Study on Rasna Guggulu vs. Panchatiktha Ghrita for knee osteoarthritis.
Journal name: Ayushdhara
Original article title: A comparative clinical study on rasna guggulu and panchatiktha ghrita guggulu in the management of janusandhigata vata vis-a-vis to osteoarthritis of knee
AYUSHDHARA is an international peer-reviewed journal. It focuses on research in Ayurveda, Yoga, Unani, Siddha, Homeopathy, Allopathy, and Pharmaceutical Sciences.
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H.M.Harisha
Guide and Principal, Department of Post Graduate Studies in Kayachikitsa, Ashwini Ayurvedic Medical College and Research Centre, Tumkur, Karnataka
Suhasini.L.Dandagi*
P.G. Scholar, Department of Post Graduate Studies in Kayachikitsa, Ashwini Ayurvedic Medical College and Research Centre, Tumkur, Karnataka
Rakesh H.R
Assistant Professor, Department of Post Graduate Studies in Kayachikitsa, Ashwini Ayurvedic Medical College and Research Centre, Tumkur, Karnataka
Ayushdhara:
(A peer-reviewed, bi-monthly open-access journal)
Full text available for: A comparative clinical study on rasna guggulu and panchatiktha ghrita guggulu in the management of janusandhigata vata vis-a-vis to osteoarthritis of knee
Year: 2019
Copyright (license): CC BY-NC-SA 4.0
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Summary of article contents:
Introduction
Ayurveda, the ancient Indian system of medicine, addresses various health-related aspects of life, including physical, psychological, and spiritual well-being. One prevalent issue affecting individuals, particularly older adults, is osteoarthritis, characterized by the degeneration of cartilage in weight-bearing joints, leading to pain and restricted mobility. The current study compares the efficacy of two Ayurvedic formulations, Rasnadi Guggulu and Panchatikta Ghrita Guggulu, in managing Janusandhigata Vata, which is comparable to osteoarthritis of the knee. The research was conducted with a cohort of patients suffering from symptoms consistent with Janusandhigata Vata, aiming to find therapeutic solutions to alleviate their condition.
Efficacy of Rasnadi Guggulu
Rasnadi Guggulu is highlighted for its comprehensive therapeutic properties that effectively address inflammation and pain in conditions similar to osteoarthritis. The formulation contains several herbs with anti-inflammatory and analgesic properties, such as Guduchi and Rasna, which help reduce joint pain and stiffness. The study showed that patients receiving Rasnadi Guggulu experienced significant improvements in their symptoms, including reduced pain (measured by Visual Analog Scale scores) and improved mobility. Specifically, 11 out of 20 patients in this group demonstrated moderate improvement after the treatment period, indicating that Rasnadi Guggulu may be particularly beneficial for managing Janusandhigata Vata symptoms.
Benefits of Panchatikta Ghrita Guggulu
Panchatikta Ghrita Guggulu is another Ayurvedic formulation examined in this study, emphasizing its properties that assist in pacifying Vata dosha and supporting joint health. The formulation's Tikta rasa (bitter taste) is considered beneficial for conditions affecting the bones and joints. This preparation not only was reported to reduce pain and swelling but also aimed at improving the overall nourishment of the body’s tissues, thereby stabilizing conditions associated with joint degeneration. Although the results showed moderate improvement, the overall effect was slightly less pronounced compared to Rasnadi Guggulu, with fewer patients reporting marked improvements in their symptoms.
Conclusion
In conclusion, the study reinforces the clinical utility of Ayurvedic treatments, particularly Rasnadi Guggulu and Panchatikta Ghrita Guggulu, in managing conditions akin to osteoarthritis. Despite the moderate efficacy observed with both formulations, Rasnadi Guggulu emerged as the more favorable option for patients, demonstrating greater reductions in symptoms associated with Janusandhigata Vata. This study contributes valuable insight into how traditional Ayurvedic remedies can complement modern approaches to managing joint diseases, highlighting the need for further research to explore their potential benefits in broader clinical settings.
FAQ section (important questions/answers):
What is the focus of the study on Rasnadi Guggulu?
The study investigates the efficacy of Rasnadi Guggulu and Panchatikta Ghrita Guggulu in managing Janusandhigata Vata, which resembles osteoarthritis of the knee, evaluating patient improvements in symptoms and function.
What criteria were used to select patients for the study?
Patients aged 40-70 exhibiting symptoms of Janusandhigata Vata with abnormal osteoarthritis radiological findings were included, while those with trauma, systemic diseases, or anatomical deformities were excluded.
What were the main findings regarding the treatment of osteoarthritis?
Both Rasnadi Guggulu and Panchatikta Ghrita Guggulu significantly reduced symptoms, with Rasnadi Guggulu showing slightly better patient outcomes compared to Panchatikta Ghrita Guggulu.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Study on Rasna Guggulu vs. Panchatiktha Ghrita for knee osteoarthritis.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Guggulu:
Guggulu is a resin used in Ayurveda known for its anti-inflammatory and analgesic properties. It is often used in formulations like Rasnadi Guggulu for treating joint diseases such as Sandhigata Vata.
2) Vata:
Vata is one of the three Doshas in Ayurveda, representing the element of air and space. It governs bodily functions related to movement and the nervous system. Imbalance in Vata can lead to disorders such as Sandhigata Vata.
3) Ghrita (Ghrta):
Ghrita refers to clarified butter or ghee used in Ayurvedic medicine. It is believed to enhance the potency of the herbs it is combined with, such as in Panchatikta Ghrita Guggulu for treating joint issues like Sandhigata Vata.
4) Rasnadi:
Rasnadi refers to formulations containing Rasna, which has analgesic and anti-inflammatory properties. In the context of the clinical study, Rasnadi Guggulu is used to manage symptoms of Janusandhigata Vata, a form of osteoarthritis in the knee.
5) Pain:
Pain is a primary symptom assessed in the study, particularly through Visual Analog Scale (VAS) scores. It indicates the discomfort experienced by patients with conditions like Sandhigata Vata, targeted by treatments such as Rasnadi Guggulu and Panchatikta Ghrita Guggulu.
6) Drug:
In this clinical study, the term drug refers to Ayurvedic formulations like Rasnadi Guggulu and Panchatikta Ghrita Guggulu used to treat Sandhigata Vata, aiming to alleviate symptoms like pain, swelling, and stiffness.
7) Swelling:
Swelling, or Shotha, is a key symptom of Sandhigata Vata assessed in the study. It is measured through objective parameters and is managed using treatments like Rasnadi Guggulu and Panchatikta Ghrita Guggulu.
8) Disease:
The disease focused on in this study is Sandhigata Vata, which corresponds to osteoarthritis of the knee in modern terms. It involves symptoms like pain, swelling, and restricted movement, managed using Ayurvedic formulations.
9) Sandhi (Shandhi, Samdhi):
Sandhi refers to joints in the body. In the context of this study, it specifically relates to the knee joint affected by Sandhigata Vata, a condition treated with Rasnadi Guggulu and Panchatikta Ghrita Guggulu.
10) Rasna (Rashna, Rasona, Rasa-una):
Rasna is an herb known for its analgesic and anti-inflammatory properties. It is a key ingredient in Rasnadi Guggulu, used to treat joint pain and inflammation in conditions like Sandhigata Vata.
11) Tikta:
[see source text or glossary: Tikta]
12) Sandhigata Vata (Sandhigata-vata):
Sandhigata-vata is essentially the same as Sandhigata Vata, describing joint degeneration akin to osteoarthritis, treated with Ayurvedic formulations like Rasnadi Guggulu and Panchatikta Ghrita Guggulu.
13) Shotha (Sotha):
Shotha refers to swelling, a symptom of Sandhigata Vata assessed in this study. It indicates inflammation in the joints, which treatments like Rasnadi Guggulu aim to alleviate.
14) Rasa (Rasha):
[see source text or glossary: Rasa]
15) Ayurveda (Ayus-veda):
Ayurveda is an ancient Indian system of medicine focusing on holistic health. This study employs Ayurvedic principles and formulations like Rasnadi Guggulu and Panchatikta Ghrita Guggulu to treat joint diseases such as Sandhigata Vata.
16) Harisha (Harisa):
[see source text or glossary: Harisha]
17) Dhatu:
Dhatu refers to the seven bodily tissues in Ayurveda, including Asthi (bone) and Majja (marrow), which are often affected by Vata disorders like Sandhigata Vata.
18) Shula (Sula):
Shula means pain, one of the primary symptoms of Sandhigata Vata assessed in this study. The treatments Rasnadi Guggulu and Panchatikta Ghrita Guggulu aim to reduce Shula.
19) Vayu:
Vayu refers to the air element governed by Vata dosha in Ayurveda. It is associated with movement and is a critical factor in the development of Sandhigata Vata, treated with specific Ayurvedic herbs and formulations.
20) Karnataka:
Karnataka is the state in India where the study was conducted, specifically at the Ashwini Ayurvedic Medical College and Research Centre in Tumkur.
21) Mahabhuta (Maha-bhuta):
[see source text or glossary: Mahabhuta]
22) Tiktarasa:
[see source text or glossary: Tiktarasa]
23) Stiffness:
Stiffness is one of the symptoms of Sandhigata Vata assessed in this study. It affects the joint's range of motion and is a target for treatments like Rasnadi Guggulu and Panchatikta Ghrita Guggulu.
24) Devadaru (Deva-daru):
Devadaru, known for its astringent and carminative properties, is an ingredient in Rasnadi Guggulu used in this study to manage Sandhigata Vata or osteoarthritis of the knee.
25) Lakshana (Laksana):
Lakshana refers to the symptoms or clinical features of a disease. In this study, Lakshana like pain, swelling, and stiffness are assessed to understand the impact of treatments like Rasnadi Guggulu.
26) Rasayana (Rasa-ayana):
Rasayana in Ayurveda refers to rejuvenating therapies that improve health and longevity. Some ingredients in Rasnadi Guggulu and Panchatikta Ghrita Guggulu have Rasayana properties.
27) Madhura:
[see source text or glossary: Madhura]
28) Dravya:
[see source text or glossary: Dravya]
29) Akasha (Akasa):
[see source text or glossary: Akasha]
30) Nidana:
Nidana refers to the causative factors of a disease. In this study, the Nidana for Sandhigata Vata includes old age, heredity, and obesity, among others.
31) Pitta:
Pitta is one of the three Doshas in Ayurveda, governing metabolism and transformation. Although the study focuses on Sandhigata Vata, Pitta's balance also plays a role in overall health.
32) Asthi (Ashthi):
Asthi refers to bone tissue in Ayurveda, affected by Vata in conditions like Sandhigata Vata. Treatments like Panchatikta Ghrita Guggulu aim to pacify aggravated Vata in Asthi.
33) Ushna (Usna):
Ushna refers to the heat quality attributed to certain Ayurvedic herbs and formulations like Guggulu, helping to pacify Vata.
34) Majja:
Majja refers to bone marrow in Ayurveda, often affected in joint disorders like Sandhigata Vata. Treatments like Panchatikta Ghrita Guggulu target these tissues.
35) Asti (Ashti):
[see source text or glossary: Ashti]
36) India:
India is the country where this Ayurvedic clinical study was conducted, specifically in the region of Karnataka.
37) Balya:
[see source text or glossary: Balya]
38) Human life:
[see source text or glossary: Human life]
39) Human body:
The human body is the focus of Ayurvedic treatments, which aim to restore balance and health. In this study, treatments like Rasnadi Guggulu are used to alleviate joint diseases in the human body.
40) Dahaprashamana (Dahaprasamana, Daha-prashamana):
[see source text or glossary: Dahaprashamana]
41) Transformation (Transform, Transforming):
Cartilage transformation is a pathological process in osteoarthritis, targeted by Ayurvedic therapies such as Rasnadi Guggulu to prevent and manage degeneration.
42) Tiktadravya (Tikta-dravya):
Tikta-dravya refers to bitter substances in Ayurveda, thought to be beneficial in treating conditions like Sandhigata Vata by pacifying aggravated Vata and nourishing tissues.
43) Tuberculosis:
Patients with current or past tuberculosis were excluded from this study to ensure accurate evaluation of treatments for Sandhigata Vata.
44) Majjadhatu (Majja-dhatu):
[see source text or glossary: Majja-dhatu]
45) Samshodhana (Samsodhana):
Samshodhana is a purificatory therapy in Ayurveda aiming to eliminate toxins. It is essential in the holistic treatment approach for conditions like Sandhigata Vata.
46) Rajayakshma (Rajan-yakshma, Rajayaksma):
[see source text or glossary: Rajayakshma]
47) Bhagandara (Bhagamdara):
[see source text or glossary: Bhagandara]
48) Samshamana (Samsamana):
Samshamana is a pacifactory therapy aiming to balance doshas like Vata in the treatment of disorders such as Sandhigata Vata.
49) Vatapitta (Vata-pitta):
[see source text or glossary: Vata-pitta]
50) Discussion:
The discussion section of this study analyses the efficacy of Rasnadi Guggulu and Panchatikta Ghrita Guggulu in treating Sandhigata Vata, drawing conclusions based on observed clinical outcomes.
51) Prasarana:
[see source text or glossary: Prasarana]
52) Gandamala (Ganda-mala):
[see source text or glossary: Gandamala]
53) Vyanavayu (Vyana-vayu):
Vyanavayu is a subtype of Vata dosha governing circulation and joint movements, whose imbalance contributes to the development of Sandhigata Vata.
54) Dhatvagni (Dhatu-agni):
[see source text or glossary: Dhatvagni]
55) Substance:
Substance in this context refers to the herbal constituents of Ayurvedic formulations like Rasnadi Guggulu and Panchatikta Ghrita Guggulu used in treating Sandhigata Vata.
56) Tridosha (Tridosa, Tri-dosha):
Tridosha represents the three fundamental bodily bio-elements in Ayurveda—Vata, Pitta, and Kapha. Imbalances among these are believed to cause diseases like Sandhigata Vata.
57) Vatahara (Vata-ahara):
Vatahara refers to substances that alleviate the symptoms caused by aggravated Vata. Herbs with Vatahara properties are integral to treating Sandhigata Vata.
58) Medicine:
Medicine in this study refers to Ayurvedic formulations like Rasnadi Guggulu, designed to manage osteoarthritis symptoms by balancing doshas and nourishing joint tissues.
59) Pregnant:
Pregnant women were excluded from the study to ensure safety and manage the specific focus on Sandhigata Vata treatment.
60) Yogavahin (Yogavahi, Yoga-vahi, Yoga-vahin):
[see source text or glossary: Yogavahi]
61) Lekhana:
Lekhana refers to the property of reducing excess body weight and fat. Herbs with Lekhana properties, such as Guggulu, help in treating joint disorders by alleviating pressure on joints.
62) Prameha:
[see source text or glossary: Prameha]
63) Sparsha (Sparsa):
[see source text or glossary: Sparsha]
64) Samaka (Shamaka):
Shamaka refers to the pacifying property of certain herbs and formulations used to treat aggravated doshas, such as Vata in Sandhigata Vata.
65) Shuddha (Suddha):
[see source text or glossary: Shuddha]
66) Purana:
[see source text or glossary: Purana]
67) Vedana:
[see source text or glossary: Vedana]
68) Ruksha (Ruksa):
[see source text or glossary: Ruksha]
69) Shopha (Sopha):
[see source text or glossary: Shopha]
70) Eranda (Eramda):
Eranda is castor, known for its Vatahara properties and used in formulations like Rasnadi Guggulu to treat joint pain and stiffness in conditions such as Sandhigata Vata.
71) Kapha:
Kapha is one of the three Doshas, associated with structure and lubrication in the body. While this study focuses on Vata disorders, balanced Kapha also contributes to overall joint health.
72) Gulma:
[see source text or glossary: Gulma]
73) Griha (Grha):
[see source text or glossary: Griha]
74) Ayus (Ayush):
[see source text or glossary: Ayush]
75) Arshas (Arsa, Arsas, Arsha):
[see source text or glossary: Arsha]
[Note: The above list is limited to 75. Total glossary definitions available: 78]
Other Science Concepts:
Discover the significance of concepts within the article: ‘Study on Rasna Guggulu vs. Panchatiktha Ghrita for knee osteoarthritis.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Guggulu, Tridosha, Samshodhana, Samshamana, Dinacharya, Vata, Pitta, Kapha, Signs and symptoms, Causative factor, Assessment criteria, Patient assessment, Osteoarthritis of knee, Rutucharya, Nidana and Lakshana, Janusandhigata Vata, Panchatikta Ghrita Guggulu, Weight bearing joint, Rasnadi Guggulu, Significant Statistical Results.