly divided into 2 groups by adapting open labelled randomization method. Bakuchi Rasayana Group: 15 patients were treated with Bakuchi Rasayana for a period of 30 days with the anupana of 24 ml of Gomutraarka during morning in empty stomach for 30 days Shashilekha vati Group: 12 patients were treated by orally administration of Tab Shashilekha vati , 125 mg, tid with anupana of Bakuchi taila 10 ml, during morning in empty stomach for 30 days. Main outcome measures: The response following the intervention was assessed every month by adapting the scoring method for colour, size, number, percentage of body area involved. Further the changes are assessed by adapting VETI score. Finally the changes observed at completion of the treatment were subjected to paired t test, unpaired t test to know the statistical significance. Results: Bakuchi Rasayana and Shashilekha Vati are effective in the remission of the symptoms of Shwitra as evidenced by statistically significant reduction in the symptom score of various subjective and objective parameters. Interpretation & Conclusion: Bakuchi Rasayana and Shashilekha Vati are effective in the remission of the symptoms of Shwitra as evidenced by statistically significant reduction in the symptom score of various subjective and objective parameters. The effectiveness of the Bakuchi Rasayana is supreme in comparison to that of Shashilekha Vati as evidenced by the various outcome measures and the statistical analysis shows that it is significant INTERNATIONAL AYURVEDIC MEDICAL JOURNAL International Ayurvedic Medical Journal, ( ISSN: 2320 5091) (September, 2017) 5(9) OPEN CONTROLLED CLINICAL STUDY EVALUATING THE THERAPEUTIC EFFECT OF BAKUCHI RASAYANA IN SHWITRA Amit Rathi 1 , G Shrinivasa Acharya 2 , Aniruddha 3 1 Final year PG Scholar, 2 Professor and Head, 3 Associate Professor,Post Graduate Department of Kayachikitsa and Manasaroga, Shri Dharmasthala Manjunatheshwara College of Ayurveda, Kuthpady, Udupi, Karnataka, India Email: dr.amitrathiosk@gmail.com ABSTRACT Objective: To evaluate the therapeutic efficacy of Bakuchi Rasayana in the remission of the symptoms of Shwitra /Vitiligo, to evaluate the therapeutic efficacy of Shashilekha Vati in the remission of the symptoms of Shwitra/Vitiligo and to compare the effect of Bakuchi Rasayana and Shashilekha Vati in bringing symptomatic relief in the patients of Shwitra /Vitiligo. Design: Open controlled clinicalstudy with pre and posttest design. Setting: I.P.D. of Shri Dharmasthala Manjunatheshwara College of Ayurveda & Hospital, Udupi. Participants: 27 patients diagnosed with Shwitra. Interventions: The patients selected were randomly divided into 2 groups by adapting open labelled randomization method. Bakuchi Rasayana Group: 15 patients were treated with Bakuchi Rasayana for a period of 30 days with the anupana of 24 ml of Gomutraarka during morning in empty stomach for 30 days Shashilekha vati Group: 12 patients were treated by orally administration of Tab Shashilekha vati , 125 mg, tid with anupana of Bakuchi taila 10 ml, during morning in empty stomach for 30 days. Main outcome measures: The response following the intervention was assessed every month by adapting the scoring method for colour, size, number, percentage of body area involved. Further the changes are assessed by adapting VETI score. Finally the changes observed at completion of the treatment were subjected to paired t test, unpaired t test to know the statistical significance. Results: Bakuchi Rasayana and Shashilekha Vati are effective in the remission of the symptoms of Shwitra as evidenced by statistically significant reduction in the symptom score of various subjective and objective parameters. Interpretation & Conclusion: Bakuchi Rasayana and Shashilekha Vati are effective in the remission of the symptoms of Shwitra as evidenced by statistically significant reduction in the symptom score of various subjective and objective parameters. The effectiveness of the Bakuchi Rasayana is supreme in comparison to that of Shashilekha Vati as evidenced by the various outcome measures and the statistical analysis shows that it is significant INTERNATIONAL AYURVEDIC MEDICAL JOURNAL International Ayurvedic Medical Journal, ( ISSN: 2320 5091) (September, 2017) 5(9) OPEN CONTROLLED CLINICAL STUDY EVALUATING THE THERAPEUTIC EFFECT OF BAKUCHI RASAYANA IN SHWITRA Amit Rathi 1 , G Shrinivasa Acharya 2 , Aniruddha 3 1 Final year PG Scholar, 2 Professor and Head, 3 Associate Professor,Post Graduate Department of Kayachikitsa and Manasaroga, Shri Dharmasthala Manjunatheshwara College of Ayurveda, Kuthpady, Udupi, Karnataka, India Email: dr.amitrathiosk@gmail.com ABSTRACT Objective: To evaluate the therapeutic efficacy of Bakuchi Rasayana in the remission of the symptoms of Shwitra /Vitiligo, to evaluate the therapeutic efficacy of Shashilekha Vati in the remission of the symptoms of Shwitra/Vitiligo and to compare the effect of Bakuchi Rasayana and Shashilekha Vati in bringing symptomatic relief in the patients of Shwitra /Vitiligo. Design: Open controlled clinicalstudy with pre and posttest design. Setting: I.P.D. of Shri Dharmasthala Manjunatheshwara College of Ayurveda & Hospital, Udupi. Participants: 27 patients diagnosed with Shwitra. Interventions: The patients selected were randomly divided into 2 groups by adapting open labelled randomization method. Bakuchi Rasayana Group: 15 patients were treated with Bakuchi Rasayana for a period of 30 days with the anupana of 24 ml of Gomutraarka during morning in empty stomach for 30 days Shashilekha vati Group: 12 patients were treated by orally administration of Tab Shashilekha vati , 125 mg, tid with anupana of Bakuchi taila 10 ml, during morning in empty stomach for 30 days. Main outcome measures: The response following the intervention was assessed every month by adapting the scoring method for colour, size, number, percentage of body area involved. Further the changes are assessed by adapting VETI score. Finally the changes observed at completion of the treatment were subjected to paired t test, unpaired t test to know the statistical significance. Results: Bakuchi Rasayana and Shashilekha Vati are effective in the remission of the symptoms of Shwitra as evidenced by statistically significant reduction in the symptom score of various subjective and objective parameters. Interpretation & Conclusion: Bakuchi Rasayana and Shashilekha Vati are effective in the remission of the symptoms of Shwitra as evidenced by statistically significant reduction in the symptom score of various subjective and objective parameters. The effectiveness of the Bakuchi Rasayana is supreme in comparison to that of Shashilekha Vati as evidenced by the various outcome measures and the statistical analysis shows that it is significant INTERNATIONAL AYURVEDIC MEDICAL JOURNAL Amit Rathi Et Al:Open Controlled Clinical Study Evaluating The Therapeutic Effect Of Bakuchi Rasayana In Shwitra IAMJ: SEPTEMBER, 2017 3267 Keywords: Shwitra, Bakuchi Rasayana, Shashilekha Vati , Vitiligo INTRODUCTION In Ayurvedic classics Kushta is considered as an important disease and is categorized as Maharoga