Evaluation of Anogeissus pendula Extracts for Antioxidant and Hepatoprotection

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Journal name: Ancient Science of Life
Original article title: Ethnopharmacological based Evaluation of Anogeissus pendula Edgew Extracts for Antioxidant and Hepatoprotective Potential
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Deeksha Singh, Uttam Singh Baghel, Manmeet Singh Pannu, Rakesh Yadav


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Ethnopharmacological based Evaluation of Anogeissus pendula Edgew Extracts for Antioxidant and Hepatoprotective Potential

Year: 2017

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

The study focuses on Anogeissus pendula, a plant known for its traditional medicinal uses, particularly in India. The research aimed to evaluate its antioxidant and hepatoprotective potential through various assays, considering its rich content of phenolic compounds. The investigation was designed to assess both in vitro antioxidant activity and in vivo hepatoprotective effects using albino rats subjected to hepatotoxicity induced by allyl alcohol.

Antioxidant and Hepatoprotective Potential

The study highlighted the remarkable antioxidant capabilities of hydro-alcoholic extracts derived from the stem bark and leaves of Anogeissus pendula. Specifically, the stem bark extract (APB) exhibited superior antioxidant activity compared to the leaf extract (APL), with a recorded IC50 value for DPPH radical scavenging at 44.29 μg/ml, indicating its efficacy in neutralizing free radicals. In terms of hepatoprotection, both extracts significantly improved liver function parameters in rats poisoned with allyl alcohol, with APB showing a more pronounced hepatoprotective effect at a dosage of 400 mg/kg. This suggests that the higher concentration of phytoconstituents in the stem bark may be responsible for its enhanced biological activity.

Conclusion

The findings of this study substantiate the traditional uses of Anogeissus pendula in treating liver disorders and providing antioxidant benefits. The results indicate that the plant could serve as a promising source of natural hepatoprotective agents. However, further exploration is necessary to isolate and identify the active compounds and to understand the underlying mechanisms of action, thereby validating its potential therapeutic applications in contemporary medicine.

FAQ section (important questions/answers):

What is the focus of the study on Anogeissus pendula?

The study evaluates the in vitro antioxidant and in vivo hepatoprotective activities of extracts from the stem bark and leaves of Anogeissus pendula, particularly in relation to its ethnomedicinal uses.

How were the antioxidant activities of the extracts measured?

Antioxidant activities were measured using DPPH radical scavenging and hydrogen peroxide scavenging assays, comparing the extracts' effectiveness to ascorbic acid as a positive control.

What animal model was used for testing hepatoprotective activity?

Albino Wistar rats were used, divided into groups receiving different treatments, including silymarin and hydro-alcoholic extracts of Anogeissus pendula, with hepatotoxicity induced by allyl alcohol.

What were the main findings regarding the extracts' effectiveness?

The stem bark extract (APB) exhibited stronger antioxidant and hepatoprotective activities compared to the leaves extract (APL), especially at the higher dosage of 400 mg/kg.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Evaluation of Anogeissus pendula Extracts for Antioxidant and Hepatoprotection”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
Activity refers to the functional capacity of a substance or extract, often in the context of biological effects. In the study of Anogeissus pendula, the activity pertains to its in vitro antioxidant potential and in vivo hepatoprotective effects, indicating its potential therapeutic applications. These activities are crucial for validating traditional medicinal claims.

2) Pharmacology:
Pharmacology is the branch of medicine that deals with the study of drugs and their effects on biological systems. This field encompasses the mechanisms of action, therapeutic uses, and potential side effects of compounds, like those derived from Anogeissus pendula, which are investigated for their beneficial health effects.

3) Lata:
Lata refers to one of the authors of the study, contributing to the research on Anogeissus pendula. The expertise and findings of authors like Lata provide credibility and context to the exploration of the plant's medicinal properties, enhancing the study's relevance in ethnopharmacological research.

4) Toxicity:
Toxicity denotes the degree to which a substance can harm living organisms. In this study, allyl alcohol-induced hepatotoxicity is a key aspect, serving as a model to assess the protective effects of Anogeissus pendula extracts. Understanding toxicity is essential for drug safety assessments and therapeutic development.

5) Drug:
A drug is a substance used for treatment, prevention, or diagnosis of diseases. This term describes the focus of pharmacological research as seen in the study of Anogeissus pendula, where the plant’s extracts are evaluated for their potential as hepatoprotective agents, emphasizing natural compounds in modern medicine.

6) Pharmacological:
Pharmacological relates to the actions and effects of drugs within biological systems. The relevance in this context emphasizes the evaluation of the pharmacological properties of Anogeissus pendula, including its antioxidant and hepatoprotective properties, enriching our understanding of how natural substances can be used therapeutically.

7) Science (Scientific):
Science is the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. In this article, science underpins the methods used to evaluate Anogeissus pendula's potential benefits, providing rigor to the claims about its medicinal properties and establishing a foundation for further research.

8) Repair:
Repair refers to the process of restoring the structure and function of damaged tissues, particularly in the context of liver health. Understanding the mechanisms of repair following toxicity, such as that induced by allyl alcohol, can lead to insights into how Anogeissus pendula assists in liver recovery, showcasing its medicinal value.

9) Water:
Water is a fundamental solvent in biological systems, facilitating reactions and transport in living organisms. In pharmacological studies, including those on Anogeissus pendula, water serves as a medium for extracting active compounds, thus influencing the efficacy of herbal therapies and their applications in traditional medicine.

10) Blood:
Blood is a transport medium in the body, carrying oxygen, nutrients, and biochemical signals. Its relevance in the study is crucial during the evaluation of hepatoprotective effects, where serum samples are analyzed to assess liver function after treatment with Anogeissus pendula extracts, emphasizing the interconnected nature of various biological systems.

11) Latta:
Latha is one of the contributing authors in the research focused on Anogeissus pendula. The involvement of researchers like Latha adds to the study’s depth by providing various disciplinary perspectives on the pharmacological properties of the plant, ensuring comprehensive assessment within the field of ethnopharmacology.

12) Button tree:
Button tree, a common name for Anogeissus pendula, relates to its identity in ethnobotanical studies. This nomenclature highlights the plant’s cultural significance and traditional uses in medicine, providing context to the scientific investigation of its bioactive compounds and supporting claims for its therapeutic potential.

13) Discussion:
Discussion in scientific literature involves interpreting results, correlating them with existing studies, and drawing conclusions based on evidence. This section is vital for contextualizing findings on Anogeissus pendula's antioxidant and hepatoprotective activities, allowing for a comprehensive understanding of the implications and future directions for research.

14) Substance:
Substance refers to a particular matter or complex of matter, including chemical compounds found in plants. In the context of the study, understanding the active substances in Anogeissus pendula helps clarify the specific agents responsible for its antioxidant and hepatoprotective properties, driving innovation in pharmacognosy and herbal medicine.

15) Flavonoid:
Flavonoids are a diverse group of plant compounds known for their antioxidant properties. In the study of Anogeissus pendula, the presence of flavonoids supports the plant’s traditional use in medicine and underscores its potential as a natural source for developing drugs aimed at oxidative stress-related conditions.

16) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing illness. This term relates closely to the study of Anogeissus pendula, as the exploration of its bioactive compounds aims to integrate traditional knowledge into modern therapeutic strategies, contributing to the development of effective natural remedies.

17) Chinna:
Chinna references one of the authors or individuals involved in the study of Anogeissus pendula. Contributions from authors like Chinna enhance the research by providing insights and expertise in the area of pharmacology and ethnomedicine, reinforcing the importance of collaboration in scientific research.

18) Reason:
Reason denotes the rationale behind conducting research, such as investigating Anogeissus pendula's medicinal properties. Establishing clear reasons for studies promotes an understanding of how traditional uses can be validated by scientific inquiry, bridging the gap between empirical evidence and ethnopharmacological practices.

19) Botany:
Botany is the branch of biology that studies plants, focusing on their structure, properties, and biochemical processes. This field is pivotal in understanding Anogeissus pendula, as botanical studies shed light on its taxonomy, morphology, and ecological significance, allowing for informed uses in pharmacognosy and herbal medicine.

20) Nama (Naman, Nãman):
Nama refers to Dr. Krishnendra Singh Nama, who authenticated the plant used in the study. The role of botanists like Nama is crucial in validating the identity of medicinal plants, thereby ensuring the integrity of research findings and promoting accurate applications in ethnopharmacology.

21) Diet:
Diet refers to the types of food consumed by living organisms. In relation to the study, understanding the dietary implications of Anogeissus pendula can contribute to the holistic view of its health benefits, especially how it may influence liver function and overall health through dietary incorporation.

22) Post:
Post often refers to the conclusion or dissemination of research findings. In this context, it may imply the presentation of results concerning Anogeissus pendula's pharmacological evaluations, highlighting the importance of sharing knowledge within the scientific community to foster advancements in natural product research and herbal medicine.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Evaluation of Anogeissus pendula Extracts for Antioxidant and Hepatoprotection’. Further sources in the context of Science might help you critically compare this page with similair documents:

Statistical analysis, Hepatoprotective activity, Histopathological study, Dose-dependent manner, Hydro alcoholic extract, Liver Functional Test, Antioxidant potential, DPPH radical scavenging activity, Hydrogen peroxide scavenging assay, Plant Extract, Albino Wistar rats, Oxidative stress parameters, Phenolic compound, Silymarin treatment, Elevated enzyme levels.

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