Evaluation of antinociceptive effects of Tragia plukenetii: A possible mechanism
Journal name: AYU (Journal of Research in Ayurveda)
Original article title: Evaluation of antinociceptive effects of Tragia plukenetii: A possible mechanism
AYU is an internationally recognized quarterly journal dedicated to advancing research in Ayurveda. The journal covers a wide range of topics, including clinical and pharmacological research in Ayurveda's eight branches, herbal remedies, phytochemistry, and ethnomedicine.
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Sama Venkatesh
Saba Fatima
AYU (Journal of Research in Ayurveda):
(An International Quarterly Journal of Research in Ayurveda)
Full text available for: Evaluation of antinociceptive effects of Tragia plukenetii: A possible mechanism
Year: 2013 | Doi: 10.4103/0974-8520.123135
Copyright (license): CC BY-NC-SA 4.0
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Summary of article contents:
Tragia plukenetii R.Smith. (Euphorbiaceae) is an erect, prostate herb with sparsely hispid stinging hairs. In the present study, ethanolic extract and its fractions of T. plukenetii aerial parts were evaluated for antinociceptive and central nervous system (CNS) depressant effects. Among all the extracts, chloroform extract has produced significant analgesic activity at a test dose of 250 mg/kg in acetic acid induced writhing test and Eddy's hotplate test. The analgesic effect of chloroform extract (68.83% inhibition) is comparable with aspirin (72.09% inhibition) in acetic acid induced writhing test. Chloroform extract significantly increased the latency time in hotplate test. In the study of CNS depressant effect, the chloroform extract was found to produce a significant (P < 0.01) reduction of the exploratory capacity and depressant effect in locomotor activity. From the point of CNS depressant and good protective effect on chemical and thermal pain stimuli, indicates that T. plukenetii chloroform extract may have morphinomimetic properties. The naloxone is not able to alter the T. plukenetii induced antinociceptive effect in writhing and hotplate test. Thus, the observed antinociceptive activity of T. plukenetii might have resulted from the activation of peripheral receptors. Keywords: Antinociceptive activity, aspirin, central nervous system depressant activity, morphine, naloxone, Tragia plukenetii
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Traditional medicine, Analgesic activity, Ethanolic extract, Locomotor activity, Chloroform extract, Central nervous system depressant activity, Acetic acid induced writhing test, Hot plate test, CNS depressant effects, Naloxone, Plant based traditional medicine, Pain stimuli, Qualitative phytochemical analysis, Antinociceptive activity, Aspirin, Analgesic, Phytoconstituent.