Amrita Guggulu Preparation and Clinical Efficacy on Vatarakta
Journal name: Ayushdhara
Original article title: Pharmaceutical Preparation of Amrita Guggulu and its Clinical Efficacy on Vatarakta
AYUSHDHARA is an international peer-reviewed journal. It focuses on research in Ayurveda, Yoga, Unani, Siddha, Homeopathy, Allopathy, and Pharmaceutical Sciences.
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Sanjiv Kumar
PG Scholar, Dept. of Ayurved Samhita evam Siddhant, Government Ayurvedic College Patna, Aryabhatt Knowledge University, Bihar, India.
Prabhat Kumar Dwivedi
Professor, Dept. of Ras Shastra and Bhaishajya Kalpana, Government Ayurvedic College Patna, Aryabhatt Knowledge University, Bihar, India.
Vijay Shankar Pandey
Professor & HOD, Dept. of Ayurved Samhita evam Siddhant, Government Ayurvedic College Patna, Aryabhatt Knowledge University, Bihar, India.
Ayushdhara:
(A peer-reviewed, bi-monthly open-access journal)
Full text available for: Pharmaceutical Preparation of Amrita Guggulu and its Clinical Efficacy on Vatarakta
Year: 2024 | Doi: 10.47070/ayushdhara.v11i2.1499
Copyright (license): CC BY-NC-SA 4.0
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Summary of article contents:
Introduction
The study focuses on the pharmaceutical preparation of Amrita Guggulu, an Ayurvedic formulation recognized for its therapeutic properties. The research aims to assess its clinical efficacy in managing Vatarakta, a condition characterized by imbalanced Vata and Pitta, often leading to inflammatory joint disorders. The preparation of Amrita Guggulu adheres to traditional preparation techniques, emphasizing the quality and potency of the final product. The research utilized a randomized, double-blind clinical trial involving 60 patients, measuring various parameters such as joint pain, inflammation, and patient-reported outcomes to evaluate the efficacy of this formulation.
Efficacy of Amrita Guggulu
The clinical trial revealed promising results indicating that Amrita Guggulu significantly alleviates symptoms related to Vatarakta. Statistical analyses showed noteworthy reductions in pain, joint function, and inflammatory markers over the treatment period of 90 days. Participants in both groups experienced substantial relief, with observed reductions in specific symptoms such as joint swelling, tenderness, and skin rashes. Notably, the study indicated that Amrita Guggulu demonstrated a decrease in serum uric acid levels, a common marker associated with Vatarakta and gouty arthritis, thereby underscoring its potential therapeutic benefits in managing inflammatory joint disorders.
Significance of Traditional Ayurvedic Methods
The study highlights the importance of traditional Ayurvedic principles in understanding and treating Vatarakta. The concepts of Dosha balance are central to Ayurveda, and treatments such as Snehan, Virechana, and the utilization of herbal formulations like Amrita Guggulu exhibit an integrative approach to health care. This research exemplifies how classical Ayurvedic formulations can provide a viable alternative in the management of modern ailments, thereby encouraging further investigation into Ayurvedic practices and their applications in contemporary medicine.
Conclusion
The findings from this clinical trial suggest that Amrita Guggulu is an effective intervention for those suffering from Vatarakta, showing significant improvements in symptoms and overall quality of life among patients. The study reinforces the value of traditional Ayurvedic formulations and their relevancy in modern therapeutic contexts. However, it emphasizes the need for further research and long-term studies to validate these findings, ensuring that Amrita Guggulu can be established as a therapeutic option for managing inflammatory joint disorders effectively.
FAQ section (important questions/answers):
What is the purpose of the study on Amrita Guggulu?
The study aims to assess the clinical efficacy of Amrita Guggulu in managing Vatarakta, a condition characterized by joint pain and inflammation. It evaluates the formulation's preparation and its effects on symptoms and objective parameters.
How was the clinical trial for Amrita Guggulu conducted?
The clinical trial was a randomized, double-blind study with 60 participants. Patients were divided into two groups, A and B, to evaluate the therapeutic effects of Amrita Guggulu on various symptoms associated with Vatarakta.
What were the primary findings of the Amrita Guggulu study?
The preliminary findings revealed significant improvements in symptoms like joint pain and inflammation, alongside reductions in serum uric acid levels. Both sample groups showed promise in alleviating the clinical features of Vatarakta.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Amrita Guggulu Preparation and Clinical Efficacy on Vatarakta”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Amrita (Amrta):
In the preparation of Amrita Guggulu, 'Amrita' is a key component noted for its immunomodulatory and therapeutic properties.
2) Guggulu:
'Guggulu' is a principal ingredient in Amrita Guggulu known for its Srotoshodhak (channel-cleansing) properties, playing a pivotal role in alleviating symptoms of Vata-rakta.
3) Vatarakta (Vata-rakta):
The term 'Vata-rakta' combines Vata and Rakta to describe a disease involving their vitiation, resulting in joint pain, swelling, and inflammatory symptoms.
4) Pain:
In the clinical study, reduction in 'pain' was a significant parameter, indicating the efficacy of Amrita Guggulu in alleviating joint discomfort associated with Vata-rakta.
5) Vata:
'Vata' is one of the three doshas in Ayurveda. In Vata-rakta, the vitiated Vata dosha contributes to symptoms like joint pain and dry skin.
6) Rakta:
'Rakta' refers to the blood. In Vata-rakta, the vitiated Rakta alongside Vata causes inflammation and other blood-related symptoms.
7) Blood:
'Blood' or Rakta is a significant dhatu (tissue) affected in Vata-rakta, leading to systemic conditions like inflammation and joint disorders.
8) Suptata (Supta-ta):
'Suptata' is a symptom in Vatarakta referring to numbness or tingling sensation in the affected areas. This parameter was used to assess the efficacy of Amrita Guggulu.
9) Disease:
'Vatarakta' is classified as an erratic 'disease' within Vatavyadhi disorders, characterized by joint pain, inflammation, and neurological symptoms.
10) Shotha (Sotha):
'Shotha' refers to swelling, which is a common symptom in Vatarakta. The reduction of shotha was significant after treatment with Amrita Guggulu.
11) Kandu (Kamdu):
'Kandu' means itching, a symptom considered in the study to assess the improvement in Vatarakta patients treated with Amrita Guggulu.
12) Daha:
'Daha' refers to a burning sensation experienced in Vatarakta. The study measured the reduction of daha as an indicator of therapeutic efficacy.
13) Burning sensation:
'Burning sensation' is synonymous with daha, a critical symptom in Vatarakta addressed in the clinical efficacy study of Amrita Guggulu.
14) Swelling:
'Swelling' or shotha is a cardinal symptom in Vatarakta, analyzed pre- and post-treatment in the clinical study of Amrita Guggulu.
15) Kumar:
'Sanjiv Kumar' is one of the authors of the study evaluating the clinical efficacy of Amrita Guggulu on Vatarakta.
16) Edema (Oedema):
'Oedema' the British spelling of Edema, which denotes swelling, a significant symptom alleviated by Amrita Guggulu in the clinical study.
17) Drug:
The herbal 'drug' formulation emphasized in the study is Amrita Guggulu, assessed for its therapeutic potential in treating Vatarakta.
18) Ayurveda (Ayus-veda):
The study revolves around 'Ayurveda', a traditional system of medicine focusing on dosha balance and using formulations like Amrita Guggulu to manage diseases.
19) Triphala (Tri-phala):
'Triphala', composed of Amalaki, Haritaki, and Vibhitaki, is a major component in Amrita Guggulu and contributes to its therapeutic effects.
20) Amalaki:
'Amalaki', part of Triphala, is used in Amrita Guggulu for its properties that help reduce the vitiation of Pitta dosha and Rakta, aiding in Vatarakta management.
21) Dravya:
'Dravya' refers to substances or medicinal ingredients, several of which like Guggulu and Amrita are utilized in the preparation of Amrita Guggulu.
22) Uttama:
'Uttama', meaning superior or excellent, is used to describe the highest level of certain examination criteria in the study (e.g., Uttama Satmya, Uttama Rogabala).
23) Dosha (Dosa):
'Dosha' in Ayurveda refers to the bodily humors (Vata, Pitta, Kapha). Imbalance in these doshas, particularly Vata and Rakta, is implicated in Vata-rakta.
24) Vibhitaki:
'Vibhitaki' is part of Triphala included in Amrita Guggulu, known for reducing vitiation of Pitta and contributing to its therapeutic benefits.
25) Vitiation (Vitiated):
'Vitiation' refers to the imbalance of doshas, in this context, Vata and Rakta, which lead to the development of symptoms in Vatarakta.
26) Haritaki:
'Haritaki', included in Triphala and Amrita Guggulu, is utilized for its effectiveness in reducing Vata and Pitta doshas.
27) Pittaja (Pitta-ja):
'Pittaja' denotes a body constitution type (prakriti) characterized by dominance of Pitta dosha, which was considered in the study's patient characteristics.
28) Kapha:
'Kapha' is one of the three doshas; its vitiation along with Vata and Rakta in Vatarakta contributes to symptoms like swelling and itching.
29) Abhyanga (Abhyamga):
'Abhyanga' is an Ayurvedic therapeutic oil massage, suggested as part of the treatment protocol for Vatarakta in the classical texts.
30) Pippali (Pippalin):
'Pippali', a component of Trikatu in Amrita Guggulu, is known for its heating properties and helps reduce vitiation of Kapha and Vata doshas.
31) Shunthi (Sunthi, Sumthi, Shumthi):
'Shunthi', dried ginger, is used in Amrita Guggulu for its anti-inflammatory properties and its role in balancing Vata and Kapha doshas.
32) Trivrit (Tri-vrit, Trivrt):
'Trivrit' is one of the ingredients in Amrita Guggulu used for reducing Pitta and Kapha doshas, aiding in the management of Vatarakta.
33) Pitta:
'Pitta' is one of the three doshas, involved in Vatarakta due to its imbalance along with Vata, resulting in symptoms like burning and inflammation.
34) Danti (Dantin, Damti):
'Danti' is an ingredient in Amrita Guggulu recognized for its Pitta and Kapha reducing properties, contributing to its efficacy in treating Vatarakta.
35) Aharashakti (Aharasakti, Ahara-shakti):
'Ahara-shakti' refers to digestive power. It was one of the parameters evaluated among patients to understand their overall health in the study.
36) Vatavyadhi (Vata-vyadhi):
'Vatavyadhi' encompasses diseases caused primarily by Vata dosha imbalance; Vatarakta is categorized under this group in Ayurveda.
37) Sadharana:
'Sadharana' denotes a type of habitat, which was categorized among the patient population in the study to analyze environmental influence on Vatarakta.
38) Knowledge:
The study was conducted by the Government Ayurvedic College Patna under Aryabhatt 'Knowledge' University, emphasizing the institution's academic commitment.
39) Substance:
In Ayurveda, 'substance' or dravya refers to medicinal ingredients like Guggulu, Amrita, and Triphala used in formulating therapies like Amrita Guggulu.
40) Prakriti (Prakrti):
'Prakriti' refers to body constitution, analyzed in the study to correlate the effectiveness of Amrita Guggulu on patients with different constitutions.
41) Trikatu (Tri-katu):
'Trikatu', comprising Pippali, Shunthi, and Maricha, is a heating formulation added to Amrita Guggulu to enhance its therapeutic effects.
42) Apathya:
'Apathya' is a term for harmful or contraindicated foods and lifestyle practices that need to be avoided during the treatment of Vatarakta.
43) Habitat:
'Habitat' or desha was considered in the study to analyze the influence of living environments (e.g., Jangal, Anupa, Sadharana) on Vatarakta progression.
44) Shakti (Sakti):
'Shakti' means power or strength, referring to various aspects such as digestive power (ahara-shakti) in the study to assess general health.
45) Satmya:
'Satmya' refers to suitability or adaptability of diet and lifestyle, evaluated among patients to ascertain influences on their overall health and disease condition.
46) Pathya:
'Pathya' refers to beneficial or prescribed foods and lifestyle practices that support treatment and overall health in Vatarakta management.
47) Sneha:
'Sneha' or unctuous substances like oils and ghee are used in Ayurvedic treatments such as Snehan, a preparatory procedure for detox therapies in Vatarakta.
48) Kalka:
'Kalka' denotes a paste or herbal bolus used in Ayurvedic formulations, such as in the preparation method for Amrita Guggulu.
49) Anupa:
'Anupa' is a type of habitat categorized in the study, representing marshy or humid regions which can influence Vatarakta symptoms.
50) Ahara:
'Ahara' means food; dietary habits play a significant role in health and disease, and are considered important in managing Vatarakta.
51) Desha (Desa):
The term 'Desha' in Ayurveda refers to the habitat or geographic region (Jangal, Anupa, etc.) which can influence a person's health and response to treatment.
52) Patna:
'Patna' is the location of the Government Ayurvedic College where the clinical study on Amrita Guggulu and its efficacy on Vatarakta was conducted.
53) Anuvasanabasti (Anuvasana-basti):
'Anuvasana-basti' is a medicated oil enema recommended in Ayurveda as part of the therapeutic approach for managing Vatarakta.
54) Atharvaveda (Atharva-Veda):
Ayurveda is referred to as 'Upveda' of 'Atharva-Veda', indicating its ancient origins and the transmission of wisdom from Vedas to sages to human physicians.
55) Transmission:
'Transmission' of medical knowledge in Ayurveda is described as originating from the Gods to sages and then to human physicians.
56) Inflammation:
'Inflammation' is a key symptom in Vata-rakta, characterized by redness, swelling, and pain in joints, addressed by Amrita Guggulu.
57) Pittadosha (Pittadosa, Pitta-dosha):
'Pitta-dosha' is one of the three primary doshas, whose imbalance along with Vata and Rakta is a central factor in the pathology of Vatarakta.
58) Raktadhatu (Rakta-dhatu):
'Raktadhatu' refers to the blood tissue, which is vitiated in Vata-rakta, leading to inflammatory and painful conditions managed by Amrita Guggulu.
59) Bhaishajya (Bhaisajya):
The term 'Bhaishajya' relates to the Ayurvedic science of pharmaceuticals, underlining the department involved in preparing Amrita Guggulu.
60) Kaphadosha (Kaphadosa, Kapha-dosha):
'Kaphadosha' is one of the three doshas, and its vitiation, along with Vata and Rakta, contributes to Vatarakta symptoms like swelling and itching.
61) Discussion:
'Discussion' in the study provides insights into treatment methods, therapeutic efficacy, and underlying mechanisms of action of Amrita Guggulu.
62) Anuvasana:
'Anuvasana Basti' involves the use of unctuous substances (oils) in enemas, highly recommended for its role in detoxifying treatments for Vatarakta.
63) Asthapana:
'Asthapana' is a type of enema used in Ayurveda, playing a significant part in the detoxification regimes proposed for Vatarakta management.
64) Samhanana:
'Samhanana' refers to the compactness or build of the body. It was evaluated in the study to correlate body constitution with response to Amrita Guggulu treatment.
65) Vatadosha (Vatadosa, Vata-dosha):
Vitiation of 'Vatadosha' is a fundamental cause of symptoms in Vatavyadhi, including Vatarakta, managed using therapeutic formulations like Amrita Guggulu.
66) Parisheka (Pariseka):
'Pariseka' or pouring medicated liquids is one of the external treatments described for managing symptoms in uttana (superficial) Vatarakta.
67) Samhita:
The research involves 'Samhita,' referencing Ayurvedic classical texts that provide guidelines on diagnosis, management, and treatment protocols.
68) Shastra (Sastra):
The term 'Shastra' denotes ancient science or scriptures, often referring to the Ayurvedic texts guiding the pharmaceutical and clinical practices.
69) Prithvi (Prthvi):
'Prithvi', meaning earth, is one of the Panchmahabhutas (five elements) cited in Ayurveda, playing a role in the constitution of bodily substances.
70) Pradeha:
'Pradeha' involves the application of pastes for therapeutic purposes, recommended in Vatarakta treatment methodologies according to Sushruta.
71) Kalpana:
'Kalpana' pertains to formulations and preparations in Ayurveda, indicating the systematic methods used to prepare remedies like Amrita Guggulu.
72) Vikara:
'Vikara' refers to disorders or diseases, and in this context, Vatarakta is considered a Vata and Rakta vikara, managed with specific Ayurvedic treatments.
73) Ruksha (Ruksa):
'Ruksha', denoting dryness, is a quality balanced in the treatment of Vatarakta, particularly when using procedures like Ruksha Virechana (dry purgation).
74) Dushya (Dusya):
'Dushya' refers to bodily elements affected by disease, and in Vata-rakta, this includes Rakta and associated tissues, influenced by vitiated Vata.
75) Vihara:
'Vihara' refers to lifestyle practices, the modern neglect of which is cited as a cause for the rising incidence of diseases like Vata-rakta.
[Note: The above list is limited to 75. Total glossary definitions available: 95]
Other Science Concepts:
Discover the significance of concepts within the article: ‘Amrita Guggulu Preparation and Clinical Efficacy on Vatarakta’. Further sources in the context of Science might help you critically compare this page with similair documents:
Dravya, Vatarakta, Pharmaceutical preparation, Statistical analysis, Inclusion criteria, Exclusion criteria, Clinical study, Clinical efficacy, Quality control measures, Immunomodulator, Laboratory investigation, Joint pain, Dietary advice, Subjective parameter, Objective parameter, Amrita guggulu, Double blind study.