Pharmacological potentials of Premna integrifolia L.

| Posted in: Science

Journal name: Ancient Science of Life
Original article title: Pharmacological potentials of Premna integrifolia L.
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Prashant Y. Mali


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Pharmacological potentials of Premna integrifolia L.

Year: 2016

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

Premna integrifolia Linn. (commonly known as Agnimanthā or Araṇi) is a significant medicinal plant in traditional Indian medicine, especially within the Ayurvedic system. It forms a critical part of the herbal formulation known as Daśamūla, consisting of ten roots, and is noted for its use in treating various ailments. This review aims to compile comprehensive pharmacological information regarding the activities of different parts of P. integrifolia. Utilizing a thorough literature search, including global electronic databases, Ayurvedic texts, and modern pharmacological studies, the researchers have gathered evidence supporting numerous ethno-medicinal claims related to this plant, confirming many through both in-vitro and in-vivo studies.

Summary of Anticancer Potential

One of the highlighted pharmacological activities of P. integrifolia is its anticancer potential. Studies have demonstrated that extracts from this plant can suppress tumor growth and enhance survival rates in animal models. Specifically, the ethanolic extract has shown favorable outcomes against Ehrlich Ascites carcinoma, resulting in reduced tumor volume and enhanced viability of treated subjects. The presence of bioactive compounds in the extract appears to play a crucial role in these anticancer effects, with the extracts exhibiting significant cytotoxic activity against various cancer cell lines. This emphasizes the potential of P. integrifolia as a lead candidate for developing natural anticancer therapies.

Conclusion

The exhaustive review of P. integrifolia reveals a wide range of pharmacological activities, including analgesic, anti-inflammatory, antibacterial, and anticancer properties. The majority of studies conducted so far have utilized methanol and ethanol as extraction solvents, which tend to yield higher quantities of beneficial phytoconstituents such as phenols and flavonoids. These findings suggest that P. integrifolia is a valuable resource for modern drug development and Ayurvedic formulations. With further research into its active constituents and validation of traditional uses, P. integrifolia can significantly contribute to the search for new therapeutic agents, presenting the opportunity for advancements in the treatment of various diseases.

FAQ section (important questions/answers):

What is the focus of the review on Premna integrifolia?

The review provides comprehensive information on the pharmacological activities of various parts of Premna integrifolia, used in traditional medicine, confirming many ethno-medicinal claims through modern pharmacological studies.

What are some pharmacological activities of Premna integrifolia?

Premna integrifolia exhibits various pharmacological activities, including analgesic, anti-inflammatory, antibacterial, anticancer, antioxidant, anti-obesity, and neuroprotective effects, making it a significant candidate for medicinal applications.

How has Premna integrifolia been studied for health benefits?

Research on Premna integrifolia has utilized in-vitro and in-vivo pharmacological studies, using different extracts and their isolates, to validate its traditional medicinal claims and explore its health benefits.

What conclusions were drawn from the review on Premna integrifolia?

The review concludes that Premna integrifolia possesses numerous therapeutic activities, highlighting the need for further scientific research to isolate active constituents and validate its traditional uses in modern medicine.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Pharmacological potentials of Premna integrifolia L.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
Activity refers to the specific action or effect a substance or compound has on biological systems, especially in pharmacology. Here, it encompasses the various pharmacological effects exhibited byPremna integrifolia and is crucial for understanding its therapeutic potential and mechanisms of action in treating different ailments, ranging from pain relief to anti-cancer effects.

2) Drug:
Drug signifies any substance that causes a physiological effect when introduced into the body. In this context, drugs derived from plant sources likePremna integrifolia are crucial for developing new treatments, especially since many modern pharmaceuticals are based on traditional herbal remedies, making understanding their effects essential for medical advancements.

3) Cancer:
Cancer signifies a group of diseases characterized by uncontrolled cell growth. The relevance toPremna integrifolia is in its reported anticancer properties, which have been validated through scientific research, highlighting the plant's potential role in cancer treatment strategies and the need for further exploration of its active compounds as novel therapies.

4) Blood:
Blood serves as a vital fluid in the body that carries oxygen and nutrients. In the context ofPremna integrifolia, research addresses its effects on blood components, including the impacts on blood sugar levels and overall health, which is significant for understanding how the plant could help manage conditions like diabetes and other blood-related diseases.

5) Pharmacological:
Pharmacological refers to the study of drugs and their effects on biological systems. This term is pivotal when discussingPremna integrifolia, as it encompasses the plant's medicinal properties, including analgesic, anti-inflammatory, and potential anticancer activities, helping to establish its value in therapeutic applications and encouraging further investigation.

6) Premna integrifolia:
Premna integrifolia is a medicinal plant of the Verbenaceae family, noted for its traditional uses in Ayurvedic and herbal medicine. Its pharmacological activities, including analgesic and anti-inflammatory effects, underscore its significance as a source for the development of new drugs and highlight its roles in traditional healing systems.

7) Antibiotic (Antibacterial):
Antibiotic refers to substances used to kill or inhibit bacterial growth. The potential antibiotic properties ofPremna integrifolia illustrate its promise as a natural alternative in treating infections, thereby contributing to the search for new antimicrobial agents amid rising antibiotic resistance in medicine.

8) Diet:
Diet pertains to the kinds of food one consumes. In the context ofPremna integrifolia, dietary influences on body weight and blood sugar regulation imply its potential role in dietary interventions for treating obesity and diabetes, indicating the importance of integrating herbal substances into modern dietary guidelines for health management.

9) Science (Scientific):
Scientific pertains to the systematic methods of investigation used to understand phenomena. The scientific inquiry surroundingPremna integrifolia elevates its profile by providing protected potential applications through rigorous research studies, validating its traditional uses, and establishing a basis for modern pharmaceutical research.

10) Edema (Oedema):
Oedema refers to the localized or generalized accumulation of excess fluid in body tissues. The study ofPremna integrifolia's effects on oedema illustrates its potential therapeutic actions, particularly in managing conditions characterized by fluid retention and chronic swelling, reinforcing its value in traditional and modern medicinal contexts.

11) Flavonoid:
Flavonoid is a class of plant secondary metabolites with known antioxidant properties. The presence of flavonoids inPremna integrifolia may contribute to its pharmacological effects, particularly its anti-inflammatory and anti-cancer activities, suggesting a critical role in enhancing the therapeutic potential of the plant's extracts.

12) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing illness. The relevance ofPremna integrifolia in medicine is underscored by its diverse pharmacological activities, which support its incorporation into therapeutic regimes, emphasizing the importance of traditional knowledge in modern medical applications.

13) Pharmacology:
Pharmacology is the study of drugs, their interactions, and their effects on living organisms. It plays a fundamental role in understanding howPremna integrifolia's compounds can be harnessed for therapeutic use, investigating the mechanisms behind its various beneficial effects and guiding drug development processes.

14) Inflammation:
Inflammation is the body’s response to injury or infection, often resulting in pain and swelling. The anti-inflammatory properties ofPremna integrifolia highlight its usefulness in treating inflammatory conditions, making it an important area for research in developing treatments for chronic inflammatory diseases.

15) Ulcer:
Ulcer is a sore that develops on the lining of organs. The potential ofPremna integrifolia in preventing or treating ulcers suggests its protective effects on the gastrointestinal tract, emphasizing the need for further research into its mechanisms and effectiveness as a natural remedy for ulcer-related issues.

16) Worm:
Worm can refer to parasitic worms that infect hosts and cause disease. In the context ofPremna integrifolia, studies indicating antiparasitic properties could indicate its potential application in treating parasitic infections, thus broadening the scope of its medicinal uses and enhancing its significance in ethnomedicine.

17) Dashamula (Dasha-mula, Dasamula, Dashan-mula):
Daśamūla is a traditional Ayurvedic formulation composed of ten plant roots, includingPremna integrifolia. Its importance lies in how this formulation is leveraged in Ayurvedic medicine for various health benefits, showcasing the integration ofPremna integrifolia into established therapeutic practices and highlighting its cultural and medicinal heritage.

18) Toxicity:
Toxicity measures the adverse effects of substances, including those derived from plants. The relevance ofPremna integrifolia in this context involves understanding the safety profile of its extracts, thereby ensuring therapeutic uses are efficacious and do not pose significant risks to human health during consumption.

19) Clerodendrum phlomidis:
Clerodendrum phlomidis is a plant commonly associated with traditional medicinal use. Its mention alongsidePremna integrifolia indicates the historical context in which herbal remedies were categorized, providing insight into the complexity of Ayurvedic medicine and the variations in plant use across different texts and formulations.

20) Accumulation (Accumulating, Accumulate):
Accumulation refers to the gradual gathering of materials or substances. In pharmacological studies, examining the accumulation of compounds in the body helps understand the efficacy and potential side effects of plant-based treatments likePremna integrifolia, guiding safe therapeutic applications and effective dosage recommendations.

21) Agnimantha (Agni-mantha, Agnimamtha):
Agnimantha is a name synonymous withPremna integrifolia in traditional medicine. Its reference highlights the plant's significance in Ayurvedic practices, particularly in formulations aimed at treating various ailments, indicating a rich historical and cultural context for the therapeutic use of this plant.

22) Substance:
Substance denotes a specific material or compound. In connection withPremna integrifolia, the term emphasizes the focus on the active constituents derived from the plant that impart its pharmacological effects, drawing attention to the importance of isolating and studying these compounds for therapeutic purposes.

23) Ayurveda (Ayus-veda):
Ayurveda is a traditional system of medicine originating from India that utilizes natural plants and holistic approaches to health. The relevance ofPremna integrifolia in Ayurveda underscores its historical and cultural significance, illustrating how traditional knowledge informs contemporary pharmacological research and drug development.

24) Siddha:
Siddha is another form of traditional medicine from India, emphasizing natural healing methods. The association ofPremna integrifolia with Siddha practices reflects the plant's importance in alternative medicine systems, showcasing the interconnection of various traditional healing modalities and its potential for research and application.

25) Arani:
Araṇi is another name forPremna integrifolia, reflecting its local nomenclature in Ayurveda. This term reinforces the plant's regional significance and its integration into various traditional formulations, emphasizing the need for preserving such local knowledge in the broader context of medicinal plant research.

26) Sugar:
Sugar generally refers to sweet, soluble carbohydrates. In the context ofPremna integrifolia, the relevance relates to its potential hypoglycemic effects, indicating its usefulness in managing blood sugar levels and indicating its significance in addressing diabetes management through natural sources.

27) Hand:
Hand can symbolize the act of healing or touch in a broader metaphorical sense. In relation toPremna integrifolia, it reflects the hands-on approach of traditional medicine practitioners who utilize plants for healing, highlighting the culturally embedded practices in herbal remedies and their importance in community wellness.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Pharmacological potentials of Premna integrifolia L.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Agnimantha, Indian system of medicine, Antibacterial activity, Pharmacological activities, Phytochemical analysis, Analgesic activity, Anticancer activity, Disc diffusion method, Ethanolic extract, In vitro studies, Antinociceptive activity, Active constituent, Anti-arthritic activity, In vivo studies, Cytotoxicity, Clinical safety, Cancer cell line, Pharmacological Potential, Silver nanoparticle, Ethno-medicinal claim.

Like what you read? Consider supporting this website: