Antihyperglycemic and antioxidant activity of Clitorea ternatea Linn. on streptozotocin-induced diabetic rats
Journal name: AYU (Journal of Research in Ayurveda)
Original article title: Antihyperglycemic and antioxidant activity of Clitorea ternatea Linn. on streptozotocin-induced diabetic rats
AYU is an internationally recognized quarterly journal dedicated to advancing research in Ayurveda. The journal covers a wide range of topics, including clinical and pharmacological research in Ayurveda's eight branches, herbal remedies, phytochemistry, and ethnomedicine.
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Karuna A. Talpate
Uma A. Bhosale
Mandar R. Zambare
Rahul Somani
AYU (Journal of Research in Ayurveda):
(An International Quarterly Journal of Research in Ayurveda)
Full text available for: Antihyperglycemic and antioxidant activity of Clitorea ternatea Linn. on streptozotocin-induced diabetic rats
Year: 2013 | Doi: 10.4103/0974-8520.127730
Copyright (license): CC BY-NC-SA 4.0
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Summary of article contents:
Ethanol extract of Clitorea ternatea Linn. (EECT) was evaluated for its antihyperglycemic and antioxidative activity in normal and streptozotocin-induced diabetic rats. Antihyperglycemic activity of EECT was studied in normal fasted and glucose fed hyperglycemic and epinephrine induced hyperglycemic rats by estimating fasting serum glucose (FSG) by glucose oxidisae or peroxidase enzymatic method. Antioxidant activity of EECT was studied by assaying lipid peroxide/Thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), total nitric oxide, catalase (CAT) and glutathione levels in diabetic rats. The EECT (200 and 400 mg/kg) showed significant antihyperglycemic activity by decreasing FSG in all hyperglycemic models except epinephrine induced hyperglycemic rats; in which improvement in FSG was observed only with EECT in 400 mg/kg dose, whereas significant decrease in TBARS (P < 0.001), nitric oxide (P < 0.001) and significant increase in SOD (P < 0.001), CAT (P < 0.01) and reduced glutathione levels (P < 0.001) was observed in animals treated with EECT (200 and 400 mg/kg) compared to diabetic control group. The results indicated that EECT has remedial effects on hyperglycemia and oxidative stress in diabetic rats. Keywords: Antioxidant, Clitorea ternatea, epinephrine, streptozotocin models
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Discover the significance of concepts within the article: ‘Antihyperglycemic and antioxidant activity of Clitorea ternatea Linn. on streptozotocin-induced diabetic rats’. Further sources in the context of Science might help you critically compare this page with similair documents:
Diabetes mellitus, Antioxidant activity, Phytochemical screening, Hypoglycemic activity, Reduced glutathione, Antihyperglycemic activity, Superoxide dismutase, Catalase, Ethanol extract, Clitorea ternatea, Streptozotocin-induced diabetic rats, Fasting serum glucose, High performance thin layer chromatogram, Acute oral toxicity test, Diabetic control group, Phytochemicals like flavonoids, Environmentally controlled room, Antioxidative activity, Glucose oxidase, Lipid peroxide, Antidiabetic study, Thiobarbituric acid reactive substance, Malondialdehyde Level, Antidiabetic agent, Oral antidiabetic agent, Glutathione level.