Efficacy of herbomineral compounds in managing Yakṛt Roga.

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Journal name: Ancient Science of Life
Original article title: Efficacy of herbomineral compounds and pathya (Ayurvedic dietary regime and physical exercise) in the management of Yakṛt Roga (Non-alcoholic fatty liver disease)
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

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Author:

Pragya Singhal, Tanuja Nesari, Girja Shankar Gupta


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Efficacy of herbomineral compounds and pathya (Ayurvedic dietary regime and physical exercise) in the management of Yakṛt Roga (Non-alcoholic fatty liver disease)

Year: 2015

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

Nonalcoholic fatty liver disease (NAFLD), characterized by excessive triglyceride accumulation in the liver, is increasingly recognized as a major cause of liver disease globally. The increasing prevalence of obesity, particularly in India where rates can reach up to 24%, correlates with the rise of this condition. In Ayurvedic medicine, conditions analogous to NAFLD are described as Yakṛt Roga and Medoroga, indicating a link between liver health and metabolic disorders. The study aimed to evaluate the efficacy of two herbomineral compounds, Ārogyavardhinī vaṭi and Triphalā Guggulu, combined with an Ayurvedic dietary regime and physical exercise (referred to as pathya), in managing NAFLD.

Efficacy of Combined Therapy

The study involved a total of 32 patients who presented with elevated alanine transaminase levels and sonography-confirmed fatty liver but had no other identifiable liver disease. Patients were divided into two groups: Group-A received a combination of herbomineral drugs and pathya, while Group-B received only the dietary regime and exercise guidance. Results indicated that Group-A showed statistically significant improvements in various clinical symptoms and biochemical parameters, including liver function tests, lipid profiles, fasting blood sugar, and body mass index (BMI). Specifically, the combined therapy group exhibited pronounced improvement in symptoms like abdominal pain and nausea, underscoring the potential of herbomineral compounds in the treatment of NAFLD compared to lifestyle modifications alone.

Conclusion

The findings of this study suggest that managing NAFLD necessitates a comprehensive approach that integrates Ayurvedic dietary principles with herbomineral therapies. While pathya alone yields some benefits, the addition of Ārogyavardhinī vaṭi and Triphalā Guggulu significantly enhances treatment outcomes, particularly in terms of liver function and reduction of fatty liver symptoms. Given the rising incidence of NAFLD and associated complications, further research with larger sample sizes is vital to confirm these results and offer more robust therapeutic recommendations for this prevalent metabolic disorder.

FAQ section (important questions/answers):

What is the primary objective of the study on NAFLD?

The study aimed to evaluate the effect of herbomineral drugs and Ayurvedic dietary regime, known as pathya, in managing Non-alcoholic fatty liver disease (NAFLD).

What were the main findings regarding the herbomineral compounds used?

The combined therapy group showed significant improvements in clinical symptoms and biochemical parameters, such as liver function tests and body mass index, compared to the group adhering only to dietary recommendations.

How many patients participated in the study and what was their demographic?

A total of 32 patients participated, predominantly males aged between 25 and 55 years. Most patients were found to have obesity-related symptoms and lived in rural areas.

What dietary regimen was advised to the patients in the study?

Patients were advised to follow pathya, involving specific dietary restrictions and physical exercise, which included foods known to reduce fat accumulation and promote liver health.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Efficacy of herbomineral compounds in managing Yakṛt Roga.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Pathya:
Pathya refers to the Ayurvedic dietary regime and lifestyle practices that promote health and balance in the body. It includes specific food choices and physical activities aimed at supporting the treatment of conditions like Non-alcoholic Fatty Liver Disease (NAFLD), ensuring a holistic approach to wellness.

2) Drug:
In the context of Ayurveda, a drug is a substance used to diagnose, cure, treat, or prevent diseases. This study highlights herbomineral drugs like Arogyavardhini Vati and Triphala Guggulu, which are used for managing liver diseases, indicating their role in enhancing liver function and treating metabolic disorders.

3) Triphala (Tri-phala):
Triphalā is an Ayurvedic herbal formulation comprising three fruits: Harītakī, Vibhītakī, and Āmalakī. Known for its detoxifying properties, Triphalā helps improve digestion and promotes liver health, making it relevant in the management of Non-alcoholic Fatty Liver Disease through its metabolic-enhancing benefits.

4) Guggulu:
Guggulu, derived from the resin of the Commiphora mukul tree, is a significant Ayurvedic herb known for its anti-inflammatory and lipid-lowering properties. In the context of this study, Guggulu is part of the herbal formulation Triphala Guggulu, aiding in the management of fatty liver disease.

5) Kapha:
Kapha is one of the three doshas in Ayurveda, representing the elements of earth and water. It governs structure, stability, and lubrication in the body. In the study, imbalances in Kapha are linked to obesity and liver diseases, underscoring the need for dietary and lifestyle adjustments.

6) Yakrit (Yakrt):
Yakṛt refers to the liver in Ayurveda. It is considered the source of overall health and vitality. In the context of this study, Yakṛt Roga pertains to liver diseases like NAFLD, emphasizing the importance of maintaining liver health through diet and treatment.

7) Roga:
Roga translates to 'disease' in Sanskrit. In Ayurveda, it denotes various health conditions that can arise from imbalances in doshas. This study focuses on Yakṛt Roga (liver disease), highlighting how Ayurvedic treatments aim to restore balance to prevent or manage such diseases.

8) Bhasma (Bhasman):
Bhasma refers to the calcined ash of minerals or herbs used in Ayurveda for therapeutic purposes. It is believed to enhance bioavailability and efficacy of herbal medicines. In managing liver diseases, certain Bhasmas provide detoxification and nourishment, supporting overall liver function.

9) Ahara:
Āhāra means 'food' or diet in Ayurveda. It involves the selection of nourishing and balancing foods suitable for individual constitutions. This study emphasizes the role of Āhāra, particularly pathya (wholesome food), in the management of NAFLD, illustrating the dietary approach in Ayurvedic treatment.

10) Blood:
Blood is crucial for transporting nutrients, oxygen, and waste products in the body. In Ayurveda, blood health is linked to the proper functioning of organs, including the liver. The study addresses blood parameters like ALT and triglycerides in assessing the progress of liver disease treatment.

11) Inflammation:
Inflammation is the body's response to injury or disease, often associated with pain and swelling. In the context of NAFLD, chronic inflammation can exacerbate liver damage. The study evaluates the impact of herbomineral drugs on inflammatory markers, highlighting their therapeutic potential.

12) Vomiting:
Vomiting is a symptom that can indicate gastrointestinal distress or liver pathology. In this study, vomiting (chardi) is examined as a clinical sign in patients with NAFLD. Addressing such symptoms is essential for effective treatment and improving the quality of life for affected individuals.

13) Nausea:
Nausea, often preceding vomiting, is a common symptom in various health conditions, including liver disease. The study identifies nausea (utkleśa) among clinical symptoms of NAFLD, pointing to the need for targeted Ayurvedic treatments to alleviate discomfort and promote better digestive health.

14) Gupta:
Gupta refers to Girja Shankar Gupta, one of the authors of the study. As a researcher, Gupta contributed to exploring the Ayurvedic approach to managing NAFLD, emphasizing the integration of traditional knowledge in modern medical research to improve patient outcomes.

15) Sugar:
Sugar, particularly glucose, is a vital energy source for the body. However, excessive blood sugar levels can indicate metabolic issues associated with conditions like NAFLD. The study evaluates fasting blood sugar levels as part of the biochemical assessments to monitor treatment efficacy.

16) Vati:
Vaṭi refers to a form of herbal medicine typically presented in the form of tablets in Ayurveda. Arogyavardhini Vaṭi, studied in this article, exemplifies how such formulations combine multiple herbs to enhance therapeutic outcomes in managing liver disorders effectively.

17) Triphalaguggulu (Triphala-guggulu):
Triphalā-guggulu is a specific herbal formulation consisting of Triphalā and Guggulu. This combination is used in Ayurvedic practices for its beneficial effects on metabolism and weight management. The study underscores its role in improving liver function in patients with Non-alcoholic Fatty Liver Disease.

18) Vibhitaki:
Vibhītakī, one of the three components of Triphalā, is recognized for its health benefits, including promoting digestion and supporting liver health. In the context of this study, Vibhītakī plays a role in the holistic treatment approach for managing NAFLD through its rejuvenating properties.

19) Lekhaniya:
Lekhanīya refers to the property of certain herbs or medicines that aid in the reduction of fat and toxins from the body. This quality is notable in the treatment of NAFLD, where Lekhanīya herbs assist in detoxifying the liver and improving metabolic function.

20) Haritaki:
Harītakī is one of the components of Triphalā known for its detoxifying and digestive properties. In this study, it complements the treatment of NAFLD by enhancing liver health and promoting overall metabolic balance through its cleansing actions.

21) Medoroga (Medas-roga):
Medoroga refers to obesity in Ayurveda, a condition linked to an imbalance in the metabolism of fat. The study connects Medoroga to NAFLD, suggesting that Ayurvedic interventions targeting body fat can improve liver function and metabolic health.

22) Amalaki:
Āmalakī is a key fruit in Ayurvedic medicine, known for its high vitamin C content and antioxidant properties. In this study, Āmalakī is part of Triphalā, contributing to liver health by supporting detoxification processes and enhancing the body's resistance to oxidative stress.

23) Pippali (Pippalin):
Pippalī (Piper longum) is a traditional Ayurvedic herb known for its benefits in digestion and metabolism. Its inclusion in herbal formulations aims to enhance health by promoting better nutrient absorption and reducing fat accumulation in the body, making it relevant in the context of NAFLD treatment.

24) Utklesha (Utklesa):
Utkleśa signifies the feeling of nausea, a common symptom associated with liver diseases. The study assesses how the combination of Ayurvedic treatments alleviates such discomfort, indicating the importance of holistic care in managing symptoms of Non-alcoholic Fatty Liver Disease.

25) Apathya:
Apathya refers to food and lifestyle choices that are detrimental to health in Ayurveda. This term contrasts with Pathya, emphasizing that avoiding Apathya is crucial in managing conditions like NAFLD, as harmful dietary habits can exacerbate liver dysfunction.

26) Katuka:
Kaṭukā (Picrorhiza kurroa) is a prominent herb in Ayurveda recognized for its hepatoprotective properties. Its use in the studied formulations aims to support liver function by promoting detoxification and reducing fatty liver conditions, underscoring its significance in Ayurvedic therapies.

27) Vyayama:
Vyāyāma means physical exercise in Ayurveda and is considered vital for maintaining health and balance. In this study, regular Vyāyāma is recommended as part of the Ayurvedic lifestyle approach to combat NAFLD, emphasizing its role in weight management and metabolic health.

28) Channel:
In Ayurveda, channels refer to the pathways through which substances like nutrients and energies flow in the body. The concept of channel blockage can lead to various diseases, including liver disorders, making it critical to maintain proper channel function through appropriate dietary and lifestyle practices.

29) Shleshma (Slesma):
Śleṣma is a term synonymous with Kapha dosha, representing stability and the elements of earth and water. An imbalance in Śleṣma can lead to health issues like obesity and liver disease, which the study addresses through dietary approaches aimed at restoring harmony within the body.

30) Pitta:
Pitta is one of the three primary doshas in Ayurveda, associated with fire and transformation in the body. It governs metabolic processes, including digestion. The study considers Pitta imbalances in patients with liver disorders, highlighting the need for appropriate dietary adjustments in treatment.

31) Karma (Karman):
Karma signifies action or effect in Ayurveda, referring to the principle that specific actions lead to particular results. Within the context of treatment for NAFLD, the Karma of herbs and lifestyle choices emphasizes a holistic approach toward achieving better health outcomes.

32) Tamra:
Tāmra (copper) is used in Ayurvedic medicine as Bhasma for its potential therapeutic effects, including improving digestion and reducing hyperlipidaemia. Its use in formulations aims to enhance liver health and reduce fatty liver conditions, reflecting a traditional approach to treating metabolic disorders.

33) Aruci:
Aruci denotes a loss of appetite, often a symptom in patients with liver disease. The study examines how treatments can help restore natural appetite and overall well-being through effective management of symptoms related to Non-alcoholic Fatty Liver Disease.

34) Yava:
Yava (barley) is recognized in Ayurveda for its health benefits and is often recommended as part of a balanced diet. It is particularly useful in dietary regimens aimed at reducing weight and improving metabolic health, making it beneficial for managing NAFLD.

35) Milk:
Milk is considered a nourishing food in many cultures, including Ayurveda. However, excessive consumption can lead to imbalances, particularly in Kapha dosha. The study addresses dietary habits, including milk intake, as factors influencing the development of conditions like NAFLD.

36) Emblica officinalis:
Emblica officinalis, commonly known as Amla, is a key herb in Ayurveda with potent antioxidant properties. Its role in the study reflects its significance in managing liver health by promoting detoxification and enhancing resilience against oxidative stress in patients with fatty liver disease.

37) Terminalia chebula:
Terminalia chebula is one of the three components of Triphalā and is known for its digestive and detoxifying properties. Its inclusion in the study underscores its role in treating liver disorders, enhancing metabolic functions, and supporting overall health.

38) Burning sensation:
Burning sensation, particularly in the abdomen, is symptomatic of various digestive issues, including liver problems. The study emphasizes the need to address such discomfort through holistic Ayurvedic treatments that improve liver function and reduce inflammation and associated symptoms.

39) Commiphora mukul:
Commiphora mukul is a medicinal plant from which Guggulu is derived. It is recognized for its anti-inflammatory and lipid-lowering properties. In the study's context, it demonstrates the efficacy of Guggulu in treating liver disorders by promoting healthier liver functions.

40) Abhrakabhasma (Abhraka-bhasma):
Abhraka-bhasma refers to the calcined preparation of mica used in Ayurveda, valued for its rejuvenating, detoxifying, and healing effects. Its application is significant for addressing liver health, as it enhances treatment outcomes for conditions such as NAFLD.

41) Tamrabhasma (Tamra-bhasma):
Tāmra-bhasma, or copper ash, is used in Ayurvedic formulations for its health benefits, particularly in managing metabolic disorders. Its therapeutic applications aim to improve digestion and liver function, highlighting traditional practices in treating ailments like fatty liver disease.

42) Kaphapitta (Kapha-pitta):
Kapha-pitta describes a constitutional type in Ayurveda that exhibits characteristics of both Kapha and Pitta doshas. Imbalances in this constitution can lead to metabolic disorders, including NAFLD, indicating the need for customized dietary and herbal treatments to restore balance.

43) Dravyaguna (Dravya-guna):
Dravyaguna is an essential branch of Ayurveda that studies the properties and effects of pharmaceutical substances. Its insights help in selecting appropriate herbs and formulations for treating conditions effectively, as demonstrated in the study on managing NAFLD using traditional Ayurvedic medicine.

44) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine originating in India, focusing on holistic health and balance. This study illustrates how Ayurvedic principles, particularly in dietary management and herbal therapies, are applied for treating Non-alcoholic Fatty Liver Disease, showcasing its enduring relevance.

45) Sthaulya:
Sthaulya refers to the condition of excess body fat or obesity in Ayurveda. It is linked to various health concerns, including liver disease. The study explores ways to address Sthaulya through combined Ayurvedic treatments to improve overall health and manage conditions like NAFLD.

46) Dipaniya:
Dīpanīya indicates substances that stimulate appetite and digestive fire in Ayurveda, aiding in effective digestion. Dīpanīya herbs are critical in treating conditions like NAFLD, ensuring that affected individuals can process nutrients properly, supporting recovery and metabolic improvement.

47) Abhraka:
Abhraka, or mica, is used in Ayurveda for its properties in rejuvenation and detoxification. In the context of this study, Abhraka serves as a key ingredient in formulations aimed at improving liver health and supporting the treatment of Non-alcoholic Fatty Liver Disease.

48) Bhavana (Bha-vana):
Bhāvanā refers to the process of potentiation in Ayurvedic medicine where components are prepared through specific processes to enhance their efficacy. This method elevates the therapeutic potential of herbs used in formulations for liver disease treatment, as highlighted in the study.

49) Prakriti (Prakrti):
Prakṛti signifies an individual's constitutional type in Ayurveda, determined by the unique balance of doshas. Understanding a patient's Prakṛti can guide personalized treatment plans for conditions like NAFLD, emphasizing the individualized approach central to Ayurvedic practice.

50) Caraka:
Caraka refers to an esteemed ancient Ayurvedic physician, renowned for his contributions to the science of Ayurveda, particularly in texts like the Caraka Saṃhitā. His teachings and methodologies influence modern Ayurvedic practices, including those investigating treatments for liver conditions.

51) Rakta:
Rakta translates to blood in Ayurveda and is deemed essential for vitality and health. It plays a role in various body functions, including detoxification. The study considers Rakta parameters when evaluating the health of patients with liver diseases, suggesting integrative approaches in treatment.

52) Mudga:
Mudga, or hyacinth bean, is often recommended in Ayurvedic diets. It is considered beneficial for health, particularly in reducing Kapha and treating conditions like obesity. This study highlights the inclusion of Mudga in dietary regimens aimed at managing Non-alcoholic Fatty Liver Disease.

53) Loha:
Loha refers to iron in Ayurveda and can signify various metal preparations used in health treatments. Its therapeutic properties are utilized in specific Bhasma formulations aimed at restoring balance in metabolic disorders like NAFLD, highlighting traditional applications of metal-based treatments.

54) Diet:
Diet encompasses the collection of foods consumed regularly, significantly influencing health outcomes. This study emphasizes the role of diet, particularly Pathya, in the management of NAFLD, showcasing how dietary choices can enhance treatment and support better liver health.

55) Piper longum:
Piper longum, or Long Pepper, is an important herb in Ayurveda, praised for its digestive benefits and ability to enhance the bioavailability of other herbs. Its inclusion in herbal formulations serves to support metabolic health, particularly in liver-related conditions.

56) Shuddhagandhaka (Suddhagandhaka, Shuddha-gandhaka):
Śuddha-gandhaka refers to purified sulfur used in Ayurvedic treatments known for its detoxifying and rejuvenative properties. Its use in formulations highlights its role in supporting liver functions and treating disorders like NAFLD, showcasing the integration of mineral therapies in Ayurveda.

57) Shuddhaparada (Suddhaparada, Shuddha-parada):
Śuddha-pārada represents purified mercury, regarded for its potent therapeutic effects in Ayurveda. It is employed in various Bhasma formulations due to its detoxifying properties, relevant in addressing liver ailments such as Non-alcoholic Fatty Liver Disease through traditional practices.

58) Accumulation (Accumulating, Accumulate):
Accumulated refers to the buildup of substances, such as fat in the liver in cases of NAFLD. The study addresses how Ayurvedic treatments target and reduce accumulated fats, highlighting the effectiveness of holistic approaches to restore liver health.

59) Sharngadhara (Sarngadhara, Sharnga-dhara):
Śārṅgadhara refers to an ancient text in Ayurveda that includes various medicinal formulations and practices. It provides the foundation for using herbs like Triphala and Guggulu in treating liver disorders, emphasizing the depth of knowledge in Ayurvedic treatment approaches.

60) Nimbapatra (Nimba-patra):
Nimba-patra refers to the leaves of the Neem tree, known for their medicinal properties, particularly in detoxification and skin health. In this study, Nimba-patra symbolizes the use of diverse herbal components in managing liver health through Ayurvedic principles.

61) Discussion:
Discussion refers to the section of the study where findings are analyzed and contextualized. It plays a crucial role in interpreting results from the research on NAFLD, evaluating the effectiveness of Ayurvedic treatments and identifying areas for future exploration.

62) Substance:
Substance encompasses the active components of herbs and drugs used in Ayurveda. In this study, understanding the various substances with therapeutic properties supports the formulation of treatments aimed at improving liver health and managing conditions like Non-alcoholic Fatty Liver Disease.

63) Gandhaka (Gamdhaka):
Gandhaka refers to sulfur and is utilized in Ayurvedic medicine for its detoxifying and rejuvenating effects. In the context of the study, Gandhaka contributes to the benefits of certain formulations designed to enhance liver function and treat metabolic disorders.

64) Rasayani:
Rasāyanī refers to rejuvenative substances in Ayurveda that promote vitality and longevity. These formulations are significant in managing liver health, as indicated by the study, emphasizing the need for treatments that restore function and improve the overall quality of life for patients.

65) Swelling:
Swelling, often associated with inflammation, can indicate underlying health issues. In the study, understanding swelling as a symptom of liver dysfunction aids in identifying holistic treatment approaches to alleviate discomfort and improve metabolic health effectively.

66) Activity:
Activity refers to the physiological effects produced by herbal substances in Ayurveda. The study assesses the activity of various components in promoting liver health in patients with NAFLD, underlining the importance of understanding herbal actions for effective treatment formulation.

67) Langhana (Lamghana):
Langhana represents the therapeutic action of reducing excess tissues or body fat in Ayurveda. This principle is critical in managing conditions like NAFLD, as highlighted in the study, demonstrating the significance of integrating lifestyle modifications and dietary practices in treatment plans.

68) Bhojana:
Bhojana refers to the act of eating or food in Ayurveda. The quality and type of Bhojana significantly influence health outcomes, particularly in managing liver diseases like NAFLD. The study emphasizes dietary changes as a key component of successful treatment.

69) Samhita:
Saṃhitā indicates a compendium or collection of texts in Ayurveda, providing structured knowledge about medicinal practices. References to Saṃhitā in the study reinforce the traditional foundations of Ayurvedic treatments for liver diseases and the importance of historical knowledge in modern research.

70) Lekhana:
Lekhana denotes actions related to scraping or reducing, often referring to therapies aimed at decreasing fat or toxins in the body. In the context of NAFLD, Lekhana emphasizes the goal of Ayurvedic treatments to enhance liver health by addressing excess body fat.

71) Cikitsa:
Cikitsā signifies treatment or therapy in Ayurveda. It encompasses various methods, including herbomineral formulations and dietary adjustments, aimed at restoring health. This study investigates Cikitsā approaches for managing Non-alcoholic Fatty Liver Disease, underscoring the depth of traditional treatment modalities.

72) Emerald:
Emerald may refer to the aesthetic quality or value of a place or object. In the context of the study, it highlights the establishment's sophistication and the pursuit of knowledge, perhaps suggesting a modern Ayurvedic institution's commitment to effective research and traditional practice.

73) Science (Scientific):
Science in this context relates to the systematic study of knowledge, emphasizing evidence-based approaches for understanding health and disease. The study of NAFLD through Ayurvedic perspectives merges traditional wisdom with scientific inquiry, fostering an integrative approach to healthcare.

74) Eranda (Eramda):
Eraṇḍa (castor oil) is an Ayurvedic substance known for its purgative properties. In the context of dietary regimens, it highlights the role of purgatives in detoxifying the body, particularly relevant for managing metabolic disorders like NAFLD through careful dietary choices and treatments.

75) Parada:
Pārada refers to mercury, a mineral used in Ayurveda, often in the form of Bhasmas for various therapeutic effects. Its inclusion in traditional formulations signals its potential benefits in promoting liver health, addressing conditions like NAFLD through time-honored practices.

[Note: The above list is limited to 75. Total glossary definitions available: 85]

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Discover the significance of concepts within the article: ‘Efficacy of herbomineral compounds in managing Yakrt Roga.’. Further sources in the context of Science might help you critically compare this page with similair documents:

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