Study on Vatari Guggulu vs. Simhanada Guggulu for Amavata.
Journal name: Ayushdhara
Original article title: A Comparative Clinical Study to Evaluate the Effect of Vatari Guggulu and Shatpushpadi Churna with Simhanada Guggulu in the Management of Amavata w.s.r. to Rheumatoid Arthritis
AYUSHDHARA is an international peer-reviewed journal. It focuses on research in Ayurveda, Yoga, Unani, Siddha, Homeopathy, Allopathy, and Pharmaceutical Sciences.
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Shivani
MD Scholar, P.G. Dept of Kayachikitsa, R.G.G.P.G. Ayurvedic College & Hospital, Paprola, Himachal Pradesh, India.
Mishra Anjana
Professor, P.G. Dept of Kayachikitsa, R.G.G.P.G. Ayurvedic College & Hospital, Paprola, Himachal Pradesh, India.
Chaudhary Vijay
Principal cum Dean, P.G. Dept of Kayachikitsa, R.G.G.P.G. Ayurvedic College & Hospital, Paprola, Himachal Pradesh, India.
Thakur Sunil
Professor, P.G. Dept of Kayachikitsa, R.G.G.P.G. Ayurvedic College & Hospital, Paprola, Himachal Pradesh, India.
Ayushdhara:
(A peer-reviewed, bi-monthly open-access journal)
Full text available for: A Comparative Clinical Study to Evaluate the Effect of Vatari Guggulu and Shatpushpadi Churna with Simhanada Guggulu in the Management of Amavata w.s.r. to Rheumatoid Arthritis
Year: 2023 | Doi: 10.47070/ayushdhara.v10i5.1395
Copyright (license): CC BY-NC-SA 4.0
Download the PDF file of the original publication
Summary of article contents:
Introduction
Amavata, a condition described in Ayurvedic literature, closely resembles Rheumatoid Arthritis (RA), characterized by the simultaneous aggravation of Vata and Ama, which leads to joint pain and swelling. This clinical study aimed to evaluate the effectiveness of two Ayurvedic formulations—Vatari Guggulu and Shatpushpadi Churna—compared to Simhanada Guggulu in managing Amavata in patients. A total of 32 participants were divided into two groups to assess the results of these treatments over a six-week period, focusing on both subjective and objective parameters related to pain, joint function, and overall health.
Efficacy of Vatari Guggulu and Shatpushpadi Churna
The evaluation of Vatari Guggulu and Shatpushpadi Churna showed significant improvements in subjective symptoms, including body ache (Angamarda), loss of taste (Aruchi), and fatigue (Alasya). Statistically significant results were noted where participants experienced an average reduction in Angamarda by 78.71% in the treatment group using these formulations. Other symptoms such as appetite loss, morning stiffness, and swelling were also substantially improved, emphasizing the efficacy of the combined treatment approach. Furthermore, the formulations positively influenced the patients' overall assessment, leading to a notable enhancement in their quality of life.
Effectiveness of Simhanada Guggulu
Simhanada Guggulu was used as a control treatment in the study. While it also yielded positive results, it was observed that the effects on symptoms and functional parameters were not as pronounced as those achieved with Vatari Guggulu and Shatpushpadi Churna. Although both treatments led to improvements in ESR and CRP levels—indicators of inflammation—Simhanada Guggulu showed a comparatively lesser degree of symptomatic relief. This distinction highlights the potential benefits of utilizing Vatari Guggulu and Shatpushpadi Churna as a preferred choice in managing Amavata.
Conclusion
The clinical study substantiates the effectiveness of Vatari Guggulu and Shatpushpadi Churna in the management of Amavata, showcasing significant improvements in various symptomatic and functional parameters. Both formulations proved to be beneficial without adverse effects, reaffirming their role in Ayurvedic treatment protocols for rheumatoid arthritis-like conditions. The findings suggest that these therapies may provide a viable alternative to conventional treatments, contributing to improved patient outcomes and a holistic approach to managing chronic inflammatory diseases.
FAQ section (important questions/answers):
What is the purpose of this clinical study?
This study evaluates the effectiveness of Vatari Guggulu and Shatpushpadi Churna compared to Simhanada Guggulu for managing Amavata, which closely resembles Rheumatoid Arthritis.
What are the key findings of the study?
Results indicated that Vatari Guggulu and Shatpushpadi Churna were more effective than Simhanada Guggulu in reducing symptoms like Angamarda and improving functional parameters like grip strength and walking time.
What were the safety results observed during the study?
Both groups reported no adverse effects during the trial period, and various hematological and biochemical parameters remained within normal ranges post-treatment.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Study on Vatari Guggulu vs. Simhanada Guggulu for Amavata.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Guggulu:
Guggulu is a key ingredient in traditional Ayurvedic formulations such as Vatari Guggulu and Simhanada Guggulu used in the management of Amavata or Rheumatoid arthritis due to its anti-inflammatory and therapeutic properties.
2) Amavata (Ama-vata):
Amavata is described in classical Ayurvedic literature and is closely resembles with Rheumatoid Arthritis. It's a condition where Vata and Ama settle in Sandhis (joints) leading to symptoms like Sandhishoola and Sandhishotha.
3) Vatari (Vata-ari, Vatavari):
Vatari refers to formulations like Vatari Guggulu, which are used to manage Amavata by alleviating associated symptoms like pain and swelling in joints.
4) Simhanada (Simha-nada):
Simhanada Guggulu is an Ayurvedic formulation that is compared with Vatari Guggulu in the management of Amavata due to its anti-inflammatory and Amapachana (digestive fire igniting) properties.
5) Drug:
In the context of this study, drugs like Vatari Guggulu, Shatpushpadi Churna, and Simhanada Guggulu are used to evaluate their effectiveness in managing Amavata, specifically targeting symptoms like pain, stiffness, and swelling.
6) Rheumatoid arthritis:
Rheumatoid arthritis is a chronic, progressive autoimmune disease characterized by the symmetrical involvement of joints and is closely paralleled by the Ayurvedic concept of Amavata.
7) Trishna (Trsna):
Trishna refers to the symptom of excessive thirst commonly experienced by patients suffering from Amavata, and is one of the parameters used to assess the effectiveness of Ayurvedic treatment.
8) Disease:
In this study, the disease Amavata is used interchangeably with Rheumatoid arthritis, reflecting a condition with symptoms such as pain, swelling, and limited mobility of joints.
9) Jadya:
Jadya or morning stiffness is a significant symptom of Amavata, reflecting limited mobility and is measured to assess the improvement in patients undergoing Ayurvedic treatment.
10) Pain:
Pain (Sandhishoola) is a primary symptom of Amavata, affecting joints and causing significant discomfort, which the Ayurvedic formulations aim to alleviate.
11) Angamarda (Anga-marda, Amgamarda):
Angamarda refers to body aches, a symptom in Amavata managed by Ayurvedic formulations like Vatari Guggulu and Shatpushpadi Churna.
12) Aruci:
Aruchi or loss of taste is another symptom of Amavata, which Ayurvedic treatments aim to improve as part of the overall management of the disease.
13) Apaka:
Apaka indicates indigestion, a commonly observed symptom in Amavata which is addressed by Ayurvedic treatments like Shatpushpadi Churna.
14) Vata:
Vata is one of the primary Doshas in Ayurveda, whose imbalance, particularly alongside Ama, leads to the development of Amavata.
15) Agnimandya (Agni-mandya, Agnimamdya):
Agnimandya refers to impaired digestive fire, contributing to the formation of Ama in Amavata, and is targeted by Ayurvedic treatments to restore digestive balance.
16) Shivani (Sivani):
[see source text or glossary: Shivani]
17) Daha:
Daha or burning sensation is a symptom observed in Amavata, attempting to alleviate it forms part of the therapeutic goals in Ayurvedic treatment.
18) Swelling:
Swelling, represented as Sandhishotha in Ayurveda, is a significant symptom of Amavata addressed by formulations like Simhanada Guggulu.
19) Sandhi (Shandhi, Samdhi):
[see source text or glossary: Shandhi]
20) Shakti (Sakti):
Shakti is used to describe the functional capacity or power, often assessed in Ayurvedic treatments to evaluate improvements in patients with Amavata.
21) Alasya:
Alasya or lack of enthusiasm is a functional symptom of Amavata, and treatments aim to ameliorate this condition alongside other symptoms.
22) Prakriti (Prakrti):
Prakriti refers to the natural constitution of an individual, which influences the susceptibility and treatment response in conditions like Amavata.
23) Shotha (Sotha):
Shotha is the Ayurvedic term for swelling, often observed in joints as a symptom of Amavata and targeted by Ayurvedic treatments.
24) Ushana (Usana):
Ushana indicates warmth, a quality often attributed to the therapeutic properties of drugs in Ayurveda used to alleviate conditions like Amavata.
25) Blood:
Blood tests such as ESR and CRP are used in this study to monitor inflammatory markers and evaluate the effectiveness of Ayurvedic treatment in Amavata.
26) Laghu:
Laghu denotes lightness, a quality of drugs used in Ayurveda to balance Doshas and treat conditions like Amavata by alleviating symptoms like heaviness (Gauravata).
27) Nidra:
Nidra refers to sleep, with disturbed sleep (Nidravipraya) being a symptom in Amavata. Ayurvedic treatments aim to restore normal sleep patterns.
28) Virya:
Virya is the potency or active principle of an Ayurvedic drug. Ushana Virya means the drug has a warming effect, useful in treating Amavata.
29) Rasa (Rasha):
Rasa refers to taste, with specific types like Katu (pungent) and Tikta (bitter) being used therapeutically in Ayurvedic treatments for conditions like Amavata.
30) Guna:
Guna or quality is an attribute in Ayurveda that affects the therapeutic actions of a substance. For example, medications with Ruksha (dry) Guna are useful for treating Amavata.
31) Food:
Food habits are crucial in Ayurveda as certain diets can aggravate or alleviate symptoms of diseases like Amavata.
32) Stiffness:
Stiffness, known as Jadya in Ayurveda, is a symptom of Amavata, and its reduction is a key therapeutic goal of Ayurvedic treatments.
33) Shodhana (Sodhana):
Shodhana or bio-purification refers to detoxification therapies in Ayurveda aimed at cleansing the body, recommended for managing Amavata.
34) Ruksha (Ruksa):
Ruksha means dryness, a quality in Ayurvedic drugs that helps balance the Doshas in conditions like Amavata by alleviating Ama accumulation.
35) Family:
[see source text or glossary: Family]
36) Kapha:
Kapha Dosha, when imbalanced with Vata, contributes to Amavata. Ayurvedic treatments aim to balance these Doshas to manage the disease.
37) Tikta:
Tikta or bitter taste is a Rasa (taste) in Ayurveda that is used to manage conditions like Amavata by aiding in digestion and detoxification.
38) Fever:
Fever or Jwara is one of the symptoms monitored in patients with Amavata, though it is not a primary focus in all cases.
39) Jaranashakti (Jaranasakti, Jarana-shakti):
Jarana-shakti refers to digestive strength, which is compromised in Amavata due to Agnimandya (weakened digestive fire), and is a target for Ayurvedic treatment.
40) Vibhitaki:
Vibhitaki, a component of formulations like Simhanada Guggulu and Vatari Guggulu, is used for its anti-inflammatory and detoxifying properties to manage Amavata.
41) Gandhaka (Gamdhaka):
Gandhaka or purified sulfur is an ingredient in Ayurvedic formulations used for its anti-inflammatory and purifying properties to manage Amavata.
42) Haritaki:
Haritaki is a component of various Ayurvedic formulations like Vatari Guggulu and Simhanada Guggulu, used for its balancing effects on Doshas and digestive benefits.
43) Medicine:
[see source text or glossary: Medicine]
44) Amalaki:
Amalaki, also known as Emblica officinalis, is used in Ayurvedic treatments for its anti-inflammatory and rejuvenating properties, especially in conditions like Amavata.
45) Anupana:
Anupana means the medium through which medicine is administered, typically lukewarm water in Ayurvedic treatments to aid the efficacy of the drugs.
46) Samana (Shamana):
Shamana or palliative therapy in Ayurveda focuses on balancing the Doshas and mitigating symptoms like those found in Amavata.
47) Jarana:
[see source text or glossary: Jarana]
48) Dosha (Dosa):
Doshas (Vata, Pitta, Kapha) are the bio-energies in Ayurveda. An imbalance, particularly of Vata and Kapha, is central to the pathology of Amavata.
49) Emblica officinalis:
Emblica officinalis, commonly known as Amalaki, is a key ingredient in Ayurvedic formulations for treating Amavata due to its antioxidant and anti-inflammatory properties.
50) Commiphora wightii:
Commiphora wightii, also known as Guggulu, is a vital component in Ayurvedic formulations like Vatari Guggulu for its anti-inflammatory properties.
51) Ricinus communis:
Ricinus communis or Eranda oil is an ingredient in Ayurvedic formulations used for its anti-inflammatory and purgative properties in managing conditions like Amavata.
52) Samshodhana (Samsodhana):
Samshodhana or bio-purification aims to cleanse the body’s channels, crucial for treating Amavata by eliminating the accumulated Ama and toxins.
53) Ayurveda (Ayus-veda):
Ayurveda is the traditional system of medicine that provides the framework for diagnosing and treating conditions like Amavata through a holistic approach.
54) Pradhana:
[see source text or glossary: Pradhana]
55) Tikshna (Tiksna):
Tikshna or sharpness is a quality indicative of the potency of a drug, beneficial in Ayurvedic treatments to quickly alleviate symptoms of diseases like Amavata.
56) Nidana:
[see source text or glossary: Nidana]
57) Kangra:
Kangra is the district in Himachal Pradesh, India, where the clinical study on the management of Amavata was conducted at R.G.G.P.G Ayurvedic College.
58) Thirst:
[see source text or glossary: Thirst]
59) Katu:
Katu or pungent taste is used in Ayurvedic treatments for its ability to stimulate digestion and balance Doshas, especially in treating conditions like Amavata.
60) Diet:
Dietary habits, such as vegetarian or mixed diets, affect the management of Amavata, as certain foods may aggravate or alleviate the disease according to Ayurvedic principles.
61) Rock salt:
Rock salt is an ingredient used in the formulation of Shatpushpadi Churna, playing a role in its therapeutic efficacy in managing Amavata.
62) Triphalaguggulu (Triphala-guggulu):
Triphala-Guggulu is an Ayurvedic formulation used for its Amapachana (digestive fire igniting) properties and is effective in treating symptoms of Amavata.
63) Madhavanidana (Madhava-nidana):
Madhava-nidana is the classical Ayurvedic text where the features of Amavata were first described, providing a diagnostic framework for the disease.
64) Embelia ribes:
Embelia ribes, known as Vaividang, is used in Ayurvedic formulations for its detoxifying properties, contributing to the management of Amavata.
65) Madhurarasa (Madhura-rasa):
Madhura-rasa or sweet taste is an important therapeutic quality in Ayurveda for balancing Doshas and is used in the treatment of conditions like Amavata.
66) Margavarodha (Marga-avarodha):
Margavarodha refers to obstruction in bodily channels, a key pathogenic factor in Amavata that Ayurvedic treatments aim to clear for symptom relief.
67) Purification:
Purification or Samshodhana therapies in Ayurveda aim to detoxify the body, an important step in the comprehensive management of Amavata.
68) Madhavakara:
Madhavakara is the author of Madhava-nidana, an authoritative Ayurvedic text that first described the features of Amavata.
69) Jatharagni (Jathara-agni):
Jatharagni or digestive fire is essential in Ayurveda for proper digestion. Its impairment leads to Ama formation, contributing to diseases like Amavata.
70) Samshamana (Samsamana):
Samshamana therapy aims at pacifying aggravated Doshas and symptoms of diseases like Amavata through lifestyle, diet, and medicinal treatments.
71) Katutikta (Katu-tikta):
Katu-tikta refers to pungent-bitter taste, which is used therapeutically in Ayurveda to balance Doshas and manage conditions like Amavata.
72) Vatadosha (Vatadosa, Vata-dosha):
Vata-dosha is one of the three Ayurvedic bio-energies. Its imbalance, especially in conjunction with Ama, leads to the manifestation of Amavata.
73) Rasadhatu (Rasa-dhatu):
Rasadhatu is the primary essence of the body's tissues. Impairments in its quality or circulation, often seen in Amavata, are corrected through Ayurvedic treatments.
74) Sadvritta (Sadvrtta, Sat-vritta):
Sadvritta refers to ethical conduct and lifestyle guidelines in Ayurveda which help maintain health and prevent diseases like Amavata.
75) Anulomana:
Anulomana means promoting the downward movement of bodily wastes, a property of certain Ayurvedic drugs used to alleviate symptoms in Amavata.
[Note: The above list is limited to 75. Total glossary definitions available: 115]
Other Science Concepts:
Discover the significance of concepts within the article: ‘Study on Vatari Guggulu vs. Simhanada Guggulu for Amavata.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Ama, Amavata, Pachana, Simhanadaguggulu, Vatadosha, Rheumatoid arthritis, Clinical study, Shodhana Therapy, Statistically Significant, Erythrocyte sedimentation rate, Deepana, Functional assessment, Subjective parameter, Vatari Guggulu, Walking time, Dietetic habit, Samshamana therapy, Ayurvedic College and Hospital, Hematological Profile, Biochemical parameter, Grip strength, Sleshmasthana.