Study of wound healing activity of Tectona grandis Linn. leaf extract on rats

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Journal name: Ancient Science of Life
Original article title: Study of wound healing activity of Tectona grandis Linn. leaf extract on rats
The ANSCI is a peer-reviewed, open-access journal focused on Ayurveda and traditional medicines. It publishes original research, reviews, and literary studies linking traditional knowledge with modern science, covering disciplines like botany, ethnomedicine, pharmacology, and clinical research.
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Original source:

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Author:

Sushilkumar B. Varma, Sapna P. Giri


Ancient Science of Life:

(A quarterly multi-disciplinary scientific research journal in Ayurveda)

Full text available for: Study of wound healing activity of Tectona grandis Linn. leaf extract on rats

Year: 2013

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

The study investigates the wound healing activity of Tectona grandis (TG) Linn. leaf extract using rat models. Natural products have gained attention for their therapeutic properties, particularly in wound healing. The leaves of T. grandis, known for their medicinal attributes in traditional medicine, such as anti-inflammatory and antimicrobial properties, were subjected to evaluation to ascertain their efficacy in promoting wound healing.

Efficacy of Tectona grandis Leaf Extract

The results indicated that the application of a 5% ointment of TG leaf extract significantly reduced the wound area starting from day eight in the excision wound model, while a 10% ointment and the standard treatment, soframycin, showed a remarkable reduction from day four. Additionally, in the incision wound model, both the 5% and 10% extracts significantly increased tensile strength, with the latter showing the most significant results when compared to the control. These findings suggest that the phytochemical constituents in TG leaves contribute to its wound healing effects, corroborating the traditional claims surrounding the plant's use in herbal remedies.

Conclusion

In conclusion, the research supports the potential of Tectona grandis leaf extract as an effective topical agent for enhancing wound healing. The significant reductions in wound area and increases in tensile strength indicate its viability as a therapeutic option. Despite these promising results, further studies are necessary to elucidate the mechanisms behind its healing properties and to optimize its application in traditional medicine.

FAQ section (important questions/answers):

What is the aim of the study on Tectona grandis leaf extract?

The study aims to determine the wound healing activity of Tectona grandis (TG) leaf extract in rats, assessing its effectiveness in excision and incision wound models.

How was the Tectona grandis leaf extract prepared for testing?

The leaves were collected, shade dried, and powdered. The powder was macerated in 70% ethanol for 24 hours, and the hydro-alcoholic extract was obtained through percolation, yielding approximately 25% extract.

What were the results regarding wound healing activity of TG extract?

Results indicated significant wound contraction with 5% and 10% TG ointments, with the 10% ointment showing highly significant reductions in wound area and improved tensile strength in comparison to control.

What is the conclusion drawn from the TG extract study?

The study concludes that Tectona grandis leaf extract demonstrates significant wound healing activity, supporting its use in traditional medicine for promoting healing, while suggesting further research on its potential therapeutic applications.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Study of wound healing activity of Tectona grandis Linn. leaf extract on rats”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Incision:
Incision refers to a surgical cut made in the skin or flesh for the purpose of access or treatment. In the study, the incision model was used to evaluate the healing properties of Tectona grandis leaf extract by measuring tensile strength after a controlled cut was made on rats.

2) Activity:
Activity in a scientific context often refers to the functional or reactive capacity of a substance. The study investigated the wound healing activity of Tectona grandis leaf extract, exploring its effectiveness in promoting healing in wound models, and comparing it to standard treatments.

3) Giri:
Giri, in the context of the research, refers to Dr. Sapna P. Giri, one of the authors involved in the study. Author affiliations and contributions are vital in academic papers, providing credibility and insight into the research team's expertise and background in pharmacology.

4) Drug:
Drug refers to a substance used for medical treatment. In the findings, Tectona grandis leaf extract prepared as an ointment acts as a therapeutic agent, demonstrating properties similar to conventional drugs like soframycin in promoting wound healing.

5) Pharmacology:
Pharmacology is the branch of medicine that focuses on drugs and their effects. This study falls under pharmacology as it assesses the healing effects of a natural extract and evaluates its efficacy compared to other pharmacological treatments.

6) Flavonoid:
Flavonoid is a type of phytochemical known for its antioxidant properties. The study suggests that flavonoids present in Tectona grandis significantly enhance wound healing by reducing inflammation and supporting the tissue regeneration process.

7) Medicine:
Medicine encompasses the field concerned with the diagnosis and treatment of illness. The research explores the medicinal properties of Tectona grandis leaves, supporting traditional medicine claims about their effectiveness in wound healing.

8) Water:
Water plays a crucial role in biological functions, and its importance extends to wound healing where hydration influences cellular processes. In the study, water is used during the surgical procedures for hemostasis and in the tensile strength evaluation of wounds.

9) Science (Scientific):
Scientific refers to the rigorous methodology and principles that guide research. The study adheres to scientific standards by employing controlled experiments to evaluate the effects of Tectona grandis leaf extract on wound healing in a laboratory setting.

10) Phytochemical:
Phytochemical indicates the chemical compounds produced by plants. The study focuses on the phytochemical constituents of Tectona grandis, attributing its wound healing properties to specific compounds that influence biological processes during healing.

11) Discussion:
Discussion sections of scientific papers interpret results and relate findings to prior research. This study's discussion highlights the significance of wound healing findings related to Tectona grandis and draws on existing literature to support conclusions about its efficacy.

12) Swelling:
Swelling is a common biological response to injury or inflammation. This study examines the wound healing process, where the management of swelling is crucial for recovery, emphasizing the medicinal potential of Tectona grandis extract in reducing such responses.

13) Vitiation (Vitiated):
Vitiated refers to an imbalance or disturbance in the body's natural state. In traditional medicine, such as Ayurveda, vitiated conditions indicate underlying issues that Tectona grandis is believed to remedy, especially in relation to skin and wound healing.

14) Leprosy:
Leprosy is an infectious disease that affects the skin, nerves, and mucous membranes. The study alludes to the traditional uses of Tectona grandis in treating various ailments, including conditions like leprosy, thus highlighting its historical medicinal significance.

15) Pitta:
Pitta is an Ayurvedic term referring to one of the three doshas or body energies. The paper mentions vitiated pitta conditions, suggesting that Tectona grandis leaf extract may help in restoring balance in bodily functions, particularly skin health.

16) Ulcer:
Ulcer refers to an open sore that can arise from various medical conditions. The study investigates Tectona grandis leaf extract's effectiveness in wound healing, extending its implications to treat ulcers, a common concern in traditional remedies.

17) Shaka (Saka):
Śāka is the Sanskrit term for Tectona grandis, highlighting its cultural and historical significance. The plant's traditional use in Ayurveda for various medicinal properties connects with the study's examination of its wound healing potential.

18) Post:
Post in this context refers to the period after an event, such as surgery or treatment. The study evaluates the effects of Tectona grandis leaf extract on wound healing during the post-wounding period, measuring outcomes over several days following treatment.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Study of wound healing activity of Tectona grandis Linn. leaf extract on rats’. Further sources in the context of Science might help you critically compare this page with similair documents:

Statistical analysis, Ethical Clearance, Anti-inflammatory properties, Free radical scavenging, Animal model, Wound healing activity, Phytochemical constituents, Excision wound model, Tensile strength, Incision wound model, Soframycin ointment, Hydro-alcoholic leaf extract, Healthy albino rats, Tectona grandis Linn.

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