Evaluation of Rasnadi Basti for Anovulation in Vandhyatva Management
Journal name: Ayushdhara
Original article title: Pharmacognostical and Pharmaceutical Evaluation of Rasnadi Basti in the Management of Vandhyatvo w.s.r to Anovulation
AYUSHDHARA is an international peer-reviewed journal. It focuses on research in Ayurveda, Yoga, Unani, Siddha, Homeopathy, Allopathy, and Pharmaceutical Sciences.
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Gaur Rasmi
P.G. Scholar, PTSR Department, ITRA, Jamnagar, Gujarat, India
Donga S. B
HOD of Prasuti Tantra Evum Stree Roga Department, ITRA, Jamnagar, Gujarat, India
Dei L.P
Former HOD of Prasuti Tantra Evum Stree Roga Department, ITRA, Jamnagar, Gujarat, India
C. R. Harisha
Head, Pharmacognosy Lab., ITRA, Jamnagar, Gujarat, India
Shukla Vinay J
Head, Pharmaceutical Lab. ITRA, Jamnagar, Gujarat, India
Ayushdhara:
(A peer-reviewed, bi-monthly open-access journal)
Full text available for: Pharmacognostical and Pharmaceutical Evaluation of Rasnadi Basti in the Management of Vandhyatvo w.s.r to Anovulation
Year: 2023 | Doi: 10.47070/ayushdhara.v10i4.1338
Copyright (license): CC BY-NC-SA 4.0
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Summary of article contents:
Introduction
Rasnadi Basti is an Ayurvedic formulation primarily indicated for managing Vataj disorders, including conditions such as infertility (Vandhyatva) associated with anovulation. Anovulation accounts for a significant percentage of female infertility and is influenced by various etiological factors. Given the role of Vata dosha in reproductive physiology, Basti (medicated enema) therapy is deemed the most appropriate treatment for restoring Vata balance and thereby promoting normal ovulation. The study aims to perform pharmacognostical and pharmaceutical evaluations of Rasnadi Basti to ensure the quality and efficacy of the herbal components used in its preparation.
Pharmacognostical Evaluation
The pharmacognostical evaluation of Rasnadi Basti included microscopic and organoleptic studies, which ensured the presence of identifying characteristics of its ingredients. Key components, such as Rasna, Eranda, Patala, and others, exhibited distinct landmarks in microscopic analysis, aiding in the authentication of the formulation. Organoleptic evaluation revealed that Rasnadi Basti has a brownish-reddish color, aromatic odor, bitter taste, and a slippery consistency. These findings confirm the genuine properties of the raw materials, contributing to the authenticity and effectiveness of the preparation.
Pharmaceutical Analysis
Pharmaceutical analysis focused on the physico-chemical properties of Rasnadi Basti, with specific gravity and solid content measured to evaluate its overall quality. The results indicated a solid content of 52.53% w/v and a specific gravity of 1.0242, both of which are within acceptable parameters for Ayurvedic formulations. This analysis supports the integrity of the formulation, confirming that it contains a valid concentration of active constituents necessary for therapeutic efficacy in treating anovulation and related disorders.
Conclusion
The comprehensive pharmacognostical and pharmaceutical evaluation of Rasnadi Basti substantiates the purity and legitimacy of the formulation. The verification of active ingredients and their respective concentrations is critical in a landscape where adulteration is prevalent in herbal products. The outcomes of this study not only contribute valuable information for future research but also serve as a reference standard for quality control in the preparation of Ayurvedic medicines, ensuring the delivery of safe and effective treatments for conditions like Vandhyatva.
FAQ section (important questions/answers):
What is Rasnadi Basti and its significance in managing anovulation?
Rasnadi Basti is an Ayurvedic formulation used for treating Vataj disorders like anovulation. It promotes reproductive health by balancing the Vata dosha, essential for normal ovulation and addressing infertility issues.
How was the Rasnadi Basti prepared and evaluated in the study?
The Rasnadi Basti was freshly prepared with specified herbal ingredients and analyzed through pharmacognostic and pharmaceutical evaluations, including organoleptic and microscopic studies to confirm the purity and quality of the formulation.
What were the results of the pharmacognostical and pharmaceutical analysis?
The analysis revealed specific identifying characteristics of the ingredients and confirmed the genuineness of Rasnadi Basti, with physicochemical observations showing a solid content of 52.53% w/v and a specific gravity of 1.0242.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Evaluation of Rasnadi Basti for Anovulation in Vandhyatva Management”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Basti:
Basti is a therapeutic measure used in Ayurvedic medicine, particularly for the treatment of Vata Dosha. In the study, Rasnadi Basti was administered to patients with infertility due to anovulation, utilizing its properties to mitigate Vata-related disorders [see source text or glossary: Basti].
2) Rasnadi:
Rasnadi refers to a specific Ayurvedic formulation used in the Basti treatment for various disorders, including Vandhyatva (infertility) due to anovulation. The formulation includes several herbs and compounds scientifically evaluated to confirm their purity and effectiveness [see source text or glossary: Rasnadi].
3) Drug:
In the context of this study, the term 'drug' refers to the raw herbs and compounds used to formulate Rasnadi Basti. These drugs were collected, identified, and authenticated at the ITRA, Ministry of Ayush, India, ensuring their genuineness and therapeutic properties for effective treatment [see source text or glossary: Drug].
4) Vata:
Vata is one of the primary doshas in Ayurvedic medicine, governing movement and physiological functions. Any vitiation in Vata can lead to reproductive issues like anovulation. Basti Karma is considered the best treatment for Vata Dosha, helping to regulate ovulation and improve fertility [see source text or glossary: Vata].
5) Pharmacognostical:
Pharmacognostical study involves the scientific analysis of raw drugs through microscopic evaluation to identify specific characteristics. This is crucial for confirming the purity and genuineness of the ingredients in Rasnadi Basti used for treating anovulation-induced infertility [see source text or glossary: Pharmacognostical].
6) Eranda (Eramda):
Eranda, or Ricinous communis, is one of the ingredients in the Rasnadi Basti formulation, primarily using its root bark. It was observed microscopically for specific characteristics such as compound starch grains and rosette crystals, confirming its presence in the formulation [see source text or glossary: Eranda].
7) Kantakari (Kamtakari):
Kantakari, known scientifically as Solanum surattense, is included in the whole plant form in Rasnadi Basti. Its diagnostic characters like annular vessels and stratified cells are identified through microscopic analysis, ensuring its genuineness and therapeutic efficacy [see source text or glossary: Kantakari].
8) Brihati (Brhati):
Brihati, or Solanum indicum, is an herb used in its whole plant form in Rasnadi Basti. Characteristics like spiral vessels and stellate trichome of Brihati were identified under microscopic evaluation, confirming its authenticity as part of the formulation [see source text or glossary: Brihati].
9) Kutaja (Kuta-ja):
Kutaja, scientifically named Holarrhena antidysenterica, is used in Rasnadi Basti for its therapeutic properties. The stem bark of Kutaja was microscopically examined to identify features like simple starch grain with hilum and spool cells, validating its incorporation in the formulation [see source text or glossary: Kutaja].
10) Musta (Mushta):
Musta, or Cyperous rotundus, is utilized in the root form in Rasnadi Basti. Upon microscopic study, characteristics such as starch grains were observed, establishing the drug’s authenticity and suitability for the Ayurvedic formulation [see source text or glossary: Musta].
11) Vandhyatva:
Vandhyatva refers to infertility in Ayurvedic texts, and it can be caused by various factors including anovulation. In this study, Rasnadi Basti has been evaluated for its effectiveness in treating Vandhyatva by addressing Vata Dosha disorders, thus enhancing fertility [see source text or glossary: Vandhyatva].
12) Gambhari:
Gambhari, with the botanical name Gmelina arborea, is used in the stem bark form in Rasnadi Basti. Identifiable microscopic characteristics include beaded parenchyma and starch grains, confirming its authenticity and efficacy within the formulation [see source text or glossary: Gambhari].
13) Patala:
Patala, or Stereospermum suaveoleus, is used for its stem bark in Rasnadi Basti. Microscopic evaluation revealed features like lignified fibres and pollen grains, ensuring the genuineness of this ingredient in the Ayurvedic formulation [see source text or glossary: Patala].
14) Agnimantha (Agni-mantha, Agnimamtha):
Agnimantha, also known as Premna mucronata, is included in Rasnadi Basti utilizing the root bark. The identification through microscopic analysis showed lignified fibres and brown constant, confirming the proper inclusion of this drug in the formulation [see source text or glossary: Agnimantha].
15) Shyonaka (Syonaka):
Shyonaka, or Oroxylum indicum, is used in its root bark form in Rasnadi Basti. Under microscopic scrutiny, features such as annular vessels and simple trichomes were identified, validating its authenticity for therapeutic use [see source text or glossary: Shyonaka].
16) Kushtha (Kustha):
[see source text or glossary: Kushtha]
17) Vaca:
Vacha, or Acorus calamus, is an integral part of Rasnadi Basti. Microscopically characterized by beaded parenchyma and pollen grains, Vacha is verified for its purity and therapeutic properties in the formulation [see source text or glossary: Vacha].
18) Shalaparni (Salaparni):
Shalaparni, scientifically Desmodim gangeticum, is utilized for its root in Rasnadi Basti. Microscopic evaluation revealed characters like simple starch grains and stone cells, ensuring the authenticity and effectiveness of Shalaparni in the formulation [see source text or glossary: Shalaparni].
19) Pippali (Pippalin):
Pippali, or Piper longum, is included in Rasnadi Basti for its fruits. Microscopic analysis identified crystal fibers and stained lignified crystals, confirming the presence and therapeutic suitability of Pippali in the Ayurvedic formulation [see source text or glossary: Pippali].
20) Dravya:
Dravya refers to the substances or raw drugs used in the preparation of Ayurvedic formulations, like Rasnadi Basti. These substances undergo rigorous evaluation for authenticity and efficacy to ensure the proper therapeutic outcomes [see source text or glossary: Dravya].
21) Rashmi (Rasmi):
[see source text or glossary: Rashmi]
22) Rasna (Rashna, Rasona, Rasa-una):
Rasna, also known as Pluchea lanceolata, is an herb used in the root form in Rasnadi Basti. It is identified by its specific microscopic features such as parenchyma cells and scalariform vessels, validating its authenticity in the formulation [see source text or glossary: Rasna].
23) Gaura:
[see source text or glossary: Gaur]
24) Yashtimadhu (Yastimadhu, Yashti-madhu):
[see source text or glossary: Yastimadhu]
25) Sarshapa (Sarsapa):
Sarsapa, or Brassica nigra, is included in Rasnadi Basti for its seeds. Microscopically, features such as starch grains with hylem and oil globules were identified, ensuring the authenticity and therapeutic properties of Sarsapa in the formulation [see source text or glossary: Sarsapa].
26) Mishra (Misra):
[see source text or glossary: Mishra]
27) Powder:
In the preparation of Rasnadi Basti, powdered forms of various herbs such as Kushtha and Mulethi are used. The powders undergo microscopic evaluation to confirm their specific identifying characteristics, ensuring their purity and efficacy [see source text or glossary: Powder].
28) Dosha (Dosa):
Doshas are fundamental bio-elements in Ayurvedic medicine that represent different physiological functions. Vata is one of these doshas, and its vitiation can lead to disorders such as anovulation, making Basti treatment significant in regulating Dosha balance [see source text or glossary: Dosha].
29) Pitta:
Pitta is one of the three doshas in Ayurveda, governing metabolism and transformation. In Rasnadi Basti treatment, balancing Vata Dosha can indirectly influence Pitta, particularly in cases of anovulation, to restore reproductive health [see source text or glossary: Pitta].
30) Shukrajanana (Shukra-janana, Sukrajanana):
Shukrajanana refers to the generation of reproductive fluids or semen. Rasnadi Basti has properties like Shukrajanana, making it beneficial in treating Vataj disorders related to reproductive health, such as Vandhyatva (infertility) [see source text or glossary: Shukrajanana].
31) Bastikarman (Bastikarma, Basti-karman, Basti-karma):
Basti-karma is a therapeutic procedure in Ayurveda used to treat Vata Dosha disorders. It involves administering herbal formulations like Rasnadi Basti rectally to regulate metabolic processes and enhance reproductive health, addressing issues like anovulation [see source text or glossary: Basti-karma].
32) Vatadosha (Vatadosa, Vata-dosha):
Vata-dosha is one of the three primary doshas in Ayurveda, responsible for movement and physiological activities. Any vitiation in Vata-dosha can lead to reproductive issues like anovulation. Basti treatments like Rasnadi Basti are utilized to correct Vata-dosha imbalances [see source text or glossary: Vata-dosha].
33) Saindhava (Saimdhava):
Saindhava, or rock salt, is included in Rasnadi Basti for its therapeutic properties. It is triturated with other ingredients to form a homogenous mixture, contributing to the effectiveness of the Basti treatment in managing Vataj disorders [see source text or glossary: Saindhava].
34) Pumsavana:
Pumsavana is a term in Ayurveda referring to a procedure or treatment aimed at promoting conception or fetal well-being. Rasnadi Basti is noted for its Pumsavana attributes, making it an effective remedy for infertility and related issues [see source text or glossary: Pumsavana].
35) Vitiation (Vitiated):
Vitiation refers to the disturbance or imbalance of doshas in Ayurvedic medicine. In the study, vitiation of Vata dosha is identified as a contributing factor to anovulation and infertility, treated effectively with Rasnadi Basti [see source text or glossary: Vitiation].
36) Vibandha:
Vibandha refers to constipation, a Vataj disorder that can be treated with Rasnadi Basti. The formulation's properties help alleviate various Vata-related conditions, making it beneficial for reproductive and digestive health [see source text or glossary: Vibandha].
37) Prameha:
Prameha is a term for urinary disorders, including diabetes, often associated with Kapha dosha imbalance. While primarily focused on Vataj disorders, Rasnadi Basti may also offer therapeutic benefits for conditions like Prameha [see source text or glossary: Prameha].
38) Pradara:
Pradara refers to abnormal menstrual discharge, a disorder indicated for treatment with Rasnadi Basti. The herbal formulation targets Vataj disorders, addressing issues like irregularities and reproductive health [see source text or glossary: Pradara].
39) Parama:
Parama signifies the supreme or highest quality. The study mentions Pumsavana Parama, indicating the excellence of Rasnadi Basti in promoting conception and treating infertility by ensuring the genuinity and purity of the formulation [see source text or glossary: Parama].
40) Purity:
Purity is crucial in Ayurvedic formulations to ensure therapeutic efficacy. The pharmacognostical and physico-chemical analysis of Rasnadi Basti confirmed its purity, validating the presence of all active ingredients and their specific properties [see source text or glossary: Purity].
41) Aruci:
Aruchi refers to loss of appetite, a Vataj disorder that Rasnadi Basti can help treat. The formulation's properties aim to alleviate various symptoms associated with Vata imbalance, including digestive and reproductive issues [see source text or glossary: Aruchi].
42) Kapha:
Kapha is one of the three Ayurvedic doshas, governing stability and structure. Though Rasnadi Basti primarily targets Vata dosha, its effects can also influence Kapha, particularly in disorders where Vata-Kapha dosha vitiation is involved [see source text or glossary: Kapha].
43) Karma (Karman):
Karma in Ayurveda refers to the action or treatment. Basti Karma, or the therapeutic administration of Basti, involves procedures like Rasnadi Basti to treat Vataj disorders, including anovulation and infertility [see source text or glossary: Karma].
44) Kalka:
Kalka refers to a paste form of herbs used in Ayurvedic formulations. In the preparation of Rasnadi Basti, herbs like Kushtha and Mulethi are used as Kalka Dravya, mixed to form a consistent emulsion for therapeutic use [see source text or glossary: Kalka].
45) Taila (Thaila):
Taila, or oil, is an essential component in Ayurvedic formulations like Rasnadi Basti. Tila taila (sesame oil) is used along with other ingredients to create a homogenous emulsion, enhancing the efficacy of the treatment for Vataj disorders [see source text or glossary: Taila].
46) Pandu (Pamdu, Pamde):
Pandu refers to anemia, which is among the Vataj disorders that Rasnadi Basti can address. The formulation's properties help treat various conditions linked to Vata dosha imbalances, including digestive and reproductive health issues [see source text or glossary: Pandu].
47) Anaha:
Anaha signifies bloating or abdominal distension, which is another Vataj disorder treated with Rasnadi Basti. The properties of the formulation help alleviate digestive discomfort and associated symptoms of Vata imbalance [see source text or glossary: Anaha].
48) India:
India is where the study on Rasnadi Basti was conducted, specifically at ITRA, Jamnagar, Gujarat. The research falls under the purview of Ayush, a ministry dedicated to traditional Indian medicine systems [see source text or glossary: India].
49) Ayus (Ayush):
Ayush is the Ministry of Ayurveda, Yoga, Unani, Siddha, and Homeopathy in India, overseeing the study and authentication of traditional medicinal systems. The Rasnadi Basti study was conducted under the guidelines and support of Ayush [see source text or glossary: Ayush].
50) Tila:
Tila refers to sesame (Sesamum indicum), specifically its oil, which is used in Rasnadi Basti. Tila taila is an essential component in the Ayurvedic formulation, contributing to the therapeutic efficacy of the treatment for Vataj disorders [see source text or glossary: Tila].
51) Kala:
Kala refers to the time or period during which a therapeutic procedure is performed. In Rasnadi Basti treatment, the Kala for administration is typically the morning, aligning with Ayurvedic principles for optimal therapeutic effect [see source text or glossary: Kala].
52) Glycyrrhiza glabra:
[see source text or glossary: Glycyrrhiza glabra]
53) Saussurea lappa:
[see source text or glossary: Saussurea lappa]
54) Solanum indicum:
[see source text or glossary: Solanum indicum]
55) Piper longum:
Piper longum, commonly known as Pippali, is used in Rasnadi Basti for its reproductive health benefits. The fruits of Pippali are microscopically identified by crystal fibers and stained lignified crystals, confirming its presence and authenticity in the formulation [see source text or glossary: Piper longum].
56) Rock salt:
Rock salt, or Saindhava, is an important ingredient in Rasnadi Basti. It is triturated with other components to form a uniform mixture, aiding in the treatment of Vataj disorders and enhancing the therapeutic efficacy of the Basti [see source text or glossary: Rock salt].
57) Oroxylum indicum:
[see source text or glossary: Oroxylum indicum]
58) Gmelina arborea:
[see source text or glossary: Gmelina arborea]
59) Sesamum indicum:
Sesamum indicum, commonly known as Tila, is crucial for its oil used in Ayurvedic preparations like Rasnadi Basti. Tila taila forms a part of the homogenous emulsion, contributing to the effectiveness of the Basti treatment for Vataj disorders [see source text or glossary: Sesamum indicum].
60) Acorus calamus:
[see source text or glossary: Acorus calamus]
61) Agnimandya (Agni-mandya, Agnimamdya):
Agnimandya refers to digestive fire impairment in Ayurveda, often linked to Vata and Kapha dosha imbalances. Rasnadi Basti, by correcting Vata-dosha, helps to alleviate Agnimandya, thereby improving overall digestion and reproductive health [see source text or glossary: Agnimandya].
62) Jatharagni (Jathara-agni):
Jatharagni refers to the digestive fire at the gastrointestinal level in Ayurvedic medicine. Issues with Jatharagni can lead to anovulation and infertility, making Rasnadi Basti relevant for restoring balance and improving reproductive health [see source text or glossary: Jatharagni].
63) Rasadhatu (Rasa-dhatu):
Rasa-dhatu represents the plasma or fluid component in Ayurvedic physiology. Dushti (vitiation) of Rasa-dhatu can affect reproductive health, thus making Rasnadi Basti, which targets Rasa-dhatu and Vata-dosha, effective in treating conditions like anovulation [see source text or glossary: Rasa-dhatu].
64) Tilataila (Tila-taila):
Tila-taila, or sesame oil, is a key ingredient in Rasnadi Basti. It serves as the Sneha (fatty substance) component, essential for the formulation, and aids in the effective treatment of Vata-dosha related disorders such as infertility [see source text or glossary: Tila-taila].
65) Pakvashaya (Pakvasaya, Pakva-ashaya):
Pakvashaya is the large intestine, referred to as the Moolasthana (root location) of Vata-dosha. Basti Karma, including Rasnadi Basti, targets Pakvashaya to regulate Vata and treat disorders like anovulation by administering the formulation rectally [see source text or glossary: Pakvashaya].
66) Discussion:
[see source text or glossary: Discussion]
[Note: The above list is limited to 75. Total glossary definitions available: 88]
Other Science Concepts:
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