Experimental study on effect of hydroalcoholic extract of Emblica officinalis fruits on glucose homeostasis and metabolic parameters

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Journal name: AYU (Journal of Research in Ayurveda)
Original article title: Experimental study on effect of hydroalcoholic extract of Emblica officinalis fruits on glucose homeostasis and metabolic parameters
AYU is an internationally recognized quarterly journal dedicated to advancing research in Ayurveda. The journal covers a wide range of topics, including clinical and pharmacological research in Ayurveda's eight branches, herbal remedies, phytochemistry, and ethnomedicine.

Original source:

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Author(s):

Snehal S. Patel
Ramesh K. Goyal
Rajendra S. Shah
Pravin R. Tirgar
Pinakin D. Jadav


AYU (Journal of Research in Ayurveda):

(An International Quarterly Journal of Research in Ayurveda)

Full text available for: Experimental study on effect of hydroalcoholic extract of Emblica officinalis fruits on glucose homeostasis and metabolic parameters

Year: 2013 | Doi: 10.4103/0974-8520.127731

Copyright (license): CC BY-NC-SA 4.0


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Summary of article contents:

Polyphenols from natural source are potential therapeutics that act alone or supplement anti-diabetic drugs in the prevention and treatment of diabetes. The present investigation was undertaken to study the effect of hydroalcoholic extract (HE) of fruits of Emblica officinalis on type 1 diabetic rats. Diabetes was induced by streptozotocin (STZ) (45 mg/kg i.v.). HE (100 mg/kg, p.o.) was administered for 4 weeks and at the end of treatment, blood samples were collected and analyzed for various biochemical parameters. STZ produced a diabetic state exhibiting all the cardinal symptoms such as loss of body weight, polydipsia, polyuria, glucosuria, polyphagia, hypoinsulinemia, and hyperglycemia associated with hypercholesterolemia and hypertriglyceridemia. Treatment with HE prevented cardinal symptoms and caused significant decrease in fasting serum glucose, AUCglucose, cholesterol, triglyceride, low-density lipoprotein (LDL) and very LDL in diabetic rats. However, insulin, AUCinsulin, and serum high-density lipoprotein level were not significantly altered by treatment. Treatment also reduced lipid peroxidation and increased anti-oxidant parameters in the liver homogenates of diabetic rats. Polyphenol enriched fraction of HE significantly improved disarranged carbohydrate and lipid metabolism of chemically induced diabetes in rats. The mechanism of its anti-diabetic activity appears to be either improvement in peripheral glucose utilization, increased insulin sensitivity, or anti-oxidant property. Keywords: Anti-diabetic, anti-hyperlipidemic, anti-oxidant, Emblica officinalis, oxidative stress, polyphenol, streptozotocin

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Discover the significance of concepts within the article: ‘Experimental study on effect of hydroalcoholic extract of Emblica officinalis fruits on glucose homeostasis and metabolic parameters’. Further sources in the context of Science might help you critically compare this page with similair documents:

Emblica officinalis, Ayurvedic system, Oxidative stress, Animal model, Anti hyperlipidemic, High-density lipoprotein, Low-density lipoprotein, Hepatoprotective activity, Lipid peroxidation, Phytochemical Investigation, Very low density lipoprotein, Superoxide dismutase, Hydroalcoholic extract, Biochemical analysis, Anti-oxidant parameters, Polyphenol content, Glucose metabolism, Oral glucose tolerance test, Insulin sensitivity, Catalase enzyme, Type 1 diabetes, Acute phase, Chronic treatment, Cardinal symptom, Anti-diabetic drug, Biochemical parameter, Blood sample.

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