Open pragmatic clinical trial evaluating the effect of virechana karma and tuvaraka rasayana in ekakushta/ psoriasis

Summary of article contents:

Objective: To evaluate the remission of the symptoms of Ekakushta / psoriasis in patients treated with Virechana karma followed by Tuvaraka Rasayana. Design of Study: It is an open pragmatic clinical study with pre test post test design. Settings: SDM Hospital of Ayurveda, Udupi, Karnataka. Sample Selection: 20 patients suffering from Ekakushta /Psoriasis were selected for the study during the period of November 2013 to march 2014. Intervention: Selected patients were treated with Kramataha Virechana karma followed by Tuvaraka Rasayana . Main Outcome of Measures: The response following the intervention was assessed before and after the treatment by adapting the individual symptom score and PASI scoring method. Further the changes observed by the completion of the treatment were subjected to paired t test to know the statistical significance. Results: The administration of the Virechana and Tuvaraka Rasayana proved to be effective in decreasing the severity of symptoms. There was marked reduction in the mean score of anhydrosis from 0.700 to 0.150 after treatment. The reduction in severity was statistically significant. The criteria of Pruritis showed improvement by reduction in mean score from 2.600 before treatment to 0.600 after treatment which was statistically highly significant. The symptom of desquamation before treatment was 3.404 which reduced to 0.613 after treatment which was statistically highly significant. Infiltration in the lesion was reduced from 3.292 before treatment to 0.559 after treatment and was statistically highly significant. The Erythema showed improvement by reduction in mean score from 3.163 to 0.783 after treatment, was statistically highly significant. The PASI scoring showed reduction in mean score from 23.512 before treatment to 4.885 after treatment which was statistically highly significant. Also, an overall improvement of 81.10% was observed in the present clinical trial INTERNATIONAL AYURVEDIC MEDICAL JOURNAL International Ayurvedic Medical Journal, ( ISSN: 2320 5091) (August, 2017) 5(8) OPEN PRAGMATIC CLINICAL TRIAL EVALUATING THE EFFECT OF VIRECHANA KARMA AND TUVARAKA RASAYANA IN EKAKUSHTA/ PSORIASIS Neeraj Sahu 1 , Shrilatha Kamath 2 , Pranavi K. 3 , V. K. Sridhar Holla 4 1 PG Scholar, Department of Kayachikitsa 2 Professor PG Department of Kayachikitsa and Manasa Roga 3 Consultant doctor 4 Professor, Department of Post Graduate Studies in KayachikitsaShri Dharamsthala Manjunatheshwara College of Ayurveda, Udupi, Karnataka, India Email: nsneerajsahu 67@gmail.com ABSTRACT Objective: To evaluate the remission of the symptoms of Ekakushta / psoriasis in patients treated with Virechana karma followed by Tuvaraka Rasayana. Design of Study: It is an open pragmatic clinical study with pre test post test design. Settings: SDM Hospital of Ayurveda, Udupi, Karnataka. Sample Selection: 20 patients suffering from Ekakushta /Psoriasis were selected for the study during the period of November 2013 to march 2014. Intervention: Selected patients were treated with Kramataha Virechana karma followed by Tuvaraka Rasayana . Main Outcome of Measures: The response following the intervention was assessed before and after the treatment by adapting the individual symptom score and PASI scoring method. Further the changes observed by the completion of the treatment were subjected to paired t test to know the statistical significance. Results: The administration of the Virechana and Tuvaraka Rasayana proved to be effective in decreasing the severity of symptoms. There was marked reduction in the mean score of anhydrosis from 0.700 to 0.150 after treatment. The reduction in severity was statistically significant. The criteria of Pruritis showed improvement by reduction in mean score from 2.600 before treatment to 0.600 after treatment which was statistically highly significant. The symptom of desquamation before treatment was 3.404 which reduced to 0.613 after treatment which was statistically highly significant. Infiltration in the lesion was reduced from 3.292 before treatment to 0.559 after treatment and was statistically highly significant. The Erythema showed improvement by reduction in mean score from 3.163 to 0.783 after treatment, was statistically highly significant. The PASI scoring showed reduction in mean score from 23.512 before treatment to 4.885 after treatment which was statistically highly significant. Also, an overall improvement of 81.10% was observed in the present clinical trial INTERNATIONAL AYURVEDIC MEDICAL JOURNAL International Ayurvedic Medical Journal, ( ISSN: 2320 5091) (August, 2017) 5(8) OPEN PRAGMATIC CLINICAL TRIAL EVALUATING THE EFFECT OF VIRECHANA KARMA AND TUVARAKA RASAYANA IN EKAKUSHTA/ PSORIASIS Neeraj Sahu 1 , Shrilatha Kamath 2 , Pranavi K. 3 , V. K. Sridhar Holla 4 1 PG Scholar, Department of Kayachikitsa 2 Professor PG Department of Kayachikitsa and Manasa Roga 3 Consultant doctor 4 Professor, Department of Post Graduate Studies in KayachikitsaShri Dharamsthala Manjunatheshwara College of Ayurveda, Udupi, Karnataka, India Email: nsneerajsahu 67@gmail.com ABSTRACT Objective: To evaluate the remission of the symptoms of Ekakushta / psoriasis in patients treated with Virechana karma followed by Tuvaraka Rasayana. Design of Study: It is an open pragmatic clinical study with pre test post test design. Settings: SDM Hospital of Ayurveda, Udupi, Karnataka. Sample Selection: 20 patients suffering from Ekakushta /Psoriasis were selected for the study during the period of November 2013 to march 2014. Intervention: Selected patients were treated with Kramataha Virechana karma followed by Tuvaraka Rasayana . Main Outcome of Measures: The response following the intervention was assessed before and after the treatment by adapting the individual symptom score and PASI scoring method. Further the changes observed by the completion of the treatment were subjected to paired t test to know the statistical significance. Results: The administration of the Virechana and Tuvaraka Rasayana proved to be effective in decreasing the severity of symptoms. There was marked reduction in the mean score of anhydrosis from 0.700 to 0.150 after treatment. The reduction in severity was statistically significant. The criteria of Pruritis showed improvement by reduction in mean score from 2.600 before treatment to 0.600 after treatment which was statistically highly significant. The symptom of desquamation before treatment was 3.404 which reduced to 0.613 after treatment which was statistically highly significant. Infiltration in the lesion was reduced from 3.292 before treatment to 0.559 after treatment and was statistically highly significant. The Erythema showed improvement by reduction in mean score from 3.163 to 0.783 after treatment, was statistically highly significant. The PASI scoring showed reduction in mean score from 23.512 before treatment to 4.885 after treatment which was statistically highly significant. Also, an overall improvement of 81.10% was observed in the present clinical trial INTERNATIONAL AYURVEDIC MEDICAL JOURNAL Neeraj Sahu Et Al: Open Pragmatic Clinical Trial Evaluating The Effect Of Virechana Karma And Tuvaraka Rasayana In Ekakushta/Psoriasis IAMJ: AUGUST, 2017 2777 Keywords: Ekakushta , Psoriasis, Virechana karma, Tuvaraka Rasayana