Pharmacological properties of leonotis nepetifolia (l) r.br - a short review
Journal name: Ayushdhara
Original article title: Pharmacological properties of leonotis nepetifolia (l) r.br - a short review
AYUSHDHARA is an international peer-reviewed journal. It focuses on research in Ayurveda, Yoga, Unani, Siddha, Homeopathy, Allopathy, and Pharmaceutical Sciences.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
*K. Vasuki
Assistant professor, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamilnadu, India.
S. Kokila priya
U.G Students, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamilnadu, India.
P. Nandhini
U.G Students, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamilnadu, India.
U. Pavithra
U.G Students, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamilnadu, India.
G. Kiruthika
U.G Students, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamilnadu, India.
Ayushdhara:
(A peer-reviewed, bi-monthly open-access journal)
Full text available for: Pharmacological properties of leonotis nepetifolia (l) r.br - a short review
Year: 2015
Copyright (license): CC BY-NC-SA 4.0
Download the PDF file of the original publication
Summary of article contents:
Introduction
Leonotis nepetifolia (L.) R.Br, commonly referred to as Lion's ear or Christmas candlestick, is a medicinal plant belonging to the Lamiaceae family. This species is highly valued in traditional Indian medicine systems such as Ayurveda, Unani, and Siddha, recognized for its diverse therapeutic properties. In India, it is known as Granthiparna and is used to treat various ailments including rheumatism, dysmenorrhea, bronchial asthma, fever, and skin conditions. The plant is characterized by its striking orange flowers and can grow up to 3 meters tall, thriving in tropical regions and often found in neglected agricultural lands.
Pharmacological Properties
Leonotis nepetifolia exhibits a wide range of pharmacological activities, including antioxidant, antidiabetic, anticancer, and anti-inflammatory effects. Scientific studies have highlighted its significant antioxidant activity, with methanol extracts showing considerable scavenging of free radicals, comparable to standard antioxidants. In terms of antidiabetic properties, high doses of the ethanolic whole plant extract have demonstrated effective results in alloxan-induced diabetic rats. Similarly, anticancer effects have been observed, with extracts leading to reduced tumor volume and improved hematological parameters in animal models, underscoring its potential as an adjunctive cancer therapy.
Therapeutic Efficacy
The therapeutic efficacy of Leonotis nepetifolia extends beyond its antioxidant and antidiabetic properties. The plant has been shown to possess anti-inflammatory effects, as evidenced by its ability to reduce edema in animal testing. Additionally, it has demonstrated antimicrobial activities, effectively inhibiting both Gram-positive and Gram-negative bacteria and dermatophytes, indicating its potential for treating skin infections. Furthermore, topical application of its ethanolic extract has shown promising wound healing capabilities, significantly improving recovery metrics compared to standard treatments. This multi-faceted therapeutic profile supports the plant's traditional applications in various medical practices.
Conclusion
The diverse pharmacological and therapeutic properties of Leonotis nepetifolia make it a valuable medicinal plant with a rich history in traditional medicine. The findings from various studies suggest that it possesses significant potential for modern therapeutic applications across several health concerns. Despite the promising results from animal studies, further clinical research is necessary to validate these effects in humans, ensuring a comprehensive understanding of its safety and efficacy in medical use. Given its established role in traditional healing practices, Leonotis nepetifolia represents a noteworthy subject for future research in herbal medicine.
FAQ section (important questions/answers):
What is the medicinal significance of Leonotis nepetifolia?
Leonotis nepetifolia possesses various therapeutic properties and is used in traditional medicine for treating conditions such as rheumatism, bronchial asthma, dysmenorrhoea, fever, and skin ailments. Its components exhibit activities such as antioxidant, anti-inflammatory, and antimicrobial, making it a valuable medicinal plant.
What are the pharmacological activities associated with Leonotis nepetifolia?
Research indicates that Leonotis nepetifolia has multiple pharmacological activities, including antioxidant, antidiabetic, anticancer, anticonvulsant, antimicrobial, and wound healing effects. These activities have been validated through various experimental studies, underscoring its potential as a beneficial medicinal herb.
What parts of Leonotis nepetifolia are used medicinally?
The leaves, flowers, and seeds of Leonotis nepetifolia are the primary medicinal parts. They are utilized in various formulations in traditional medicine systems like Ayurveda to treat diverse ailments and contribute to the plant's therapeutic benefits.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Pharmacological properties of leonotis nepetifolia (l) r.br - a short review”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) India:
India is a country gifted with immense edaphic and climatic resources, significantly contributing to agriculture, traditional medicine, and the study of medicinal plants. The medicinal uses of Leonotis nepetifolia are extensively reported in various parts of India.
2) Medicine:
Leonotis nepetifolia is an economically significant medicinal plant used traditionally in Indian systems of medicine such as Ayurveda, Unani, and Siddha. It possesses various pharmacological activities, making it a valuable resource in medicine.
3) Pharmacological:
Leonotis nepetifolia exhibits a range of pharmacological activities including antioxidant, antidiabetic, anticancer, anti-inflammatory, anticonvulsant, antimicrobial, wound healing, and hepatoprotective activities. These pharmacological properties make it a highly therapeutic plant.
4) Taila:
The roots of Leonotis nepetifolia are used in Ayurvedic formulations such as 'Brihat Guduchi taila', 'Himasagar taila', 'Nakula taila', and 'Mritasanjivani sur', underscoring its application in traditional medicinal preparations.
5) Animal:
Most therapeutic properties of Leonotis nepetifolia are demonstrated in animal experiment models, indicating the need for controlled clinical studies to gather more data supporting its effectiveness in humans.
6) Drug:
The indigenous system of medicine practiced in India uses around 8000 species of plants including Leonotis nepetifolia. A drug source not adequately understood in terms of nomenclature, identity, properties, and applications may lead to misuse and untoward effects.
7) Vasuki:
K. Vasuki is the corresponding author of the article and an Assistant Professor in the Department of Pharmacognosy at Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamilnadu, India.
8) Family:
Leonotis nepetifolia belongs to the Lamiaceae family, which is known for its diverse medicinal properties. It shares this family with many other plants utilized in traditional and modern medicine.
9) Genu:
[see source text or glossary: Genu]
10) Lion:
Leonotis nepetifolia is commonly known as Lion’s ear, a name derived from the shape of its flowers which resemble the ear of a lion. This common name highlights the plant’s distinctive morphology.
11) Phytochemical:
Phytochemical examination of Leonotis nepetifolia indicates the presence of numerous bioactive compounds including alkaloids, iridoid glycosides, diterpenoids, flavonoids, volatile oil, tannins, and vitamin A. These compounds are responsible for its pharmacological effects.
12) Granthiparna (Granthi-parna, Gramthiparna):
Leonotis nepetifolia is referred to as Granthiparna in Ayurveda, which highlights its significance in traditional Indian medicine. The plant is known for its therapeutic properties and is included in various Ayurvedic formulations.
13) Tiruchengode (Tiruchengodu):
Tiruchengode is the location of Swamy Vivekanandha College of Pharmacy in Tamilnadu, India, where research on Leonotis nepetifolia and its pharmacological properties is being conducted.
14) Bronchial asthma:
Leonotis nepetifolia has been used to treat bronchial asthma among many other conditions, including its therapeutic properties in traditional medicine practices in Madagascar, Brazil, Canada, Kenya, and African countries.
15) Mritasanjivani (Mrtasanjivani, Mrtasamjivani, Mrita-samjivani, Mritasamjivani, Mrita-sanjivani):
Leonotis nepetifolia’s root is used in the Ayurvedic formulation 'Mritasanjivani sur' which is part of various traditional treatments, showing the plant’s integration into complex medicinal recipes.
16) Dysmenorrhea (Dysmenorrhoea):
Leonotis nepetifolia is utilized in traditional medicine to treat conditions like dysmenorrhoea, demonstrating its broad spectrum of therapeutic applications for various ailments including menstrual pain.
17) Granthiparni (Granthi-parni):
In Ayurveda, Leonotis nepetifolia is also known by the name Granthiparni and is widely used in Indian traditional systems of medicine for its numerous therapeutic properties.
18) Tamilnadu (Tamil-nadu):
[see source text or glossary: Tamil-nadu]
19) Flavonoid:
Phytochemical studies reveal that Leonotis nepetifolia contains flavonoids including rutin, quercetin, hyperoside, and apigenin, which contribute to its antioxidant and other pharmacological activities.
20) Disease:
Leonotis nepetifolia has been traditionally used in various countries for treating multiple diseases such as kidney disease, rheumatism, dysmenorrhoea, bronchial asthma, fever, and diarrhea.
21) Nakula:
Leonotis nepetifolia is a component of the Ayurvedic formulation 'Nakula taila’, used in traditional medicine for its known therapeutic benefits.
22) Brihat (Brhat):
The medicinal formulations like 'Brihat Guduchi taila,' which include Leonotis nepetifolia, emphasize its integration into traditional Ayurvedic medicine.
23) Indian:
The Indian traditional systems of medicine, including Ayurveda, Unani, and Siddha, extensively use medicinal plants like Leonotis nepetifolia for treating various conditions.
24) Fever:
Leonotis nepetifolia is used traditionally to treat fever among other ailments, highlighting its versatility in therapeutic applications.
25) Tamil:
In Tamil, Leonotis nepetifolia is known as 'Then thumbai,' reflecting its regional vernacular name and traditional usage in Southern India.
26) Guma:
In Hindi, Leonotis nepetifolia is referred to as 'Bara guma' or 'Lal guma,' indicating its local names and use in traditional medicine.
27) Pain:
Leonotis nepetifolia is traditionally used for pain management including menstrual pain and rheumatic pain, demonstrating its analgesic properties.
28) Southern India:
Leonotis nepetifolia is native to tropical Africa and Southern India, and is found growing in regions such as Southern India where it plays a role in traditional medicine.
29) Civilization:
Since human civilization, plants like Leonotis nepetifolia have been used for nutrition and medicinal purposes, indicating the long-standing importance of medicinal plants in human history.
30) Agriculture:
The plant Leonotis nepetifolia grows abundantly in rainy seasons along roadsides or barren, unused agricultural land, demonstrating its resilient nature in varying agricultural landscapes.
31) Granthika (Gramthika):
[see source text or glossary: Granthika]
32) Substance:
The traditional Indian systems of medicine utilize not just plants but also animals, metallic, and mineral substances, indicating a diverse range of materials used in traditional remedies.
33) Ayurveda (Ayus-veda):
Leonotis nepetifolia is recognized in Ayurveda as 'Granthiparna' and is included in several Ayurvedic medicinal formulations for its therapeutic properties.
34) Swelling:
In India, Leonotis nepetifolia is used to treat conditions such as burns, breast swelling, and other skin afflictions, demonstrating its efficacy in managing swelling and inflammation.
35) Epilepsy:
Pharmacological tests on Leonotis nepetifolia have shown anticonvulsant activity, which supports its traditional use in the treatment of epilepsy.
36) Sanskrit:
In Sanskrit, Leonotis nepetifolia is referred to by multiple names such as Granthi, granthika, Granthiparna, and Granthiparni, highlighting its historical and cultural relevance in traditional Indian medicine.
37) Granthi (Gramthi):
In Sanskrit, the name 'Granthi' refers to Leonotis nepetifolia, showcasing its traditional nomenclature in Ayurvedic medicinal texts.
38) Marathi:
In Marathi, Leonotis nepetifolia is known as 'Deepmal,' showing its regional nomenclature and usage in traditional medicine practices within Maharashtra.
39) Habitat:
Leonotis nepetifolia is often found as a pan tropical weed, thriving along roadsides and in abandoned cultivations, indicating its adaptive habitat preferences.
40) Mineral:
Traditional Indian medicine uses a combination of plants, animals, metallic, and mineral substances, illustrating the diverse raw materials incorporated in ancient healing systems.
41) Siddha:
Leonotis nepetifolia holds significance in the Siddha system, alongside Ayurveda and Unani, highlighting its widespread use in different traditional Indian medical practices.
42) Kokila:
S. Kokila Priya is one of the co-authors and a U.G. student involved in the research on the pharmacological properties of Leonotis nepetifolia from Swamy Vivekanandha College of Pharmacy, Tamilnadu.
43) Harini:
The DPPH radical scavenging assay used to evaluate the antioxidant activity of Leonotis nepetifolia was based on a method proposed by Harini et al., with slight modifications.
44) Cancer:
Leonotis nepetifolia exhibits anticancer properties, as demonstrated by experimental studies on ethanolic extracts administered to animal models, showing potential in tumor reduction and extended survival time.
45) Nature:
Nature provides a rich variety of plant species like Leonotis nepetifolia, which have been used for nutritional, medicinal, and various other purposes since ancient times.
46) Kandu (Kamdu):
In traditional therapy, Leonotis nepetifolia is used for treating 'Kandu,' a term related to itching or pruritus in Ayurvedic medicine.
47) Priya:
[see source text or glossary: Priya]
48) Ayus (Ayush):
AYUSHDHARA is the journal in which the article on the pharmacological properties of Leonotis nepetifolia is published, contributing to research in AYUSH and allied systems.
49) Edema (Oedema):
Anti-inflammatory tests on Leonotis nepetifolia involving TPA-induced edema in mice show the plant's potential in reducing inflammation and swelling.
50) Hindi (Himdi):
In Hindi, Leonotis nepetifolia is called 'Bara guma' or 'Lal guma,' conveying its regional names and traditional applications in North Indian medicine.
51) Birth:
Traditional healers, including birth attendants, utilize medicinal plants like Leonotis nepetifolia for managing various health conditions.
52) Oriya:
In Oriya, Leonotis nepetifolia is known as 'Barcha,' reflecting its vernacular name and usage in traditional medicine in Odisha.
53) Bara:
[see source text or glossary: Bara]
54) Visha (Visa):
In traditional Indian medicine, Leonotis nepetifolia is used to treat 'Visa,' which refers to poisons or toxic conditions.
55) Nadu:
[see source text or glossary: Nadu]
56) Worm:
Leonotis nepetifolia is traditionally applied to treat skin afflictions like ringworm, showcasing its broad range of dermatological applications.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Pharmacological properties of leonotis nepetifolia (l) r.br - a short review’. Further sources in the context of Science might help you critically compare this page with similair documents:
Therapeutic properties, Medicinal use, Anti-inflammatory activity, Antioxidant activity, Pharmacological activities, Wound healing activity, Antimicrobial activity, Hepatoprotective activity, Anticancer activity, Traditional systems of medicine, Antidiabetic activity, Botanical classification, Anticonvulsant activity, Antidiarrheal activity, Phytochemical examination, Important formulation, Ayurvedic name.