Study of individual’s prakriti and gene polymorphism correlation of p2y12 gene
Journal name: Ayushdhara
Original article title: Study of individual’s prakriti and gene polymorphism correlation of p2y12 gene
AYUSHDHARA is an international peer-reviewed journal. It focuses on research in Ayurveda, Yoga, Unani, Siddha, Homeopathy, Allopathy, and Pharmaceutical Sciences.
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Shekhar Gopalrao Uike
Assistant Professor, Dept. of Kriyasharir, Shri K.R. Pandav Ayurved College, Nagpur
Ayushdhara:
(A peer-reviewed, bi-monthly open-access journal)
Full text available for: Study of individual’s prakriti and gene polymorphism correlation of p2y12 gene
Year: 2018
Copyright (license): CC BY-NC-SA 4.0
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Summary of article contents:
Introduction
Ayurveda, an ancient system of medicine, emphasizes the understanding of individual constitution, known as Prakruti, which is believed to be formed at the time of conception based on genetic codes and the predominance of Panchamahabhautic doshas. This unique constitution can be classified into three primary types: Vata, Pitta, and Kapha, each exhibiting specific biological variations in terms of structure, functionality, and behavior. Additionally, the Raktadhatu or blood tissue is considered vital for nourishing all other tissue due to its essential role in maintaining health. The study conducted by Shekhar Gopalrao Uike focuses on the correlation between individual Prakruti and genetic polymorphisms, particularly exploring the P2Y12 gene, which is instrumental in platelet aggregation.
The Importance of Prakruti
Prakruti, as defined in Ayurveda, encompasses an individual's unique physical and mental attributes. This constitution influences responses to environmental changes and disease susceptibility. The study elucidates the close relationship between Raktadhatu and Prakruti, suggesting that different Prakritis may manifest varying blood properties, affecting aspects like platelet aggregation. This investigation into Prakruti is significant not only for individual health management but also for understanding genetic predispositions related to health conditions. Knowledge of one’s Prakruti can therefore assist in tailoring dietary and lifestyle choices to promote optimal health.
Connection Between Genetics and Platelet Aggregation
A pivotal focus of the study is the P2Y12 gene, a key receptor on platelets that mediates aggregation, playing a crucial role in the formation of blood clots. Polymorphisms in this gene can affect how individuals respond to blood-thinning medications and their susceptibility to cardiovascular diseases. By examining variations in platelet aggregation in relation to Prakruti, the study aims to determine whether specific genetic patterns are associated with individual constitutions. The findings indicate that Kapha Prakriti individuals tend to have higher platelet aggregation, while those with Vata Prakriti show a correlation with less aggregation under certain conditions of the P2Y12 gene polymorphism.
Conclusion
The research reveals that understanding an individual’s Prakriti can provide valuable insights into genetic predispositions and health outcomes. The correlation between platelet aggregation and the P2Y12 gene polymorphisms highlights the importance of integrating traditional Ayurvedic insights with modern genetic research. The study suggests that Prakriti can serve as a practical tool for predicting the risk of atherosclerosis and guiding personalized treatment approaches. Overall, these findings underscore the potential benefits of considering individual constitutional types in conjunction with genetic markers in health assessments and interventions.
FAQ section (important questions/answers):
What is the significance of Prakruti in Ayurveda?
Prakruti represents an individual's unique constitution in Ayurveda, encompassing physical and mental attributes. It dictates responses to environmental changes and promotes disease proneness when imbalanced, forming the basis for personalized health recommendations.
How does the P2Y12 gene relate to platelet aggregation?
The P2Y12 gene encodes a receptor on platelets that initiates aggregation upon ADP binding. Variations in the gene can influence how effectively platelets aggregate, which is crucial for understanding conditions like atherosclerosis and managing antiplatelet therapies.
What were the outcomes of the study on platelet aggregation?
The study found significant variations in platelet aggregation levels among different Prakriti types, with Kapha subjects showing the highest aggregation and Pitta subjects the least. This suggests that Prakruti can help predict individual risks for certain health conditions.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Study of individual’s prakriti and gene polymorphism correlation of p2y12 gene”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Prakriti (Prakrti):
Prakriti is the unique constitution or nature of an individual, central to Ayurveda. It is framed at the time of conception as a genetic code or predominant dosha and includes three types: Vata, Pitta, and Kapha, governing the body's biological and behavioral variations.
2) Blood:
Blood is a specialized connective tissue circulating in a closed system of vessels. It is denser and more viscous than water. Platelets in blood aggregate to form clots, a process relevant to different Prakriti types and their susceptibility to atherosclerosis or bleeding disorders.
3) Raktadhatu (Rakta-dhatu):
Raktadhatu, or blood tissue, is considered the fourth important Dosha in Ayurveda. It nourishes all other Dhatus and is essential for life. Variations in Raktadhatu are linked to differences in Prakriti, which can influence health outcomes and disease proneness.
4) Ayurveda (Ayus-veda):
Ayurveda is an ancient science of self-understanding, emphasizing individualized healthcare based on one's Prakriti. It classifies individuals into three dosha types: Vata, Pitta, and Kapha, and provides guidelines for diet, lifestyle, and treatment to maintain optimal health.
5) Dosha (Dosa):
Dosha refers to the three fundamental energies governing the body's constitution and functions in Ayurveda: Vata, Pitta, and Kapha. These doshas are dynamic forces that influence individual health, disease tendencies, and responses to environmental changes.
6) Pitta:
Pitta is one of the three doshas in Ayurveda, representing fire and water elements. It governs metabolism, digestion, and transformation in the body. Pitta Prakriti individuals may have specific health tendencies and responses to genetic factors like P2Y12 gene polymorphism.
7) Kapha:
Kapha is one of the three doshas in Ayurveda, representing earth and water elements. It is responsible for growth, structure, and stability in the body. Kapha Prakriti individuals may exhibit higher platelet aggregation and specific responses to genetic factors like the P2Y12 gene.
8) Dhatu:
Dhatu refers to the seven fundamental tissues in Ayurveda, including Raktadhatu (blood). Each Dhatu has unique functions and contributes to overall health. Prakriti influences how well these Dhatus are nourished and maintained, affecting susceptibility to various conditions.
9) Sugar:
[see source text or glossary: Sugar]
10) Vata:
Vata is one of the three doshas in Ayurveda, representing air and ether elements. It controls movement, nerve impulses, and elimination. Vata Prakriti individuals may exhibit varied health tendencies and responses to genetic factors, affecting their overall well-being.
11) Pradhan:
[see source text or glossary: Pradhan]
12) Disease:
Disease in Ayurveda is often seen as an imbalance in the individual's doshas. The Prakriti of a person influences their susceptibility to certain diseases and the effectiveness of treatments, such as dietary and lifestyle changes, to restore balance.
13) Drug:
Drug therapy effectiveness in Ayurveda can be influenced by an individual’s Prakriti, with specific types of Prakriti responding differently to antiplatelet drugs. Ayurveda also utilizes natural and herbal drugs to align with an individual's unique constitution for optimal health.
14) Tridosha (Tridosa, Tri-dosha):
Tridosha refers to the three doshas: Vata, Pitta, and Kapha, which together govern the body's functions and health. Understanding the balance and interplay of Tridosha is essential in Ayurveda for diagnosing and treating health conditions.
15) Family:
[see source text or glossary: Family]
16) Nature:
Nature or Prakriti in Ayurveda signifies the innate qualities and constitution of an individual, determining their physiological and psychological traits. This understanding is crucial for personalized healthcare and maintaining balance through diet and lifestyle tailored to one's nature.
17) Nagapura (Naga-pura):
Nagpur is the location of Shri K.R. Pandav Ayurved College, where the study on Prakriti and gene polymorphism correlation of P2Y12 was conducted. It underscores the city's role in advancing Ayurvedic research and education in India.
18) Rakta:
Rakta, or blood, is considered the fourth Dosha in Ayurveda, crucial for nourishing other Dhatus and maintaining life. The study shows a close relationship between Rakta and Prakriti, which can affect an individual's health and susceptibility to disorders.
19) India:
India is the origin of Ayurveda, the ancient science of self-understanding and individualized healthcare. Research conducted in India, such as the study on Prakriti and gene polymorphism, continues to explore and validate Ayurvedic principles in modern contexts.
20) Death:
[see source text or glossary: Death]
21) Shri (Sri, Sr):
[see source text or glossary: Shri]
22) Discussion:
[see source text or glossary: Discussion]
23) Knowledge:
[see source text or glossary: Knowledge]
24) Substance:
[see source text or glossary: Substance]
25) Lakshana (Laksana):
[see source text or glossary: Lakshana]
26) Medicine:
[see source text or glossary: Medicine]
27) Pregnant:
Pregnant women were excluded from the study due to potential health risks and altered physiological conditions during pregnancy, which could affect the measurement of platelet aggregation and skew the results related to Prakriti and gene polymorphism in healthy individuals.
28) Dravata:
[see source text or glossary: Dravata]
29) Nashik:
Nashik refers to the location of MUHS University, which provided the questionnaire format used to assess Prakriti in the study. The involvement of Nashik's academic resources highlights the methodological rigor and standardized tools used in Ayurvedic research.
30) Repair:
[see source text or glossary: Repair]
31) Ayus (Ayush):
[see source text or glossary: Ayush]
32) Aahar:
Aahar refers to diet in Ayurveda, which is tailored to an individual's Prakriti to maintain balance and health. The study suggests that understanding one’s Prakriti can guide dietary choices to prevent bleeding or clotting disorders and promote overall well-being.
33) Beta:
[see source text or glossary: Beta]
34) Diet:
Diet in Ayurveda is customized according to an individual's Prakriti to maintain dosha balance and health. The study implies that knowing one's Prakriti can inform dietary recommendations to prevent or manage conditions like atherosclerosis or bleeding disorders.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Study of individual’s prakriti and gene polymorphism correlation of p2y12 gene’. Further sources in the context of Science might help you critically compare this page with similair documents:
Raktadhatu, Vata, Pitta, Kapha, Ayurvedic approach, Atherosclerosis, Single nucleotide polymorphism, Alkaline phosphatase, Hemostasis, Platelet aggregation, Haplotype, Gene polymorphism.