Therapeutic potential of wheatgrass (triticum aestivum) against oxidative stress by platinium containing drugs during cancer chemotherapy: a future prospective

Summary of article contents:

Oxidative stress is thought to be involved in the development of many diseases or may exacerbate their symptoms including cancer in human. Free radicals can cause toxicity and damage to many components of cells including proteins, DNA and lipids by the production of peroxides. Platinium containing drugs such as Cisplatin and Carboplatin can produce reactive oxygen species during their activity on the cancerous cell, which ultimately leads to an increased levels of oxidative stress during chemotherapy which slows down the replication of Cancerous cells, however, chemotherapeutic drugs are able only to kill highly dividing cells, so it ultimately interferes the antineoplastic activity of the drug. Oxidative stress also causes necrosis, depletion of ATP, prevent the control apoptotic death and causing the cells to simply fall apart, which can lead to a tumor formation further. Wheatgrass ( Triticum aestivum) contains high amount of antioxidants, and almost no sideeffects, so it can be use as an antioxidant phytomedicine against oxidative stress caused by chemotherapeutic drugs and can also increase the antineoplastic activity of the drug. Keywords: Oxidative stress, Antioxidant, Chemotherapy, Wheatgrass Sachin Sharma et