Sesamin - an active lignin compound from psilanthes travencorensis, a member of rubiaceae

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Psilanthustravancorensis (Wt. & Arn.) Leroy (Rubiaceae), a medicinal plant, as it popularly called ‘Pushkaramulla’, is distributed in southern Western Ghats in India and Sri Lanka The root is primarily used in Indian Systems of Medicine and folk medicines. However, no systematic documentation of the phytochemical constituents of the plant has been made till date. This paper reports the phytochemical screening of Psilanthustravancorensis (root) by qualitative and gas chromatographymass spectroscopy (GC-MS) analysis for the first time. The qualitative analysis of root has revealed the presence of alkaloids, flavonoids, glycosides, phenols, terpenoids and steroids. The GC-MS analysis of isolated fractions of the plant extract through column chromatography revealed the presence of so many active compounds such assantalol,eugenol,oleic acid, etc. An active e lignancompound namely sesamin{5, 5' -(tetrahydro 1 H, 3 H -furo [3,4-c-] furan-1, 4-diyl) bis-, [1 S-(1α, 3α, 4β, 6α)] 1,3-benzodioxole} was isolated,which is established as an inhibitor of pregnane X receptor (PXR) and reports show that this compound may be useful for modulating drugmetabolizing enzymes (DMEs) expression and drug efficacies. Besides these compounds, so many hydrocarbons, fatty acids, fatty acid esters, alcohols, ketones, aldehydes and phenolic compounds were identified. These different phytochemical constituents may be responsible for pharmacological activities of the plant. Keywords: Psilanthustravancorensis , phytochemical analysis, GC-MS How to cite this URL: V. Gayathri Devi Et Al: Sesamin - An Active Lignin Compound From Psilanthes Travencorensis, A Member Of Rubiaceae. International Ayurvedic medical Journal {online} 2016 {cited 2016 July} Available from:http://www.iamj.in/posts/images/upload/2890_2897.pdf SESAMIN - AN ACTIVE LIGNIN COMPOUND FROM PSILANTHES TRAVENCORENSIS , A MEMBER OF RUBIACEAE R. Sreekala Devi 1 , P.M. Radhamany 1 V. Gayathri Devi 2 1 R. Sreekala Devi, Research scolar, 1 Dr. P.M. Radhamany, Professor,Department of Botany, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, India 2 Dr. V. Gayathri Devi, Research Officer (Chemistry), Siddha Regional Research Institute,Poojappura, Thiruvananthapuram - 695012, Kerala, India INTRODUCTION Psilanthustravancorensis (Wt. &Arn.) Leroy belonging to the family Rubiaceae, whichis ofthe majorgroup Angiosperms (Flowering plants), is a medicinal plant popularlyknown as ‘ Pushkkaramulla ’ The plant is distributed insouthern Western Ghats in India and in Sri Lanka. The plant, a rare and endemic species, was abundant in the Kerala forest in the past, but now very scarce 2. The plant is alsoknown as cherumulla and kattumulla 1. Theroot is used in Indian systems of medicines and folk medicines. It is reported to cure anaemia, cardiac diseases, skin diseases, oedema and also diseases due to kapha and vata. A paste of the root is applied to indo- Review Article International Ayurvedic Medical Journal ISSN:2320 5091 ABSTRACT Psilanthustravancorensis (Wt. & Arn.) Leroy (Rubiaceae), a medicinal plant, as it popularly called ‘Pushkaramulla’, is distributed in southern Western Ghats in India and Sri Lanka The root is primarily used in Indian Systems of Medicine and folk medicines. However, no systematic documentation of the phytochemical constituents of the plant has been made till date. This paper reports the phytochemical screening of Psilanthustravancorensis (root) by qualitative and gas chromatographymass spectroscopy (GC-MS) analysis for the first time. The qualitative analysis of root has revealed the presence of alkaloids, flavonoids, glycosides, phenols, terpenoids and steroids. The GC-MS analysis of isolated fractions of the plant extract through column chromatography revealed the presence of so many active compounds such assantalol,eugenol,oleic acid, etc. An active e lignancompound namely sesamin{5, 5' -(tetrahydro 1 H, 3 H -furo [3,4-c-] furan-1, 4-diyl) bis-, [1 S-(1α, 3α, 4β, 6α)] 1,3-benzodioxole} was isolated,which is established as an inhibitor of pregnane X receptor (PXR) and reports show that this compound may be useful for modulating drugmetabolizing enzymes (DMEs) expression and drug efficacies. Besides these compounds, so many hydrocarbons, fatty acids, fatty acid esters, alcohols, ketones, aldehydes and phenolic compounds were identified. These different phytochemical constituents may be responsible for pharmacological activities of the plant. Keywords: Psilanthustravancorensis , phytochemical analysis, GC-MS How to cite this URL: V. Gayathri Devi Et Al: Sesamin - An Active Lignin Compound From Psilanthes Travencorensis, A Member Of Rubiaceae. International Ayurvedic medical Journal {online} 2016 {cited 2016 July} Available from:http://www.iamj.in/posts/images/upload/2890_2897.pdf SESAMIN - AN ACTIVE LIGNIN COMPOUND FROM PSILANTHES TRAVENCORENSIS , A MEMBER OF RUBIACEAE R. Sreekala Devi 1 , P.M. Radhamany 1 V. Gayathri Devi 2 1 R. Sreekala Devi, Research scolar, 1 Dr. P.M. Radhamany, Professor,Department of Botany, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, India 2 Dr. V. Gayathri Devi, Research Officer (Chemistry), Siddha Regional Research Institute,Poojappura, Thiruvananthapuram - 695012, Kerala, India INTRODUCTION Psilanthustravancorensis (Wt. &Arn.) Leroy belonging to the family Rubiaceae, whichis ofthe majorgroup Angiosperms (Flowering plants), is a medicinal plant popularlyknown as ‘ Pushkkaramulla ’ The plant is distributed insouthern Western Ghats in India and in Sri Lanka. The plant, a rare and endemic species, was abundant in the Kerala forest in the past, but now very scarce 2. The plant is alsoknown as cherumulla and kattumulla 1. Theroot is used in Indian systems of medicines and folk medicines. It is reported to cure anaemia, cardiac diseases, skin diseases, oedema and also diseases due to kapha and vata. A paste of the root is applied to indo- Review Article International Ayurvedic Medical Journal ISSN:2320 5091 ABSTRACT Psilanthustravancorensis (Wt. & Arn.) Leroy (Rubiaceae), a medicinal plant, as it popularly called ‘Pushkaramulla’, is distributed in southern Western Ghats in India and Sri Lanka The root is primarily used in Indian Systems of Medicine and folk medicines. However, no systematic documentation of the phytochemical constituents of the plant has been made till date. This paper reports the phytochemical screening of Psilanthustravancorensis (root) by qualitative and gas chromatographymass spectroscopy (GC-MS) analysis for the first time. The qualitative analysis of root has revealed the presence of alkaloids, flavonoids, glycosides, phenols, terpenoids and steroids. The GC-MS analysis of isolated fractions of the plant extract through column chromatography revealed the presence of so many active compounds such assantalol,eugenol,oleic acid, etc. An active e lignancompound namely sesamin{5, 5' -(tetrahydro 1 H, 3 H -furo [3,4-c-] furan-1, 4-diyl) bis-, [1 S-(1α, 3α, 4β, 6α)] 1,3-benzodioxole} was isolated,which is established as an inhibitor of pregnane X receptor (PXR) and reports show that this compound may be useful for modulating drugmetabolizing enzymes (DMEs) expression and drug efficacies. Besides these compounds, so many hydrocarbons, fatty acids, fatty acid esters, alcohols, ketones, aldehydes and phenolic compounds were identified. These different phytochemical constituents may be responsible for pharmacological activities of the plant. Keywords: Psilanthustravancorensis , phytochemical analysis, GC-MS How to cite this URL