Immunomodulatory effect of ethanolic extract of Shirishadi compound
Journal name: AYU (Journal of Research in Ayurveda)
Original article title: Immunomodulatory effect of ethanolic extract of Shirishadi compound
AYU is an internationally recognized quarterly journal dedicated to advancing research in Ayurveda. The journal covers a wide range of topics, including clinical and pharmacological research in Ayurveda's eight branches, herbal remedies, phytochemistry, and ethnomedicine.
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Divya Kajaria
Jyoti Shankar Tripathi
Shri Kant Tiwari
Bajrangi Lal Pandey
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AYU (Journal of Research in Ayurveda):
(An International Quarterly Journal of Research in Ayurveda)
Full text available for: Immunomodulatory effect of ethanolic extract of Shirishadi compound
Year: 2013 | Doi: 10.4103/0974-8520.123136
Copyright (license): CC BY-NC-SA 4.0
Summary of article contents:
Immunomodulators are substances that helps to regulate the immune system. The basic mechanisms by which the herbs defend the body against infection have two probable ways- one by destroying pathogens and other by enhancing the body immunity. Shirishadi compound is a polyherbal drug used in Ayurvedic system of medicine for the management of allergic disorders such as allergic rhinitis, allergic asthma etc., The present study was carried out to evaluate the immunomodulatory activity of ethanolic extract of polyherbal compound “Shirishadi” on Swiss albino mice. Cyclophosphamide (CP) induced immunosuppression model was used to assess the activity of drug. CP was given in the dose of 30 mg/kg body weight through i.p route. 500 mg/kg body weight of Shirishadi polyherbal drug was given through oral route. The extent of protection against immunosuppression caused by CP was evaluated after 14 days of drug administration, by estimating hematological parameters and neutrophil adhesion test. Ethanolic extracts of Shirishadi compound showed pronounced immunoprotective activity by increasing the depleted levels of total WBC count and RBC, % Hb, and % neutrophils adhesion. The extract was found to be an effective immunomodulatory agent. Keywords: Shirishadi compound, cyclophosphamide, immunomodulatory activity
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Cyperus rotundus, Ayurvedic system of medicine, Complementary and alternative medicine, Immunomodulatory activity, Complementary and alternative medicine (CAM), Hematological Parameters, Secondary metabolite, Ethanolic extract, Analytical grade, Acute toxicity study, Swiss albino mice, Cyclophosphamide, Total WBC count, RBC count, Neutrophil adhesion test, Herbal medicines research, Immunostimulatory agent, Solanum surattense, Hydroalcoholic Extraction, Total leukocyte count, Neutrophil index, Immunostimulatory activity, Expression level, Phytoconstituent.