A pharmaceutico-analytical study of amritadya guggulu

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Journal name: Ayushdhara
Original article title: A pharmaceutico-analytical study of amritadya guggulu
AYUSHDHARA is an international peer-reviewed journal. It focuses on research in Ayurveda, Yoga, Unani, Siddha, Homeopathy, Allopathy, and Pharmaceutical Sciences.
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Author(s):

Swati Sharma
Assistant Professor, Shiva Ayurvedic Medical College & Hospital, Chandpur, Dist. Bilaspur HP,
Manoj Sharma
Assistant Professor, Shiva Ayurvedic Medical College & Hospital, Chandpur, Dist. Bilaspur HP
Sudarshan Kumar Thakur
Lecturer P.G. Deptt. of Rasa Shastra evum Bhaishjya Kalpana, R.G.Govt. P.G. Ayurvedic College & Hospital Paprola, HP


Ayushdhara:

(A peer-reviewed, bi-monthly open-access journal)

Full text available for: A pharmaceutico-analytical study of amritadya guggulu

Year: 2020 | Doi: 10.47070/ayushdhara.v7i2.525

Copyright (license): CC BY-NC-SA 4.0


Download the PDF file of the original publication


Summary of article contents:

Introduction

The study presents a pharmaceutico-analytical exploration of Amritadya Guggulu, a notable preparation in Ayurveda used for treating several ailments, including conditions related to obesity and metabolic disorders. Guggulu, derived from the resin of the plant Commiphora mukul, necessitates a purification process known as Shodhana to eliminate impurities and enhance its therapeutic properties. The aim of the study was to develop standard operating procedures for the preparation of this drug and to assess its safety, purity, and quality through various analytical tests.

Purification Process (Shodhana)

The initial step in the preparation of Amritadya Guggulu involved the method of Shodhana, where the raw Guggulu was treated to remove physical impurities like stones and bark. This was achieved by bundling the Guggulu in a cotton cloth and subjecting it to heat in Trifala Kwatha, a decoction made from three medicinal fruits. The Guggulu was macerated, allowing it to dissolve into the decoction, thus purifying it further. This step resulted in a significant weight loss, indicating the removal of impurities, with the final product being brownish black in color and exhibiting a characteristic odor. This purification is essential for ensuring the safety and efficacy of the drug.

Analytical Study Results

An extensive analytical study followed the preparation of Amritadya Guggulu, evaluating its macroscopic and physicochemical properties. Important findings included a moisture content of 6.2%, low total ash at 6.03%, and a low acid insoluble ash content of just 1.08%, which indicated minimal adherent impurities. The presence of specific compounds, such as tannins, was confirmed, and thin-layer chromatography illustrated the successful integration of key herbal ingredients. These analytical findings reinforce the authenticity and quality of the Amritadya Guggulu preparation, aligning with the standards set by the Ayurvedic Pharmacopoeia of India.

Conclusion

The study conclusively verifies that the pharmaceutico-analytical processes applied to Amritadya Guggulu substantiate its quality and safety for medicinal use. The results of the purification and analysis affirm that the preparation meets the established standards, making it a reliable reference for future research and application in Ayurvedic medicine. The development of a comprehensive procedural guideline ensures that practitioners can consistently achieve a high-quality product, thereby potentially enhancing its therapeutic efficacy in treating various health conditions.

FAQ section (important questions/answers):

What is Amritadya Guggulu and its importance in Ayurveda?

Amritadya Guggulu is an Ayurvedic preparation derived from Guggulu, primarily used for treating conditions like Sthaulya. It undergoes a purification process known as Shodhana to remove impurities and enhance its therapeutic properties, confirming its authenticity and quality.

What was the aim of the pharmaceutico-analytical study?

The study aimed to develop a standard operative procedure for preparing Amritadya Guggulu and to analyze its safety and purity. Various pharmacological processes were applied, assessing both the physical and chemical properties of the drug to ensure its quality.

What were the remarkable findings of the analytical study?

The study found a weight loss of 50% during Guggulu purification, with low moisture content (6.2%), and low acid insoluble ash (1.08%), which enhances longevity and therapeutic value. Identification tests confirmed the presence of various beneficial components in the preparation.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “A pharmaceutico-analytical study of amritadya guggulu”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Guggulu:
Guggulu is the gummy resin obtained from the Indian plant bdellium, scientifically known as Commiphora mukul. It is extensively used in Ayurvedic medicine for its therapeutic properties and is always subjected to Shodhana (purification) before usage to ensure safety and efficacy.

2) Drug:
In the context of Ayurveda, a drug refers to a medicinal substance derived from plants, minerals, or animals. Amritadya Guggulu is a drug preparation mentioned in the study, composed of various herbal ingredients like Guggulu, Bibhitaka, Haritaki, and others.

3) Shodhana (Sodhana):
Shodhana is the purification process that Guggulu undergoes to remove impurities and enhance its therapeutic properties. The process often involves soaking, boiling, or other methods to prepare the substance for safe internal use.

4) Powder:
Powder form refers to the consistency of many herbs and ingredients used in Ayurvedic preparations like Amritadya Guggulu. Each herbal ingredient is separately dried, ground, and sieved to form a fine powder before being mixed for therapeutic use.

5) Bibhitaka:
Bibhitaka is one of the key ingredients in Amritadya Guggulu. Scientifically known as Terminalia belerica, its fruit pericarp is used for its medicinal properties and is processed into a powder for the preparation of the drug.

6) Haritaki:
Haritaki, or Terminalia chebula, is another important ingredient in Amritadya Guggulu. Its fruit pericarp is known for its health benefits and is processed by washing, drying, and grinding it into powder form to be mixed with Guggulu.

7) Kalpana:
[see source text or glossary: Kalpana]

8) Vidanga (Vidamga):
Vidanga, scientifically known as Embelia ribes, is also an ingredient in Amritadya Guggulu. The fruit of this plant is used in powdered form to contribute to the overall therapeutic efficacy of the Ayurvedic preparation.

9) Sharman (Sarma, Sharma, Sarman):
Sharma refers to Swati Sharma, one of the authors of the study on Amritadya Guggulu. She is an Assistant Professor at Shiva Ayurvedic Medical College & Hospital, Bilaspur, HP.

10) Amalaki:
Amalaki, or Emblica officinalis, is another key ingredient in Amritadya Guggulu. The fruit pericarp of Amalaki is used for its potent medicinal properties and is processed into a fine powder for inclusion in the formula.

11) Ghrita (Ghrta):
Ghrita, clarified butter, was used during the pounding process of preparing Guggulu to prevent it from sticking to the container. Specifically, Go-ghrita, sourced from cow's milk, was utilized in this study.

12) Kutaja (Kuta-ja):
Kutaja, Holarrhena antidysenterica, is included in Amritadya Guggulu. Its bark is known for its therapeutic qualities and is processed into a fine powder, which is then mixed with purified Guggulu.

13) Bitter:
Bitter describes the taste of some of the ingredients used in the preparation of Amritadya Guggulu, contributing to its final overall taste profile.

14) Goghrita (Goghrta, Go-ghrita):
Go-ghrita is clarified butter made from cow's milk used in the pounding process of Guggulu preparations to prevent the mixture from sticking. It helps facilitate a smoother mixture.

15) Laghu:
[see source text or glossary: Laghu]

16) Paka:
Paka refers to the process of heating in the preparation of Ayurvedic medicines. In the study, Amritadya Guggulu was prepared without Paka, meaning no heating method was used.

17) Discussion:
[see source text or glossary: Discussion]

18) Sthaulya:
Sthaulya refers to obesity or corpulence in Ayurvedic medicine. Amritadya Guggulu is mentioned as a treatment for conditions like Sthaulya in ancient texts.

19) Bilaspur:
Bilaspur is the district in Himachal Pradesh, India, where Shiva Ayurvedic Medical College is located, and where co-author Swati Sharma works.

20) Cotton:
Cotton cloth was used in the Shodhana process of Guggulu. A piece of cotton cloth is employed to filter the melted Guggulu from the impurities during its purification with Trifala Kwatha.

21) Shiva (Siva):
[see source text or glossary: Shiva]

22) India:
India is the country where the study on Amritadya Guggulu was conducted. The institutions involved, Shiva Ayurvedic Medical College & Hospital and R.G.Govt. P.G. Ayurvedic College & Hospital, are located in India.

23) Emblica officinalis:
Emblica officinalis, commonly known as Amalaki, is one of the ingredients in Amritadya Guggulu. Its fruit pericarp is used for its potent medicinal properties.

24) Terminalia chebula:
Terminalia chebula, also known as Haritaki, is included in the Amritadya Guggulu formulation. The fruit pericarp is utilized for its health benefits and is made into a powder form.

25) Commiphora mukul:
Commiphora mukul is the botanical name for the plant that produces Guggulu, the primary resin used and purified in the preparation of Amritadya Guggulu.

26) Aushadhakalpana (Ausadhakalpana, Aushadha-kalpana):
[see source text or glossary: Aushadha-kalpana]

27) Kashayaskandha (Kasayaskandha, Kashaya-skandha):
[see source text or glossary: Kashaya-skandha]

28) Embelia ribes:
Embelia ribes, or Vidanga, is another ingredient in Amritadya Guggulu. The fruits of the plant are used in powdered form for their therapeutic properties.

29) Rasashastra (Rasa-shastra, Rasasastra):
[see source text or glossary: Rasa-shastra]

30) Dolayantra (Dola-yantra, Dolayamtra):
Dola-yantra is a traditional apparatus used in Ayurveda for the swedana (sweating) or boiling process. It was used in the study for the Shodhana of Guggulu in Trifala Kwatha.

31) Mahakashaya (Mahakasaya, Maha-kashaya):
[see source text or glossary: Mahakashaya]

32) Kaphadosha (Kaphadosa, Kapha-dosha):
Kapha-dosha is one of the three biological energies in Ayurveda. The study mentions Amritadya Guggulu's effectiveness in balancing Kapha dosha, particularly in conditions dominated by Medodhatu (fat tissue).

33) Bhagandara (Bhagamdara):
Bhagandara refers to fistula-in-ano in Ayurvedic terms. Amritadya Guggulu, studied in the text, is mentioned for treatment in such conditions.

34) Medoroga (Medas-roga):
Medo-roga refers to ailments related to adipose tissue or diseases caused by excessive fat. The drug Amritadya Guggulu is indicated for such conditions in Ayurveda.

35) Ayurveda (Ayus-veda):
Ayurveda is the ancient Indian system of medicine focused on physical, mental, and spiritual health. The study conducted on Amritadya Guggulu is an example of research aimed at standardizing Ayurvedic preparations.

36) Aushadha (Ausadha):
[see source text or glossary: Aushadha]

37) Gomutra (Go-mutra):
Go-mutra is cow's urine, sometimes used traditionally in Ayurveda. The context does not elaborate on its use.

38) Sthapana:
[see source text or glossary: Sthapana]

39) Medicine:
Medicine in this context refers to prescribed formulations like Amritadya Guggulu, which are prepared according to Ayurvedic texts to treat various ailments.

40) Skandha (Skamdha, Skamda):
[see source text or glossary: Skandha]

41) Shastra (Sastra):
[see source text or glossary: Shastra]

42) Kashaya (Kasaya):
[see source text or glossary: Kashaya]

43) Disease:
Disease in the context refers to various health conditions that Ayurveda aims to treat, such as Pidika (boils), Bhagandara (fistula), and Sthaulya (obesity). The study validates Amritadya Guggulu for these ailments.

44) Yantra (Yamtra):
As an apparatus, Yantra includes devices like Dola-yantra used in the Shodhana process, where herbal medicines undergo specific treatments to remove impurities.

45) Pidika:
Pidika refers to boils or small abscesses in Ayurvedic terms. Amritadya Guggulu is reputed to treat such skin conditions, according to the study.

46) Family:
Family refers to the botanical family classification of herbal ingredients used in the study, such as Combretaceae for Bibhitaka and Euphorbiaceae for Amalaki.

47) Purity:
Purity involves ensuring the absence of impurities and confirming the drug's safety and therapeutic quality, as demonstrated in the study of Amritadya Guggulu.

48) Indian:
Indian here likely refers to the origin of Ayurvedic practices and the sources of the herbal ingredients, such as Guggulu sourced from the Indian plant Commiphora mukul.

49) Dosha (Dosa):
Dosha refers to the three fundamental bodily bio-elements—Vata, Pitta, and Kapha—in Ayurveda. The study mentions how Amritadya Guggulu balances these Doshas.

50) Kapha:
Kapha is one of the three Doshas, representing water and earth elements. The study indicates the relevance of Amritadya Guggulu in managing conditions where Kapha is imbalanced.

51) Mutra:
[see source text or glossary: Mutra]

52) Kumar:
Kumar refers to Sudarshan Kumar Thakur, one of the authors of the study, who is a Lecturer in the P.G. Deptt. of Rasa Shastra evum Bhaishjya Kalpana.

53) Ghana:
[see source text or glossary: Ghana]

54) Ayus (Ayush):
[see source text or glossary: Ayush]

55) Roga:
Roga means disease or illness in Ayurveda. The study aims to validate the efficacy of Amritadya Guggulu in treating certain diseases like Pidika and Bhagandara.

56) Rasa (Rasha):
[see source text or glossary: Rasa]

57) Vati:
Vati kalpana refers to the Ayurvedic formulation involving pills or tablets. Guggulu kalpana, under which Amritadya Guggulu falls, is a type of Vati kalpana.

58) Vata:
Vata is one of the three Doshas representing the elements of space and air. The study mentions the therapeutic application of Amritadya Guggulu in conditions involving Vata imbalance.

59) Tola:
[see source text or glossary: Dola]

Other Science Concepts:

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Discover the significance of concepts within the article: ‘A pharmaceutico-analytical study of amritadya guggulu’. Further sources in the context of Science might help you critically compare this page with similair documents:

Goghrita, Aushadhakalpana, Loss on drying, Thin Layer Chromatography, Moisture content, Pharmaceutico-analytical study, Physical and chemical properties, Shodhana of Guggulu, Macroscopic analysis, Total solids, Guggulu Kalpana, Characterization study, Medicinal Field, Amritadyaguggulu.

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