Assessment of the anti-inflammatory effect of a folklore medicinal plant – tiliacora acuminata miers

Summary of article contents:

The plant Tiliacora acuminata is a Menispermaceae member found all over India. The plant is well known for its folklore uses as an analgesic and antiinflammatory drug. Diclofenac sodium was used as the standard drug and the test drug used was the kashaya (decoction) of the whole plant. Both the test drug and the standard drug in the corresponding doses were administered orally to the respective groups for 5 consecutive days. 24 hours after the 5 th dose oedema was induced in the left hind paw of all the animals using 20µl of 1%carageenan in normal saline. The paw thickness measurement was taken using vernier calipers before induction, just after injection of carageenan, then every hour upto the 6 th hour and then the 24 th hour . The acute antiinflammatory study done in carageenan induced paw oedema model showed significant results in the high dose treated group comparable with that of the standard drug Diclofenac sodium Keywords: Tiliacora acuminata, Antiinflammatory, paw oedema, acute inflammation Vadakkath Anjaly Das