Nagakesara in clinical study for managing PCOD.
Journal name: Ayushdhara
Original article title: A clinical study of market samples of nagakesara in the management of poly cystic ovarian disease (pcod)
AYUSHDHARA is an international peer-reviewed journal. It focuses on research in Ayurveda, Yoga, Unani, Siddha, Homeopathy, Allopathy, and Pharmaceutical Sciences.
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Nikath. S
P.G.Scholar, Department of Dravyaguna, S.V. Ayurvedic College, Tirupati, A.P.
Sitaram Bulusu
Professor, Department of Dravyaguna, S.V. Ayurvedic College, Tirupati, A.P.
Suneela.P
Associate Professor, Department of Dravyaguna, S.V. Ayurvedic College, Tirupati, A.P.
Ayushdhara:
(A peer-reviewed, bi-monthly open-access journal)
Full text available for: A clinical study of market samples of nagakesara in the management of poly cystic ovarian disease (pcod)
Year: 2018
Copyright (license): CC BY-NC-SA 4.0
Download the PDF file of the original publication
Summary of article contents:
Introduction
The clinical study aimed to evaluate the efficacy of different market samples of Nagakesara (Mesua ferrea) in managing Poly Cystic Ovarian Disease (PCOD), a common health issue affecting women of reproductive age. PCOD is characterized by symptoms such as irregular menstruation, obesity, hirsutism, and acne vulgaris. Recognizing the significance of Ayurveda in treating lifestyle disorders, the study involved 30 patients divided into three groups, each receiving different formulations of Nagakesara for three months, with regular assessments of subjective and objective parameters.
Efficacy of Mesua ferrea in Managing PCOD
The results indicated that Mesua ferrea was the most effective treatment among the three market samples tested. In Group 1, patients experienced significant improvements in key symptoms, including a 67.85% reduction in the duration of menstruation, a 65.62% decrease in gaps between cycles, and a 66.66% improvement in menstrual bleeding quantity. Statistically significant outcomes (p < 0.001) confirm that Mesua ferrea not only promotes regular menstruation but also alleviates associated symptoms effectively compared to other samples tested.
Comparison with Other Samples
In contrast, the other two groups, which received Ochrocarpus longifolius and Cinnamomum tamala, showed lesser efficacy in managing PCOD symptoms. For Ochrocarpus longifolius, significant improvements were noted mostly in the quantity of menstrual bleeding (44.44%) and pain during menstruation (50%), but other symptoms did not show comparable results. Similarly, Cinnamomum tamala showed moderate efficacy in specific parameters but failed to demonstrate significant improvement overall. These discrepancies emphasize the superior therapeutic capability of Mesua ferrea in addressing the multifaceted symptoms of PCOD.
Conclusion
The study concludes that Mesua ferrea is a highly effective treatment for managing PCOD due to its ability to regulate menstrual cycles and alleviate various associated symptoms. While Ochrocarpus longifolius and Cinnamomum tamala exhibited some beneficial effects, they did not match the efficacy of Mesua ferrea. These findings support the traditional use of Nagakesara in Ayurvedic medicine and suggest that it could be integrated into broader treatment protocols for PCOD, especially when paired with complementary therapies to enhance its efficacy.
FAQ section (important questions/answers):
What was the aim of the clinical study on Nagakesara?
The study aimed to evaluate the efficacy of different market samples of Nagakesara in managing Poly Cystic Ovarian Disease (PCOD) by assessing various subjective and objective parameters before and after treatment.
What were the three groups in the clinical trial?
The three groups included: Group 1 received Mesua ferrea, Group 2 received Ochrocarpus longifolius, and Group 3 received Cinnamomum tamala, with all patients taking these drugs in powdered form mixed with milk for three months.
What were the results of the study regarding effectiveness?
In Group 1, 10% of patients were completely cured and 55.09% showed moderate improvement. Group 2 had similar results, while Group 3 showed no complete recoveries, indicating Mesua ferrea was more effective in treating PCOD.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Nagakesara in clinical study for managing PCOD.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Mesua ferrea:
Mesua ferrea is a type of plant used in the study. It showed the most significant clinical efficacy in managing PCOD symptoms, including duration and quality of menstruation. It is associated with Nagakesara and is considered the best option for addressing Artava vikara in PCOD.
2) Drug:
In this study, drug refers to various formulations made from different market samples of Nagakesara, including Mesua ferrea and Cinnamomum tamala. The drugs were processed into tablets and administered to patients to evaluate their effectiveness in treating PCOD.
3) Nagakesara (Nagakeshara, Naga-kesara):
Nagakesara is a classical Ayurvedic drug mentioned in traditional texts, used in the study to treat PCOD. Different market samples, including Mesua ferrea, Ochrocarpus longifolius, and Cinnamomum tamala, were analyzed for their efficacy in managing symptoms associated with PCOD.
4) Disease:
Disease in this context refers to Poly Cystic Ovarian Disease (PCOD), a condition with symptoms like irregular menstruation, infertility, obesity, and hirsutism. The study aims to find effective Ayurvedic treatments for this disorder.
5) Pain:
Pain, particularly menstrual pain, was one of the subjective parameters measured in the study. The effectiveness of the drugs in reducing pain during menstruation was evaluated and deemed significant in patients treated with Mesua ferrea.
6) Milk:
Milk was used as Anupana, or a vehicle, for administering the powdered drug tablets to patients across all three study groups. It helps aid the body's absorption of the Ayurvedic formulations.
7) Cinnamomum tamala:
Cinnamomum tamala is one of the market samples of Nagakesara tested in the study for its efficacy in managing PCOD symptoms. Though it showed some effectiveness, it was not as significant as Mesua ferrea.
8) Tamala:
[see source text or glossary: Tamala]
9) Mud:
Mood changes were one of the subjective parameters assessed in the study. The effectiveness of the drugs in alleviating mood swings associated with PCOD was included but showed statistically insignificant results.
10) Powder:
Powder refers to the form in which the Nagakesara plant samples were processed for the study. The powdered herbs were used to make tablets administered to patients to evaluate their clinical efficacy against PCOD.
11) Hair:
Hair, particularly related to hirsutism, was one of the symptoms assessed. Hirsutism, or excessive hair growth, is associated with PCOD and was measured in the study to gauge the effectiveness of the drug treatments.
12) Artava:
Artava refers to the menstrual flow or menstruation in Ayurvedic terminology. The effectiveness of Nagakesara and its variants in promoting and regulating Artava (menstruation) was a central focus in treating PCOD symptoms.
13) Tamalapatra (Tamala-patra):
[see source text or glossary: Tamalapatra]
14) Dravyaguna (Dravya-guna):
Dravyaguna is the department of Ayurveda that deals with the study of medicinal properties of herbs and other substances. The researchers from the Dravyaguna Department of S.V. Ayurvedic College conducted the study on Nagakesara for managing PCOD.
15) Discussion:
Discussion refers to the analysis and interpretation of the study's results. It includes evaluating the efficacy of different market samples of Nagakesara in PCOD treatment, highlighting the superior effectiveness of Mesua ferrea.
16) Ayurveda (Ayus-veda):
Ayurveda is the ancient Indian system of medicine focused on natural healing and balance. The study's foundation rests on Ayurvedic principles and treatments for managing PCOD through herbal formulations like Nagakesara.
17) Tirupati (Thirupati, Tiruppati):
Tirupati is the location of S.V. Ayurvedic College, where the research was conducted. The study involved the Department of Dravyaguna at this institution for evaluating the efficacy of different Nagakesara samples in managing PCOD.
18) Anartava:
Anartava is a term used in Ayurveda to describe the absence or irregularity of menstruation. PCOD patients in the study often exhibited Anartava, and the efficacy of Nagakesara in addressing this symptom was evaluated.
19) Nature:
[see source text or glossary: Nature]
20) India:
India is the country where the study was conducted, specifically at S.V. Ayurvedic College in Tirupati. Ayurveda, the medicinal system used in the study, originates from ancient Indian texts and traditions.
21) Artavajanana:
Artavajanana refers to the stimulation or promotion of menstrual flow. Mesua ferrea in the study was found to be particularly effective in Artavajanana, making it beneficial in treating PCOD-related menstrual irregularities.
22) Shrinivasa (Shri-nivasa, Srinivasa):
[see source text or glossary: Srinivasa]
23) Tirupathi:
Tirupathi, often interchangeably used with Tirupati, is the location of Srinivasa Ayurveda Pharmacy where the market samples of Nagakesara were processed into tablets for the study on PCOD.
24) Inference:
Inference in this study relates to the conclusions drawn from data analysis regarding the effectiveness of different Nagakesara market samples on PCOD symptoms. Mesua ferrea was inferred to be the most effective.
25) Prameha:
Prameha is an Ayurvedic term associated with urinary disorders but also mentioned in the research context of diseases that share a complex pathology like PCOD. It's one of the broader health issues linked to lifestyle disorders.
26) Anupana:
Anupana refers to the vehicle or medium used to facilitate the intake of a medicinal substance in Ayurveda. In this study, milk was used as Anupana to help administer the Nagakesara powder tablets to patients.
27) Pradara:
Pradara in Ayurvedic terms refers to abnormal discharge or excessive menstrual bleeding. The study mentions that Nagakesara can be used effectively in conditions like Pradara, which include heavy menstrual bleeding.
28) Vandhya (Vamdhya):
Vandhya is an Ayurvedic term for infertility, a common symptom in PCOD patients. The study assesses how effectively Nagakesara samples address related PCOD symptoms including infertility.
29) Chennai:
Chennai is one of the locations where market samples of Nagakesara were acquired for the study. The efficacy of these samples in treating PCOD was then compared with other samples.
30) Vikara:
Vikara refers to a pathological condition or disorder in Ayurveda. The study treats PCOD as a type of Artava Vikara to evaluate Nagakesara's effectiveness in managing this disorder.
31) Kshaya (Ksaya):
Kshaya in Ayurveda describes depletion or deficiency. Conditions like Artava Kshaya (menstrual irregularity) were considered in the study, which evaluated Nagakesara's efficacy in alleviating such deficiencies in PCOD patients.
32) Yavana:
[see source text or glossary: Yavana]
33) Nidana:
Nidana refers to the cause or etiology of a disease in Ayurveda. The study focused on the Nidana of PCOD, particularly the involvement of Vata and Kaphadushti, to understand how Nagakesara acts in treating PCOD.
34) Pidaka:
[see source text or glossary: Pidaka]
35) Shuddha (Suddha):
[see source text or glossary: Suddha]
36) Arshas (Arsa, Arsas, Arsha):
[see source text or glossary: Arsha]
37) Ayus (Ayush):
[see source text or glossary: Ayush]
38) Blood:
Blood and its disorders are critical in the study as PCOD affects menstrual blood flow. The Nagakesara samples were evaluated for their efficacy in regulating menstrual bleeding and addressing related blood irregularities in PCOD.
39) Veda:
Veda, particularly the Atharva Veda, is one of the oldest texts where Ayurvedic knowledge, including medicinal plants like Nagakesara, is recorded. The study roots its methodology and drug usage in such ancient Vedic traditions.
40) Rasa (Rasha):
Rasa refers to the essential fluid or essence related to dhatus (tissues) in Ayurveda. Nagakesara's effectiveness in clearing Rasa-Raktavaha channels might contribute to alleviating PCOD symptoms like acne and hirsutism.
41) Vata:
Vata is one of the three doshas (Vata, Pitta, Kapha) in Ayurveda. The study considers disturbances in Vata, along with Kapha, as underlying causes of PCOD, which Nagakesara aims to balance and treat.